scholarly journals Dietary Vitamin D Increases Percentages and Function of Regulatory T Cells in the Skin-Draining Lymph Nodes and Suppresses Dermal Inflammation

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Shelley Gorman ◽  
Sian Geldenhuys ◽  
Melinda Judge ◽  
Clare E. Weeden ◽  
Jason Waithman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lymph Nodes ◽  
Chemokine Receptors ◽  
Inflammatory Responses ◽  
Skin Inflammation ◽  
Dietary Vitamin ◽  
Suppressive Activity ◽  
Mesenteric Lymph Nodes ◽  
Dietary Vitamin D ◽  
Draining Lymph Nodes

Skin inflammatory responses in individuals with allergic dermatitis may be suppressed by dietary vitamin D through induction and upregulation of the suppressive activity of regulatory T (TReg) cells. Vitamin D may also promoteTRegcell tropism to dermal sites. In the current study, we examined the capacity of dietary vitamin D3to modulate skin inflammation and the numbers and activity ofTRegcells in skin and other sites including lungs, spleen, and blood. In female BALB/c mice, dietary vitamin D3suppressed the effector phase of a biphasic ear swelling response induced by dinitrofluorobenzene in comparison vitamin D3-deficient female BALB/c mice. Vitamin D3increased the percentage ofTReg(CD3+CD4+CD25+Foxp3+) cells in the skin-draining lymph nodes (SDLN). The suppressive activity ofTRegcells in the SDLN, mesenteric lymph nodes, spleen, and blood was upregulated by vitamin D3. However, there was no difference in the expression of the naturally occurringTRegcell marker, neuropilin, nor the expression of CCR4 or CCR10 (skin-tropic chemokine receptors) onTRegcells in skin, SDLN, lungs, and airway-draining lymph nodes. These data suggest that dietary vitamin D3increased the percentages and suppressive activity ofTRegcells in the SDLN, which are poised to suppress dermal inflammation.

DIETARY VITAMIN D

The Lancet ◽  
1979 ◽  
Vol 314 (8150) ◽  
pp. 1021 ◽  
Author(s):  
D.E.M Lawson
Keyword(s):  
Vitamin D ◽  
Dietary Vitamin ◽  
Dietary Vitamin D

scholarly journals Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140370 ◽  
Author(s):  
Christopher C. Gibson ◽  
Chadwick T. Davis ◽  
Weiquan Zhu ◽  
Jay A. Bowman-Kirigin ◽  
Ashley E. Walker ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dietary Vitamin ◽  
Dietary Vitamin D

Association of vitamin D with incident glaucoma: findings from the Women’s Health Initiative

2021 ◽  
pp. jim-2020-001645
Author(s):  
Laura D Carbone ◽  
Karen Johnson ◽  
Joseph C Larson ◽  
Fridtjof Thomas ◽  
Jean Wactawski-Wende ◽  
...  
Keyword(s):  
Vitamin D ◽  
Women's Health ◽  
Postmenopausal Women ◽  
Serum Levels ◽  
Dietary Vitamin ◽  
Health Initiative ◽  
Vitamin D Intake ◽  
Vitamin D Supplements ◽  
Dietary Vitamin D ◽  
The Women’S Health Initiative

The relationship between vitamin D and glaucoma is controversial. The objective of this study was to examine women from the Women’s Health Initiative (WHI) to determine if there is an association between vitamin D and incident glaucoma in postmenopausal women. We examined the association between dietary vitamin D intake, vitamin D supplements and serum 25 hydroxyvitamin D (25(OH)D) levels and the risk of developing glaucoma. 143,389 postmenopausal women from the WHI including a subset with serum 25(OH) D measurements were examined to determine the association of dietary, supplemental and serum levels of vitamin D to the development of glaucoma. Dietary intakes of vitamin D, use of vitamin D supplements and serum levels of 25(OH) D were predictors examined for the main outcome of incident glaucoma. In multivariable models adjusted for demographic, clinical variables and medication use, dietary vitamin D, vitamin D supplements, total vitamin D intake (diet plus supplements) and serum 25 (OH) D measurements were not significantly associated with incident glaucoma. In the CaD placebo-controlled intervention clinical trial, there was also no association in the active intervention arm with glaucoma. We conclude that dietary vitamin D intake, supplements and serum levels are not significantly related to the risk of developing glaucoma in postmenopausal women.

