scholarly journals Seasonal Temperature Changes Do Not Affect Cardiac Glucose Metabolism

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Jukka Schildt ◽  
Antti Loimaala ◽  
Eero Hippeläinen ◽  
Päivi Nikkinen ◽  
Aapo Ahonen
Keyword(s):  
Glucose Metabolism ◽  
Fasting Blood Glucose ◽  
Seasonal Temperature ◽  
Outdoor Temperature ◽  
Myocardial Glucose Metabolism ◽  
Cardiac Inflammation ◽  
Fdg Uptake ◽  
Standardized Uptake Values ◽  
Significant Difference ◽  
Fdg Pet Ct

FDG-PET/CT is widely used to diagnose cardiac inflammation such as cardiac sarcoidosis. Physiological myocardial FDG uptake often creates a problem when assessing the possible pathological glucose metabolism of the heart. Several factors, such as fasting, blood glucose, and hormone levels, influence normal myocardial glucose metabolism. The effect of outdoor temperature on myocardial FDG uptake has not been reported before. We retrospectively reviewed 29 cancer patients who underwent PET scans in warm summer months and again in cold winter months. We obtained myocardial, liver, and mediastinal standardized uptake values (SUVs) as well as quantitative cardiac heterogeneity and the myocardial FDG uptake pattern. We also compared age and body mass index to other variables. The mean myocardial FDG uptake showed no significant difference between summer and winter months. Average outdoor temperature did not correlate significantly with myocardial SUVmax in either summer or winter. The heterogeneity of myocardial FDG uptake did not differ significantly between seasons. Outdoor temperature seems to have no significant effect on myocardial FDG uptake or heterogeneity. Therefore, warming the patients prior to attending cardiac PET studies in order to reduce physiological myocardial FDG uptake seems to be unnecessary.

Abstract 1766: Diet-Induced Obesity Causes Inflammation by Activating Toll-Like Receptor 4 Signaling and Downregulates AMPK in Heart

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Hwi Jin Ko ◽  
Dae Young Jung ◽  
Zhexi Ma ◽  
Jason K Kim
Keyword(s):  
Glucose Metabolism ◽  
Whole Body ◽  
Chow Diet ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Myocardial Glucose Metabolism ◽  
Cardiac Inflammation ◽  
Protein Levels ◽  
Diet Induced Obesity

Increasing evidence implicates the role of inflammation in diabetes and complications. Macrophages are shown to infiltrate adipose tissue in obesity, and inflammatory cytokines alter glucose metabolism in peripheral organs. Male C57BL/6 mice were fed high-fat diet (HFD; 55% fat by calories) or chow diet for 6 weeks, and heart samples were taken for analysis (n = 5~7). Chronic HFD increased whole body fat mass, measured by 1 H-MRS, by 3-fold, and elevated plasma IL-6 and TNF-α levels by 40%. Diet-induced obesity caused inflammation in heart and increased macrophage-specific CD68 levels by 5-fold (Fig. 1) (* P < 0.05 vs Chow). Diet-induced cardiac inflammation was associated with significant increases in toll-like receptor 4 (TLR4) and MyD88 levels in heart (Fig. 2). HFD also increased cardiomyocyte SOCS3 levels by more than 3-fold (Fig. 3). Myocardial glucose metabolism was measured using intravenous injection of 2-[ 14 C]deoxyglucose in awake mice (n = 6). Chronic HFD reduced myocardial glucose uptake by 50%, and this was associated with significant reductions in total GLUT4 and GLUT1 protein levels. Further, Thr 172 phosphorylation of AMPK, a critical regulator of energy balance, was markedly reduced in heart following HFD (Fig. 4). These results demonstrate that diet-induced obesity causes macrophage infiltration and inflammation in heart by increasing TLR4 signaling in cardiomyocytes. Similar to the effects of inflammation on peripheral glucose metabolism, diet-induced cardiac inflammation reduced myocardial glucose metabolism by downregulating AMPK and GLUT protein levels. Thus, our findings underscore an important role of inflammation in diabetic heart.

Does incidental FDG PET uptake in the prostate have significance?

