scholarly journals Extramedullary Plasmacytoma of the Larynx Treated by a Surgical Endoscopic Approach and Radiotherapy

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Massimiliano Pino ◽  
Filippo Farri ◽  
Pietro Garofalo ◽  
Fausto Taranto ◽  
Andrea Toso ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Soft Tissues ◽  
Neck Region ◽  
Extramedullary Plasmacytoma ◽  
Head And Neck Region ◽  
History Of ◽  
Uncommon Case ◽  
Disseminated Disease ◽  
Transoral Resection ◽  
Suspension Laryngoscopy

Extramedullary plasmacytoma (EMP) is a rare variant of plasma cell myeloma that affects soft tissues. The head and neck region are the most affected sites, although others have also been described. Herein we report an uncommon case of EMP of the larynx in a 65-year-old male who presented with a history of progressive dysphonia and hoarseness. Laryngeal fiberscopy evidenced a reddish pedicled voluminous mass in the left false cords and ventricle. Microscopic suspension laryngoscopy was performed under general anaesthesia and a 4 W Acublade CO2 Laser was used for transoral resection of the lesion. This was followed by adjuvant radiotherapy, with the widely recommended doses on the supraglottic region, to achieve better local control. Diagnosis of EMP is based on immunohistochemistry and the exclusion of systemic plasma cell proliferative disorders. Diagnosis of solitary EMP can be made only if studies for disseminated disease and X-ray and/or magnetic resonance imaging of the spine, pelvis, femurs, and humerus and bone marrow biopsy are negative. As there are no internationally established guidelines, treatment of EMP is mainly based on consensus of expert opinion.

scholarly journals Solitary Plasmacytoma of The Jaws: Therapeutically Considerations and Prognosis: A Case Report

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Mohamed Hamdy Helal ◽  
Ahmed Mohamed Bader ◽  
Mohamed A. Fouad ◽  
Malak Yousef Mohamed shoukheba
Keyword(s):  
Soft Tissues ◽  
Plasma Cells ◽  
Malignant Neoplasm ◽  
Neck Region ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Upper Respiratory Tract ◽  
Head And Neck Region ◽  
Plasma Cell Neoplasm ◽  
Disseminated Disease

The plasma cell neoplasm is a rare malignant neoplasm of plasma cells that may present as Extramedullary Plasmacytoma (EMP) in soft tissues especially in the upper respiratory tract, in the bone as a Solitary Plasmacytoma of bone (SPB), or as a part of the multifocal disseminated disease as Multiple Myeloma (MM). The majority of 80% occurs in the head and neck region. In our case, a 23-year-old female patient presented with a non-tender swelling of the gingiva in the upper and lower jaws with the mobility of all teeth. The radiological examination showed severe destruction of bone around all teeth.

scholarly journals Extramedullary Plasmacytoma of the Tonsil

2011 ◽  
Vol 2011 ◽  
pp. 1-2 ◽  
Author(s):  
Kevin C. Huoh ◽  
Annemieke Van Zante ◽  
David W. Eisele
Keyword(s):  
Plasma Cell ◽  
Unusual Case ◽  
Plasma Cells ◽  
Tertiary Care ◽  
Neck Region ◽  
Extramedullary Plasmacytoma ◽  
University Hospital ◽  
Rare Form ◽  
Head And Neck Region ◽  
Radiologic Evaluation

Plasma cell tumors are a diverse group of neoplasms characterized by monoclonal proliferation of plasma cells. Extramedullary plasmacytoma (EMP) is a rare form of localized plasma cell tumor that arises most often in the head and neck region. We present an unusual case of EMP of the palatine tonsil from a tertiary care university hospital. We discuss the histopathologic and radiologic evaluation as well as treatment of EMP.

scholarly journals Plasma cell tumors of the head and neck. Analysis of diagnostic difficulties based on literature and own data

