scholarly journals Ameloblastic Fibrodentinoma Presenting as a False Gingival Enlargement in the Maxillary Anterior Region

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Shiny Joseph ◽  
Lakshmi Priya ◽  
Dinesh Gopal ◽  
Mary Devachen ◽  
Ajay Narayan ◽  
...  
Keyword(s):  
Microscopic Examination ◽  
Anterior Region ◽  
Excision Biopsy ◽  
Common Site ◽  
Dental Papilla ◽  
Odontogenic Epithelium ◽  
Gingival Enlargement ◽  
Hematoxylin And Eosin ◽  
Stellate Reticulum ◽  
Odontogenic Neoplasm

Ameloblastic fibrodentinoma is a rare benign mixed odontogenic neoplasm usually occurring in the first two decades of life. It is more common in males and the most common site of occurrence is in the mandibular premolar molar area. This report presents a case of ameloblastic fibrodentinoma in a 12-year-old boy in the maxillary anterior region, a less common site for the occurrence of ameloblastic fibrodentinoma. A 12-year-old boy presented with a midline diastema in 11 and 21 region and a swelling in the palatal aspect of 11 and 12. Intraoral periapical radiograph showed the presence of rarefaction of bone on the mesial aspect of the cervical and middle third of the root of 11. Excision biopsy was done. The specimen was processed and stained with hematoxylin and eosin. Microscopic examination showed islands, chords and strands of odontogenic epithelium in a primitive ectomesenchyme resembling dental papilla. The odontogenic epithelium exhibited peripheral ameloblast-like and central stellate reticulum-like cells. The presence of dentinoid material was seen adjacent to the odontogenic epithelium in some foci. The lesion was diagnosed as ameloblastic fibrodentinoma.

scholarly journals Dentinogenic Ghost Cell Tumor of the Peripheral Variant Mimicking Epulis

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Uddipan Kumar ◽  
Hitesh Vij ◽  
Ruchieka Vij ◽  
Jitin Kharbanda ◽  
IN Aparna ◽  
...  
Keyword(s):  
Microscopic Examination ◽  
Definitive Diagnosis ◽  
Cell Tumor ◽  
Current Concept ◽  
Odontogenic Tumor ◽  
Ghost Cell ◽  
Microscopic Appearance ◽  
Odontogenic Epithelium ◽  
Gingival Enlargement ◽  
Dentinogenic Ghost Cell Tumor

Dentinogenic ghost cell tumor (DGCT) is an uncommon locally invasive odontogenic tumor regarded by many as a variant of calcifying odontogenic cyst. The peripheral variant of this clinical rarity appears as a well-circumscribed mass mimicking a nonspecific gingival enlargement. Microscopic appearance of odontogenic epithelium admixed with focal areas of dentinoid formation and sheets of ghost cells giving the definitive diagnosis of dentinogenic ghost cell tumor imply that microscopic examination is compulsory for any gingival mass. Van Gieson histochemical stain further confirmed the nature of dentinoid-like material. A complete workup of a case of peripheral dentinogenic ghost cell tumor is presented in this paper and the current concept as well as the appraisal of literature is presented.

Histotopography of haemorrhagic infiltration in the hanging cutaneous furrow: Where to look for haemorrhagic infiltration in hanging

2021 ◽  
pp. 002580242110232
Author(s):  
Guendalina Gentile ◽  
Stefano Tambuzzi ◽  
Salvatore Andreola ◽  
Riccardo Zoja
Keyword(s):  
Adipose Tissue ◽  
Microscopic Examination ◽  
Subcutaneous Adipose Tissue ◽  
Transition Point ◽  
Striated Muscle ◽  
Forensic Evidence ◽  
Hematoxylin And Eosin ◽  
Compression Area ◽  
Subcutaneous Adipose ◽  
Masson Trichrome Staining

