scholarly journals Cisplatin-Associated Ototoxicity: A Review for the Health Professional

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Jessica Paken ◽  
Cyril D. Govender ◽  
Mershen Pillay ◽  
Vikash Sewram
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
At Risk ◽  
Hearing Loss ◽  
Clinical Signs ◽  
Policy Formulation ◽  
Incidence Rates ◽  
Health Care Practitioners ◽  
Mesh Terms

Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin’s ototoxic properties and the clinical signs to identify patients at risk of developing hearing loss. English peer-reviewed articles from January 1975 to July 2015 were assessed from PubMed, Science Direct, and Ebscohost. Seventy-nine articles and two books were identified for this review, using MeSH terms and keywords such as “ototoxicity”, “cisplatin”, “hearing loss”, and “ototoxicity monitoring”. This review provides an up-to-date overview of cisplatin-associated ototoxicity, namely, its clinical features, incidence rates, and molecular and cellular mechanisms and risk factors, to health care practitioners managing the patient with cancer, and highlights the need for a team-based approach to complement an audiological monitoring programme to mitigate any further loss in the quality of life of affected patients, as there is currently no otoprotective agent recommended routinely for the prevention of cisplatin-associated ototoxicity. It also sets the platform for effective dialogue towards policy formulation and strengthening of health systems in developing countries.

scholarly journals A Review of Cisplatin-Associated Ototoxicity

2019 ◽  
Vol 40 (02) ◽  
pp. 108-121 ◽  
Author(s):  
Jessica Paken ◽  
Cyril Govender ◽  
Mershen Pillay ◽  
Vikash Sewram
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
At Risk ◽  
Health Care Professionals ◽  
Monitoring Program ◽  
Clinical Signs ◽  
Incidence Rates ◽  
Cellular Mechanisms ◽  
Patients At Risk

AbstractCisplatin, an effective antineoplastic drug used in the treatment of many cancers, has ototoxic potential, thus placing cancer patients, receiving this treatment, at risk of hearing loss. It is therefore important for health care professionals managing these patients to be aware of cisplatin's ototoxic properties and its clinical signs to identify patients at risk of developing a hearing impairment. Eighty-five English peer-reviewed articles and two books, from January 1975 to July 2015, were identified from PubMed, ScienceDirect, and EBSCOhost. An overview of cisplatin-associated ototoxicity, namely its clinical features, incidence rates, molecular and cellular mechanisms, and risk factors, is presented in this article. This review further highlights the importance of a team-based approach to complement an audiological monitoring program in reducing any further loss in the quality of life of affected patients, as there is currently no otoprotective agent routinely recommended for the prevention of cisplatin-associated ototoxicity.

scholarly journals Oral health-related quality of life in patients with X-linked hypophosphatemia: a qualitative exploration

2021 ◽  
Author(s):  
Caroline Nguyen ◽  
Elisabeth Celestin ◽  
Delphine Chambolle ◽  
Agnès Linglart ◽  
Martin Biosse Duplan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Oral Health ◽  
Care Pathway ◽  
Clinical Signs ◽  
Oral Health Care ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Abstract Background. X-linked hypophosphatemia (XLH) is a rare, hereditary, and lifelong phosphate wasting disorder characterized by rickets in childhood and impaired teeth mineralization. In the oral cavity, spontaneous abscesses can often occur without any clinical signs of alteration of the causal tooth. The objective of our study was to evaluate the oral care pathway and the oral health-related quality of life (OHRQoL) of patients followed in an expert oral medicine department located within a Parisian hospital and working in close collaboration with an endocrinology department expert in this pathology. Methods. This study employed a qualitative descriptive design including semi-structured interviews using guiding themes. Results. Twenty-one patients were included in the study. The topics brought up exceeded the initial objectives as the patients mostly addressed the alteration of their oral and general quality of life; a very chaotic oral health care pathway with oral health professionals not aware of their pathology; consequences on their social, professional, and school integration; access to care complicated by financial factors. Patients declared the importance of having a multidisciplinary team around them, including medical and dental professionals.Conclusions. The variety of manifestations in patients with XLH necessitates a high coordination of multidisciplinary patient care to optimize quality of life and reduce disease burden. Oral health care pathways are very chaotic for patients who have difficulty finding professionals with sufficient knowledge of the disease. OHRQoL is therefore diminished. This situation improves when patients enter a coordinated care network.

scholarly journals Patients’ Communication Preferences Around Cancer Symptom Reporting During Cancer Treatment: A Phenomenological Study

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Sharyn Carrasco, PhD, RN
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Symptom Management ◽  
Phenomenological Study ◽  
Symptom Reporting ◽  
Communication Preferences ◽  
Health Care Practitioners