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 115-115
Author(s):  
Anna Mary Brown ◽  
Maria Liza Lindenberg ◽  
Sandeep Sankineni ◽  
Linda M Johnson ◽  
Suneha Pruthy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fdg Pet ◽  
Final Analysis ◽  
Multiple Comparisons ◽  
Dynamic Contrast Enhancement ◽  
Predictive Values ◽  
Fdg Uptake ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
Fdg Pet Ct

115 Background: 18F-FDG PET/CT is widely used to diagnose malignancy, but is not recommended for localized prostate cancer. This study explores the value of multi-parametric MRI (mpMRI) in characterizing incidentally detected prostate FDG uptake. Methods: Thirty-one patients who underwent FDG PET/CT and prostate MRI were eligible for this study. 14 patients were excluded (n=8 insufficient histopathology, n=6 radical prostatectomy before PET), with final analysis of 17 patients. The mpMRI sequences included T2-weighted, dynamic contrast enhancement (DCE), apparent diffusion coefficient (ADC), and MR spectroscopy (MRS). Nuclear medicine physicians, blinded to clinicopathologic findings, identified suspicious areas and maximum standardized uptake values (SUVmax) on FDG PET/CT. The lesion and sector-based imaging findings were correlated with annotated histopathology from whole-mount or MRI/TRUS fusion biopsy samples. Positive predictive values (PPVs) were estimated using generalized estimating equations with logit link. Results were evaluated with Kruskal-Wallis and Dunn’s multiple comparisons tests. Results: The PPV of FDG PET alone in detecting prostate cancer was 0.56. Combining FDG (base parameter) with mpMRI modalities (T2, DCE, ADC, MRS) increased the sector-based PPV to 0.79, 0.82, 0.80, and 0.89, respectively. All benign lesions had SUVmax < 5, and malignant lesions had higher mean SUVmax values that correlated with Gleason scores [Table]. This relationship between SUVmax and Gleason score was significant, with p=0.012 on the Kruskal-Wallis test and p=0.015 on the Dunn’s multiple comparisons test for Gleason 0 vs Gleason ≥ 4+5. Conclusions: Incidental prostate FDG uptake has low clinical utility alone, but these areas may harbor high-grade prostate cancer, especially if the SUVmax is greater than 5. [Table: see text]

scholarly journals “Visualization” of Pain using Cerebral 18 F-FDG PET/CT Following Surgical Treatment of Lumbar Disc Herniation

2021 ◽  
Author(s):  
Christian Christensen Støttrup ◽  
Caius Constantinescu ◽  
Reza Piri ◽  
Mohsen Khosravi ◽  
Andrew Newberg ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Glucose Metabolism ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Fdg Pet ◽  
Lumbar Disc ◽  
Leg Pain ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract We hypothesised that unilateral leg pain following surgical treatment of lumbar disc herniation (LDH) is associated with an increase in the glucose metabolism of the contralateral thalamus. Patients scheduled for surgery due to LDH underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) less than two weeks prior to surgery. Their thalamic FDG uptake was measured and expressed as the mean and partial volume corrected mean standardized uptake values (SUVmean and cSUVmean). These measures were compared with patient-related outcome measures collected pre- and 1-year postoperatively: back and leg pain on a 0-100 VAS scale and health related quality of life as measured by the EuroQol-5D (EQ-5D). Twenty-six patients (10 females) aged 49.7 ± 7.4 (mean ± SD) years were included. There was a significant correlation between painful body side and increased contralateral thalamic uptake of FDG, with regard to cSUVmean values. Correlation analyses including clinical parameters and cSUVmean indicated some association with 1-year change in EQ-5D. These preliminary data sustain the hypothesis that unilateral pain in patients with LDH is associated with increased glucose metabolism in the contralateral thalamus, suggestion a central role of thalamus in chronic pain perception.

scholarly journals [F18] FDG-PET/CT for manual or semiautomated GTV delineation of the primary tumor for radiation therapy planning in patients with esophageal cancer: is it useful?