2021 ◽  
Vol 16 (3) ◽  
pp. 50-57
Author(s):  
F. Sh. Kamolova ◽  
L. Yu. Grivtsova ◽  
S. M. Samborskiy ◽  
V. B. Larionova ◽  
Yu. E. Ryabukhina ◽  
...  
Keyword(s):  
Head And Neck ◽  
Plasma Cell ◽  
Soft Tissues ◽  
Radiation Treatment ◽  
Diagnostic Errors ◽  
Neck Region ◽  
Ulcer Formation ◽  
Immunological Study ◽  
Head And Neck Region ◽  
Hodgkin's Lymphomas

Background. Extramedullary plasmacytoma (EP) of soft tissues, which in most cases affects the organs of the head and neck region, is a relatively rare malignant tumor. Until now, there are no consensus approaches to the diagnosis and treatment of EP. Differentiating EP from other types of non-Hodgkin’s lymphomas is difficult. There are difficulties in the differential diagnosis of EP and carcinomas in the head and neck region. Given the rare occurrence of this nosological form, the frequency of diagnostic errors is quite high, which dictates the need for a thorough description of each head and neck EP case.Objective of the study: analysis of possible difficulties and reasons for incorrect interpretation of diagnostic data, and treatment for head and neck EP.Materials and methods. Clinical and morphoimmunological data of 97 primary patients with B-cell non-Hodgkin’s lymphomas (B-NHLs) of the head-neck region were analyzed.Results. In our cohort we identified 2 tumor cases of a plasma cell nature, which amounted to 2 % among all B-NHLs. In one case, the process was located in the nasal cavity and clinically manifested itself with nosebleeds. The second case is a lesion of the mouth floor, primarily with the ulcer formation. In the first cases, at diagnosis, the immunohistochemistry (IHC) test was performed after patient’s chemotherapy and radiation treatment, which distorted the tumor immunophenotype. In the second cases with extensive process in maxillary sinuses, a complete and very detailed IHC test was carried out; however the data did not allow for a definitive diagnosis. Difficulties apparently arose in the interpretation of CD38 expression – main marker of plasmacytic line cells, as well as due to the unusual morphology.Conclusion. The described diagnostic situations dictate the need for a comprehensive algorithm in the diagnosis of head and neck tumors. It is advisable to perform an extended morpho-immunophenotypic study of the tumor (IHC, immunocytology, flow cytometry, etc.), if a tumor of a plasma cell nature is suspected, a morpho-immunological study of the bone marrow is indicated.

scholarly journals Extramedullary Plasmacytoma of Head and Neck Region: Report of Six Cases with Different Localizations

2013 ◽  
Vol 5 (3) ◽  
pp. 157-163
Author(s):  
Kerem Öztürk ◽  
Mustafa Şahin ◽  
Raşit Midilli ◽  
Gülce Gürsan ◽  
Nazan Özsan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Soft Tissues ◽  
Plasma Cells ◽  
Neck Region ◽  
Extramedullary Plasmacytoma ◽  
Mastoid Cavity ◽  
Upper Respiratory Tract ◽  
Head And Neck Region ◽  
Systemic Dissemination ◽  
Upper Respiratory

ABSTRACT Extramedullary plasmacytoma (EMP) is a rarely seen neoplasm of plasma cells which may be locally destructive by involving submucosal soft tissues of upper respiratory tract but without systemic dissemination. It comprises less than 1% of head and neck malignities. Clinical presentation depends on tumor's effect and its involvement site. Diagnosis is made with histopathologic examination of tissue biopsy. Responses to its treatment with local radiotherapy and surgery are similar. In this article; it is intended to update our knowledge regarding EMP and remind this rarely encountered disease by presenting various cases detected in nasopharynx, tonsil, buccal mucosa, larynx, mastoid cavity and sphenoid sinus, with literature line. How to cite this article Öztürk K, Şahin M, Midilli R, Gürsan G, Özsan N, Savaş R. Extramedullary Plasmacytoma of Head and Neck Region: Report of Six Cases with Different Localizations. Int J Otorhinolaryngol Clin 2013;5(3):157-163.

scholarly journals A Rare Case of Prostate Carcinoma Metastasis in the Orbital Apex

