scholarly journals Is There Really Relationship between Androgenetic Alopecia and Metabolic Syndrome?

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Seyran Ozbas Gok ◽  
Asli Akin Belli ◽  
Emine Dervis
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Age Groups ◽  
Androgenetic Alopecia ◽  
Control Group ◽  
Metabolic Disturbances ◽  
Anthropometric Measures ◽  
Significant Difference ◽  
Age Range

Background.There are several studies investigating the relationship between androgenetic alopecia (AGA) and metabolic syndrome (MS) with conflicting results.Objective.We sought to investigate whether there is a relationship between AGA and MS.Methods.A case-control study including 74 male patients with AGA and 42 male controls was conducted. Age, duration of AGA, AGA onset age, anthropometric measures, body mass index, lipid parameters, fasting blood glucose, blood pressure, and presence of MS were recorded.Results.Of the 74 male AGA patients (age range 20–50 years, mean 32.14), 24 were in stage 2, 26 were in stage 3, 17 were in stage 3V, 1 was in stage 5, and 6 were in stage 7. There was no significant difference in the rate of MS between AGA and control groups(P=0.135). Among the evaluated parameters, only systolic blood pressure in AGA group was significantly higher than control group.Conclusion.In contrast to the most of the previous studies, our study does not support the link between AGA and MS. To exclude confounding factors such as advanced age and therefore metabolic disturbances, further studies are needed with large group of AGA patients including different age groups and varying severity.

scholarly journals ASSOCIATION BETWEEN SERUM URIC ACID AND METABOLIC SYNDROME

2018 ◽  
Vol 11 (10) ◽  
pp. 400 ◽  
Author(s):  
Thaslima Nandhini Js ◽  
Savitha Basker G ◽  
Vishnupriya V
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Venous Blood ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Serum Triglycerides ◽  
Significant Difference ◽  
Disease Condition ◽  
Student’S T ◽  
Student’S T Test

Objective: Metabolic syndrome is a cluster of disease condition characterized by truncal obesity, hypertriglyceridemia, elevated blood pressure, and insulin resistance. An excessive circulating uric acid (UA) level even within normal range is always comorbid with metabolic syndrome and its components. The aim of the current study was to investigate the association between metabolic syndrome and serum UA level.Methods: A total of 60 subjects were divided into two groups of healthy (30 individuals) and metabolic syndrome patients (30 individuals) from dental outpatient department of Saveetha Dental College and Hospitals. 5 ml of fasting venous blood was collected in the plain collection tubes and centrifuged, and then serum was separated. Then, the serum was used to analyze the fasting blood glucose, serum triglycerides (TGLs), and serum UA by GOD-POD, enzymatic colorimetric, and uricase method, respectively. A statistical analysis was performed using Student’s t-test. p<0.05 was considered to be statistically significant.Result: Mean body mass index (BMI), fasting blood sugar (FBS), TGL, and UA level of control group were 23.36±1.81, 84.45±13.1, 110.9±22.6, and 3.48±1.21 respectively. Mean BMI, FBS, TGL, and UA level of study group were 35.24±3.04, 122.85±23.3, 212.1±39.6 and 9.08±2.63 respectively. There is a significant difference between these two groups with p<0.0001.Conclusion: This study showed that those individuals with metabolic syndrome have higher UA level that indicates hyperuricemia which is a significant predictor of metabolic syndrome.

scholarly journals Cholesterol Transporters ABCA1 and ABCG1 Gene Expression in Peripheral Blood Mononuclear Cells in Patients with Metabolic Syndrome

Cholesterol ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Zahra Tavoosi ◽  
Hemen Moradi-Sardareh ◽  
Massoud Saidijam ◽  
Reza Yadegarazari ◽  
Shiva Borzuei ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Mononuclear Cells ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Regulation Mechanism ◽  
Healthy Individuals ◽  
Peripheral Blood Mononuclear ◽  
Significant Difference ◽  
Abca1 Expression

