scholarly journals The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
D. O. Yetkin ◽  
B. Dogantekin
Keyword(s):  
Thyroid Autoimmunity ◽  
Vascular Diseases ◽  
Hashimoto Thyroiditis ◽  
Control Group ◽  
Thyroid Function Tests ◽  
Lipoprotein A ◽  
Sh Group ◽  
Premenopausal Female ◽  
The Relationship ◽  
Lipid Parameters

Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relationship between Lp(a) levels and thyroid hormones in Hashimoto patients.Method. 154 premenopausal female Hashimoto patients (48 patients with overthypothyroid (OH), 50 patients with subclinical hypothyroid (SH), and 56 patients with euthyroid Hashimoto to (EH)) were enrolled in this study. The control group consists of 50 age matched volunteers. In every group, thyroid function tests and lipid parameters with Lp(a) were measured. Lp(a) excess was defined as Lp(a) > 30 mg/dL.Results. Total-C, LDL-C, TG, and Lp(a) levels were increased in Hashimoto group. Total-C, LDL-C, and TG levels were higher in SH group than in the control group. Total-C and LDL-C levels were also higher in EH group compared to controls. Lp(a) levels were similar in SH and EH groups with controls. However, excess Lp(a) was more common in subclinical hypothyroid and euthyroid Hashimoto group than in the control group.Conclusion. The Total-C and LDL-C levels and excess Lp(a) were higher even in euthyroid Hashimoto patients. Thyroid autoimmunity may have some effect on Lp(a) and lipid metabolism.

scholarly journals The Evaluation of Thyroid Diseases in Patients with Pemphigus Vulgaris

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Mukaddes Kavala ◽  
Esra Kural ◽  
Emek Kocaturk ◽  
Ilkin Zindanci ◽  
Zafer Turkoglu ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Systemic Corticosteroid ◽  
Thyroid Autoimmunity ◽  
Pemphigus Vulgaris ◽  
Hashimoto Thyroiditis ◽  
Thyroid Diseases ◽  
Control Group ◽  
Thyroid Disorders ◽  
Thyroid Function Tests ◽  
Antithyroid Antibodies

Background. Thyroid disorders may affect all of the organ systems of the body and they are also highly associated with a wide variety of skin disorders. The aim of this study was to investigate the prevalence of thyroid function abnormalities and thyroid autoimmunity in patients with pemphigus vulgaris (PV) and to determine the association between thyroid disorders and clinical involvement and systemic corticosteroid treatment in patients with PV.Methods. The study consisted of eighty patients with PV and eighty healthy individuals. Thyroid functions (fT3, fT4, and TSH) and thyroid autoimmunity (anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg) antibodies) were investigated in both groups. Primary thyroid disease (PTD) was diagnosed with one or more of the following diagnostic criteria: (i) positive antithyroid antibodies, (ii) primary thyroid function abnormalities.Results. Significant changes in the serum thyroid profile were found in 16% (13/80) of the PV group and 5% (4/80) of the control group. Positive titers of antithyroid antibodies (anti-TPO and anti-Tg) were observed in 7 patients (9%) with PV and one in the control group (1,2%). Hashimoto thyroiditis was diagnosed in 9% of PV patients and it was found to be more prevalent in the mucosal form of PV. PTD was found in 13 of (%16) PV patients which was significantly high compared to controls. PTD was not found to be associated with systemic corticosteroid use. Free T3 levels were significantly lower in PV group compared to the control group and free T4 levels were significantly higher in PV group compared to the controls.Conclusions. PV may exist together with autoimmune thyroid diseases especially Hashimoto thyroiditis and primer thyroid diseases. Laboratory work-up for thyroid function tests and thyroid autoantibodies should be performed to determine underlying thyroid diseases in patients with PV.

scholarly journals Lipoprotein (a) levels, apolipoprotein (a) phenotypes and thyroid autoimmunity

