scholarly journals Differences in miRNA and mRNA Profile of Papillary Thyroid Cancer Variants

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Tomasz Stokowy ◽  
Danuta Gawel ◽  
Bartosz Wojtas
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cancer Biology ◽  
Mirna Gene ◽  
The Cancer Genome Atlas ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Regulatory Pathways ◽  
Cell Variant ◽  
New Perspective

Papillary thyroid cancer (PTC) can be divided into classical variant of PTC (cPTC), follicular variant of PTC (fvPTC), and tall cell variant (tcPTC). These variants differ in their histopathology and cytology; however, their molecular background is not clearly understood. Our results shed some new light on papillary thyroid cancer biology as new direct miRNA-gene regulations are discovered. The Cancer Genome Atlas (TCGA) 466 thyroid cancer samples were studied in parallel datasets to discover potential miRNA-mRNA regulations. Additionally, miRNAs and genes differentiating PTC variants (cPTC, fvPTC, and tcPTC) were indicated. Putative miRNA regulatory pairs were discovered: hsa-miR-146b-5p with PHKB and IRAK1, hsa-miR-874-3p with ITGB4 characteristic for classic PTC samples, and hsa-miR-152-3p with TGFA characteristic for follicular variant PTC samples. MiRNA-mRNA regulations discovery opens a new perspective in understanding of PTC biology. Furthermore, our successful pipeline of miRNA-mRNA regulatory pathways discovery could serve as a universal tool to find new miRNA-mRNA regulations, also in different datasets.

scholarly journals Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer

Diagnostics ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 280 ◽  
Author(s):  
Kung-Chen Ho ◽  
Jie-Jen Lee ◽  
Chi-Hsin Lin ◽  
Ching-Hsiang Leung ◽  
Shih-Ping Cheng
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
The Cancer Genome Atlas ◽  
Papillary Thyroid ◽  
Immunohistochemical Expression ◽  
Follicular Variant ◽  
Chromatin Remodeling Complex ◽  
Cancer Genome Atlas ◽  
Integrase Interactor 1 ◽  
Benign Thyroid

Alterations in the switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complex are enriched in advanced thyroid cancer. Integrase interactor 1 (INI1), encoded by the SMARCB1 gene on the long arm of chromosome 22, is one of the core subunits of the SWI/SNF complex. INI1 immunohistochemistry is frequently used for the diagnosis of malignant rhabdoid neoplasms. In the present study, we found normal and benign thyroid tissues generally had diffusely intense nuclear immunostaining. Loss of INI1 immunohistochemical expression was observed in 8% of papillary thyroid cancer and 30% of follicular thyroid cancer. Furthermore, loss of INI1 expression was associated with extrathyroidal extension (p < 0.001) and lymph node metastasis (p = 0.038). Analysis of The Cancer Genome Atlas database revealed that SMARCB1 underexpression was associated with the follicular variant subtype and aneuploidy in papillary thyroid cancer. We speculate that SMARCB1 is an important effector in addition to NF2 and CHEK2 inactivation among thyroid cancers with chromosome 22q loss.

scholarly journals Follicular Variant of Papillary Thyroid Cancer with Breast Metastasis

2016 ◽  
Vol 7 (3) ◽  
pp. 356-358
Author(s):  
Syed Nusrath ◽  
Munish Mahajan ◽  
T. Subramanyeshwar Rao ◽  
K. V. V. N. Raju ◽  
Sudha S. Murthy
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Breast Metastasis ◽  
Follicular Variant

scholarly journals BCL2 and hsa-miR-181a-5p are potential biomarkers associated with papillary thyroid cancer based on bioinformatics analysis

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Cong Zhang ◽  
Chunrui Bo ◽  
Lunhua Guo ◽  
Pingyang Yu ◽  
Susheng Miao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Gene Regulatory Network ◽  
Papillary Thyroid Cancer ◽  
Regulatory Network ◽  
Mirna Gene ◽  
Cancer Type ◽  
Papillary Thyroid ◽  
Ppi Network ◽  
Gene Regulatory

Abstract Background The morbidity of thyroid carcinoma has been rising worldwide and increasing faster than any other cancer type. The most common subtype with the best prognosis is papillary thyroid cancer (PTC); however, the exact molecular pathogenesis of PTC is still not completely understood. Methods In the current study, 3 gene expression datasets (GSE3678, GSE3467, and GSE33630) and 2 miRNA expression datasets (GSE113629 and GSE73182) of PTC were selected from the Gene Expression Omnibus (GEO) database and were further used to identify differentially expressed genes (DEGs) and deregulated miRNAs between normal thyroid tissue samples and PTC samples. Then, Gene Ontology (GO) and pathway enrichment analyses were conducted, and a protein-protein interaction (PPI) network was constructed to explore the potential mechanism of PTC carcinogenesis. The hub gene detection was performed using the CentiScaPe v2.0 plugin, and significant modules were discovered using the MCODE plugin for Cytoscape. In addition, a miRNA-gene regulatory network in PTC was constructed using common deregulated miRNAs and DEGs. Results A total of 263 common DEGs and 12 common deregulated miRNAs were identified. Then, 6 significant KEGG pathways (P < 0.05) and 82 significant GO terms were found to be enriched, indicating that PTC was closely related to amino acid metabolism, development, immune system, and endocrine system. In addition, by constructing a PPI network and miRNA-gene regulatory network, we found that hsa-miR-181a-5p regulated the most DEGs, while BCL2 was targeted by the most miRNAs. Conclusions The results of this study suggested that hsa-miR-181a-5p and BCL2 and their regulatory networks may play important roles in the pathogenesis of PTC.

scholarly journals Radiologic and Pathologic Findings of a Follicular Variant of Papillary Thyroid Cancer with Extensive Stromal Fat: A Case Report

2015 ◽  
Vol 16 (6) ◽  
pp. 1349 ◽  
Author(s):  
Jin Woo Choi ◽  
Tae Hyung Kim ◽  
Hong Gee Roh ◽  
Won-Jin Moon ◽  
Sang Hwa Lee ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Case Report ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Pathologic Findings

scholarly journals Central Neck Compartment Metastases in Tall-Cell Variant of Papillary Thyroid Cancer

2011 ◽  
Vol 145 (2_suppl) ◽  
pp. P162-P162
Author(s):  
Benjamin R. Roman ◽  
Elana Opher ◽  
Gady Har-El ◽  
John Carew
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Tall Cell Variant ◽  
Tall Cell ◽  
Cell Variant

Pathologic Reporting of Tall-Cell Variant of Papillary Thyroid Cancer: Have We Reached a Consensus?

Thyroid ◽  
2017 ◽  
Vol 27 (12) ◽  
pp. 1498-1504 ◽  
Author(s):  
Juan C. Hernandez-Prera ◽  
Rosalie A. Machado ◽  
Sylvia L. Asa ◽  
Zubair Baloch ◽  
William C. Faquin ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Tall Cell Variant ◽  
Tall Cell ◽  
Cell Variant
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