2020 ◽  
pp. 014556132097378
Author(s):  
Kento Wada ◽  
Takeshi Tsuda ◽  
Yukiko Hanada ◽  
Yohei Maeda ◽  
Kiyoshi Mori ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Vision Loss ◽  
Neck Region ◽  
Sinus Surgery ◽  
Pathological Examination ◽  
Orbital Apex ◽  
Orbital Mass ◽  
Head And Neck Region ◽  
History Of ◽  
Head Computed Tomography

Prostate cancer (PC) is prone to bone metastases, but very rarely it can spread to soft tissues. In the head and neck region, PC can metastasize to the orbital soft tissue, causing various symptoms such as vision loss. In this report, we describe the case of a 79-year-old man with PC metastasis in the orbital apex. He presented to an ophthalmologist at our hospital with progressively worsening vision in his left eye over 3 to 4 months. He complained of a drooping eyelid in the same eye; thus, intracranial disease was suspected. Closer inspection with head computed tomography revealed a space-occupying lesion from the orbit to the posterior ethmoid sinus, and he was referred to our department. He had a history of PC, and we performed endoscopic sinus surgery for the diagnosis of malignancy, including metastasis of PC. As a result, the mass was diagnosed as PC metastasis by pathological examination. The patient began androgen blockade therapy and 3 months postoperatively, magnetic resonance imaging revealed that the extraconal orbital mass had decreased significantly. It is important to determine the metastases of PC in the paranasal region when the patient has a preexisting medical history.

scholarly journals Extramedullary plasmacytoma of the nasal cavity: A case report

2018 ◽  
Vol 8 (32) ◽  
pp. 233-234
Author(s):  
Paskaramoorthy Sasitharan ◽  
Nor Idayu Mohd Yusof ◽  
Kugan Varatha Raju
Keyword(s):  
Nasal Cavity ◽  
Plasma Cells ◽  
Clinical Laboratory ◽  
Neck Region ◽  
Young Female ◽  
Extramedullary Plasmacytoma ◽  
Head And Neck Region ◽  
Systemic Involvement ◽  
History Of ◽  
Histopathologic Findings

Abstract Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells. It is most often located in the head and neck region. Extramedullary Plasmacytomas are more predominant in males who are in the 5th – 6th decade. In this report, this patient, who is a young female, presented to our clinic with history of intermittent nasal obstruction for the past year. She was diagnosed with extramedullary plasmacytoma and was subjected to radiotherapy. The clinical and histopathologic findings of plasmacytoma are discussed. In order to exclude systemic involvement, a systematic approach using clinical, laboratory and radiologic investigations was performed. Extramedullary plasmacytoma of the nasal cavity is rare and should be considered in the differential diagnosis of nasal cavity masses, especially in the young age group.

scholarly journals Extramedullary Plasmacytoma of Nasal Cavity

2016 ◽  
Vol 9 (1) ◽  
pp. 50-52
Author(s):  
Ravi Meher ◽  
Swati Tandon
Keyword(s):  
Nasal Cavity ◽  
Head And Neck ◽  
Soft Tissues ◽  
Plasma Cells ◽  
Neck Region ◽  
Extramedullary Plasmacytoma ◽  
Upper Aerodigestive Tract ◽  
Head And Neck Region ◽  
Plasma Cell Neoplasms ◽  
Extramedullary Plasmacytomas

ABSTRACT Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells in soft tissues. Extramedullary plasmacytomas constitute 3 to 5% of all plasma cell neoplasms. Most lesions occur in the head and neck, primarily in the upper aerodigestive tract, with 75% occurring in nose and paranasal sinuses. To the best of our knowledge, only few cases of sinonasal extramedullary plasmacytomas have been reported in the literature. It is important for otolaryngologists to acquire knowledge of this disease as 80 to 90% occur in the head and neck region. We report a rare case of extramedullary plasmacytoma of the nasal cavity in a 60-year-old male managed by surgery and radiotherapy. How to cite this article Tandon S, Meher R, Chauhan A. Extramedullary Plasmacytoma of Nasal Cavity. Clin Rhinol An Int J 2016;9(1):50-52.

