scholarly journals Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Jintana Sirivarasai ◽  
Sukhumpun Kaojarern ◽  
Suwannee Chanprasertyothin ◽  
Pachara Panpunuan ◽  
Krittaya Petchpoung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Oxidative Stress Marker ◽  
Blood Levels ◽  
Cross Sectional ◽  
Cat Gene

Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P<0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L,P<0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.

scholarly journals Blood lead level in school going children of Jodhpur, Rajasthan, India

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Shailja Sharma ◽  
Prasenjit Mitra ◽  
Pankaj Bhardwaj ◽  
Praveen Sharma
Keyword(s):  
Lead Exposure ◽  
Blood Lead Level ◽  
Local Population ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Primary School Children ◽  
Urban Region ◽  
Limited Information ◽  
Cross Sectional

Abstract Objectives Lead exposure in children contributes to 600,000 new cases of intellectual disabilities every year with maximum occurrence in developing countries. Currently limited information is available on the blood lead level (BLL) in children of India. The aim was to estimate BLL in the school going children of local population of Jodhpur. Methods Four hundred twenty-six primary school children of government and private schools participated in this cross sectional study. Information regarding possible lead exposure was collected. BLL was estimated on Lead Care II analyser (Magellan Diagnostics, USA). Results The mean and median BLL were 4.25 ± 1.75 μg/dL (<3.3–22.6 μg/dL) and 3.5 μg/dL (Inter Quartile Range 0.9). BLL was higher in children of illiterate mothers, those residing near traffic dense areas, urban region and studying in government schools of urban region. Conclusions BLL in children residing in Jodhpur is much higher in comparison to western counterparts. Screening and awareness programs regarding potential sources of lead exposure can help in improving BLL.

scholarly journals Examining the relationship between blood lead level and stunting, wasting and underweight- A cross-sectional study of children under 2 years-of-age in a Bangladeshi slum

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197856 ◽  
Author(s):  
Mohammad Jyoti Raihan ◽  
Emily Briskin ◽  
Mustafa Mahfuz ◽  
M. Munirul Islam ◽  
Dinesh Mondal ◽  
...  
Keyword(s):  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

scholarly journals Childhood Lead Exposure from Battery Recycling in Vietnam

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
William E. Daniell ◽  
Lo Van Tung ◽  
Ryan M. Wallace ◽  
Deborah J. Havens ◽  
Catherine J. Karr ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Soil Lead ◽  
Effective Strategies ◽  
Battery Recycling ◽  
Home Based ◽  
Lead Levels

Background. Battery recycling facilities in developing countries can cause community lead exposure.Objective. To evaluate child lead exposure in a Vietnam battery recycling craft village after efforts to shift home-based recycling outside the village.Methods. This cross-sectional study evaluated 109 children in Dong Mai village, using blood lead level (BLL) measurement, parent interview, and household observation. Blood samples were analyzed with a LeadCare II field instrument; highest BLLs (≥45 μg/dL) were retested by laboratory analysis. Surface and soil lead were measured at 11 households and a school with X-ray fluorescence analyzer.Results. All children had high BLLs; 28% had BLL ≥45 μg/dL. Younger age, family recycling, and outside brick surfaces were associated with higher BLL. Surface and soil lead levels were high at all tested homes, even with no recycling history. Laboratory BLLs were lower than LeadCare BLLs, in 24 retested children.Discussion. In spite of improvements, lead exposure was still substantial and probably associated with continued home-based recycling, legacy contamination, and workplace take-home exposure pathways. There is a need for effective strategies to manage lead exposure from battery recycling in craft villages. These reported BLL values should be interpreted cautiously, although the observed field-laboratory discordance may reflect bias in laboratory results.

scholarly journals Correlation of blood lead level and intelligence quotient in children

2014 ◽  
Vol 54 (3) ◽  
pp. 127
Author(s):  
Lilian Gunawan ◽  
Nurhayati Masloman
Keyword(s):  
Rural Area ◽  
Negative Correlation ◽  
Blood Lead Level ◽  
Graphite Furnace ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
North Sulawesi ◽  
Poisoning In Children

