scholarly journals Mucoepidermoid Carcinoma of the Palatine Tonsil

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Lucas Novaes Teixeira ◽  
Victor Angelo Martins Montalli ◽  
Luiz Carlos Santana Teixeira ◽  
Fabrício Passador-Santos ◽  
Andresa Borges Soares ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Mucoepidermoid Carcinoma ◽  
Unusual Case ◽  
Cell Types ◽  
Palatine Tonsil ◽  
Soft Mass ◽  
Salivary Gland Malignancy ◽  
Adults And Children ◽  
Intermediate Cells

Mucoepidermoid carcinoma (MEC) is the most common primary salivary gland malignancy in both adults and children. It has a slight female predilection and usually presents as a painless, rubber-like or soft mass, which may be fixed or mobile. Histologically, MEC is comprised of a mixture of cell types including mucous, epidermoid, and intermediate cells that can be arranged in solid nests or cystic structures. In the oral cavity, it most frequently occurs at the palate or buccal mucosa. The present paper aimed to describe an unusual case of MEC arising in the palatine tonsil.

scholarly journals PD-1/PD-L1-negative tracheal mucoepidermoid carcinoma: A case report and systematic review of the literature

2021 ◽  
Author(s):  
Ying Ying Liu ◽  
Jian Guo ◽  
Ji Chen ◽  
Hai Xia Li ◽  
Zeng Tao Wang ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Checkpoint Inhibitors ◽  
Small Cell Lung Carcinoma ◽  
Cell Types ◽  
Intermediate Cell ◽  
Sleeve Lobectomy ◽  
Cell Lung Carcinoma ◽  
Segmental Bronchus ◽  
Intermediate Cells ◽  
Chinese Male

Abstract Background: Tracheal mucoepidermoid carcinoma is a rare form of non-small cell lung carcinoma and is defined as a tumor characterized by a combination of squamous, mucus-secreting, and intermediate cell types. This carcinoma is usually located in the lobar or segmental bronchus. Currently, surgery is the preferred treatment for this disease, which includes pneumonectomy, lobectomy, and sleeve lobectomy. Case presentation: A 50-year-old Chinese male presented with cough, shortness of breath and hemoptysis, and the effect of antibiotic therapy was not good. Subsequently, the airway occupied lesion was found by chest CT, and he was transferred to our hospital for surgical resection. Histologically, the tumor contained squamous epidermal cells, mucoepidermoid cells and intermediate cells. Immunohistochemistrically, the tumor cells were positive for p63, CK5/6, CK7 and Ki67. However, the tumor is generally negative for TTF-1 and neuroendocrine markers. The patient had no recurrence 15 months after the surgery.Conclusions: We report a rare case of mucoepidermoid carcinoma in the distal trachea in which the surgery was difficult and could not be performed like a traditional pulmonary resection. We first provide a comprehensive description of airway management and anesthesia intubation. After surgery, we reviewed the literature and found that PD-1/PD-L1 detection had never been reported in tracheal mucoepidermoid carcinoma. Therefore, we studied the PD-1/PD-L1 pathway in this patient, and the results were negative, which may indicate that potential adjuvant therapy with immune checkpoint inhibitors (ICIs) is not useful in this case.

scholarly journals PD-1/PD-L1-negative tracheal mucoepidermoid carcinoma: A case report and systematic review of the literature

2022 ◽  
pp. 260
Author(s):  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Checkpoint Inhibitors ◽  
Small Cell Lung Carcinoma ◽  
Cell Types ◽  
Intermediate Cell ◽  
Sleeve Lobectomy ◽  
Cell Lung Carcinoma ◽  
Segmental Bronchus ◽  
Intermediate Cells ◽  
Chinese Male

