scholarly journals Myxoid Epithelial Leiomyoma of the Vulva: A Case Report and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ting Zhao ◽  
Xishi Liu ◽  
Yuan Lu
Keyword(s):  
Estrogen Receptor ◽  
Case Report ◽  
Literature Review ◽  
Progesterone Receptor ◽  
Tumor Cells ◽  
Pathological Examination ◽  
Myxoid Stroma ◽  
Epithelioid Leiomyoma ◽  
Vulvar Mass

Leiomyoma of vulva is rare, and usually misdiagnosed clinically as Bartholin cyst. It usually presents spindle-shaped tumor cells, but some rare cases consisted mainly of atypical epithelioid tumor cells. We report here a case of 30-year-old woman consulting with a vulvar mass of 7 cm in the Bartholin glands area. The lesion was surgically excised with its capsule completely. Pathological examination and immunochemistry showed characteristic of epithelioid leiomyoma with myxoid stroma with both estrogen receptor (ER) and progesterone receptor (PR) staining negative, which was really rare as only 2 cases of vulvar leiomyoma with both ER and PR were reported before.

NUT midline carcinoma of the mediastinum showing two types of poorly differentiated tumor cells: A case report and a literature review

2015 ◽  
Vol 211 (1) ◽  
pp. 92-98 ◽  
Author(s):  
Harumi Nakamura ◽  
Koji Tsuta ◽  
Hitoshi Tsuda ◽  
Yuki Katsuya ◽  
Go Naka ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Tumor Cells ◽  
Nut Midline Carcinoma ◽  
Poorly Differentiated

scholarly journals Primary Vulval Rhabdoid Tumor in an Adult: A Case Report, Immunohistochemical Profile and Literature Review

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Maria A. Arafah ◽  
Muna I. Aljuboury
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Tumor Cells ◽  
Rare Case ◽  
Rhabdoid Tumor ◽  
Hormonal Receptors ◽  
Immunohistochemical Profile

We report a rare case of primary vulval rhabdoid tumor in an adult. The diagnosis was confirmed using the recently emerging INI1/BAF47 immunostain. We also demonstrate the expression of ER and PR hormonal receptors by the tumor cells.

scholarly journals Estrogen Receptor- and Progesterone Receptor-Positive Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma: A Case Report

2013 ◽  
Vol 6 (1) ◽  
pp. 216-223 ◽  
Author(s):  
Yuichi Kinoshita ◽  
Kosho Takasu ◽  
Takashi Yuri ◽  
Kastuhiko Yoshizawa ◽  
Yuko Emoto ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Case Report ◽  
Papillary Thyroid Carcinoma ◽  
Progesterone Receptor ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Diffuse Sclerosing Variant

scholarly journals Anterior Mediastinal Leiomyosarcoma: A Case Report and Literature Review

2021 ◽  
pp. 101-106
Author(s):  
Akira Ishikawa ◽  
Kazuya Kuraoka ◽  
Junichi Zaitsu ◽  
Akihisa Saito ◽  
Atsushi Kamigaichi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Literature Review ◽  
Tumor Cells ◽  
Growth Pattern ◽  
Mediastinal Mass ◽  
Smooth Muscle Actin ◽  
Anterior Mediastinum ◽  
Anterior Mediastinal Mass ◽  
Muscle Actin

Primary mediastinal sarcomas are extremely rare. Additionally, mediastinal leiomyosarcomas account for approximately 9% of mediastinal sarcoma cases. Until date, only few cases of anterior mediastinal leiomyosarcomas have been reported. Herein, we report a case of an 85-year-old female with an anterior mediastinal mass of 15 mm. Histological examination revealed spindle tumor cells showing a fascicular growth pattern. Immunohistochemically, the tumor cells were focal positive for desmin, calponin, and α-smooth muscle actin. The pathological diagnosis was leiomyosarcoma. In conclusion, we encountered a case of a very rare leiomyosarcoma that occurred in the anterior mediastinum, and our report may contribute to the understanding of this disease.

scholarly journals Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review

2016 ◽  
pp. 1641 ◽  
Author(s):  
Ken-ichi Ito ◽  
Takaaki Oba ◽  
Mayu Ono ◽  
Asumi Iesato ◽  
Toru Hanamura ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Case Report ◽  
Literature Review ◽  
Carcinoma Of The Breast

scholarly journals Lymphomatoid papulosis localized to the oral mucosa: case report and literature review