The forensic evidence of hanging is based on the autopsy demonstration of the traces left by the noose or the ligature on the neck, as well as on the histological assessment of the hanging mark vitality. However, the specific topography of haemorrhagic infiltration in the context of the cervical damaged tissues involved in hanging is not known. We carried out an extensive microscopic examination to identify if haemorrhagic infiltration in hanging appeared in specific topographic locations that could have been considered as elective. From 102 victims of suicidal hanging, a skin fragment was sampled from the maximum compression area of the sulcus, including the skin portions immediately above and below it. The sampling was also extended to collect the subcutaneous adipose tissue and part of the striated muscle. A standard histological examination was performed on all the samples, and hematoxylin and Eosin, Weigert’s resorcin-fuchsin and Goldner’s Masson trichrome staining were performed. In all the cases assessed, the microscopic examination allowed the detection of haemorrhagic infiltration mainly in the deepest areas under the sulcus and especially in the deep dermis and at the transition point between the dermis and the subcutaneous adipose tissue, as well as in the context of its supporting connective tissue. Such areas could therefore be considered as regions in which the presence of haemorrhagic infiltration is more likely to be demonstrated. Accordingly, we recommend performing sampling similar to ours and focusing the search for haemorrhagic infiltration as suggested.

scholarly journals A Transient Developmental Background Finding in the Retina Observed in Neonatal Dogs in Juvenile Toxicology Studies

2019 ◽  
Vol 47 (4) ◽  
pp. 528-541 ◽  
Author(s):  
Janet M. Petruska ◽  
Amera K. Remick ◽  
Typhaine Lejeune ◽  
Mark Vezina ◽  
Keith Robinson ◽  
...  
Keyword(s):  
Microscopic Examination ◽  
Bipolar Cells ◽  
Unexpected Finding ◽  
Beagle Dogs ◽  
Full Field ◽  
Tissue Sections ◽  
Light Microscopic Examination ◽  
Age Related ◽  
Transmission Electron ◽  
Hematoxylin And Eosin

In a juvenile toxicology program, an unexpected finding of vacuolation of inner nuclear, ganglion cell, and nerve fiber layers of the retina was observed microscopically in routine Davidson’s fixed and hematoxylin and eosin–stained tissue sections of eyes in beagle dogs at approximately 5 weeks of age. There was no necrosis or degeneration of the affected cells and no associated inflammation. Fluorescein angiography revealed no vascular leakage. Optical coherence tomography (OCT) indicated swollen cells in the same layers of the retina as observed at light microscopic examination. Transmission electron microscopy revealed that the retinal vacuolation likely was consistent with intracellular swelling of amacrine, horizontal, and/or bipolar cells of the inner nuclear layer as affected cells had an expanded cytoplasm but contained normal nucleus and organelles. As assessed by animal behavior and full-field electroretinography, the retinal vacuolation appeared to have no impact on visual function. Retinal vacuolation was seen in approximately 40% of dogs at 5 weeks of age using OCT and/or light microscopic examination. Because the change was transient and age related, did not result in degenerative retinal changes, and was not present in dogs older than 5 weeks of age, it was considered a background developmental observation in beagle dogs.

scholarly journals A Histopathological and Immunohistochemical Analysis of Ameloblastic Fibrodentinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Ronell Bologna-Molina ◽  
Sirced Salazar-Rodríguez ◽  
Ana María Bedoya-Borella ◽  
Ramón Gil Carreón-Burciaga ◽  
Gabriel Tapia-Repetto ◽  
...  
Keyword(s):  
Histone H3 ◽  
Immunohistochemical Analysis ◽  
Odontogenic Tumor ◽  
Rare Entity ◽  
Ki 67 ◽  
Dental Papilla ◽  
Odontogenic Epithelium ◽  
Ameloblastic Fibroma ◽  
Large Panel

Ameloblastic fibrodentinoma (AFD) is considered a mixed odontogenic tumor that is characterized by conserved epithelial and ectomesenchymal neoplastic components. AFD is composed of long narrow cords and islands of odontogenic epithelium; the epithelial strands lie in a myxoid cell-rich ectomesenchymal tissue with stellate-shaped fibroblasts that exhibit long slender cytoplasmic extensions that resemble dental papilla. The lesions show the presence of dysplastic dentin. Although AFD is a rare entity and its very existence is not completely accepted, based on the extent of histodifferentiation, it is considered to represent a stage between ameloblastic fibroma and ameloblastic fibroodontoma. This study aimed to provide a histopathological and immunohistochemical characterization of this infrequent tumor. A large panel of antibodies including amelogenin, Ck 19, calretinin, syndecan-1, E-cadherin, MSH2, histone H3, and Ki-67 was used to illustrate the nature of the tumor.