ABCA1 and ABCG1 genes encode the cholesterol transporter proteins that play a key role in cholesterol and phospholipids homeostasis. This study was aimed at evaluating and comparing ABCA1 and ABCG1 genes expression in metabolic syndrome patients and healthy individuals. This case-control study was performed on 36 patients with metabolic syndrome and the same number of healthy individuals in Hamadan (west of Iran) during 2013-2014. Total RNA was extracted from mononuclear cells and purified using RNeasy Mini Kit column. The expression of ABCA1 and ABCG1 genes was performed by qRT-PCR. Lipid profile and fasting blood glucose were measured using colorimetric procedures. ABCG1 expression in metabolic syndrome patients was significantly lower (about 75%) compared to that of control group, while for ABCA1 expression, there was no significant difference between the two studied groups. Comparison of other parameters such as HDL-C, FBS, BMI, waist circumference, and systolic and diastolic blood pressure between metabolic syndrome patients and healthy individuals showed significant differences (P<0.05). Decrease in ABCG1 expression in metabolic syndrome patients compared to healthy individuals suggests that hyperglycemia, related metabolites, and hyperlipidemia over the transporter capacity resulted in decreased expression of ABCG1. Absence of a significant change in ABCA1 gene expression between two groups can indicate a different regulation mechanism for ABCA1 expression.

scholarly journals Aortae of Young Rats with Metabolic Syndrome Exhibit Enhanced Vasoconstrictor Activity Than Older Rats

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
R H Ali ◽  
N M B Gamil ◽  
A M Abdelrahman ◽  
M A Ahmed ◽  
G K Megahed ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Young Adult ◽  
Fasting Blood Glucose ◽  
Age Groups ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Functional Changes ◽  
Vasoconstrictor Response ◽  
Nitrite Content

Abstract Background Metabolic syndrome (MetS) causes pathological remodeling of the heart and adjacent vessels. The functional changes in the big vessels in different age groups had not been fully delineated. Aim of the work The present study was planned to investigate aortic vasodilator and vasoconstrictor reactivity in young, adult and old female rats with MetS. Design: The experimental study was performed on 90 female albino rats randomized into 6 groups: young, adult and old rats with MetS and their respective control groups. Methods MetS was induced by feeding rats 41% fructose -containing diet and giving fructose solution (5 g fructose in 4 ml distilled water/day) by gavage in two sessions (2 ml/session). On the 8th week, all rats were sacrificed and were subjected to determination of body weight (BW), body mass index (BMI), absolute and relative visceral fat weight (VF), fasting blood glucose (FBG), plasma insulin (PI), homeostasis model of insulin resistance (HOMA-IR) and plasma lipid profile. All rats’ aortae were subjected to study of vascular reactivity to Potassium chloride (KCL), phenylephrine (PE) and acetyl choline (A.Ch) as well as estimation of nitrite content. Results On the 8th week of the study, all MetS groups developed criteria of metabolic syndrome as evidenced by the significant increase in final BW, BMI, absolute and relative VF weights, FBG, PI and HOMA-IR compared to their control group values. Also, MetS rat groups exhibited evident dyslipidemia in the form of significant increase in plasma levels of triglycerides, total cholesterol and significant decrease in HDL-cholesterol compared to their control group values. Aortae of young and adult MetS rat groups showed significant increase in their vasoconstrictor response to KCl and PE and decrease in A.Ch/KCL% and A.Ch/PE % compared to their controls, while old MetS rat group showed significantly increased vasoconstrictor response only to KCL compared to their controls. When compared to each other, young age MetS group had significantly higher vasoconstrictor response to PE compared to old MetS group despite comparable nitrite content. Conclusion Met.S causes functional vascular changes in all age groups with unexpectedly enhanced vasoconstrictor response in the young group compared to old.

scholarly journals HUBUNGAN KUALITAS TIDUR DENGAN 5 INDIKATOR SINDROMA METABOLIK PADA PERAWAT DI RUMAH SAKIT UMUM PUSAT HAJI ADAM MALIK MEDAN

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
Simon Simon
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Sleep Quality ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
T Test ◽  
Human Beings ◽  
Glucose Content ◽  
Significant Difference

 ABSTRACTHigh death rate caused by non-transmitted diseases in the world is begun with metabolic syndrome in human beings such the increase in IMT (Body Mass Index) to be obesity, the increase in blood pressure to be hypertension, the increase in blood glucose to be diabetes mellitus, and abnormality of triglycerides, and  HDL cholesterol. Many factors which trigger the indicator abnormality, and of them is bad sleep quality. The research used cross sectional design by analyzing the correlation between sleep quality and 5 metabolic syndrome indicator in female nurses in the operation room of Adam Malik Medan hospital. Sleep quality was measured by using questionnaire of Pittsburg Sleep Quality Index (PSQI), body height and weight were measured to get IMT value, blood pressure was measured by using tensimeter, blood glucose and blood lipid were measured by getting the respondent’s vena blood samples. The data were processed and analysis with independent t-test.The result with independent t-test showed that there was significant difference in IMT (sig=0,003), systolic blood pressure (sig=0,028), and fasting blood glucose content (sig=0,00). However, there was no significant difference in trigliyceride content (sig=0,519), HDL cholesterol content (sig=0,300),). The conclusion was that sleep quality was correlated with three metabolic syndrome indicators: IMT, blood pressure, and blood glucose content, but there was no correlation with trigliyceride and HDL cholesterol.Keywords: Sleep Quality, Metabolic Syndrome , T-Test, 

scholarly journals Effects of Supplementing the Usual Diet with a Daily Dose of Walnuts for Two Years on Metabolic Syndrome and Its Components in an Elderly Cohort

