scholarly journals Changes of Corneal Wavefront Aberrations in Dry Eye Patients after Treatment with Artificial Lubricant Drops

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Ning Lu ◽  
Fangyu Lin ◽  
Zhu Huang ◽  
Qin He ◽  
Wei Han
Keyword(s):  
Dry Eye ◽  
Spherical Aberration ◽  
Optical Quality ◽  
Control Group ◽  
Eye Drops ◽  
Artificial Eye ◽  
Corneal Surface ◽  
Wavefront Aberrations ◽  
Corneal Aberrations

Purpose.To evaluate the corneal aberration changes in dry eye patients after treatment with artificial eye drops.Methods.Thirty mild to moderate dry eye patients treated with artificial eye drops and twenty comparable dry eye patients were recruited as controls. Anterior corneal aberrations over 3 mm and 5 mm analytical zones including total, 3rd to 5th high order aberrations (HOAs), spherical aberration (SA), and vertical (V-coma) and horizontal coma (H-coma) obtained from corneal topography data at baseline and 2 weeks after treatment were evaluated.Results.For 3 mm zone, trefoils, V-coma, H-coma terms, and 3rd and 5th HOAs were significantly decreased (p<0.05) in the treatment group. For 5 mm zone, instillation of eye drops reduced H-coma, SA terms, 3rd to 5th orders, and total HOAs all showed a significant decrease (p<0.05). The root mean square analysis of the Zernike terms also showed similar statistical results. For control group, all individual terms and total HOAs did not have significant changes over 3 mm and 5 mm zones (p>0.05).Conclusions.Treatment with artificial eye drops can effectively improve the corneal optical quality of dry eye patients by ameliorating the HOAs of anterior corneal surface.

scholarly journals Changes of wavefront aberrations and corneal surface regularity in dry eye patients measured with OPD Scan III

2020 ◽  
Author(s):  
Rongjun Liu ◽  
Baikai Ma ◽  
Yufei Gao ◽  
Yiyun Liu ◽  
HONG QI
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Spherical Aberration ◽  
Normal Group ◽  
Surface Irregularity ◽  
Corneal Surface ◽  
Wavefront Aberrations ◽  
Corneal Aberrations ◽  
New Instrument ◽  
Surface Regularity

Abstract Background To evaluate changes of wavefront aberrations and corneal surface regularity in dry eye (DE) patients with OPD Scan-III (NIDEK, JPN). Methods Twenty-seven right eyes of 27 DE patients and 23 right eyes of normal subjects were included. The examinations for ocular surface including the Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT) and corneal fluorescein staining (CFS). OPD Scan-III was used to measure anterior corneal aberrations including total corneal aberrations, high order aberration (HOA), spherical aberration (SA), coma and trefoil aberration, standard deviation of corneal power (SDP), surface regularity index (SRI) and surface asymmetry index (SAI). Statistical analysis were assessed with one sample t-test. Correlations between those parameters were also analyzed. Results Wavefront aberrations parameters including total corneal aberrations, HOA, SA, coma and trefoil in DE group were significantly higher than in normal group (P < 0.05). Corneal surface regularity parameters including SRI and SAI in DE group were significantly higher than in normal group (P < 0.05). TBUT had negative correlations with total corneal aberrations and coma (P < 0.05). Both CFS scores and central CFS scores had no correlations with wavefront aberrations parameters and had positive correlations with SDP and SRI (P༜0.05). Central CFS scores also positively correlated with SAI ( P < 0.05). Conclusions Wavefront aberrations and corneal surface irregularity are increased in DE patients. OPD Scan III was have potential to be a new instrument to evaluate the severity of DE and monitor the treatment of DE.

