scholarly journals Review on the Applications and Molecular Mechanisms ofXihuangPill in Tumor Treatment

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Qiujun Guo ◽  
Jinyin Lin ◽  
Rui Liu ◽  
Yebo Gao ◽  
Shulin He ◽  
...  
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Molecular Mechanisms ◽  
18Th Century ◽  
Basic Research ◽  
Clinical Effects ◽  
Antitumor Effects ◽  
Non Hodgkin Lymphoma ◽  
Growth Of Tumor ◽  
Complementary And Alternative

Xihuangpill (XH) is a complementary and alternative medicine that has been used in traditional Chinese medicine (TCM) for the treatment of tumors since the 18th century. XH has clinical effects on non-Hodgkin lymphoma, breast cancer, gastric cancer, liver cancer, and bone metastasis. XH can also inhibit the growth of tumor cells and cancer stem cells, prevent tumor invasion and angiogenesis, and regulate the tumor microenvironment. XH is composed ofRu Xiang(olibanum),Mo Yao(Commiphora myrrha),She Xiang(Moschus), andNiu Huang(Calculus bovis). Some of the compounds found in these ingredients exert multiple antitumor effects and may synergize with the other ingredients. We aimed to summarize the clinical applications and molecular mechanisms of XH and its chemical composition. This review will provide potential new strategies and alternative perspectives for tumor treatments and basic research into complementary and alternative medicine.

scholarly journals Complementary and alternative medicine use among infertile women attending infertility specialty clinics in South Korea: does perceived severity matter?

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jung Hye Hwang ◽  
Yi Young Kim ◽  
Hyea Bin Im ◽  
Dongwoon Han
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Conventional Treatment ◽  
Well Being ◽  
Infertility Treatment ◽  
Clinical Effects ◽  
Perceived Severity ◽  
Infertile Women ◽  
Cam Use ◽  
Complementary And Alternative

Abstract Background Complementary and alternative medicine (CAM) use among infertile women is popular in many countries, including Korea. Previous research has repeatedly found more than half of infertile women surveyed use CAM therapies for fertility enhancement and overall well-being. However, there is currently little evidence to support this practice, and this raises the question of infertile women’s experiences in the uptake of those modalities and sociodemographic and psychological factors associated with CAM use. Thus, this study aims to explore the perceptions and experiences of infertile women with regard to their use of CAM in Korea. Methods A cross-sectional study was conducted using data from 263 infertile women attending infertility specialty clinics in Seoul, Korea, in June 2012. The survey instrument included 47 questions on the use of CAM, demographic characteristics, health status, and infertility related factors such as duration and type of infertility, experience and satisfaction of conventional treatment, and self-perceived severity of infertility condition. Chi-square test and logistic regression were used for data analysis. Results Among 286 respondents (response rate, 95.3%), a total of 263 women were included in the final analysis. 63.5% of respondents used one or more types of CAM modalities during infertility treatment. The utilization of CAM was associated with employment status, duration of infertility treatment, and self-perceived severity of the disease. The most commonly used CAM modalities were multivitamin and herbal medicine, and differences in types of CAM modalities used were found between the group with a higher rating of self-perceived disease severity and the lower perceived severity group. Conclusions High prevalence of CAM use among infertile women was observed in Korea. Our findings support that infertile women’s own understanding of their illness and physical condition influences self-care behavior such as CAM use. This calls for an urgent need for further in-depth study of the clinical effects of popular CAM modalities among infertile women when used in conjunction with conventional treatment.

scholarly journals Widespread use of complementary and alternative medicine among non-Hodgkin lymphoma survivors

2014 ◽  
Vol 56 (2) ◽  
pp. 434-439 ◽  
Author(s):  
Sarah Rausch Osian ◽  
Alexis D. Leal ◽  
Cristine Allmer ◽  
Matthew J. Maurer ◽  
Grezegorz Nowakowski ◽  
...  
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Hodgkin Lymphoma ◽  
Non Hodgkin Lymphoma ◽  
Lymphoma Survivors ◽  
Complementary And Alternative

scholarly journals Targeting Sonic Hedgehog Signaling by Compounds and Derivatives from Natural Products