2020 ◽  
Author(s):  
Franziska Walter ◽  
Constanze Jell ◽  
Barbara Zollner ◽  
Claudia Andrae ◽  
Sabine Gerum ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Primary Tumor ◽  
Fdg Pet ◽  
Interobserver Variability ◽  
Target Volume ◽  
Standardized Uptake Values ◽  
Positron Emission ◽  
Pet Ct ◽  
Significant Difference ◽  
Fdg Pet Ct

Abstract Background Target volume definition of the primary tumor in esophageal cancer is usually based on computed tomography (CT) supported by endoscopy and/or endoscopic ultrasound and can be difficult given the low soft-tissue contrast of CT resulting in large interobserver variability. We evaluated the value of a dedicated planning [F18] FDG-Positron emission tomography/computer tomography (PET/CT) for harmonization of gross tumor volume (GTV) delineation and the feasibility of semiautomated structures for planning purposes in a large cohort. Methods Patients receiving a dedicated planning [F18] FDG-PET/CT (06/2011–03/2016) were included. GTV was delineated on CT and on PET/CT (GTVCT and GTVPET/CT, respectively) by three independent radiation oncologists. Interobserver variability was evaluated by comparison of mean GTV and mean tumor lengths, and via Sørensen–Dice coefficients (DSC) for spatial overlap. Semiautomated volumes were constructed based on PET/CT using fixed standardized uptake values (SUV) thresholds (SUV30, 35, and 40) or background- and metabolically corrected PERCIST-TLG and Schaefer algorithms, and compared to manually delineated volumes. Results 45 cases were evaluated. Mean GTVCT and GTVPET/CT were 59.2/58.0 ml, 65.4/64.1 ml, and 60.4/59.2 ml for observers A–C. No significant difference between CT- and PET/CT-based delineation was found comparing the mean volumes or lengths. Mean Dice coefficients on CT and PET/CT were 0.79/0.77, 0.81/0.78, and 0.8/0.78 for observer pairs AB, AC, and BC, respectively, with no significant differences. Mean GTV volumes delineated semiautomatically with SUV30/SUV35/SUV40/Schaefer’s and PERCIST-TLG threshold were 69.1/23.9/18.8/18.6 and 70.9 ml. The best concordance of a semiautomatically delineated structure with the manually delineated GTVCT/GTVPET/CT was observed for PERCIST-TLG. Conclusion We were not able to show that the integration of PET/CT for GTV delineation of the primary tumor resulted in reduced interobserver variability. The PERCIST-TLG algorithm seemed most promising compared to other thresholds for further evaluation of semiautomated delineation of esophageal cancer.

Different Histopathological Subtypes of Hodgkin Lymphoma Have Significantly Different Levels of FDG Uptake.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 969-969
Author(s):  
Martin Hutchings ◽  
Annika L. Jakobsen ◽  
Mads T. Hansen ◽  
Elisabeth Ralfkiaer ◽  
Lena Specht
Keyword(s):  
Lymph Node ◽  
Hodgkin Lymphoma ◽  
Fdg Pet ◽  
Lymph Node Biopsy ◽  
T Test ◽  
The Body ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Significant Difference ◽  
Fdg Pet Ct

