scholarly journals Epiphyseal Sparing and Reconstruction by Frozen Bone Autograft after Malignant Bone Tumor Resection in Children

Sarcoma ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Ahmed Hamed Kassem Abdelaal ◽  
Norio Yamamoto ◽  
Katsuhiro Hayashi ◽  
Akihiko Takeuchi ◽  
Shinji Miwa ◽  
...  
Keyword(s):  
Functional Outcome ◽  
Limb Salvage ◽  
Bone Tumor ◽  
Treatment Options ◽  
Tumor Resection ◽  
Limb Salvage Surgery ◽  
Leg Length ◽  
Primary Bone Tumors ◽  
Bone Tumor Resection ◽  
Bone Autograft

Limb salvage surgery has become the standard treatment for malignant primary bone tumors in the extremities. Limb salvage represents a challenge in skeletally immature patients. Several treatment options are available for limb reconstruction after tumor resection in children. We report our results using the technique of epiphyseal sparing and reconstruction with frozen autograft bone in 18 children. The mean follow-up period for the all patients included in this study is 72 ± 26 m. Eight patients remained disease-free, seven patients lived with no evidence of disease, two were alive but with disease, and one patient died of the disease. Five- and ten-year rates of survival were 94.4%. Graft survival at 5 and 10 years was 94.4%. Functional outcome using the Enneking scale was excellent in 17 patients (94.4%) and poor in one patient (5.5%). Complications include 2 nonunions, 2 fractures, 2 deep infections, 1 soft tissue recurrence, and leg length discrepancy in 7 cases. This technique is a good reconstructive choice in a child with a nonosteolytic primary or secondary bone tumor, responsive to chemotherapy, without involvement of the articular cartilage. It is a straight forward, effective, and biological technique, which affords immediate mobilization of joints and possible cryoimmune effects, with excellent long term functional outcome and less complication.

Bone tumor resection guide using three-dimensional printing for limb salvage surgery

2018 ◽  
Vol 118 (6) ◽  
pp. 898-905 ◽  
Author(s):  
Jong Woong Park ◽  
Hyun Guy Kang ◽  
Kwun Mook Lim ◽  
Dae Woo Park ◽  
June Hyuk Kim ◽  
...  
Keyword(s):  
Limb Salvage ◽  
Bone Tumor ◽  
Salvage Surgery ◽  
Tumor Resection ◽  
Three Dimensional ◽  
Limb Salvage Surgery ◽  
Three Dimensional Printing ◽  
Bone Tumor Resection ◽  
Dimensional Printing

scholarly journals Assessment of Resection Margins in Bone Tumor Surgery

Sarcoma ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Corentin Malherbe ◽  
Bernard Crutzen ◽  
Jean Schrooyen ◽  
Giovanni Caruso ◽  
Frédéric Lecouvet ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Resection ◽  
Pathological Examination ◽  
Patient Specific ◽  
Resection Margins ◽  
Limb Salvage Surgery ◽  
Tumor Surgery ◽  
Surgical Guide ◽  
Median Error ◽  
Bone Tumor Resection

Limb salvage surgery is now the preferred procedure for bone tumor surgery. To decrease the risk of local recurrence, it is crucial to obtain adequate resection margins. The obtained margins must be evaluated postoperatively because they influence what treatment is given subsequently when margins are not adequate (e.g., surgical revision and radiotherapy). The study aims to evaluate margin assessment of tumor specimen by MRI compared to conventional histology (to establish the viability of using MRI) and assess the accuracy of a patient-specific instrument when narrow margins were aimed. The resection margins in 12 consecutive patients that were operated on for bone tumor resection were prospectively analyzed using three methods: MRI of the resection specimen, macroscopic evaluation of specimen slices, and microscopic pathological evaluation. The assessments were qualitative (R0, R1, and R2) and quantitative (distance in mm). MRI, macroscopic, and microscopic margins generated similar results for both the qualitative (all resections were R0) and quantitative assessments. The median error in safe margins was 2 mm with a surgical guide (PSI) and 5 mm without a surgical guide. Local recurrences were not detected after a mean follow-up period of 3.7 years (range, 2.1–5 years); however, four patients died during the study. In conclusion, MRI is a valuable tool for assessing safe margins. When specimens are not available for pathological assessment (e.g., extracorporeally irradiated autograft or autoclaved autograft), MRI could be used to evaluate margins. In particular, when tumor volume is high, MRI could also help to focus the pathological examination on areas of concern.

