scholarly journals Association of Auricular Reflective Points and Status of Type 2 Diabetes Mellitus: A Matched Case-Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Lorna Kwai-Ping Suen ◽  
Chao Hsing Yeh ◽  
Jojo Yee Mei Kwan ◽  
Paul Hong Lee ◽  
Grace Sau Ping Yeung ◽  
...  

The reflexive property of the ear can cause various physical attributes to appear on the auricle in the presence of bodily disorders. The association of auricular signals (presence or absence of discoloration, marks after pressing, tenderness, and electrical resistance) and diabetes mellitus (DM) should be further investigated because auricular diagnosis is an objective, painless, and noninvasive method that provides rapid access to information. A matched case-control study on 282 subjects was conducted. Cases (n=141) were defined as those diagnosed with type 2 DM (T2DM). Every subject in the case group was matched with the control by age and gender. Ear diagnosis was conducted in three aspects: inspection, electrical detection, and tenderness testing. Results suggest that the tenderness and electrical conductivity of some auricular points, including “pancreas and gallbladder,” “endocrine,” “kidney,” “lower tragus,” “heart,” and “eyes,” were associated with T2DM status in Chinese population. In the subgroup analyses, certain auricular signals were also associated with glycemic control, disease duration, and related complications. Auricular diagnosis could be considered as a screening method for vulnerable populations with T2DM risk. Thus, appropriate interventions can be implemented to prevent or delay the progression of T2DM.

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82158 ◽  
Author(s):  
Hasaan G. Mohamed ◽  
Shaza B. Idris ◽  
Mutaz F. Ahmed ◽  
Olav E. Bøe ◽  
Kamal Mustafa ◽  
...  

2021 ◽  
Author(s):  
Yirou wang ◽  
Yufei Xu ◽  
Yao Chen ◽  
Yabin Hu ◽  
Qun Li ◽  
...  

Abstract Background: Kabuki syndrome (KS) is a monogenic disorder leading to special facial features, mental retardation, and multiple system malformations. KDM6A (MIM*300128) is the pathogenic gene of Kabuki syndrome type 2 (KS2, MIM#300867), which accounts for only 5%–8% of KS. Previous studies suggested that female patients with KS2 may have a milder phenotype. Thus, we summarized the phenotype and genotype of KS2 patients who were diagnosed in Shanghai Children’s Medical Center since July 2017 and conducted a 1:3 matched case-control study according to age and sex to investigate sex-specific differences between patients with and without KS2. Results There were 12 KS2 cases in this study, and 8 of them matched with 24 controls. The intelligence quotient (IQ) score of the case group was significantly lower than that of the control group (P <0.001). In addition, both the incidence of intellectual disability (ID) (IQ <70) and moderate-to-severe ID (IQ <55) were significantly higher in the case group than those in the control group (P <0.05). No sex-specific difference was found in the incidence of ID or moderate-to-severe ID between the female cases and female controls (P>0.05), whereas there was a significant difference between male cases and male controls (P <0.01). Furthermore, the rate of moderate-to-severe ID and congenital heart disease (CHD) was significantly higher in the male group than that in the female group (P <0.05).Conclusions Our results showed that a sex-specific difference was exhibited in the clinical phenotypes of KS2 patients. The incidence of CHD was higher in male patients, and mental retardation was significantly impaired. However, the female patients’ phenotype was mild.


Author(s):  
Zahra Heidari ◽  
Awat Feizi ◽  
Ammar Hassanzadeh Keshteli ◽  
Hamid Afshar ◽  
Hamidreza Roohafza ◽  
...  

2004 ◽  
Vol 21 (9) ◽  
pp. 1035-1040 ◽  
Author(s):  
A. L. Marshall ◽  
A. Chetwynd ◽  
J. A. Morris ◽  
M. Placzek ◽  
C. Smith ◽  
...  

2020 ◽  
Author(s):  
So Yeon Park ◽  
JIN SEO LEE ◽  
Jihyu Oh ◽  
Ji-Young Park

Abstract Background: Delayed antifungal therapy for candidemia leads to increased mortality. Discriminating bacterial infection from candidemia in systemic inflammatory response syndrome (SIRS) patients is very complex and difficult. Delta Neutrophil Index (DNI) is recently considered as a new factor which can distinguish infections from non-infections and reflect the severity of sepsis. We aimed to assess whether DNI can predict and provide a prognosis for candidemia in SIRS patients.Methods: A matched case-control study was conducted from July 2016 to June 2017 at Kangdong Sacred Heart Hospital. Among patients with comorbidity of SIRS, those with candidemia were classified as the case group, while those with negative blood culture results were classified as the control group. The matching conditions included age, blood culture date, and SIRS onset location. To evaluate DNI as a predictive and prognostic factor for candidemia, multivariate logistic regression was performed.Results: The 140 included patients were assigned to each group in a 1:1 ratio. DNI-D1 values measured on the blood culture date were higher in the case group ( p <0.001). In the multivariate analyses, DNI_D1 (Odds ration〔ORs〕2.138, 95% confidential interval 〔CI〕1.421-3.217, P <0.001) and Candida colonization were confirmed as predictive factors for candidemia. The cutoff value of DNI for predicting candidemia was 2.75%. The area under the curve for DNI value was 0.804 (95% CI, 0.719-0.890, p<0.001), with a sensitivity and specificity of 72.9% and 78.6%, respectively. Analysis of 14-day mortality was conducted for patients with candidemia. DNI_D1 and DNI_48, measured 2 days after the onset of candidemia, were both significantly high in the non-survivor group.Conclusion: DNI was identified to be a predictive factor for candidemia in patients wit SIRS and a prognostic factor that predicts 14-day mortality in candidemia patients. DNI, along with clinical characteristics of patients, were useful in determining the occurrence of candidemia in patients with SIRS.


2005 ◽  
Vol 14 (6) ◽  
pp. 417-425 ◽  
Author(s):  
Bruce L. Lambert ◽  
Chia-Hung Chou ◽  
Ken-Yu Chang ◽  
Eskinder Tafesse ◽  
William Carson

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