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Yu-Chuen Huang ◽  
K. S. Clifford Chao ◽  
Hui-Fen Liao ◽  
Yu-Jen Chen
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Sonic Hedgehog ◽  
Anticancer Agents ◽  
Invasion And Metastasis ◽  
Antitumor Effects ◽  
Shh Signaling ◽  
Shh Pathway ◽  
Complementary And Alternative

Cancer stem cells (CSCs) are a major cause of cancer treatment failure, relapse, and drug resistance and are known to be responsible for cancer cell invasion and metastasis. The Sonic hedgehog (Shh) signaling pathway is crucial to embryonic development. Intriguingly, the aberrant activation of the Shh pathway plays critical roles in developing CSCs and leads to angiogenesis, migration, invasion, and metastasis. Natural compounds and chemical structure modified derivatives from complementary and alternative medicine have received increasing attention as cancer chemopreventives, and their antitumor effects have been demonstrated bothin vitroandin vivo. However, reports for their bioactivity against CSCs and specifically targeting Shh signaling remain limited. In this review, we summarize investigations of the compounds cyclopamine, curcumin, epigallocatechin-3-gallate, genistein, resveratrol, zerumbone, norcantharidin, and arsenic trioxide, with a focus on Shh signaling blockade. Given that Shh signaling antagonism has been clinically proven as effective strategy against CSCs, this review may be exploitable for development of novel anticancer agents from complementary and alternative medicine.

scholarly journals The Flexner Report of 1910 and Its Impact on Complementary and Alternative Medicine and Psychiatry in North America in the 20th Century

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Frank W. Stahnisch ◽  
Marja Verhoef
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
20Th Century ◽  
Psychiatric Treatment ◽  
Basic Research ◽  
Modern Medicine ◽  
Biomedical Science ◽  
Major Influence ◽  
Flexner Report ◽  
Complementary And Alternative

America experienced a genuinely vast development of biomedical science in the early decades of the twentieth century, which in turn impacted the community of academic psychiatry and changed the way in which clinical and basic research approaches in psychiatry were conceptualized. This development was largely based on the restructuring of research universities in both of the USA and Canada following the influential report of Johns Hopkins-trained science administrator and politician Abraham Flexner (1866–1959). Flexner’s report written in commission for the Carnegie Foundation for the Advancement of Teaching in Washington, DC, also had a major influence on complementary and alternative medicine (CAM) in psychiatry throughout the 20th century. This paper explores the lasting impact of Flexner’s research published on modern medicine and particularly on what he interpreted as the various forms of health care and psychiatric treatment that appeared to compete with the paradigm of biomedicine. We will particularly draw attention to the serious effects of the closing of so many CAM-oriented hospitals, colleges, and medical teaching programs following to the publication of the Flexner Report in 1910.

scholarly journals Resistance to Antibiotics and Antifungal Medicinal Products: Can Complementary and Alternative Medicine Help Solve the Problem in Common Infection Diseases? The Introduction of a Dutch Research Consortium

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Esther T. Kok ◽  
Miek C. Jong ◽  
Barbara Gravendeel ◽  
Willem B. Van Leeuwen ◽  
Erik W. Baars
Keyword(s):  
Antibiotic Resistance ◽  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Therapeutic Interventions ◽  
Vaginal Candidiasis ◽  
Sufficient Evidence ◽  
Clinical Effects ◽  
Positive Effects ◽  
Cochrane Reviews ◽  
Complementary And Alternative

The increase of antibiotic resistance worldwide, rising numbers of deaths and costs associated with this, and the fact that hardly any new antimicrobial drugs have been developed during the last decade have increased the interest in Complementary and Alternative Medicine (CAM) therapeutic interventions, if proven safe and effective. Observational studies on clinical CAM practices demonstrate positive effects of treatment of infections with CAM therapies (clinical effects, patient satisfaction) in combination with small percentages of antibiotics prescription. However, Cochrane reviews and other studies demonstrate that in most instances the quality of clinical trials on CAM treatment of infections is currently too low to provide sufficient evidence. Therefore a Dutch consortium on (in vitro and clinical) scientific research on CAM and antibiotic resistance has been formed. The aim and objective of the consortium is to establish an enduring partnership and to develop expertise to further develop and investigate safe and effective CAM treatments for infectious diseases of humans (and animals). A first ongoing project on the development of safe and effective biobased CAM antimycotics in women with (recurrent) vaginal candidiasis infection is introduced.

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