Background: Tracheal mucoepidermoid carcinoma is a rare form of non-small cell lung carcinoma and is defined as a tumor characterized by a combination of squamous, mucus-secreting, and intermediate cell types. This carcinoma is usually located in the lobar or segmental bronchus. Currently, surgery is the preferred treatment for this disease, which includes pneumonectomy, lobectomy, and sleeve lobectomy. Case presentation: A 50-year-old Chinese male presented with cough, shortness of breath and hemoptysis, and the effect of antibiotic therapy was not good. Subsequently, the airway occupied lesion was found by chest CT, and he was transferred to our hospital for surgical resection. Histologically, the tumor contained squamous epidermal cells, mucoepidermoid cells and intermediate cells. Immunohistochemistrically, the tumor cells were positive for p63, CK5/6, CK7 and Ki67. However, the tumor is generally negative for TTF-1 and neuroendocrine markers. The patient had no recurrence 15 months after the surgery. Conclusions: We report a rare case of mucoepidermoid carcinoma in the distal trachea in which the surgery was difficult and could not be performed like a traditional pulmonary resection. We first provide a comprehensive description of airway management and anesthesia intubation. After surgery, we reviewed the literature and found that PD-1/PD-L1 detection had never been reported in tracheal mucoepidermoid carcinoma. Therefore, we studied the PD-1/PD-L1 pathway in this patient, and the results were negative, which may indicate that potential adjuvant therapy with immune checkpoint inhibitors (ICIs) is not useful in this case.

Isolated mucoepidermoid carcinoma in the neck

1998 ◽  
Vol 119 (4) ◽  
pp. 398-399 ◽  
Author(s):  
Manish K. Wani ◽  
K. Thomas Robbins ◽  
Frank S. H. Wong ◽  
Todd E. Stiles
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Mucoepidermoid Carcinoma ◽  
Cervical Lymph Node ◽  
Common Type ◽  
Primary Site ◽  
Cervical Lymph Nodes ◽  
Salivary Gland Malignancy

Mucoepidermoid carcinoma is a common type of salivary gland malignancy with metastasis to the cervical lymph nodes occurring in up to 29% of patients. 1 We describe three patients presenting with isolated mucoepidermoid carcinoma in a cervical lymph node without an obvious primary site of origin.

scholarly journals Comparative Cytokeratin Expression in the Different Cell Types of Salivary Gland Mucoepidermoid Carcinoma

2008 ◽  
Vol 2 (4) ◽  
pp. 257-264 ◽  
Author(s):  
Rebeca Souza Azevedo ◽  
Oslei Paes de Almeida ◽  
Luiz Paulo Kowalski ◽  
Fábio Ramôa Pires
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Cell Types ◽  
Cytokeratin Expression ◽  
Different Cell Types

scholarly journals Sclerosing variant of mucoepidermoid carcinoma: a case report and review of literature

2020 ◽  
Vol 8 (11) ◽  
pp. 4124
Author(s):  
Radhika S. ◽  
Deepak Burad ◽  
Tushar Yashwant Sonwane ◽  
Balaji Vishwanath
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Mucoepidermoid Carcinoma ◽  
Malignant Tumour ◽  
Review Of Literature ◽  
Benign Lesions ◽  
Intermediate Cells ◽  
Mucoid Cells

Mucoepidermoid carcinoma, a malignant tumour of the salivary gland is histologically characterized by the presence of mucoid cells, epidermoid cells and intermediate cells. There are many variants of this tumour. A particular variant, sclerosing variant of mucoepidermoid carcinoma is presented due to its rarity and chances of misdiagnosis as benign lesions due to the presence of extensive sclerosing stroma.

scholarly journals Mucoepidermoid carcinoma of the palatine tonsil: a case report and review of the literature

2017 ◽  
Vol 3 (4) ◽  
pp. 1111
Author(s):  
Ponnuswamy Karkuzhali ◽  
Bijayalaxmi Sahoo
Keyword(s):  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Histological Grade ◽  
Clinical Stage ◽  
Palatine Tonsil ◽  
Salivary Gland Neoplasm ◽  
Adults And Children ◽  
Uncommon Case ◽  
Slow Growing ◽  
Firm Mass