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 451 ◽  
Author(s):  
Ahmed Al Abdrabalnabi ◽  
Sujatha Rajaram ◽  
Edward Bitok ◽  
Keiji Oda ◽  
W. Lawrence Beeson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Retention Rate ◽  
Fasting Blood Glucose ◽  
Group Differences ◽  
Control Group ◽  
Habitual Diet ◽  
Daily Dose ◽  
Elderly Cohort ◽  
And Control

Accumulating evidence links nut consumption with an improved risk of metabolic syndrome (MetS); however, long-term trials are lacking. We examined the effects of a daily dose of walnuts for two years on MetS in a large elderly cohort. A total of 698 healthy elderly participants were randomly assigned to either a walnut supplemented or a control diet. The participants in the walnut group were provided with packaged walnuts (1, 1.5, or 2 oz. or ~15% of energy) and asked to incorporate them into their daily habitual diet. The participants in the control group were asked to continue with their habitual diet and abstain from eating walnuts and other tree nuts. Intake of n-3 fatty acid supplements was not permitted in either group. Fasting blood chemistries, blood pressure, and anthropometric measurements were obtained at baseline and at the end of intervention. A total of 625 participants (67% women, mean age 69.1 y) completed this two-year study (90% retention rate). Triglycerides decreased in both walnut (−0.94 mg/dl) and control (−0.96 mg/dl) groups, with no significant between-group differences. There was a non-significant decrease in systolic and diastolic blood pressure in the walnut group (−1.30 and −0.71 mm Hg, respectively) and no change in the control group. Fasting blood glucose decreased by ~1 point in both the walnut and control groups. There were no significant between-group differences in the development or reversion of MetS. In conclusion, supplementing the diet of older adults with a daily dose of walnuts had no effect on MetS status or any of its components, although the walnut group tended to have lower blood pressure.

scholarly journals The Effects of Combined Fruit-Infused Water (Apple, Pineapple, Strawberry, Cucumber) on Blood Pressure and Fasting Blood Glucose in Patients with Metabolic Syndrome

2021 ◽  
Vol 5 (4) ◽  
pp. 313
Author(s):  
Astri Purwanti ◽  
Sugiarto Sugiarto ◽  
Dono Indarto
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Radical Reaction ◽  
Control Group ◽  
Chi Square ◽  
Control Group Design ◽  
Before And After ◽  
Randomized Control

ABSTRACTBackground: Fruit-infused water (FIW) contains antioxidants and potassium as a antihyperglycemic and antihypertension via inhibition or break the chain of radical reaction but has not been proven in patients with MS.Purpose: To evaluate the effects of FIW on blood pressure and fasting blood glucose (FBG) in patients with MS.Method: This is a Randomized-Control Trial with pre-posttest control group design. 24 patients of Cakranegara Health Center who fulfilled the criteria were randomly divided into control (given counseling only) and treatment (counseling + FIW consists of apple, cucumber, pineapple and strawberry in 250 ml water for 14 days) groups. Blood pressure and FBG were measured before and after intervention. Chi Square was used for descriptive analyze, whereas T-test, Mann Whitney and Wilcoxon was used for differences in means.Result: In the treatment group (n=11), systolic and diastolic mean levels were decreased by 5,4 mmHg (p=0,140) and 0,9 mmHg (p=0,792) respectively. However, FBG levels were increased by 9,2 mg/dL (p=0.929). There were no differences on systolic (p=0,448), diastolic (p=0,835) and FBG (p=0,599) between two groups.Conclusion: FIW consumption are unable to improve blood pressure and FBG levels on metabolic syndrome. Keywords: Fruit-Infused Water, Blood Pressure, Fasting Blood Sugar Level, Metabolic Syndrome

scholarly journals Early-onset Male Androgenetic Alopecia and Metabolic Syndrome: Are They Associated?