Background: The purpose of this descriptive phenomenological study was to gain an in-depth understanding of cancer patients’ experiences and perspectives on self-reporting their symptoms. Patients with cancer experience a wide variety of symptoms from both their disease and treatment, yet clinicians are often unaware of their patients’ symptoms due to poor reporting methods. Poorly documented symptoms are more likely to go untreated, causing increased symptom distress and decreased quality of life for patients. Effective, real-time communication between patients and health-care practitioners is key to symptom assessment and management. Moreover, it is important for patients’ communication preferences to be taken into account when developing symptom management plans. Methods: This qualitative study focused on the symptom reporting experiences of 13 adults in the United States with advanced or metastatic cancer who were undergoing systemic cancer treatment. Data were collected via interviews. Results: The findings revealed that a personalized symptom management plan, prompt reporting, and timely communication with health-care practitioners improved patients’ physical and emotional wellbeing. Conclusions: A better understanding of cancer patients’ experiences self-reporting their symptoms may lead to improved communication methods and more effective reporting systems, which ultimately reduce patient burden and enhance patients’ self-advocacy. Ensuring that patients’ preferences for reporting their symptoms are met may positively influence the likelihood and timeliness of symptom self-reporting. Developing new and improved ways for health-care teams to manage symptoms is vital to improving patients’ quality of life.

scholarly journals Geographical Residency and Quality of Life in Adults with and without Hearing Loss

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 854-854
Author(s):  
Marcia Hay-McCutcheon ◽  
Xin Yang
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Hearing Loss ◽  
Well Being ◽  
Normal Limits ◽  
Quality Of Life Inventory ◽  
Physical Disorders ◽  
Hearing Health ◽  
The Impact

Abstract There is an increased interest in the impact that hearing loss has on general well-being, including overall quality of life (QOL). The Quality of Life Inventory (QOLI), the Charlson Comorbidity Index and an Accessibility to Health Care questionnaire were administered to 108 participants. For adults with hearing loss who did not have access to hearing health care, lower QOL scores were reported compared to those with access to hearing health care, but this finding was not significant. Effect size calculations indicated that adults with hearing loss who lived in the most rural regions of Alabama, had lower reported QOL scores than their counterparts who had hearing within normal limits. Finally, those with higher incomes, who were older, and who had fewer physical disorders reported higher QOL compared to those with lower incomes, were younger, and who had more physical ailments. Part of a symposium sponsored by the Mental Health Practice and Aging Interest Group.

scholarly journals The Psychosocial Impact of Hearing Loss on the Quality of life in Adults with Multi-Drug Resistant Tuberculosis (Preprint)

2019 ◽  
Author(s):  
Amanda Thusi ◽  
Jessica Paken
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Hearing Loss ◽  
Well Being ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multi Drug Resistant Tuberculosis ◽  
Mdr Tb

BACKGROUND Aminoglycoside treatment used for MDR-TB is likely to result in ototoxicity. The effects of a hearing loss with a MDR-TB diagnosis are likely to have an increased impact on the overall quality of life of an individual. However, there is minimal research in the area, which would therefore indicate a possible lack of awareness to the effect of aminoglycoside treatment on the quality of life of patients. While most studies on drug resistant TB are focused on the public health concerns of the disease, the human costs of MDR-TB are sometimes overlooked. OBJECTIVE This study aims to describe the psychological, social, economic and vocational impact of hearing loss on the quality of life of adults with Multi-Drug Resistant Tuberculosis. METHODS A Qualitative Phenomenological research study will be conducted on 10 participants. All participants will have a laboratory confirmed diagnosis of Multi-Drug Resistant Tuberculosis. A semi-structured interview questionnaire will be used to collect data. Face-to-face interviews will be conducted and the participants will be audio recorded. All interviews will be conducted by the researcher. RESULTS The study has not concluded. CONCLUSIONS The quality of life of a patient needs to be considered in the health care system during treatment, as this data may drive improved national health care planning with regards to treatment of patients diagnosed with MDR-TB. Therefore, for a comprehensive assessment of patient’s health status, it is very much essential to assess the overall impact of MDR-TB on health and patient’s perception of well-being. Besides routine clinical and bacteriological assessments, this assessment can be done by assessing quality of life which has several domains. Patients diagnosed with MDR-TB who further acquire an aminoglycoside induced hearing loss may have life-long effects on their quality of life even after completion of treatment.

scholarly journals Oral Health-Related quality of life in patients with X-linked hypophosphatemia: a qualitative exploration

2021 ◽  
Author(s):  
Caroline Nguyen ◽  
Elisabeth Celestin ◽  
Delphine Chambolle ◽  
Agnès Linglart ◽  
Martin Biosse Duplan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Oral Health ◽  
Care Pathway ◽  
Clinical Signs ◽  
Oral Health Care ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Introduction. X-linked hypophosphatemia (XLH) is a rare, hereditary, and lifelong phosphate wasting disorder characterized by rickets in childhood and impaired teeth mineralization. In the oral cavity, spontaneous abscesses can often occur without any clinical signs of alteration of the causal tooth. The objective of our study was to evaluate the oral care pathway and the oral health-related quality of life (OHRQoL) of patients followed in an expert oral medicine department located within a Parisian hospital and working in close collaboration with an endocrinology department expert in this pathology. Methods. This study employed a qualitative descriptive design including semi-structured interviews using guiding themes. Results. Twenty-one patients were included in the study. The topics brought up exceeded the initial objectives as the patients mostly addressed the alteration of their oral health-related and general quality of life; a very chaotic oral health care pathway with oral health professionals not aware of their pathology; consequences on their social, professional, and school integration. Patients declared the importance of having a multidisciplinary team around them, including medical and dental professionals. Conclusions. The variety of manifestations in patients with XLH necessitates a high coordination of multidisciplinary patient care to optimize quality of life and reduce disease burden. Oral health care pathways are very chaotic for patients who have difficulty finding professionals with sufficient knowledge of the disease. OHRQoL is therefore diminished. This situation improves when patients enter a coordinated care network.