Abstract Background: Functional imaging with positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) is an important tool in the staging of Hodgkin lymphoma (HL). FDG-PET enables quantitative information about the tumour metabolism, most commonly measured as the semiquantitative standardised uptake value (SUV). The aim of this study was to investigate if the level of FDG uptake varies between the different subtypes of HL. Methods: Sixty consecutive patients with newly diagnosed HL were prospectively included in the protocol. At least one lymph node biopsy was obtained from each patient and all patients underwent an FDG-PET/CT scan along with other staging procedures. The highest SUV in each patient (SUVmax/total) and in each affected region or organ (SUVmax) was recorded. Differences in SUVmax between histopathological subgroups were analysed with independent-samples student’s t-test and one-way analysis of variance (ANOVA). Results: 38 patients had nodular sclerosis (NS), 11 patients had mixed cellularity (MC), seven patients had nodular lymphocyte predominance (NLP) and four patients had classical HL, not otherwise specified (CHL-NOS). Mean SUVmax/total was 9.3 g/ml in NLP patients, 16.3 g/ml in NS patients, 20.8 g/ml in MC patients, and 19.5 g/ml in CHL-NOS patients (Figure 1). The difference between the histopathological subgroups was highly significant (ANOVA, p = 0.011). Out of 780 potential sites of disease (600 lymph node regions plus 180 organs), 208 sites were affected with HL. Mean SUVmax was 8.3 g/ml in the 12 sites affected with NLP, 11.2 g/ml in the 147 sites affected with NS, 14.6 g/ml in the 36 sites affected with MC, and 13.1 g/ml in the 13 sites affected with CHL-NOS (ANOVA, p = 0.011, Figure 2). Mean SUVmax in sites with NS was significantly higher than in sites with NLP (t-test, p = 0.042) and significantly lower than in sites with MC (t-test, p = 0.011). Conclusion: There is a significant difference in FDG/glucose uptake between the different histopathological subtypes of HL. The SUVs in NLP, NS and MC lymphomas are significantly different, while the uptake in CHL-NOS lymphomas resembles the uptake in MC lymphomas. SUV analysis is frequently used in situations where the qualitative evalutation of a site on FDG-PET is uncertain. In those situations, it is helpful to know that the level of uptake varies from subtype to subtype. Since the subtypes have different FDG metabolism, they should ideally be regarded separately in future studies of FDG-PET and FDG-PET/CT in HL. 1. Highest SUV anywhere in the body of each patient 1. Highest SUV anywhere in the body of each patient

Myocardial Glucose Metabolism Is Increased in Newly Diagnosed Lung Adenocarcinoma

Cardiology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Jiaoyan Wu ◽  
Li Wang ◽  
Yuetao Wang ◽  
Min-Fu Yang
Keyword(s):  
Bone Marrow ◽  
Glucose Metabolism ◽  
Lung Adenocarcinoma ◽  
Fdg Pet ◽  
Arterial Wall ◽  
Left Ventricular ◽  
Newly Diagnosed ◽  
Myocardial Glucose Metabolism ◽  
Pet Ct ◽  
Fdg Pet Ct

<b><i>Background:</i></b> Cardiac metabolism alterations may be involved in abnormalities of cancer patients’ cardiovascular system. This study aimed to explore whether left ventricular myocardial glucose metabolism is altered and its related factors in newly diagnosed patients with lung adenocarcinoma (LAD) who underwent fluorine-18 fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT). <b><i>Methods:</i></b> From our <sup>18</sup>F-FDG PET/CT imaging database, 171 patients with newly diagnosed LAD and 43 nononcologic subjects with matched age and sex were retrospectively analyzed. The included patients underwent conventional <sup>18</sup>F-FDG PET/CT imaging with a &#x3e;12-h fasting before <sup>18</sup>F-FDG administration. The standardized uptake values (SUVs) of the left ventricular (LV) myocardium, arterial wall, epicardial adipose tissue (EAT), spleen, and bone marrow were separately measured. Laboratory parameters and echocardiographic results were collected as well. LAD patients were divided into 2 groups based on the 95th percentile of LV maximal SUV (SUV<sub>max</sub>) obtained from the 43 nononcologic subjects. Univariate analysis and multiple logistic regression analysis were used to identify significant factors. <b><i>Results:</i></b> Higher LV SUV<sub>max</sub> was found (3.8 [2.4, 7.7] vs. 3.0 [2.0, 5.4], <i>p</i> = 0.052) in LAD than that in nononcologic patients, whereas no significant differences of <sup>18</sup>F-FDG uptake were found in the arterial wall, EAT, spleen, or bone marrow between LAD patients and controls. The maximum diameter (<i>D</i><sub>max</sub>) of the LAD lesion, SUV<sub>max</sub> of spleen, and SUV<sub>max</sub> of EAT were related to LV SUV<sub>max</sub> in LAD. <b><i>Conclusions:</i></b> Myocardial glucose metabolism is increased in patients with newly diagnosed LAD. <i>D</i><sub>max</sub> of LAD lesion, spleen activity, and EAT activity contribute to the increased LV activity in LAD.

