scholarly journals Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Wen Fang ◽  
Shifang Zhao ◽  
Fuming He ◽  
Li Liu ◽  
Guoli Yang
Keyword(s):  
Animal Model ◽  
Bone Formation ◽  
Electrochemical Process ◽  
New Bone Formation ◽  
Bone Implant ◽  
Natural Bone ◽  
Porous Implant ◽  
Bone Implant Contact ◽  
Dose Effects ◽  
Ovariectomized Animal

The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone. This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects of these simvastatin-HA coatings on implant surfaces in an animal model of osteoporosis. In this study, simvastatin-HA coated implants were inserted into the tibia of osteoporotic rats. After 2, 4, and 12 weeks, tissue was retrieved for histomorphometric evaluation. The results indicated that the simvastatin-HA coatings increased bone-implant contact and new bone formation around implant surfaces. In conclusion, implants loaded with simvastatin by an electrochemical process improved implant osseointegration in osteoporotic rats. Furthermore, the increased concentration of simvastatin could affect the osseointegration, but the dose-effects also need further investigation.

scholarly journals Histomorphometric evaluation of new bone formation in diabetic rats submitted to insertion of temporary implants

2004 ◽  
Vol 15 (2) ◽  
pp. 87-92 ◽  
Author(s):  
Cyro Eduardo de Carvalho Ottoni ◽  
Renato Paulo Chopard
Keyword(s):  
Bone Formation ◽  
Light Microscopy ◽  
Contact Area ◽  
Wistar Rats ◽  
Diabetic Rats ◽  
Fluorescent Light ◽  
New Bone Formation ◽  
Bone Implant ◽  
Bone Implant Contact ◽  
Cortical Regions

This study aimed to quantify new bone formation in the femurs of diabetic Wistar rats. Over an eight-week period, MTI-MP® implants were evaluated in control rats and in diabetic rats. At several points during this period, various markers for bone deposit were introduced. The material was observed under fluorescent light microscopy. New bone formation in periosteal and cortical regions linked to the implant did not vary significantly between the groups. However, there were significant differences in total new bone formation in the medullar canal and in bone/implant contact area in the medullar portion. Bone deposits attached to the surface of the temporary implants demonstrated that they are biocompatible and capable of osseointegration.

In Vivo and In Vitro Evaluation of Coated HAp Films with Different Surface Morphology

2007 ◽  
Vol 539-543 ◽  
pp. 710-715
Author(s):  
Kotaro Kuroda ◽  
Ryoichi Ichino ◽  
Masazumi Okido
Keyword(s):  
Bone Formation ◽  
Surface Morphology ◽  
New Bone Formation ◽  
Contact Ratio ◽  
Bone Implant ◽  
Ft Ir ◽  
Mouse Osteoblast ◽  
Surface Morphologies

Hydroxyapatite (HAp) coatings were formed on cp titanium plates and rods by the thermal substrate method in an aqueous solution that included 0.3 mM Ca(H2PO4)2 and 0.7 mM CaCl2. The coating experiments were conducted at 40-140 oC and pH = 8 for 15 or 30 min. The properties for the coated samples were studied using XRD, EDX, FT-IR, and SEM. All the specimens were covered with HAp, which had different surface morphologies such as net-like, plate-like and needle-like. After cleaning and sterilization, all the coated specimens were subjected to in vivo and vitro testing. In the in vitro testing, the mouse osteoblast-like cells (MC3T3-E1) were cultured on the coated and non-coated specimens for up to 30 days. Moreover, the specimens (φ2 x 5 mm) were implanted in rats femoral for up to 8 weeks, the osseoinductivity on them were evaluated. In in vitro evaluations, there were not significant differences between the different surface morphologies. In in vivo evaluations, however, two weeks postimplantation, new bone formed on both the HAp coated and non-coated titanium rods in the cancellous and cortical bone. The bone-implant contact ratio, which was used for the evaluation of new bone formation, was significantly dependent on the surface morphology of the HAp, and the results demonstrated that the needle-like coating appears to promote rapid bone formation.