2019 ◽  
Vol 25 (3) ◽  
pp. 30
Author(s):  
S. Bretsztajn ◽  
T. Leturc ◽  
E. Euvrard ◽  
A.-G. Bodard
Keyword(s):  
Inflammatory Bowel Disease ◽  
Case Report ◽  
Prognostic Factor ◽  
Literature Review ◽  
Middle Finger ◽  
Pathological Examination ◽  
Lymphomatoid Papulosis ◽  
Mucosal Involvement ◽  
Inflammatory Bowel ◽  
Left Middle

Introduction: Lymphomatoid papulosis is a primary CD 30+ cutaneous lymphoproliferation. Observation: We report the case of a 39-year-old patient who presented with ulcers on the back of the tongue, gums, buccal mucosa, and soft palate, which evolved as spontaneously regressive flare-ups. The diagnosis of inflammatory bowel disease was initially proposed. Several years later, the patient presented an ulcer on the left middle finger. Histological examination confirmed the diagnosis of lymphomatoid papulosis. Discussion: This chronic dermatosis manifests a single rash or multiple papulonodular rashes, evolving as spontaneously regressive flare-ups. Mucosal involvement is rare, and no prognostic factor for this location has been highlighted to this date. Pathological examination is essential. Conclusion: The mucosal involvement of lymphomatoid papulosis is one of the diagnoses to be considered for recurrent mouth ulcers.

Independent characterization by duel staining of progesterone receptor (PR) and estrogen receptor (ER) in breast cancer (BC).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 596-596
Author(s):  
Alexander A. Zukiwski ◽  
Jean-Michel Caillaud ◽  
Jacques Bosq ◽  
Suzanne A. W. Fuqua ◽  
Carol A. Lange ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Tumor Cells ◽  
Cellular Level ◽  
Rank Test ◽  
Double Staining ◽  
Level 2 ◽  
Positive Results ◽  
Number Of Cells

596 Background: The oncology literature indicates that ER and PR are linked and in BC the presence of PR usually indicates functional ER. BCs express both ER and PR to varying degree, but little has been published on expression of ER + PR in individual cancer cells. The goal of this study is to 1. Determine the expression ER and PR at the cellular level, 2. Determine if ER and PR are expressed in the same BC cells. If ER and PR are separate, this may indicate that antiestrogens and antiprogestins may target different cells. Methods: Archived 1° BC specimens were processed using standard IHC techniques for ER/PR testing. The procedure consisted of sequential double staining on the same microtone section, where the PR was visualized through brown staining using HRP/DAB, and the ER was visualized through red staining using AP/Permanent Red. The initial testing on 13 tumor samples utilized a duel anti-PR-A/B antibody (Ab) and an ER Ab. The next 63 tumor samples utilized; 1. anti-ER and anti-PR-A Abs, 2. anti-ER and anti-PR-B Abs. A pathologist experienced with IHC, interpreted and enumerated the cells staining positive for ER only, for PR only and cells staining positive for both ER & PR. The number of cells expected to be stained for both ER & PR by chance can be calculated as the rate of total ER by the rate of total PR and compared with the observed rate (paired rank test). ER/PR positivity is defined as ≥ 5% cells positive. Results: In the first series, 11/13 tumors were ERpos, 13/13 were PRpos, 7/13 tumors had both ER & PR expressed in 5-20% (median 5%) of the same tumor cells. In the 2nd series of 63 tumors; 1. 50/53 were ERpos, 52/53 were PRApos and 44/53 had both ER & PRA expressed in <5-20% (median 5%) of the same tumor cells, 2. 44/52 were ERpos, 52/52 were PRBpos and 42/52 tumors had both ER & PRB expressed in <5-20% (median 10%) of the same tumor cells. Areas of ER or PR only predominance were frequent. A paired rank test indicates that the observed rate (median 9%) of ER/PR duel staining is less than predicted (median 18%, p <0.000). Conclusions: ER & PR were expressed in the majority of tumors examined with a minority the tumor cells expressing both ER & PR. These data support evaluating antiprogestins as a different therapeutic target from ER.

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