1999 ◽  
pp. 474-476 ◽  
Author(s):  
ET Bairaktari ◽  
AD Tselepis ◽  
HJ Millionis ◽  
MS Elisaf
Keyword(s):  
Molecular Weight ◽  
Thyroid Autoimmunity ◽  
Inverse Correlation ◽  
Serum Lipoprotein ◽  
Control Group ◽  
Lipoprotein A ◽  
Apolipoprotein A ◽  
Median Serum ◽  
Lipid Parameters ◽  
Age And Sex

It has been reported that euthyroid normolipidemic males and postmenopausal females exhibit significantly higher serum lipoprotein (a) (Lp(a)) levels compared with age- and sex-matched normolipidemic controls. However, it is well known that there is an inverse correlation between Lp(a) concentration and apolipoprotein (a) (apo(a)) isoform size. Thus, it is imperative to exclude differences in apo(a) isoform frequencies between subjects with or without thyroid autoimmunity in order to verify if there is an association between thyroid autoimmunity and increased Lp(a) concentration. To exclude such an effect of different apo(a) isoform frequencies, we determined apo(a) phenotypes in 22 patients (9 males and 13 postmenopausal females) with thyroid autoimmunity and in 64 (29 males and 35 females) age- and sex-matched individuals without thyroid autoimmunity (control group). There were no significant differences in the values of lipid parameters between the two groups, including Lp(a). We did not detect any significant differences in the apo(a) phenotype frequencies between the two groups. Additionally, in neither of the subgroups formed according to the presence of low molecular vs high molecular weight apo(a) isoforms were there any significant differences in median serum Lp(a) levels between patients with and without thyroid autoimmunity. Thus, our results contradict the previously reported association between thyroid autoimmunity and Lp(a) concentrations.

Impact of Physical Activity on the Incidence of Vascular Diseases in Adults with Type 2 Diabetes Mellitus

2019 ◽  
Vol 8 ◽  
pp. 1549
Author(s):  
Babak Pezeshki ◽  
Ehsan Bahramali ◽  
Amir Ansari ◽  
Aliasghar Karimi ◽  
Mojtaba Frajam ◽  
...  
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Vascular Function ◽  
Vascular Diseases ◽  
Major Complication ◽  
Control Group ◽  
Case Group ◽  
Vascular Events ◽  
The Relationship

Background: Diabetes mellitus (DM) is a common metabolic disease worldwide and has many complications. The vascular events are the major complication of DM that have an important effect on mortality and disability. The physical activity (PA) enhances the vascular function by several pathways. The aim of this study was to evaluation of the relationship between PA and vascular diseases in patients with DM.Materials and Methods: This research was performed as the case-control study that was extracted from a prospective epidemiological research study in Iran (PERSIAN). The patients with type 2 DM more than six months defined as case group and the non-DM subjects in control group with ratio 1:2, and both groups were matched in the term of age and sex. The MET score was used to evaluate the level of PA and blood glucose, lipid profile, body mass index, overweight, dyslipidemia, glomerular filtration rate, myocardial infarction (MI), unstable angina, and stroke.Results: Overall, 1242 patients with DM were extracted, and 2484 non-diabetic subjects were investigated. In the case group, 355(28.6 %) and 887(71.4%) were men and women, respectively, the and 710 (28.6%) men and 1774(71.4%) women in control group. The mean MET score was 30 and 40.97 in the DM and non-DM groups, respectively (P˂0.001). The frequency of MI, stroke, and cardiac ischemia were 44 (3.5%), 37 (3%), and 267 (21.5%), respectively in DM group, and 54 (2.2%), 43 (1.7%), and 389 (15.7%), respectively in non-DM group.Conclusion: The incidence of vascular events associated with PA level in patients with DM and adherence to regular PA reduce the vascular events and DM complications. [GMJ.2019;inpress:e1549]

scholarly journals Evaluation of serum anti-Mullerian hormone levels in women with Hashimoto thyroiditis in the reproductive age