Alendronate-loaded hydroxyapatite-TiO2 nanotubes for improved bone formation in osteoporotic rabbits

2016 ◽  
Vol 4 (8) ◽  
pp. 1423-1436 ◽  
Author(s):  
Xinkun Shen ◽  
Pingping Ma ◽  
Yan Hu ◽  
Gaoqiang Xu ◽  
Kui Xu ◽  
...  
Keyword(s):  
Bone Formation ◽  
Tio2 Nanotubes ◽  
New Bone Formation ◽  
Bone Implant

Alendronate-loaded hydroxyapatite-TiO2 nanotubes were fabricated for locally improving new bone formation at the bone–implant interface in osteoporotic rabbits.

scholarly journals Enhanced osteogenesis of quasi-three-dimensional hierarchical topography

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Mengfei Yu ◽  
Yu Liu ◽  
Xiaowen Yu ◽  
Jianhua Li ◽  
Wenquan Zhao ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Extracellular Matrices ◽  
New Bone Formation ◽  
Bone Implant ◽  
Multi Scale ◽  
Bone Implant Contact ◽  
Implant Coatings ◽  
Important Design ◽  
Multi Scales

Abstract Natural extracellular matrices (ECMs) are three-dimensional (3D) and multi-scale hierarchical structure. However, coatings used as ECM-mimicking structures for osteogenesis are typically two-dimensional or single-scaled. Here, we design a distinct quasi-three-dimensional hierarchical topography integrated of density-controlled titania nanodots and nanorods. We find cellular pseudopods preferred to anchor deeply across the distinct 3D topography, dependently of the relative density of nanorods, which promote the osteogenic differentiation of osteoblast but not the viability of fibroblast. The in vivo experimental results further indicate that the new bone formation, the relative bone-implant contact as well as the push-put strength, are significantly enhanced on the 3D hierarchical topography. We also show that the exposures of HFN7.1 and mAb1937 critical functional motifs of fibronectin for cellular anchorage are up-regulated on the 3D hierarchical topography, which might synergistically promote the osteogenesis. Our findings suggest the multi-dimensions and multi-scales as vital characteristic of cell-ECM interactions and as an important design parameter for bone implant coatings.

A pilot study of Cerasorb and Bio-Oss enhanced new bone formation in animal model

2008 ◽  
Vol 59 (3) ◽  
pp. 327-334
Author(s):  
Danica Matusovits ◽  
Zsuzsanna Suba ◽  
D. Takács ◽  
Kinga Turzó ◽  
K. Donath ◽  
...  
Keyword(s):  
Animal Model ◽  
Pilot Study ◽  
Bone Formation ◽  
New Bone Formation

scholarly journals Characteristics of 2 Different Commercially Available Implants with or without Nanotopography

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Ali Alenezi ◽  
Yoshihito Naito ◽  
Martin Andersson ◽  
Bruno R. Chrcanovic ◽  
Ann Wennerberg ◽  
...  
Keyword(s):  
Bone Formation ◽  
Noble Gas ◽  
Optical Microscope ◽  
Bone Area ◽  
New Bone Formation ◽  
Bone Implant ◽  
Early Healing ◽  
Rabbit Femur ◽  
Phosphate Incorporation

The aim of this study was to assess histologically and histomorphometrically the early bone forming properties after 3 weeks for 2 commercially available implants, one supposedly possessing nanotopography and one without, in a rabbit femur model. Twenty-four implants divided equally into 2 groups were utilized in this study. The first group (P-I MICRO+NANO) was a titanium oxide (TiO2) microblasted and noble gas ion bombarded surface while the second group (Ospol) was anodic oxidized surface with calcium and phosphate incorporation. The implants were placed in the rabbit femur unicortically and were allowed to heal for 3 weeks. After euthanasia, the samples were subjected to histologic sectioning and bone-implant contact and bone area were evaluated histomorphometrically under an optical microscope. The histomorphometric evaluation presented that the P-I MICRO+NANO implants demonstrated significantly higher new bone formation as compared to the Ospol implants. Within the limitations of this study, the results suggested that nanostructures presented significantly higher bone formation after 3 weeksin vivo, and the effect of chemistry was limited, which is indicative that nanotopography is effective at early healing periods.

scholarly journals Strontium-calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model

2008 ◽  
Vol 27 (6) ◽  
pp. 758-762 ◽  
Author(s):  
Zhaoyang Li ◽  
William W. Lu ◽  
Peter K.Y. Chiu ◽  
Raymond W.M. Lam ◽  
Bing Xu ◽  
...  
Keyword(s):  
Animal Model ◽  
Bone Formation ◽  
Bone Matrix ◽  
Large Animal Model ◽  
Large Animal ◽  
New Bone Formation ◽  
Factor Expression ◽  
Osteogenic Factor
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