Background Lead poisoning is a source of health problems inhumans. A chronic complication oflead poisoning in children ispermanent intellectual impairment.Objective To assess for a correlation of blood lead levels andintelligence quotient (IQ) in children.Methods A cross-sectional study was performed in children aged6 to 8 years in th e Talawaan (a rural area) and Wenang (an urbanarea) Distticts, North Sulawesi, from April to July 2012. Blood leadlevels were measured using the graphite furnace atomic absorptionspectrometry technique; and intelligence was meas ured with theWechsler Intelligence Scale for Children-Indonesian version.Results There were 50 subjects from the Talawaan District and 54subjects from the Wenang Disttict in this study. The mean bloodlead level in the Talawaan District subjects was significantly higherthan that of the Wenang Disttict subjects [25.8 (SD 16.98) μgidLvs 11.4 (SD 13.81) μgidL, respectively; (P<0.001)]. There was aweak negative correlation between blood lead level and IQ in theTalawaan Disttict children (P= 0.038; r= -0.3). As such, there wasa 0.05 IQ point decrement associated with each increase of 1 μ gidLin blood lead level in Talawaan District children. However, therewas no correlation between blood lead level and IQ in the WenangDisttict children (P=0.42; r =0.03).Conclusion There is a weak negative correlation between bloodlead level and IQ in children living in a rural area, howevei; thiscorrelation is not found in children living in an urban area.

scholarly journals Blood Lead Level among school children in an Industrial city of Nepal

2017 ◽  
Vol 7 (1) ◽  
pp. 1091-1094 ◽  
Author(s):  
K Gautam ◽  
S Pradhan ◽  
V Thuppil ◽  
D Pyakurel ◽  
A Shrestha
Keyword(s):  
Blood Lead Level ◽  
Large Population ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Industrial City ◽  
The Mean ◽  
Low Levels ◽  
High Level

Background: Widespread use of lead has caused extensive environmental contamination and health problems in many parts of the world. Children are particularly vulnerable and even relatively low levels of exposure can cause serious health conditions. Our objective was to determine the prevalence of blood lead level in children in industrial city of Nepal, Birgunj.Materials and Methods: The cross sectional study was done on 50 school going student in Birgunj city, Nepal from November 2016 to January 2017. Questionnaire was used to collect data. Capillary blood was drawn and Blood Lead Level was measured immediately. SPSS ver. 22 was used to analyze the data.Results: The mean age of children in study was 12.5 ± 1.11 years.Among 50 children, 54% were male and 46% were female. The mean blood lead level was 20.33±9.36 μg/dl (male 21.08±8.87μg/dl, female 19.46±10.92 μg/dl). All the children in the study have elevated blood lead level and 84% of them have >10 μg/dl. About 26% of children have blood lead level between 15-20 μg/dl, 12% have level 20-25 μg/dl and 4% of them have more than 35 μg/dl.Conclusion: The prevalence of blood lead level in children from the industrial city of Nepal is alarmingly high. Children exposed with chipped paints have high level of blood lead level. However, further study in large population is required to address the current situation regarding the lead exposure to children.  

scholarly journals Effects of oxidative stress on blood pressure and electrocardiogram findings in workers with occupational exposure to lead

2019 ◽  
Vol 47 (6) ◽  
pp. 2461-2470 ◽  
Author(s):  
Wei Qu ◽  
Guo-Li Du ◽  
Bin Feng ◽  
Hua Shao
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Stress Index ◽  
High Dose ◽  
Oxidative Stress Index ◽  
Two Populations

Objective To observe the correlation between the oxidative stress index and cardiovascular system damage in a population with lead exposure. Methods Two populations (144 manufacturing workers and 94 administrators) from a lead–acid battery manufacturer in Shandong Province in China were recruited. The blood lead level, oxidative stress index, blood pressure, electrocardiogram findings, and their correlations were analyzed in both groups. Results The blood lead level was significantly higher in manufacturing workers than administrators (254.34 vs. 65.32 µg/L, respectively). The differences in the oxidative stress index, serum total superoxide dismutase (T-SOD) concentration, and malondialdehyde (MDA) concentration between the two populations were statistically significant. The rates of abnormal blood pressure and electrocardiogram findings were significantly higher in manufacturing workers than administrators. Workers with middle- and high-dose lead exposure had lower T-SOD and higher MDA concentrations than those with low-dose lead exposure. Significant correlations were found between the blood lead level and the MDA concentration, systolic pressure, diastolic pressure, and electrocardiogram findings. Linear multiple regression analysis showed that T-SOD was negatively associated with blood lead, electrocardiogram findings, and MDA. Conclusion Lead exposure can lead to oxidative stress, increased blood pressure, and abnormal electrocardiogram findings and may impact cardiovascular diseases through oxidative stress.