2020 ◽  
Author(s):  
Ilknur Ozturk Unsal ◽  
Sema Hepsen ◽  
Pinar Akhanli ◽  
Murat Calapkulu ◽  
Muhammed Erkam Sencar ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Thyroid Autoimmunity ◽  
Premenopausal Women ◽  
Hashimoto Thyroiditis ◽  
Reproductive Age ◽  
Control Group ◽  
Autoimmune Thyroid ◽  
High Prevalence ◽  
Healthy Control ◽  
Antibody Levels

Abstract Background Autoimmune thyroid disease in women is associated with subfertility and early pregnancy loss, and patients with primary ovarian insufficiency have a high prevalence of thyroid autoimmune disorders. The aim of this study was to investigate the association between Hashimoto thyroiditis and ovarian reserve. Methods Levels of serum thyroid stimulating hormones, thyroid autoantibodies, and anti-Mullerian hormone (AMH) were measured in women with Hashimoto thyroiditis (HT) and a healthy control group between 2018 and 2019. Result Evaluation was made of 108 premenopausal women with Hashimoto thyroiditis. A control group was formed of 172 healthy female subjects with normal anti-thyroid antibody levels and thyroid function. Serum AMH levels were determined to be significantly lower in the HT group compared to the control group. Conclusion Ovarian reserve evaluated by serum AMH concentration is affected by thyroid autoimmunity independently of anti-thyroid antibodies type or titers.

scholarly journals The effect of Thyroid Autoimmunity on Dyslipidemia in patients with Euthyroid Hashimoto Thyroiditis

2021 ◽  
Vol 37 (5) ◽  
Author(s):  
Hasret Cengiz ◽  
Taner Demirci ◽  
Ceyhun Varım ◽  
Ali Tamer
Keyword(s):  
Total Cholesterol ◽  
Significant Positive Correlation ◽  
Thyroid Autoimmunity ◽  
Hashimoto Thyroiditis ◽  
Negative Control ◽  
Correlation Relationship ◽  
Positive Correlation ◽  
Creative Commons ◽  
University Medicine ◽  
The Relationship

Background & Objective: The relationship between thyroid disorders and dyslipidemia has now been clearly demonstrated, but the relationship between thyroid autoimmunity and dyslipidemia in euthyroid patients is still controversial. Our aim in this study was to determine whether there is a risk of dyslipidemia in our patients with euthyroid hashimoto thyroiditis. Methods: Fifty-five autoantibody positive hashimoto patients and 55 antibody negative control groups who came to Sakarya University Medicine Faculty Endocrinology Outpatient Clinics between January 2018 and November 2019 were included in our case control study. The groups were similar in terms of age, cardiovascular risk factors and BMI. Both groups were compared according to the lipid profile results. Results: All type of lipids; including LDL (p = 0.008), HDL (p = 0.041), triglyceride (p = 0.045) and total cholesterol (p = 0.002), were higher in the patient group, and these differences were statistically significant. Anti-TPO and Anti-TG antibody titers and lipid levels were evaluated by separate correlation analysis. There was a significant positive correlation between Anti-TPO and LDL (r = 0.331, p <0.001), triglyceride (r = 0.267, p = 0.005) and total cholesterol (r = 0.316, p = 0.001), however no significant correlation was observed between Anti-TPO and HDL. Similarly, there was a significant positive correlation between Anti-TG and LDL (r = 0.318, p = 0.001), triglyceride (r = 0.218, p = 0.022), and total cholesterol (r = 0.301, p = 0.001), but HDL correlation relationship was not detected. Conclusion: The relationship between thyroid autoimmunity and dyslipidemia has been demonstrated in our study even in the euthyroid phase. Whether antibody positive patients should be followed more closely for dyslipidemia and cardiovascular events is still controversial. This question will be answered with larger randomized controlled trials. doi: https://doi.org/10.12669/pjms.37.5.3883 How to cite this:Cengiz H, Demirci T, Varim C, Tamer A. The effect of Thyroid Autoimmunity on Dyslipidemia in patients with Euthyroid Hashimoto Thyroiditis. Pak J Med Sci. 2021;37(5):---------. doi: https://doi.org/10.12669/pjms.37.5.3883 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract 427: Plasma PCSK9 Levels Are Positively Correlated With LDL-Cholesterol Concentrations in Familial Hypercholesterolemia