Therapy and regeneration-combined bone cements for minimally invasive treatment of neoplastic bone defects

2021 ◽  
Author(s):  
Yu Qu ◽  
Hui Zhuang ◽  
Meng Zhang ◽  
Yufeng Wang ◽  
Dong Zhai ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Minimally Invasive ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Bone Defects ◽  
Bone Cements ◽  
Invasive Treatment ◽  
Calcium Phosphate Cements ◽  
Bone Tumor Resection

Although calcium phosphate cements (CPC) have been clinically used to repair bone defects caused by bone tumor resection, traditional CPC cannot kill the remaining tumor cells after surgery and prevent...

scholarly journals The Accuracy of Three-Dimensional Planned Bone Tumor Resection Using Patient-Specific Instrument

2020 ◽  
Vol Volume 12 ◽  
pp. 6533-6540
Author(s):  
Daniel A Müller ◽  
Yannik Stutz ◽  
Lazaros Vlachopoulos ◽  
Mazda Farshad ◽  
Philipp Fürnstahl
Keyword(s):  
Bone Tumor ◽  
Tumor Resection ◽  
Three Dimensional ◽  
Patient Specific ◽  
Specific Instrument ◽  
Bone Tumor Resection

scholarly journals Functional Outcome in Sarcomas Treated With Limb-Salvage Surgery or Amputation

Sarcoma ◽  
1998 ◽  
Vol 2 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Rikke Johansen ◽  
Ole S. Nielsen ◽  
Johnny Keller
Keyword(s):  
Functional Outcome ◽  
Limb Salvage ◽  
Salvage Surgery ◽  
Univariate Analysis ◽  
Soft Tissue Sarcomas ◽  
Post Treatment ◽  
Limb Salvage Surgery ◽  
Functional Evaluation ◽  
Functional Scores

Purpose.In all patients treated at the Centre for Bone and Soft Tissue Sarcomas of Aarhus the functional outcome is prospectively evaluated by use of the Enneking system for the functional evaluation after surgical treatment of tumours of the musculoskeletal system. This system has been accepted by the Musculoskeletal Tumour Society and the International Symposium on Limb Salvage.Patients/methods.In the present study the functional outcome after limb-salvage surgery (89 patients) and amputation (58 patients) was compared. In the limb-salvage group the treatment was surgery alone in 50% and surgery combined with either radiotherapy in 39% or chemotherapy in 11%. Inclusion criteria were: Deep seated extremity sarcomas, age >14 years, more than 1 year post-treatment follow-up time and alive at the end of the study. Median age was 49 years (range 14–88 years). Median tumour diameter was 8 cm (range 1–20 cm), median follow-up time was 4.8 years (range 1–11 years). Wilcoxon andχ2-tests were used for statistical analyses.Results.The two groups were comparable according to age, sex, size of tumour, type of tumour, location of tumour, as well as post-treatment follow-up time. The functional scores were significantly higher after limb-salvage surgery as compared to amputation, the median scores being 85 and 47, respectively (p<0.001). A similar difference was observed if the Enneking scores were subdivided into general health-related scores and extremity-related scores. No association was found between functional scores and the following factors by use of univariate analysis: size of tumour, radiation therapy, localization of tumour and surgical margin.Discussion.We conclude that this study indicates that limb-salvage surgery is associated with a better functional outcome than that observed after amputation. However, whether this also indicates a difference in quality of life needs further studies.

Arthrodeses After Malignant Bone Tumor Resection in Children

Limb Salvage ◽  
1991 ◽  
pp. 543-551
Author(s):  
R. Capanna ◽  
M. Manfrini ◽  
D. Donati ◽  
A. Ferruzzi ◽  
M. Campanacci
Keyword(s):  
Bone Tumor ◽  
Tumor Resection ◽  
Malignant Bone Tumor ◽  
Bone Tumor Resection

SURVIVAL OF TOTAL KNEE REPLACEMENT WITH A MEGAPROSTHESIS AFTER BONE TUMOR RESECTION

2006 ◽  
Vol 88 (6) ◽  
pp. 1285-1293 ◽  
Author(s):  
DAVID BIAU ◽  
FLORENT FAURE ◽  
SANDRINE KATSAHIAN ◽  
CÉCILE JEANROT ◽  
BERNARD TOMENO ◽  
...  
Keyword(s):  
Total Knee Replacement ◽  
Knee Replacement ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Total Knee ◽  
Bone Tumor Resection

scholarly journals Fixed-hinge cemented modular implants: An effective reconstruction technique following primary distal femoral bone tumor resection. A 136-case multicenter series

2020 ◽  
Vol 106 (3) ◽  
pp. 397-402
Author(s):  
Jean Camille Mattei ◽  
Benjamin Chapat ◽  
Benjamin Ferembach ◽  
Louis-Romée Le Nail ◽  
Vincent Crenn ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Resection ◽  
Reconstruction Technique ◽  
Femoral Bone ◽  
Modular Implants ◽  
Bone Tumor Resection
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