scholarly journals Ameloblastic Fibroodontoma: Uncommon Case Presentation in a 6-Year-Old Child with Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Anshad Mohamed Abdulla ◽  
G. Sivadas ◽  
L. K. Surej Kumar ◽  
C. S. Sheejith Hari Peeceeyen ◽  
Vaishnavi Vedam
Keyword(s):  
Review Of The Literature ◽  
Radiographic Findings ◽  
Case Presentation ◽  
Irregular Shapes ◽  
Odontogenic Epithelium ◽  
Ameloblastic Fibroma ◽  
Complex Odontoma ◽  
Uncommon Case ◽  
Odontogenic Neoplasm ◽  
Unerupted Teeth

Ameloblastic fibroodontoma is a benign mixed odontogenic neoplasm considered in patients with asymptomatic swelling and unerupted teeth that exhibit histologic features between ameloblastic fibroma and complex odontoma. Radiographically, this lesion appears as radiolucency admixed with focal radio opaque masses of irregular shapes and sizes. This lesion is confirmed by the presence of proliferating odontogenic epithelium, ectomesenchyme, and dental hard tissue formation on pathological analysis supplementing clinical and radiographic findings. As this tumour is less commonly seen in routine clinical practice, ameloblastic fibroodontoma with detailed orofacial features and periodic approach to its diagnosis is discussed. This paper reports a case of ameloblastic fibroodontoma of the mandible in a 6-year-old male patient with an uncommon case presentation and review of the literature.

scholarly journals Adenoameloblastoma: A Dilemma in Diagnosis

2012 ◽  
Vol 13 (6) ◽  
pp. 925-929 ◽  
Author(s):  
Uma Shankar ◽  
A Radhika ◽  
Afshan Laheji ◽  
S Sakharde ◽  
S Chidambaram ◽  
...  
Keyword(s):  
Male Patient ◽  
Microscopic Examination ◽  
Rare Case ◽  
Dentigerous Cyst ◽  
Odontogenic Tumor ◽  
Anterior Region ◽  
Adenomatoid Odontogenic Tumor ◽  
Rare Finding ◽  
Odontogenic Origin ◽  
Epithelial Lesion

ABSTRACT Adenoameloblastoma or adenomatoid odontogenic tumor (AOT) is an uncommon, benign, epithelial lesion of odontogenic origin. It is a rare benign odontogenic tumor of the jaw affecting mostly young individuals with predominance in female. It occurs mostly in maxillary anterior region. On the basis of clinical and radiographical picture, it is often misdiagnosed as an odontogenic cyst. We report on a rare case of a 13-year-old male patient with a follicular variety of AOT in mandibular left anterior region which is unusual for the same. Clinically and radiographically, the lesion was mimicking as a dentigerous cyst. Later surgical enucleation was done and specimen was sent for microscopic examination and was diagnosed as AOT along with a dentinoid-like deposits which is a rare finding. How to cite this article Laheji A, Sakharde S, Chidambaram S, Gondhalekar RR, Shankar U, Radhika A. Adenoameloblastoma: A Dilemma in Diagnosis. J Contemp Dent Pract 2012;13(6): 925-929.

scholarly journals The “Epulis” Dilemma. Considerations from Provisional to Final Diagnosis. A Systematic Review

Oral ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 224-235
Author(s):  
Paola Costa ◽  
Matteo Peditto ◽  
Antonia Marcianò ◽  
Antonio Barresi ◽  
Giacomo Oteri
Keyword(s):  
Systematic Review ◽  
Microscopic Examination ◽  
Wide Spectrum ◽  
Data Extraction ◽  
Final Diagnosis ◽  
Electronic Search ◽  
Wide Range ◽  
Gingival Enlargement ◽  
Neoplastic Lesions ◽  
Slow Growing

