scholarly journals MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Beatriz Aparecida Fioruci-Fontanelli ◽  
Luiz Gustavo A. Chuffa ◽  
Leonardo O. Mendes ◽  
Patricia Fernanda F. Pinheiro ◽  
Flávia Karina Delella ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Seminal Fluid ◽  
Negative Impact ◽  
Ethanol Intake ◽  
Chronic Ethanol ◽  
Prostatic Tissue ◽  
Rat Models ◽  
Ethanol Drinking ◽  
Prostatic Diseases

We investigated whether chronic ethanol intake is capable of altering the MMP-2 and MMP-9 activities and TIMP-2 and TIMP-1 expression in the dorsal and lateral prostatic lobes of low (UChA) and high (UChB) ethanol-preferring rats. MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression were significantly reduced in the lateral prostatic lobe of the ethanol drinking animals. Dorsal prostatic lobe was less affected showing no significant alterations in these proteins, except for a reduction in the TIMP-1 expression in UChA rats. These important findings demonstrate that chronic ethanol intake impairs the physiological balance of the prostate extracellular matrix turnover, through downregulation of MMPs, which may contribute to the development of prostatic diseases. Furthermore, since these proteins are also components of prostate secretion, the negative impact of chronic ethanol intake on fertility may also involve reduction of MMPs and TIMPs in the seminal fluid.

Detection of prostatic tissue and seminal plasma peptides reacting with human seminal fluid acid phosphatase antibodies

1986 ◽  
Vol 18 (11) ◽  
pp. 1005-1013 ◽  
Author(s):  
Radosława Kuciel ◽  
Izydor Apostoł ◽  
Ewa Wasylewska ◽  
Włodzimierz S. Ostrowski ◽  
Iga Steuden ◽  
...  
Keyword(s):  
Acid Phosphatase ◽  
Seminal Plasma ◽  
Seminal Fluid ◽  
Prostatic Tissue

Oxidative damage after chronic ethanol intake in rat tissues: Prophylaxis of Ginkgo biloba extract

2006 ◽  
Vol 99 (2) ◽  
pp. 305-314 ◽  
Author(s):  
Ping Yao ◽  
Ke Li ◽  
You Jin ◽  
Fangfang Song ◽  
Shaoliang Zhou ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Ethanol Intake ◽  
Chronic Ethanol ◽  
Rat Tissues

The concentration of thiamphenicol in seminal fluid and prostatic tissue

1978 ◽  
Vol 4 (1) ◽  
pp. 65-71 ◽  
Author(s):  
T. A. Plomp ◽  
J. J. Mattelaer ◽  
R. A. A. Maes
Keyword(s):  
Seminal Fluid ◽  
Prostatic Tissue

scholarly journals Copulation, genital damage and early death in Callosobruchus maculatus

2006 ◽  
Vol 274 (1607) ◽  
pp. 247-252 ◽  
Author(s):  
Paul E Eady ◽  
Leticia Hamilton ◽  
Ruth E Lyons
Keyword(s):  
Reproductive Tract ◽  
Callosobruchus Maculatus ◽  
Seminal Fluid ◽  
Negative Impact ◽  
Early Death ◽  
Female Reproductive Tract ◽  
Mating Frequency ◽  
Trade Off ◽  
Female Longevity ◽  
Fluid Transfer

Antagonistic sexual coevolution stems from the notion that male and female interests over reproduction are in conflict. Such conflicts appear to be particularly obvious when male genital armature inflicts damage to the female reproductive tract resulting in reduced female longevity. However, studies of mating frequency, genital damage and female longevity are difficult to interpret because females not only sustain more genital damage, but also receive more seminal fluid when they engage in multiple copulations. Here, we attempt to disentangle the effects of genital damage and seminal fluid transfer on female longevity in the beetle Callosobruchus maculatus (Coleoptera: Bruchidae). Males copulating for the sixth time in succession inflicted greater levels of genital damage, but transferred smaller ejaculates in comparison with virgin males. The number of copulations performed by males was negatively related to female fecundity and positively related to female longevity, suggesting a trade-off between fecundity and longevity. However, inclusion of fecundity as a covariate revealed sperm and/or seminal fluid transfer to have a negative impact on female longevity above that caused by the fecundity–longevity trade-off. The consequences of multiple copulations on female longevity were examined. Females that mated twice laid more eggs and died sooner than those that mated once. However, incorporation of fecundity as a covariate into our statistical model removed the effect of female mating frequency on female longevity, indicating that double-mated females suffer greater mortality owing to the trade-off between fecundity and longevity. Males of this species are known to transfer very large ejaculates (up to 8% of their body weight), which may represent a significant nutritional benefit to females. However, the receipt of large ejaculates appears to carry costs. Thus, the interpretation of multiple mating experiments on female longevity and associated functional explanations of polyandry in this species are likely to be complex.

scholarly journals Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice

2020 ◽  
Vol 15 ◽  
pp. 263310552097541
Author(s):  
Kolter B Grigsby ◽  
Antonia M Savarese ◽  
Pamela Metten ◽  
Barbara J Mason ◽  
Yuri A Blednov ◽  
...  
Keyword(s):  
Risk Model ◽  
Ethanol Intake ◽  
Blood Alcohol ◽  
Saccharin Intake ◽  
Ethanol Drinking ◽  
Wide Range ◽  
Blood Alcohol Levels ◽  
Drinking In The Dark ◽  
Compare And Contrast

High Drinking in the Dark (HDID-1) mice represent a unique genetic risk model of binge-like drinking and a novel means of screening potential pharmacotherapies to treat alcohol use disorders (AUDs). We tested the effects of tacrolimus (0, 0.5, 1, and 2 mg/kg), sirolimus (0, 5, 10, and 20 mg/kg), palmitoylethanolamide (PEA; 0, 75, 150, and 225 mg/kg), and secukinumab (0, 5, 20, and 60 mg/kg) on binge-like ethanol intake (2-day, “Drinking in the Dark” [DID]) and blood alcohol levels (BALs) in HDID-1 mice. Tacrolimus reduced ethanol intake and BALs. Tacrolimus had no effect on water intake, but reduced saccharin intake. There was no effect of sirolimus, PEA, or secukinumab on ethanol intake or BALs. These results compare and contrast with previous work addressing these compounds or their targeted mechanisms of action on ethanol drinking, highlighting the importance of screening a wide range of models and genotypes to inform the role of neuroimmune signaling in AUDs.

scholarly journals Chronic ethanol drinking increases during the luteal menstrual cycle phase in rhesus monkeys: implication of progesterone and related neurosteroids

2019 ◽  
Vol 236 (6) ◽  
pp. 1817-1828 ◽  
Author(s):  
Brandy L. Dozier ◽  
Cara A. Stull ◽  
Erich J. Baker ◽  
Matthew M. Ford ◽  
Jeremiah P. Jensen ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Rhesus Monkeys ◽  
Chronic Ethanol ◽  
Cycle Phase ◽  
Menstrual Cycle Phase ◽  
Ethanol Drinking

Deposition of ethyl glucuronide in WHP rat hair after chronic ethanol intake

2012 ◽  
Vol 64 (3) ◽  
pp. 586-593 ◽  
Author(s):  
Anna Małkowska ◽  
Mirosław Szutowski ◽  
Wanda Dyr
Keyword(s):  
Ethanol Intake ◽  
Chronic Ethanol ◽  
Ethyl Glucuronide
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