Dietary vitamin D: growth, physiological and health consequences in broiler production

2021 ◽  
pp. 1-7
Author(s):  
Rifat Ullah Khan ◽  
Shabana Naz ◽  
Hammad Ullah ◽  
Nazir Ahmad Khan ◽  
Vito Laudadio ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dietary Vitamin ◽  
Health Consequences ◽  
Broiler Production ◽  
Dietary Vitamin D

scholarly journals CLEC-2 promotes inflammatory peritoneal macrophage emigration to draining lymph nodes during endotoxemia

2020 ◽  
Author(s):  
Joshua H. Bourne ◽  
Nonantzin Beristain-Covarrubias ◽  
Malou Zuidscheroude ◽  
Joana Campos ◽  
Ying Di ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lymph Nodes ◽  
Chronic Inflammation ◽  
Peritoneal Macrophages ◽  
Sterile Inflammation ◽  
Mesenteric Lymph Nodes ◽  
Specific Strategy ◽  
Inflammatory Macrophages ◽  
Draining Lymph Nodes ◽  
Macrophage Accumulation

AbstractMacrophage recruitment during sterile inflammation and infection is essential to clear pathogens, apoptotic cells and debris. However, persistent macrophage accumulation leads to chronic inflammation. Platelets are emerging as key modulators of the inflammatory response. Here, we identify that platelet C-type-lectin-like receptor-2 (CLEC-2) is a crucial immunomodulatory receptor through the interaction with podoplanin, upregulated on inflammatory macrophages.Mechanistically, platelet CLEC-2 upregulates the expression of podoplanin and its co-ligands CD44 and ERM proteins, leading to actin rearrangement and promotion of cell migration; this is mimicked by recombinant CLEC-2-Fc (rCLEC-2-Fc). Treatment of LPS-challenged mice with rCLEC-2-Fc induces a rapid emigration of peritoneal macrophages to mesenteric lymph nodes, through a gradient generated by the podoplanin ligand, CCL21, to prime T cells. We propose that crosslinking podoplanin using rCLEC-2-Fc is a novel, cell-specific strategy to accelerate macrophage removal from the site of inflammation, and hence promote the resolution of the inflammatory response.Visual AbstractSummaryPersistent macrophage accumulation in inflamed tissue leads to chronic inflammation and organ damage. Bourne et al. identify recombinant CLEC-2-Fc crosslinking podoplanin on inflammatory macrophages, as a cell-specific strategy to accelerate their emigration to draining lymph nodes, and reduce local inflammation.

scholarly journals High Prevalence of Vitamin D Inadequacy During Late Postpartum in Canadian Mothers

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 790-790
Author(s):  
Sarah Montgomery ◽  
Angella Lee ◽  
Nasime Sarbar ◽  
Deborah Zibrik ◽  
Yvonne Lamers
Keyword(s):  
Vitamin D ◽  
British Columbia ◽  
Dietary Intake ◽  
Dietary Vitamin ◽  
Nutrient Deficiencies ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Vitamin D Intake ◽  
Pregnancy And Postpartum ◽  
Dietary Vitamin D