2014 ◽  
Vol 34 (suppl_1) ◽  
Author(s):  
Jean-Philippe Drouin-Chartier ◽  
André J Tremblay ◽  
Jean-Charles Hogue ◽  
Teik C Ooi ◽  
Benoît Lamarche ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Autosomal Dominant ◽  
Ldl Cholesterol ◽  
Ldl Receptor ◽  
Lipid Lowering ◽  
Control Group ◽  
Ldlr Gene ◽  
Lipoprotein A ◽  
Intracellular Degradation ◽  
The Relationship

Autosomal dominant familial hypercholesterolemia (FH) is caused by mutations in the LDL receptor (LDLR), its ligand apoB or proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. PCSK9 regulates LDL-C levels by binding to LDLR, thereby enhancing its intracellular degradation. Although PCSK9 levels have been shown to be elevated in FH subjects, the extent to which PCSK9 levels correlate with LDL-C concentrations in FH has not been examined. Therefore, the objective of the present study was to assess the relationship between PCSK9 and LDL-C levels in a large cohort of genetically defined French-Canadian (FC) FH subjects. A total of 292 FH heterozygotes (heFH) carrying one of the nine FC mutations in the LDLR gene were recruited. 226 subjects were carriers of a negative receptor (NR) mutation in the LDLR gene, while the other 66 were carriers of a defective (DR) LDLR gene mutation. 56 control subjects matched for gender and body mass index (BMI) were also recruited. Fasting blood samples were collected after a 6-week period without lipid lowering medication. PCSK9 levels were significantly higher in the heFH group than in the control group (317.9 ng/ml vs 203.3 ng/ml; P<0.001). In the heFH group, PCSK9 levels were positively and independently correlated with LDL-C concentrations and predicted 8.1% (P<0.001) of the variability in LDL-C levels. Age, the type of LDLR mutation (NR vs DR), and BMI were also significantly associated with the variability in LDL-C levels, predicting 13.6% (P<0.001), 3.9% (P<0.001), and 1.8% (P=0.02) of the LDL-C variance, respectively. Interestingly, PCSK9 levels were also positively correlated with lipoprotein(a) levels in heFH (r=0.20; P<0.001). These results indicate that PCSK9 levels are positively correlated with LDL-C and lipoprotein(a) concentrations in heFH.

scholarly journals Evaluation of serum anti-Mullerian hormone levels in women with Hashimoto thyroiditis in the reproductive age

2020 ◽  
Author(s):  
Ilknur Ozturk Unsal ◽  
Sema Hepsen ◽  
Pinar Akhanli ◽  
Murat Calapkulu ◽  
Muhammed Erkam Sencar ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Thyroid Autoimmunity ◽  
Premenopausal Women ◽  
Hashimoto Thyroiditis ◽  
Reproductive Age ◽  
Control Group ◽  
Autoimmune Thyroid ◽  
High Prevalence ◽  
Healthy Control ◽  
Antibody Levels

Abstract Background: Autoimmune thyroid disease in women is associated with subfertility and early pregnancy loss, and patients with primary ovarian insufficiency have a high prevalence of thyroid autoimmune disorders. The aim of this study was to investigate the association between Hashimoto thyroiditis (HT) and ovarian reserve.Methods: Levels of serum thyroid stimulating hormones, thyroid autoantibodies, and anti-Müllerian hormone (AMH) were measured in women with HT and a healthy control group between 2018 and 2019. Result: Evaluation was made of 108 premenopausal women with HT. A control group was formed of 172 healthy female subjects with normal anti-thyroid antibody levels and thyroid function. Serum AMH levels were determined to be significantly lower in the HT group compared to the control group.Conclusion: Ovarian reserve evaluated by serum AMH concentration is affected by thyroid autoimmunity independently of anti-thyroid antibodies type or titers.