Effects of tear film dynamics on quality of vision

2018 ◽  
Vol 102 (12) ◽  
pp. 1615-1620 ◽  
Author(s):  
Shizuka Koh ◽  
Cynthia I Tung ◽  
Yasushi Inoue ◽  
Vishal Jhanji
Keyword(s):  
Dry Eye ◽  
Current Knowledge ◽  
Tear Film ◽  
Optical Quality ◽  
Eye Drops ◽  
Wavefront Sensors ◽  
Wavefront Aberrations ◽  
Quality Of Vision ◽  
Definition Of

The precorneal tear film is maintained by blinking and exhibits different phases in the tear cycle. The tear film serves as the most anterior surface of the eye and plays an important role as a first refractive component of the eye. Alterations in tear film dynamics may cause both vision-related and ocular surface-related symptoms. Although the optical quality associated with the tear film dynamics previously received little attention, objective measurements of optical quality using wavefront sensors have enabled us to quantify optical aberrations induced by the tear film. This has provided an objective method for assessing reduced optical quality in dry eye; thus, visual disturbances were included in the definition of dry eye disease in the 2007 Dry Eye Workshop report. In addition, sequential measurements of wavefront aberrations have provided us with valuable insights into the dynamic optical changes associated with tear film dynamics. This review will focus on the current knowledge of the mechanisms of wavefront variations that are caused by different aspects of tear film dynamics: specifically, quality, quantity and properties of the tear film, demonstrating the respective effects of dry eye, epiphora and instillation of eye drops on the quality of vision.

scholarly journals Anatomical and Visual Outcomes after LASIK Performed in Myopic Eyes with the WaveLight® Refractive Suite (Alcon® Laboratories Inc., USA)

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Imene Salah-Mabed ◽  
Sarah Moran ◽  
Emmanuelle Perez ◽  
Guillaume Debellemanière ◽  
Damien Gatinel
Keyword(s):  
Contrast Sensitivity ◽  
Dry Eye ◽  
High Myopia ◽  
Spherical Aberration ◽  
Case Series ◽  
Corneal Aberrations ◽  
Quality Of Vision ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Purpose. To evaluate changes in corneal anatomy and quality of vision following LASIK refractive surgery for mild to high myopia using the WaveLight® Refractive Suite (Alcon® Laboratories Inc., USA). Setting. Rothschild Foundation, Paris, France. Design. Prospective interventional case series. Methods. We examined 60 myopic eyes (average SE −4.5 D, from −9.3 to −0.75 D) of 30 patients from 21.3 to 38.7 years old. Pachymetry, keratometry, Q factor, corneal aberrations, visual acuity (VA), contrast sensitivity, dry eye assessment, and quality of vision were measured preoperatively, one day (D1), and 1, 3, and 6 months postoperatively. Results. 6 months postoperatively, keratometry became flatter, and the Q factor became more oblate (from −0.18 ± 0.08 to +0.19 ± 0.06). Pachymetry decreased by 117.9 ± 62.2 µm at D1 and increased by 37.87 ± 32.6 µm between D1 and M6. Refraction was emmetropic at D1 and remained stable thereafter. Six months after surgery, VA was slightly but nonsignificantly improved (<0.05 log MAR), whereas contrast sensitivity remained unchanged. Quality of vision was not affected by surgery and was more related to dry eye symptoms than to corneal HOAs (r2 = 0.49; p<0.001 vs. r2 = 0.03; p<0.001). Conclusions. LASIK surgery for moderate to high myopia, performed with the WaveLight® Refractive Suite, showed good postoperative outcomes, with demonstrated safety, predictability, efficiency, and stability. This is probably due to well-controlled spherical aberration and the use of large optical zones. Besides, we can assume that the patients’ quality of vision depends more on the postoperative dry eye disease generated by the laser than on the induced HOAs.