Suppression of myocardial glucose metabolism in FDG PET/CT: impact of dose variation in heparin bolus pre-administration

2020 ◽  
Vol 47 (11) ◽  
pp. 2698-2702 ◽  
Author(s):  
A. M. Scholtens ◽  
A. M. van den Berk ◽  
N. L. van der Sluis ◽  
J. P. Esser ◽  
G. K. Lammers ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Fdg Pet ◽  
Myocardial Glucose Metabolism ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Dose Variation

scholarly journals Peculiarities of glucose intake in fetal tissues in chronic hypoxemia

2018 ◽  
Vol 22 (1) ◽  
pp. 29-32
Author(s):  
V.I. Oshovskyy
Keyword(s):  
Glucose Metabolism ◽  
Glucose Uptake ◽  
Chronic Hypoxia ◽  
Fetal Brain ◽  
Metabolic Changes ◽  
Laser Coagulation ◽  
Fetal Sheep ◽  
Fdg Uptake ◽  
Pregnant Sheep ◽  
Significant Difference

Objective — to investigate fetal blood distribution and glucose metabolism of heart, liver and brain during chronic hypoxaemia. Establishment of a model of real time measurement of the metabolic changes during chronic fetal hypoxaemia using PET-CT measurement in pregnant sheep after iatrogenic induction of chronic fetal hypoxaemia. Laser coagulation of placental vessels was performed in pregnant sheep in order to cause fetal hypoxaemia 14 days before the PET-procedure. The following PET-Scans were performed after 18F-FDG was injected into the jugular vein of the sheep. Fetal glucose uptake was scanned in fetal brain, liver, heart and kidneys during a period of 60 min after injection of the FDG tracer. Glucose uptake of these organs was measured in comparison with placental glucose uptake during the above-called 60 minutes course. Here we present the analysis of the metabolic changes in fetal hypoxaemia in a small series of 8 fetal sheep. It was found that FDG Uptake in the placenta, brain, liver and heart of the fetus was measured at normal oxygenation and in chronic hypoxia in 8 sheep fetuses, between 112 and 135 days of pregnancy (gestational age) 125±4 days (mean±SD). Umbilical cord artery resistance was significantly higher in hypoxemic fetuses compared to normoxemic. Venous duct reactions as a respond to hypoxia was observed. Index of pulsation in the umbilical artery was not significantly increased during hypoxia (1,06±0,18 та 1,67±0,12, р=0,018). PI in venous duct during chronic hypoxia (0,62±0,25) was increased in compare with normoxemic (0,41±0,2), but not significantly. Relative FDG uptake was about 3.8 times higher in brain of hypoxemic fetuses (0.019±0.005) compared to normoxemic (0.005±0.002), (р=0,02). In contrast, hypoxic fetal heart showed no significant difference in absorption of FDG compared to normoxemic fetal brain (p=0.11). Relative FDG uptake in the liver did not differ substantially between the two groups (p=0.97). Thus, it was shown that chronic maternal hypoxemia led to decreased placental and increased brain blood flow, although, glucose metabolism was not decreased in the fetal liver and heart.

scholarly journals One patient with two different 18-fluorodeoxyglucose positron emission tomography/computed tomography views

2014 ◽  
Vol 1 (2) ◽  
pp. 114
Author(s):  
Meryem Ö Özkan ◽  
Mine Şencan Eren ◽  
Sibel Göksel ◽  
Yakup Yürekli ◽  
Sabri Barutça
Keyword(s):  
Computed Tomography ◽  
Fasting Blood Glucose ◽  
Primary Lesion ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Fdg Uptake ◽  
Positron Emission ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Fluorodeoxyglucose Positron Emission

A normoglycemic patient with a diagnosis of laryngeal cancer underwent F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (F-18 FDG PET/CT) for staging purposes and two different results were obtained. In the first assessment, F-18 FDG uptake of the primary lesion was very low, but a significant F-18 FDG uptake was noted in the second evaluation. F-18 FDG PET/CT is used for the diagnosis, staging and re-staging, as well as for the assessment of response to treatment in oncological patients. F-18 FDG uptake is associated with fasting blood glucose levels and satiety. The lower and upper limit of fasting blood glucose is variable between centers. In this present case report, we want to discuss the factors responsible for not detecting F-18 FDG uptake in the area of primary lesion in a normoglycemic patient with laryngeal cancer.

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