Abstract Objectives To assess maternal dietary intake and adequacy at postpartum and to determine whether lifestyle characteristics and breastfeeding status are related to nutrient intakes. Methods We analyzed cross-sectional data from a convenience sample of 129 mothers at 18-mo postpartum, whose families were enrolled into a randomized toddler intervention trial, in the Lower Mainland, British Columbia, Canada. The Canadian Diet History Questionnaire II (C-DHQ II) was used to estimate usual dietary intake in the mothers during the preceding 12 months (i.e., between 6- to 18-mo postpartum). Implausible energy intakes were defined as <600 kcal/day or >3500 kcals/day, and excluded from analysis. Demographic and lifestyle characteristic data about the pregnancy and postpartum time period were collected using a questionnaire. Results Maternal mean (SD) age at birth was 33.5 (4.0) years and most women were of European (46%) or Asian (38%) ethnicity, and had Bachelor's degree or higher education (70%). About 75%, 88%, and 89% did not meet their dietary requirements (i.e., intake below the EAR) for fiber, potassium, and vitamin D intakes, from food only, respectively. Considering total dietary intake from food and supplements, the prevalence of dietary vitamin D inadequacy was 25%. Women of European ethnicity had higher vitamin D intake (median (IQR) in mg/1000kcal/day: 19.5 (7.26,101)) compared to Asian women (10.8 (3.87, 21.1); P < 0.05). Dietary vitamin D intake was higher in breastfeeding (i.e., providing breastmilk as primary milk source, i.e., ³2 times/day, to their 18-mo old toddlers) compared to non- or occasionally breastfeeding mothers (20.0 (10.5, 61.1) versus 14.9 (4.28, 26.7) mg/1000kcal/day; P < 0.05). Conclusions While most Canadian mothers in this sample met the EARs for most nutrients, the prevalence of dietary inadequacy was very high for vitamin D, potassium, and fiber. Some population groups may be especially at risk of developing nutrient deficiencies in this period of life characterized by postpartum recovery and transition; targeted public health strategies may be needed to address these deficiencies. Funding Sources This study is supported by The University of British Columbia, and the British Columbia Children's Hospital Research Institute, Canada, and is funded by Société des Produits Nestlé S.A.

scholarly journals Altered ratio of dendritic cell subsets in skin-draining lymph nodes promotes Th2-driven contact hypersensitivity

2021 ◽  
Vol 118 (3) ◽  
pp. e2021364118
Author(s):  
Hannah L. Miller ◽  
Prabhakar Sairam Andhey ◽  
Melissa K. Swiecki ◽  
Bruce A. Rosa ◽  
Konstantin Zaitsev ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
Diphtheria Toxin ◽  
Fluorescein Isothiocyanate ◽  
Skin Inflammation ◽  
Contact Hypersensitivity ◽  
Type I ◽  
Th2 Response ◽  
Draining Lymph Nodes

Plasmacytoid dendritic cells (pDCs) specialize in the production of type I IFN (IFN-I). pDCs can be depleted in vivo by injecting diphtheria toxin (DT) in a mouse in which pDCs express a diphtheria toxin receptor (DTR) transgene driven by the human CLEC4C promoter. This promoter is enriched for binding sites for TCF4, a transcription factor that promotes pDC differentiation and expression of pDC markers, including CLEC4C. Here, we found that injection of DT in CLEC4C-DTR+ mice markedly augmented Th2-dependent skin inflammation in a model of contact hypersensitivity (CHS) induced by the hapten fluorescein isothiocyanate. Unexpectedly, this biased Th2 response was independent of reduced IFN-I accompanying pDC depletion. In fact, DT treatment altered the representation of conventional dendritic cells (cDCs) in the skin-draining lymph nodes during the sensitization phase of CHS; there were fewer Th1-priming CD326+ CD103+ cDC1 and more Th2-priming CD11b+ cDC2. Single-cell RNA-sequencing of CLEC4C-DTR+ cDCs revealed that CD326+ DCs, like pDCs, expressed DTR and were depleted together with pDCs by DT treatment. Since CD326+ DCs did not express Tcf4, DTR expression might be driven by yet-undefined transcription factors activating the CLEC4C promoter. These results demonstrate that altered DC representation in the skin-draining lymph nodes during sensitization to allergens can cause Th2-driven CHS.

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