Combined modality therapy for naso-oropharyngeal solitary extramedullary plasmacytoma: case report

2017 ◽  
Vol 3 (4) ◽  
pp. 1105
Author(s):  
Andrea Masarykova ◽  
Marin Dzongov ◽  
Alexandra Hanicova ◽  
Ingrid Zavacka ◽  
Danijela Scepanovic
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Plasma Cell ◽  
Fdg Pet ◽  
Neck Region ◽  
Extramedullary Plasmacytoma ◽  
Head And Neck Region ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Solitary Extramedullary Plasmacytoma

<p>Most patients with plasma cell neoplasia have generalized disease at diagnosis. However, some patients have a solitary extramedullary plasmacytomas (SEPs). SEPs are rare, typically solitary tumors comprising approximately 3–5% all plasma cell neoplasms. Almost 90% arise in the head and neck region, especially in the nasal cavity, sinuses, oropharynx, salivary glands and larynx. Solitary extramedullary plasmacytoma (SEP) has a predilection for the male gender and occurs most frequently in patients 50 years and older. SEP often runs an indolent clinical course with a tendency for local recurrence, and progresses to plasma cell myeloma in about 15% of patients. In this paper, we have reported the case of SEP of the naso-oropharynx in 55 years old woman who was presented with a sense of the nasal obstruction. The resection was performed and a mature plasmacytoma was demonstrated histologically. However, ENT examination and positron emission tomography/computed tomography examination with 18-fluorodeoxyglucose (18-FDG PET/CT) have shown that the patient had residual naso-oropharyngeal disease after surgery. A negative bone marrow biopsy and 18-FDG PET/CT have confirmed that it was a solitary extramedullary plasmacytoma of the head and neck region. Following the surgery, intensity modulated radiotherapy (IMRT) was administered. No relapse or progression to the multiple myeloma was recorded during the 3.5 years of follow-up. This case report, which describes a rare tumor of the naso-oropharynx, is expected to improve the recognition and referral of this condition in medical practice. </p>

scholarly journals Extramedullary Plasmacytoma of Head and Neck Region: Report of Six Cases with Different Localizations

2014 ◽  
Vol 6 (3) ◽  
pp. 10-16 ◽  
Author(s):  
Kerem Öztürk ◽  
Mustafa Şahin ◽  
Raşit Midilli ◽  
Gülce Gürsan ◽  
Nazan Özsan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Soft Tissues ◽  
Plasma Cells ◽  
Neck Region ◽  
Extramedullary Plasmacytoma ◽  
Mastoid Cavity ◽  
Upper Respiratory Tract ◽  
Head And Neck Region ◽  
Systemic Dissemination ◽  
Upper Respiratory

ABSTRACT Extramedullary plasmacytoma (EMP) is a rarely seen neoplasm of plasma cells which may be locally destructive by involving submucosal soft tissues of upper respiratory tract but without systemic dissemination. It comprises less than 1% of head and neck malignities. Clinical presentation depends on tumor's effect and its involvement site. Diagnosis is made with histopathologic examination of tissue biopsy. Responses to its treatment with local radiotherapy and surgery are similar. In this article; it is intended to update our knowledge regarding EMP and remind this rarely encountered disease by presenting various cases detected in nasopharynx, tonsil, buccal mucosa, larynx, mastoid cavity and sphenoid sinus, with literature line.

scholarly journals Multiple Extramedullary Plasmacytoma Arising in the Head and Neck Region; A Case Report.

1996 ◽  
Vol 89 (11) ◽  
pp. 1377-1381 ◽  
Author(s):  
Sanson HAN ◽  
Hiroyuki KITAMURA ◽  
Shin-ichi TAKAGITA ◽  
Ryo ASATO ◽  
Yuka IWAHASHI ◽  
...  
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Neck Region ◽  
Extramedullary Plasmacytoma ◽  
Head And Neck Region
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