2016 ◽  
Vol 02 (01) ◽  
pp. 005-009
Author(s):  
Sampada Thakare ◽  
Adarshlata Singh
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Early Onset ◽  
Tertiary Care ◽  
Androgenetic Alopecia ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Large Sample Size

Abstract Aims and objectives: To study the pattern of early-onset male androgenetic alopecia (AGA) and its association with metabolic syndrome (MetS). Study design: A case–control study was conducted in the tertiary care center, Department of Dermatology, from year 2012 to 2014. Materials and methods: A total number of 100 patients, 50 male patients with early-onset AGA cases and 50 age-matched controls, were enrolled. The Norwood–Hamilton classification was used to assess the grade of AGA. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Blood pressure, blood glucose, and lipid parameters along with waist circumference were assessed in all the study participants. Statistical analysis was done by using descriptive and inferential statistics using chi-square test and Z test for difference between two means. The statistical software used in the analysis was Statistical Package for the Social Sciences 17.0 and Graph Pad Prism 5.0, and the results with (p < 0.05) were considered significant. Results: Most common grades of early-onset male AGA were 38% with grade IV, 26% with grade IIIv (vertex), and 16% with grade III. 50% of the case group with early-onset male AGA and 10% of control group patients had MetS (p < 0.05). As compared with controls, patients with early-onset AGA had a statistically significant mean value for fasting blood sugar level (p-value 0.001), triglyceride level (p-value 0.013), waist circumference (p-value 0.004), systolic blood pressure (p-value 0.006), and diastolic blood pressure (p-value 0.010) respectively. There was no significant association between early-onset male AGA and serum levels of HDL, LDL, VLDL, and cholesterol (p > 0.05). Conclusion: It is inferred from this study that the most common grade of early-onset male AGA was grades IV and III vertex. There also was association of early-onset male AGA with MetS. More prospective studies are required with a large sample size to justify the association between early-onset male AGA and MetS.

scholarly journals Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents

2020 ◽  
Vol 33 (2) ◽  
pp. 279-288 ◽  
Author(s):  
Valeria Calcaterra ◽  
Daniela Larizza ◽  
Annalisa De Silvestri ◽  
Riccardo Albertini ◽  
Federica Vinci ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Fasting Blood Glucose ◽  
Treatment Strategies ◽  
Normal Weight ◽  
Model Assessment ◽  
Significant Difference ◽  
Gender Based

AbstractBackgroundWe depicted gender-differences in metabolic syndrome (MS) clustering before and after puberty in pediatrics, in order to develop gender specific preventive strategies for childhood obesity.MethodsWe considered 1079 children and adolescents (529 females and 550 males; mean age 11.5 ± 2.8 year). According to body mass index (BMI) percentiles the subjects were classified as normal weight BMI <75th, overweight BMI 75–95th and with obesity BMI >95th. MS was diagnosed when three of the following criteria for age and sex percentiles were met: BMI >95th, triglycerides (TGs) level >95th, high-density lipoprotein-cholesterol (HDL-c) level <5th, blood pressure (blood pressure) >95th percentile, fasting blood glucose (FBG) >100 mg/dL and/or homeostatic model assessment- insulin resistance (HOMA-IR) >97.5th percentile.ResultsThe prevalence of dismetabolic factors was similar in both genders, except for pathological BP, which was higher in males (p = 0.02). MS was detected only in patients with obesity, with a higher prevalence in pubertal than late/post-pubertal subjects (p < 0.001), without any significant difference between gender. In pre-puberty, the most common MS combination was obesity (HBMI) + hypertension (HBP) + hyperglycemia/insulin resistance (HGLY/IR) followed by HBMI + low HDL-levels (LHDL) + HGLY/IR versus HBMI + HBP + HGLY/IR followed by HBMI + HBP + LHDL, respectively, in females and males. In the early and late/post-pubertal periods, the most prevalent combination remained similar to pre-puberty, additionally in both sexes other combinations, such as HBMI + HTG + HBP + HGLY/IR, HBMI +  HBP + LHDL + HGLY/IR, HBMI + HTG + LHDL + HGLY/IR and HBMI + HTG + LHDL + HBP + HGLY/IR were also detected, differently distributed in males and females.ConclusionsWe confirm that MS is an important consequence related to obesity, particularly in the post-puberty stage. Some gender-based differences should be considered early in order to identify specific preventive and treatment strategies.

scholarly journals Evaluation of serum asprosin levels in women with metabolic syndrome in Duhok City-Kurdistan Region/Iraq