Access to Hearing Health Care, Geographical Residency, and Quality of Life in Adults With and Without Hearing Loss

2019 ◽  
Author(s):  
Marcia J. Hay-McCutcheon ◽  
Mildred Threadgill ◽  
Xin Yang ◽  
Frank Phillips
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Hearing Loss ◽  
Well Being ◽  
Analysis Of Covariance ◽  
Normal Limits ◽  
Geographical Regions ◽  
Hearing Health ◽  
The Impact

Background: There is an increased interest in the impact that hearing loss has on general well-being,including overall quality of life (QOL), to improve and expand care that is provided to individuals withhearing loss.<br />Purpose: To evaluate QOL in adults with and without access to hearing health care (HHC).<br />Research Design: A cross-sectional study examined QOL across groups of individuals with and withouthearing loss.<br />Study Sample: One hundred eight participants from West Central and South Alabama received puretonehearing evaluations. Thirty-two adults had hearing within normal limits and 76 had at least a mildhearing loss in one ear.<br />Data Collection and Analysis: The Quality of Life Inventory (QOLI), the Charlson Comorbidity Index,and an Accessibility to Health Care questionnaire were administered to all participants. The QOLI outcomeswere used as the dependent variable for the analysis of covariance (ANCOVA) statistical procedures.<br />Results: For adults with hearing loss who did not have access to HHC, lower QOL scores were reportedcompared with those with access to HHC, but this finding was not significant. Although ANCOVA resultsdid not suggest QOL differences across geographical regions, effect size calculations indicated thatadults with hearing loss who lived in the most rural regions of Alabama had lower reported QOL scoresthan their counterparts who had hearing within normal limits. Finally, those with higher incomes, whowere older, and who had fewer physical disorders reported higher QOL than those with lower incomes,who were younger, and who had more physical ailments.<br />Conclusions: Adults with hearing loss who live in regions without access to HHC might be at risk fordecreased QOL. A number of models for improving access to HHC will be necessary to decrease thispotential risk.<br />

scholarly journals Exploring the Experiences of Cancer Patients With Chemotherapy-Induced Ototoxicity: Qualitative Study Using Online Health Care Forums (Preprint)

2018 ◽  
Author(s):  
Stephanie E Pearson ◽  
John Taylor ◽  
Derek J Hoare ◽  
Poulam Patel ◽  
David M Baguley
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Hearing Loss ◽  
Cancer Patients ◽  
Health Care Professionals ◽  
Online Forums ◽  
Online Social Support ◽  
Lack Of Information ◽  
Coding Manual

BACKGROUND Many cancer patients and survivors experience permanent and life-debilitating effects, such as ototoxicity, from treatment. Ototoxicity manifests as high-frequency hearing loss and tinnitus, which can have a detrimental effect on the quality of life (QoL) of those affected. Currently, there is little information and support offered to these patients who experience ototoxicity, potentially leading to many being undiagnosed and untreated. OBJECTIVE The aim of this study was to explore the extent of ototoxic side effects, such as hearing loss and tinnitus, and their impact on cancer patients following chemotherapy treatment. Secondary objectives included detecting the time periods of onset and duration of the ototoxicity and identifying what support was available to this population. METHODS Posts from publicly available online forums were thematically analyzed using the guidelines by Braun and Clarke. A coding manual was iteratively developed to create a framework for the analysis of the ototoxicity experience among the cancer population. RESULTS A total of 9 relevant online forums were identified, consisting of 86 threads and 570 posts from 377 members. Following the bottom-up thematic analysis, 6 major themes were identified: nature of ototoxicity, time of experienced ototoxicity, information on ototoxicity, quality of life, therapies, and online social support. CONCLUSIONS There was a significant number of reports expressing concerns about the lack of information on the risk of ototoxicity. More support for those suffering is needed; for example, improved interdepartmental communication between oncology and audiology services could optimize patient care. Patients should also be encouraged to communicate with their health care professionals about their ototoxicity and relay how their QoL is impacted by ototoxicity when accessing support. Tinnitus was the most common concern and was associated with distress. Hearing loss was less common; however, it was associated with fear and employment issues. Those who reported preexisting conditions were fearful about worsening their condition as their QoL was already impacted.

Quality of Life of Youth With Hearing Loss

ASHA Leader ◽  
2010 ◽  
Vol 15 (15) ◽  
pp. 5-6
Author(s):  
Anne Skalicky ◽  
Brenda Schick ◽  
Donald Patrick
Keyword(s):  
Quality Of Life ◽  
Hearing Loss
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