“Epulis” is a widely used term to describe a localized gingival enlargement. However, a wide range of neoformations might present as localized, slow-growing, asymptomatic gingival masses. A systematic review was conducted to outline the pathological entities that were provisionally dignosed as “epulis” and whose final diagnosis was made after microscopic examination. An electronic search of PubMed, Google Scholar and Scopus databases from January 2000 to February 2021 was performed. An initial search of the databases identified a total of 864 documents, and after a careful process of screening and selection, 14 studies were included in this systematic review and processed for data extraction. The results show that histological examination, sometimes combined with immunohistochemistry, might reveal a wide spectrum of lesions, including hamartomatous lesions, non-neoplastic lesions, benign and malign neoplasms and metastases from distant cancers.

scholarly journals HEREDITORY GINGIVAL FIBROMATOSIS IN A 7-YEAR-OLD GIRL: A CASE REPORT

2017 ◽  
Vol 10 (3) ◽  
pp. 1
Author(s):  
Sandeep A Bailwad ◽  
Navin Patil ◽  
Sivakumar Nuvulla ◽  
Yogesh Chhaparwal ◽  
Saurabh Kumar ◽  
...  
Keyword(s):  
Case Report ◽  
Case Management ◽  
Clinical Diagnosis ◽  
Microscopic Examination ◽  
Periodontal Treatment ◽  
Complex Nature ◽  
Gingival Enlargement ◽  
Gingival Fibromatosis ◽  
Autosomal Inheritance

ABSTRACTThis paper presents a case of hereditary gingival fibromatosis, a rarely reported disorder and addresses the complex nature of oral diagnosis,treatment and long-term case management in the hereditary form of recurrent gingival fibromatosis. Case management is discussed in relation toa 7-year-old girl who presented with recurrent, progressive gingival enlargement requiring consecutive periodontal treatment. The initial course oftreatment included 4-quadrant gingivectomy with excisional bevel incisions, followed by microscopic examination of the gingivectomy specimenswhich supported the clinical diagnosis. 1 year later, recurrence of the condition was observed in all quadrants. It is recommended that patients withthis condition be monitored closely after gingivectomy so that the treatment requirements of localized areas can be addressed as needed.Keywords: Heredity, Genome, Phenotype, Chromosome, Autosomal inheritance.

scholarly journals Immunophenotyping in incidental gastrointestinal neuroendocrine tumors: study at tertiary care centre

2020 ◽  
Vol 10 (2) ◽  
pp. 1751-1755
Author(s):  
Rachana R Lakhe ◽  
Ravi M Swami ◽  
Purva Kulkarni ◽  
Preeti Rajeev Doshi ◽  
Narayanan Subramanian Mani
Keyword(s):  
Neuroendocrine Tumors ◽  
Tertiary Care ◽  
Gastrointestinal Tumors ◽  
Common Site ◽  
Tertiary Care Centre ◽  
Ki 67 ◽  
Hematoxylin And Eosin ◽  
Diagnostic Modalities ◽  
Grade 3 ◽  
Slow Growing

Background: Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct histological, biological, and clinical characteristics that have increased in incidence and prevalence in the last few decades. This study is aimed to find out the incidence of neuroendocrine tumors among the gastrointestinal tumors and to grade gastrointestinal neuroendocrine tumors. Materials and Methods: A total of 119 cases of gastrointestinal tumors of gastrointestinal neuroendocrine was included in the study. The paraffin blocks were retrieved and slides were stained with routine Hematoxylin and Eosin, synaptophysin, chromogranin, and Ki67. The histologic grading was done based on mitosis and Ki-67 index as per WHO 2017 classification. Results: Out of 119 cases of Gastrointestinal Tract tumor, 13 (10.92%) constituted neuroendocrine tumors. Duodenum was the most common site (38%) followed by the appendix (23%). The majority (1.9%) of the cases were categorized as of grade 1 followed by 2.3% of grade 2 and 1.19% of grade 3.  Immunohistochemically, chromogranin, and synaptophysin were strongly expressed in all ten cases of neuroendocrine tumors. The Ki67 labeling index was <3 % in 10 cases, while it was in the range of 3 – 20 % in 2 cases and >20 % in one case. Conclusions: The incidence of gastrointestinal neuroendocrine tumors is on the rise. They should be considered in developing a differential diagnosis. Hence use of diagnostic modalities such as immunohistochemistry should be implemented for better treatment.

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