scholarly journals Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Kai Zhu ◽  
Jun Li ◽  
Yulin Wang ◽  
Hao Lai ◽  
Chunsheng Wang
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Stem Cell Therapy ◽  
Chemical Properties ◽  
Genetically Engineered ◽  
Ischemic Heart

Stem cell therapy has attracted increasing attention as a promising treatment strategy for cardiac repair in ischemic heart disease. Nanoparticles (NPs), with their superior physical and chemical properties, have been widely utilized to assist stem cell therapy. With the help of NPs, stem cells can be genetically engineered for enhanced paracrine profile. To further understand the fate and behaviors of stem cells in ischemic myocardium, imaging NPs can label stem cells and be trackedin vivounder multiple modalities. Besides that, NPs can also be used to enhance stem cell retention in myocardium. These facts have raised efforts on the development of more intelligent and multifunctional NPs for cellular application. Herein, an overview of the applications of NPs-assisted stem cell therapy is given. Key issues and future prospects are also critically addressed.

New strategies for improving stem cell therapy in ischemic heart disease

2016 ◽  
Vol 21 (6) ◽  
pp. 737-752 ◽  
Author(s):  
Peisen Huang ◽  
Xiaqiu Tian ◽  
Qing Li ◽  
Yuejin Yang
Keyword(s):  
Stem Cell ◽  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Stem Cell Therapy ◽  
Ischemic Heart ◽  
New Strategies

Stem cell therapy in ischemic heart disease

2006 ◽  
Vol 21 (4) ◽  
pp. 327-342 ◽  
Author(s):  
Julia N. E. Sunkomat ◽  
Mohamed A. Gaballa
Keyword(s):  
Stem Cell ◽  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Stem Cell Therapy ◽  
Ischemic Heart

scholarly journals Stem Cell Therapy for Ischemic Heart Disease

2010 ◽  
Vol 13 (12) ◽  
pp. 1879-1897 ◽  
Author(s):  
Mohammad Nurulqadr Jameel ◽  
Jianyi Zhang
Keyword(s):  
Stem Cell ◽  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Stem Cell Therapy ◽  
Ischemic Heart

scholarly journals Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-analysis

2018 ◽  
Vol 11 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Hyunsuk Jeong ◽  
Hyeon Woo Yim ◽  
Hun-Jun Park ◽  
Youngseung Cho ◽  
Hanter Hong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Heart Disease ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Stem Cell Therapy ◽  
Meta Analysis ◽  
Ischemic Heart ◽  
Mesenchymal Stem Cell Therapy

scholarly journals Cardiomyocyte Death and Genome-Edited Stem Cell Therapy for Ischemic Heart Disease

2021 ◽  
Author(s):  
Hyun-Min Cho ◽  
Je-Yoel Cho
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Stem Cell ◽  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Genome Editing ◽  
Stem Cell Therapy ◽  
Stem Cell Therapies ◽  
Cell Therapies

AbstractMassive death of cardiomyocytes is a major feature of cardiovascular diseases. Since the regenerative capacity of cardiomyocytes is limited, the regulation of their death has been receiving great attention. The cell death of cardiomyocytes is a complex mechanism that has not yet been clarified, and it is known to appear in various forms such as apoptosis, necrosis, etc. In ischemic heart disease, the apoptosis and necrosis of cardiomyocytes appear in two types of programmed forms (intrinsic and extrinsic pathways) and they account for a large portion of cell death. To repair damaged cardiomyocytes, diverse stem cell therapies have been attempted. However, despite the many positive effects, the low engraftment and survival rates have clearly limited the application of stem cells in clinical therapy. To solve these challenges, the introduction of the desired genes in stem cells can be used to enhance their capacity and improve their therapeutic efficiency. Moreover, as genome engineering technologies have advanced significantly, safer and more stable delivery of target genes and more accurate deletion of genes have become possible, which facilitates the genetic modification of stem cells. Accordingly, stem cell therapy for damaged cardiac tissue is expected to further improve. This review describes myocardial cell death, stem cell therapy for cardiac repair, and genome-editing technologies. In addition, we introduce recent stem cell therapies that incorporate genome-editing technologies in the myocardial infarction model.

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