<p class="normal">Mucoepidermoid Carcinoma is the most common malignant salivary gland neoplasm. It is seen in both the adults and children and shows a slight female predilection. It presents, usually, as a painless, slow-growing, firm mass, with varied clinical behaviour depending on its clinical stage and histological grade. The majority of the cases occur in the major salivary glands, though it can also arise from minor salivary glands. It occurs, most commonly, in the buccal mucosa and palate in the oral cavity. Other sites, in which it has been reported, include maxilla, mandible, breast tissue, skin and thymus. To our knowledge, only three cases, have been reported in tonsils so far, and hence we report an uncommon case of mucoepidermoid carcinoma of the Palatine tonsil.</p>

scholarly journals Aquaporin 1, 3, and 5 Patterns in Salivary Gland Mucoepidermoid Carcinoma: Expression in Surgical Specimens and an In Vitro Pilot Study

2020 ◽  
Vol 21 (4) ◽  
pp. 1287 ◽  
Author(s):  
Mérin Barbara Stamboni ◽  
Ágatha Nagli de Mello Gomes ◽  
Milena Monteiro de Souza ◽  
Katia Klug Oliveira ◽  
Claudia Fabiana Joca Arruda ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Tumor Biology ◽  
Tumor Stroma ◽  
Cell Phenotype ◽  
Mucosal Cells ◽  
Aqp1 Expression ◽  
Salivary Gland Malignancy ◽  
Vitro Model

Salivary gland aquaporins (AQPs) are essential for the control of saliva production and maintenance of glandular structure. However, little is known of their role in salivary gland neoplasia. Salivary gland tumors comprise a heterogeneous group of lesions, featuring variable histological characteristics and diverse clinical behaviors. Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. The aim of this study was to evaluate the expression of AQP1, AQP3, and AQP5 in 24 MEC samples by immunohistochemistry. AQP1 expression was observed in vascular endothelium throughout the tumor stroma. AQP3 was expressed in epidermoid and mucosal cells and AQP5 was expressed in mucosal cells of MEC. These proteins were expressed in the human MEC cell line UH-HMC-3A. Cellular ultrastructural aspects were analyzed by electron microscopy to certificate the tumor cell phenotype. In summary, our results show that, despite the fact that these molecules are important for salivary gland physiology, they may not play a distinct role in tumorigenesis in MEC. Additionally, the in vitro model may offer new possibilities to further investigate mechanisms of these molecules in tumor biology and their real significance in prognosis and possible target therapies.

scholarly journals Radiotherapy in Inoperable Mucoepidermoid Parotid Cancer: A Case Report

2021 ◽  
Vol 15 (2) ◽  
pp. 95
Author(s):  
Steven Octavianus ◽  
Henry Kodrat
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Postoperative Radiotherapy ◽  
Salivary Gland Cancer ◽  
Case Presentation ◽  
Tumor Mass ◽  
Definitive Radiotherapy ◽  
Salivary Gland Malignancy ◽  
Clinical Benefits ◽  
The Right

Introduction: Salivary gland cancer is an uncommon malignancy in the head and neck. The most common histopathologic type in salivary gland malignancies is mucoepidermoid carcinoma (MEC). Radiotherapy has a role in salivary gland malignancy, especially in inoperable cases and postoperative settings. Definitive or postoperative radiotherapy with or without chemotherapy can improve locoregional control (LRC) in patients with parotid mucoepidermoid carcinoma. Case Presentation: We report a case of a 77-year-old male with inoperable MEC of the right parotid, who received definitive radiotherapy. From the three-month evaluation after radiation therapy, we found a significant reduction in the tumor mass. Conclusions: Surgery remains the treatment of choice for patients with salivary gland malignancies. Definitive radiotherapy can be a treatment modality in inoperable cases or patients who refuse surgery. Although the result is not satisfactory, radiotherapy can still give clinical benefits to patients.

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