scholarly journals Blood Pressure and Oxidative Stress among U.S. Adults Exposed to Lead in Military Environments—A Preliminary Study

Diseases ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 97 ◽  
Author(s):  
Emmanuel Obeng-Gyasi ◽  
Barnabas Obeng-Gyasi
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Gamma Glutamyl Transferase ◽  
Clinical Markers ◽  
Cross Sectional ◽  
Lead Levels ◽  
Glutamyl Transferase

In this cross-sectional study, lead exposure among those with a history in military environments was examined. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) are clinical markers of blood pressure, while gamma-glutamyl transferase (GGT) is a marker of oxidative stress. These markers and their effects on those exposed to military environments were explored using National Health and Nutrition Examination Survey (NHANES) data from 2009 to 2016. Mean SBP and GGT were significantly elevated in those exposed to military environments, with a moderately significant association existing between blood lead levels (BLLs) and SBP. More attention must be given to lead exposure in military environments to mitigate the risk of exposure.

scholarly journals Association between blood lead level and risk of stroke in Korean adults: a cross-sectional study in the Korea National Health and Nutrition Examination Survey 2008–2013

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035725
Author(s):  
Minkyeong Kim ◽  
Sang-Moon Yun ◽  
Jihyun Jeong ◽  
Chulman Jo ◽  
Young Ho Koh
Keyword(s):  
Blood Lead Level ◽  
Lead Concentration ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
High Level ◽  
Level Group

ObjectivesAlthough lead is a potential risk factor for cardiovascular diseases such as stroke, research on this association in the Korean population remains limited. Therefore, we aimed to investigate the association between lead level and stroke in Korean adults.DesignA population-based cross-sectional study.SettingThe Korea National Health and Nutrition Examination Survey 2008–2013, which enrolled a representative sample of the Korean population.ParticipantsWe excluded participants younger than 20 years, missing weight data, pregnant or lactating, and missing blood lead and stroke data. A total of 11 510 participants were included in this analysis.Primary and secondary outcome measurementThe participants were classified by blood lead concentration into the low-level (≤2.189 µg/dL, n=5756) and high-level (>2.189 µg/dL, n=5754) groups. The main outcome, stroke, was assessed by information from physician diagnosis, prevalence of stroke or treatment for stroke. The ORs and 95% CIs were calculated to evaluate the association between blood lead level and stroke using multivariate logistic regression analysis.ResultsAlthough blood lead level was not significantly associated with stroke (OR: 1.30, 95% CI: 0.66–2.58) in the multivariate-adjusted model, in individuals with hypertension, the high-level group was 2.36-fold higher odds of stroke (OR: 2.36, 95% CI: 1.02–5.44) compared to that in the low-level group. No association was observed in individuals with normotension (OR: 0.42, 95% CI: 0.13–1.38, p for interaction=0.007).ConclusionThe association between blood lead concentration and stroke may be influenced by hypertension status. Our findings suggest the need for closer attention to lead exposure in patients with hypertension.

Study of the impact of blood lead level on humoral immunity in humans

2002 ◽  
Vol 18 (1) ◽  
pp. 39-44 ◽  
Author(s):  
M ohammad Ayatollahi
Keyword(s):  
Blood Lead Level ◽  
Venous Blood ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
The Body ◽  
Cross Sectional ◽  
System A ◽  
Organ Systems ◽  
The Impact

The objective was to study the impact of blood lead level (BLL) on serum immunoglobulin levels (SIL; IgG, IgM, IgA) in people with high-risk professions. It has been characterized that BLL / 25 g/dL can cause dysfunctions in different organ systems of the body, such as the immune system. A cross-sectional study was carried out in relation to this, by using a pretested questionnaire to collect data on demographic factors and socioeconomic status, which was completed by subjects studied, such as car battery shop workers, car painters and welders of car radiators and exhausts, printing office workers (typesetters and nontypesetters) who were aged between 15 and 70 years. Venous blood was sampled to measure the BLL (by atomic absorption spectroscopy) and SIL (by SRID). The results, when analysed, suggested a reduction in SIL with emphasis on IgG in comparison with standard levels.

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