Dry Eye Syndrome-Related Quality of Life in Glaucoma Patients

2009 ◽  
Vol 19 (4) ◽  
pp. 572-579 ◽  
Author(s):  
Gemma Caterina Maria Rossi ◽  
Carmine Tinelli ◽  
Gian Maria Pasinetti ◽  
Giovanni Milano ◽  
Paolo Emilio Bianchi
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Ocular Surface ◽  
Cross Sectional Study ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Ocular Surface Disease Index ◽  
Symptom Scale ◽  
Cross Sectional

Purpose To verify the presence of dry eye syndrome (DES) in treated patients with glaucoma and to analyze DES's impact on the patients' quality of life (QOL) versus the control group. Methods In this observational cross-sectional study, 61 patients were enrolled at a clinical practice. Patients were divided into three groups by number of glaucoma drops instilled per day (G1=1 drop/day, G2=2 drops/day, G3=3 drops/day). A control group of 20 subjects was also selected (G0). All subjects were submitted to a complete ocular examination (including tear function and ocular surface status) and completed the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ), Glaucoma Symptom Scale (GSS) questionnaire, and Ocular Surface Disease Index (OSDI). DES was defined as presence of punctate keratitis and decreased break-up time. Statistical analysis was performed applying the Kruskal-Wallis analysis of variance and Mann-Whitney U tests (to compare median values between groups) as well as the χ2 and Fisher test (to verify significant differences). Results A total of 40% of G3 and 39% of G2 patients presented DES versus 11% of G1 and 5% of G0 (p=0.01). QOL was significantly influenced and altered (NEI-VFQ 25 total mean and GSS total mean and symptoms average: p=0.0085, p=0.006, and p=0.03, respectively). OSDI pointed out differences by group: 26% of G2 and 15% of G3 presented moderate OSDI and 15% of G3 and 8.7% of G2 severe OSDI (p>0.05). Conclusions Patients with topically treated glaucoma present DES more often than a similar control group (p=0.01). The presence of DES negatively influences the patient's QOL. The patients with glaucoma's ocular surface status should be evaluated regularly to ensure the timely detection and treatment of pathologic signs on the ocular surface.

scholarly journals Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Mária Budai-Szűcs ◽  
Gabriella Horvát ◽  
Barnabás Áron Szilágyi ◽  
Benjámin Gyarmati ◽  
András Szilágyi ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Thiol Groups ◽  
Physiological Properties ◽  
Disulphide Bond Formation ◽  
Polymer Bearing

Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups. The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation. The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface. The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease.

scholarly journals Postkeratoplasty Anterior and Posterior Corneal Surface Wavefront Analysis: Descemet’s Stripping Automated Endothelial Keratoplasty versus Penetrating Keratoplasty

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Maria L. Salvetat ◽  
Marco Zeppieri ◽  
Flavia Miani ◽  
Paolo Brusini
Keyword(s):  
Penetrating Keratoplasty ◽  
Imaging System ◽  
Case Series ◽  
Optical Quality ◽  
Endothelial Keratoplasty ◽  
Corneal Surface ◽  
Scheimpflug Imaging ◽  
Quality Of Vision ◽  
Range Test

Purpose. To compare the higher-order aberrations (HOAs) due to the anterior and posterior corneal surfaces in patients that underwent either Descemet-stripping-automated-endothelial-keratoplasty (DSAEK) or penetrating keratoplasty (PK) for endothelial dysfunction and age-matched controls. Methods. This retrospective, observational, case series included 28 patients after PK, 30 patients after DSAEK, and 30 healthy controls. A Scheimpflug imaging system was used to assess the HOAs due to the anterior and posterior corneal surfaces at 4 mm and 6 mm optical zones. Total, 3rd and 4th order HOAs were considered. Intra- and intergroup differences were assessed using the Friedman and the Kruskal-Wallis tests, respectively; paired comparisons were performed using Duncan's multiple range test. Results. Total, 3rd and 4th order HOAs due to both corneal surfaces at 4 mm and 6 mm optical zones were significantly higher in the PK group, intermediate in the DSAEK group, and lower in controls (). The most important HOAs components in both PK and DSAEK groups were trefoil and coma from the anterior corneal surface () and trefoil from the posterior corneal surface (). Conclusions. The optical quality of both corneal surfaces appeared significantly higher after DSAEK than after PK, which can increase the postoperative patient's quality of vision and satisfaction.