2021 ◽  
Vol 9 (8) ◽  
pp. 2240
Author(s):  
Dhia M. Sulaiman
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Demographic Data ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Control Group ◽  
Fasting Insulin ◽  
Kurdistan Region ◽  
Cross Sectional ◽  
Significant Difference

Background: Serum asprosin, a recently discovered hormone as a new adipocytokine, which has been associated with the regulation of both glucose and lipid metabolism, and insulin resistance. Metabolic syndrome considered as a disorder of lipid and glucose metabolism, with impairment in insulin function, which might be associated with serum asprosin, therefore, new researches focused on the role of asprosin in the pathogenesis of metabolic syndrome to clarify such relationship. This study aimed to evaluate serum asprosin levels in women with metabolic syndrome and compared with a woman without metabolic syndrome.Methods: This study was performed at Obstetrics and Gynecology Hospital, and Mazi medical clinics in Duhok, Kurdistan Region-Iraq, the study was established from June, 2020 to January, 2021. In this cross-sectional study, serum asprosin concertation in 40 women with metabolic syndrome were compared with a 131 women without metabolic syndrome. The demographic data were collected, serum asprosin levels, lipid profile, fasting blood glucose, fasting insulin were biochemically analyzed by using the autoanalyzer machine COBASS series 6000 and ELISA technique.Results: The mean age of women with metabolic syndrome was (24.36±3.23) and women without metabolic syndrome was (23.18±3.87), serum aspersion in women with metabolic syndrome was (18.34±5.4) ng/ml, while in women without metabolic syndrome was (7.48±5.82) with significant difference (p<0.001). In study population, there was a positive correlation between asprosin and body mass index, waist circumference, triglyceride, total cholesterol, fasting blood glucose, fasting insulin, and HOMA-IR (p<0.0001), while serum asprosin was negatively correlated with high density lipoprotein- cholesterol (p<0.01).Conclusions: The study confirms that serum asprosin in women with metabolic syndrome was higher than in the control group.  

scholarly journals Precision Nutrition Assessment of Risk for Metabolic Syndrome in Active Duty Service Members

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 943-943
Author(s):  
Mary McCarthy ◽  
Evelyn Elshaw ◽  
Barbara Szekely ◽  
Zachary Colburn ◽  
Laurel Gillette ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Behavior Change ◽  
Primary Outcome ◽  
Control Group ◽  
Nutrition Counseling ◽  
Significant Difference

Abstract Objectives Precision nutrition leverages the specificity of molecular and phenotypic differences in personalizing diet and lifestyle interventions.Objective for this phase of the study: 1) examine the effectiveness of gene-based nutrition counseling on behavior change measured by weight, body mass index (BMI), blood glucose, lipids, 25-hydroxyvitamin (OH) D, %body fat (BF), waist circumference, and blood pressure. Methods In this prospective multisite RCT, a baseline genomic profile from 70 diet-responsive genes/80 variants, is augmented by biomarkers specific to metabolic syndrome (MetS) risk for each subject. Treatment group (TG) receives gene-based nutrition counseling for six weekly sessions; Control group (CG) receives evidence-based nutrition content in pamphlets directed at preventing metabolic syndrome. A digital app provides real-time health data capture with continuous feedback and is validated by in-person interviews. Primary outcome is weight loss at 12 weeks. Results Army NW cohort has enrolled 90 subjects to date; 49 are assigned to the TG. Sample demographics: males (70%), mean age 32 yrs, 58% married, 75% Caucasian, non-Hispanic, and 78% report some college education. In females, mean BMI 28.3, %BF 34.2, waist circumference 32.2 in; males mean BMI 30.1, %BF 29, waist circumference 40 in. For MetS components, 27/90 subjects show no abnormal components yet 41/90 have 2 or 3 alterations. Elevations noted as follows: fasting blood glucose in 47%, blood pressure in 38%, and waist circumference in 30%. High variant presence is noteworthy for genes with a role in obesity and hypertension. In 71% of subjects baseline 25(OH) D ≤ 30 ng/mL. Preliminary results for primary outcome of weight loss at 12 weeks reveal no change in TG (n = 21), an average loss of 5 lbs in CG (n = 21) within groups, and a significant difference between groups; TG 197.4 (39.3) vs CG 192.6 (40.3), p &lt; .001. Conclusions Digital health integration, along with genomic data and family history, can reveal early signals of risk in a young, generally healthy, military population. Health promotion efforts must drive behavior change at both the individual and population level. Funding Sources The TriService Nursing Research Program

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