Adolescents’ self-mutilation - Relationship with dependent behaviour

2003 ◽  
Vol 62 (4) ◽  
pp. 241-249 ◽  
Author(s):  
M. Bolognini ◽  
B. Plancherel ◽  
J. Laget ◽  
P. Stéphan ◽  
O. Halfon
Keyword(s):  
Suicide Attempts ◽  
Clinical Sample ◽  
Control Sample ◽  
Clinical Population ◽  
Control Group ◽  
Clinical Group ◽  
Self Mutilation ◽  
Self Harm ◽  
Partial Overlap ◽  
The Relationship

The aim of this study, which was carried out in the French-speacking part of Switzerland, was to examine the relationship between suicide attempts and self-mutilation by adolescents and young adults. The population, aged 14-25 years (N = 308), included a clinical sample of dependent subjects (drug abuse and eating disorders) compared to a control sample. On the basis of the Mini Neuropsychiatric Interview ( Sheehan et al., 1998 ), DSM-IV criteria were used for the inclusion of the clinical population. The results concerning the occurrence of suicide attempts as well as on self-mutilation confirm most of the hypotheses postulated: suicidal attempts and self-mutilation were more common in the clinical group compared to the control group, and there was a correlation between suicide attempts and self-mutilation. However, there was only a partial overlap, attesting that suicide and self-harm might correspond to two different types of behaviour.

Plasma Levels of Lipoprotein(a) Are Elevated in Patients with the Antiphospholipid Antibody Syndrome

1994 ◽  
Vol 71 (04) ◽  
pp. 424-427 ◽  
Author(s):  
Masahide Yamazaki ◽  
Hidesaku Asakura ◽  
Hiroshi Jokaji ◽  
Masanori Saito ◽  
Chika Uotani ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Active Form ◽  
Plasminogen Activator Inhibitor ◽  
Arterial System ◽  
Control Group ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Lipoprotein A ◽  
Soluble Thrombomodulin ◽  
Relationship Of

SummaryThe mechanisms underlying clinical abnormalities associated with the antiphospholipid antibody syndrome (APAS) have not been elucidated. We measured plasma levels of lipoprotein(a) [Lp(a)], the active form of plasminogen activator inhibitor (active PAI), thrombin-antithrombin III complex (TAT) and soluble thrombomodulin (TM), to investigate the relationship of these factors to thrombotic events in APAS. Mean plasma levels of Lp(a), TAT, active PAI and TM were all significantly higher in patients with aPL than in a control group of subjects. Plasma levels of Lp(a) and active PAI were significantly higher in patients with aPL and arterial thromboses than in patients with aPL but only venous thromboses. There was a significant correlation between plasma levels of Lp(a) and active PAI in patients with aPL. These findings suggest that patients with aPL are in hypercoagulable state. High levels of Lp(a) in plasma may impair the fibrinolytic system resulting in thromboses, especially in the arterial system.

Endothelial Dysfunction and Inflammatory Markers of Vascular Disease

2020 ◽  
Vol 19 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Sevket Balta
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Disease ◽  
Inflammatory Markers ◽  
Vascular Diseases ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Non Invasive ◽  
Von Willebrand ◽  
The Relationship ◽  
Willebrand Factor

: Vascular diseases are the main reason for morbidity and mortality worldwide. As we know, the earlier phase of vascular diseases is endothelial dysfunction in humans, the endothelial tissues play an important role in inflammation, coagulation, and angiogenesis, via organizing ligand-receptor associations and the various mediators’ secretion. We can use many inflammatory non-invasive tests (flowmediated dilatation, epicedial fat thickness, carotid-intima media thickness, arterial stiffness and anklebrachial index) for assessing the endothelial function. In addition, many biomarkers (ischemia modified albumin, pentraxin-3, E-selectin, angiopoietin, endothelial cell specific molecule 1, asymmetrical dimethylarginine, von Willebrand factor, endothelial microparticles and endothelial progenitor cells) can be used to evaluate endothelial dysfunction. We have focused on the relationship between endothelial dysfunction and inflammatory markers of vascular disease in this review.

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