Optical Quality of the Eye Degraded by Time-Varying Wavefront Aberrations with Tear Film Dynamics

2007 ◽  
Vol 51 (4) ◽  
pp. 258-264 ◽  
Author(s):  
Yoko Hirohara ◽  
Toshifumi Mihashi ◽  
Shizuka Koh ◽  
Sayuri Ninomiya ◽  
Naoyuki Maeda ◽  
...  
Keyword(s):  
Tear Film ◽  
Optical Quality ◽  
Time Varying ◽  
Wavefront Aberrations

scholarly journals On the Relationship between Corneal Biomechanics, Macrostructure and Optical Properties

2021 ◽  
Author(s):  
Francisco J. Ávila ◽  
Laura Remón ◽  
Maria Concepción Marcellán
Keyword(s):  
Optical Properties ◽  
Biomechanical Properties ◽  
Optical Quality ◽  
Optical Transparency ◽  
Optical Aberrations ◽  
Corneal Aberrations ◽  
Scheimpflug Imaging ◽  
The Hierarchical Structure ◽  
The Relationship

Optical properties of the cornea are responsible for correct vision, ultrastructure allows optical transparency and biomechanical properties governs the shape, elasticity or stiffness of the cor-nea affecting ocular integrity and intraocular pressure. Therefore, optical aberrations, corneal transparency, structure and biomechanics play a fundamental role in the optical quality of hu-man vision, ocular health and refractive surgery outcomes. However, the convergence of those properties is not yet reported at macroscopic scale within the hierarchical structure of the cornea. This work explores the relationships between biomechanics, structure and optical properties (corneal aberrations and optical density) at macrostructural level of the cornea through dual Placido-Scheimpflug imaging and air-puff tonometry systems in a healthy young adult popula-tion. Results showed convergence between optical transparency, corneal macrostructure and biomechanics.

scholarly journals Deciphering the Action of Perfluorohexyloctane Eye Drops to Reduce Ocular Discomfort and Pain

2021 ◽  
Vol 8 ◽  
Author(s):  
Miguel Delicado-Miralles ◽  
Enrique Velasco ◽  
Ariadna Díaz-Tahoces ◽  
Juana Gallar ◽  
M. Carmen Acosta ◽  
...  
Keyword(s):  
Surface Temperature ◽  
Dry Eye ◽  
Meibomian Gland ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Phenol Red ◽  
Corneal Surface ◽  
Healthy Humans ◽  
Ocular Discomfort

Perfluorohexyloctane (F6H8) eyedrops have been recently introduced in Europe as a product to treat dry eye disease, based on its ability to reduce tear film instability in Meibomian gland dysfunction and evaporative dry eye disease, although its mechanism of action is still unknown. In the present pilot study, we evaluated the effects of the ocular instillation of a single drop of commercial F6H8 eyedrops in 20 healthy humans (9 women/11 men), measuring: (a) Corneal surface temperature (CST) from infrared video images; (b) tear volume using phenol red threads; (c) blinking frequency; and (d) ocular surface sensations (cold, dryness, pricking, foreign body, burning, itching, gritty, eye fatigue, watering eyes, and light-evoked discomfort sensations; scored using 10 cm Visual Analog Scales), before and 5–60 min after F6H8 or saline treatment. CST decreased and tearing and blinking frequency increased significantly after F6H8 but not after saline solution. When applied unilaterally, CST decreased only in the F6H8-treated eye. No sensations were evoked after F6H8 or saline. The corneal surface temperature reduction produced by topical F6H8 does not evoke conscious ocular sensations but is sufficient to increase the activity of corneal cold thermoreceptors, leading to an increased reflex lacrimation and blinking that may relieve dry eye condition thus reducing ocular discomfort and pain.

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