scholarly journals Leukogram Profile and Clinical Status invivaxandfalciparumMalaria Patients from Colombia

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Alberto Tobón-Castaño ◽  
Esteban Mesa-Echeverry ◽  
Andrés Felipe Miranda-Arboleda
Keyword(s):  
Hematological Parameters ◽  
Clinical Status ◽  
Clinical Complications ◽  
Cell Counts ◽  
Leukocyte Counts ◽  
White Blood Cell Counts ◽  
Hematologic Profile ◽  
Monitoring Treatment ◽  
The Relationship ◽  
Hematological Alterations

Introduction. Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malariavivaxpredominance, the hematologic profile in malaria patients is not well characterized. The aim of this study was to characterize the leukogram in malaria patients and to analyze its alterations in relation to the clinical status.Methods. 888 leukogram profiles of malaria patients from different Colombian regions were studied: 556 withP. falciparuminfection (62.6%), 313 withP. vivaxinfection (35.2%), and 19 with mixed infection by these species (2.1%).Results. Leukocyte counts at diagnosis were within normal range in 79% of patients and 18% had leucopenia; the most frequent alteration was lymphopenia (54%) followed by monocytosis (11%); the differential granulocyte count in 298 patients revealed eosinophilia (15%) and high basophil counts (8%). Leukocytosis, eosinopenia, and neutrophilia were associated with clinical complications. The utility of changes in leukocyte counts as markers of severity should be explored in depth. A better understanding of these hematological parameters will allow their use in prompt diagnosis of malaria complications and monitoring treatment response.

scholarly journals Postoperative Rise of Circulating Mitochondrial DNA Is Associated with Inflammatory Response in Patients following Pancreaticoduodenectomy

2021 ◽  
pp. 1-7
Author(s):  
Niv Pencovich ◽  
Nadav Nevo ◽  
Roi Weiser ◽  
Ekaterina Bonder ◽  
Yoel Bogoch ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Inflammatory Response ◽  
Delayed Gastric Emptying ◽  
Clinical Course ◽  
Severe Trauma ◽  
Postoperative Fever ◽  
Postoperative Course ◽  
Cell Counts ◽  
White Blood Cell Counts ◽  
The Relationship

<b><i>Introduction:</i></b> Accumulation of plasma mitochondrial DNA (mtDNA) following severe trauma has been shown to correlate with the development of systemic inflammatory response syndrome (SIRS) and may predict mortality. Our objective was to investigate the relationship between levels of circulatory mtDNA following pancreaticoduodenectomy (PD) and the postoperative course. <b><i>Methods:</i></b> Levels of plasma mtDNA were assessed by real-time PCR of the mitochondrial genes <i>ND1</i> and <i>COX3</i> in 23 consecutive patients who underwent PD 1 day prior to surgery, within 8 h after surgery, and on postoperative day (POD)1 and POD5. The abundance of mtDNA was assessed relative to preoperative levels and in relation to parameters reflecting the postoperative clinical course. <b><i>Results:</i></b> When pooled for all patients, the circulating mtDNA levels were significantly increased after surgery. However, while a significant (at least &#x3e;2-fold and up to &#x3e;20-fold) rise was noted in 11 patients, no change in mtDNA levels was noted in the other 12 following surgery. Postoperative rise in circulating mtDNA was associated with an increased rate of postoperative fever until day 5, decreased hemoglobin and albumin levels, and increased white blood cell counts. These patients also suffered from increased rates of delayed gastric emptying. No significant differences were demonstrated in other postoperative parameters. <b><i>Conclusion:</i></b> Circulating mtDNA surge is associated with an inflammatory response following PD and may potentially be used as an early marker for postoperative course. Studies of larger patient cohorts are warranted.

Abstract P45: White Blood Cell Counts in Aneurysmal Subarachnoid Hemorrhage Patients as a Predictor of Cardiac Injury

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Tiffany Cheng ◽  
Joseph R Geraghty ◽  
Neil S Saini ◽  
Yonatan Hirsch ◽  
Tyler J Lung ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cardiac Dysfunction ◽  
Leukocyte Count ◽  
Cardiac Injury ◽  
Total Leukocyte Count ◽  
Monocyte Count ◽  
Cell Counts ◽  
Leukocyte Counts ◽  
Blood Leukocyte ◽  
The Relationship

Introduction: Up to 50% of subarachnoid hemorrhage (SAH) patients develop cardiac injury. The relationship between early systemic inflammation and cardiac injury after SAH is unknown. Here we examined changes in blood leukocyte counts and their relationship to cardiac dysfunction. Methods: We reviewed the medical records of 288 SAH patients admitted to our Comprehensive Stroke Center. Patients were dichotomized based on elevated (≥0.04ng/mL) or normal (<0.04ng/mL) troponin I (TnI). Demographics and labs from admission were then compared among the two groups by Chi-Square or Mann-Whitney test. Ejection fraction (EF) was stratified into low (<50%), normal (50-70%), or high (>70%) from echocardiogram data. We performed univariate and multivariate logistic regression to establish the relationship between blood leukocyte counts and cardiac injury. Results: Of 288 SAH patients, 241 had TnI levels performed at the time of admission and 119 (49.4%) of these had elevated TnI on admission. Patients with elevated TnI were significantly older, had higher grade SAH, abnormal EF, and were more likely to have hypertension and dyslipidemia. 10 (4.1%) had low EF while 58 (24.1%) had high EF on admission echocardiogram. In univariate analysis, total leukocyte count (p<0.0001), absolute neutrophil count (p=0.037), absolute monocyte count (p=0.014), and neutrophil-lymphocyte ratio (p=0.010) were associated with elevated TnI. Multivariate analysis adjusting for covariates showed that only total leukocyte count remained a significant predictor of elevated TnI (OR = 1.104, 95% CI= 1.020 - 1.195; p=0.014). Receiver operating characteristic (ROC) analysis demonstrated that adjusted total leukocyte count distinguishes between SAH patients with normal and elevated TnI (area under the curve = 0.787, p=0.001), with the optimal cutoff being 0.521 (sensitivity of 67.0% and specificity of 80.6%). Conclusions: Blood total leukocyte count is an independent predictor of cardiac injury in SAH patients. This highlights the role of inflammation in mediating cardiac dysfunction after brain hemorrhage, and raises questions regarding the potential of anti-inflammatory therapy for cardioprotection in SAH.

scholarly journals Effect of bioactive compounds extracted from euphorbious plants on hematological and biochemical parameters of Channa punctatus

2011 ◽  
Vol 53 (5) ◽  
pp. 259-263 ◽  
Author(s):  
Jaya Shahi ◽  
Ajay Singh
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Hematological Parameters ◽  
Channa Punctatus ◽  
Mean Corpuscular Hemoglobin ◽  
Hematological Indices ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts ◽  
Sublethal Concentrations

Channa punctatus was exposed to four different concentrations of Rutin, Taraxerol and Apigenin. Changes in some hematological parameters of Channa punctatus were assessed to determine the influence of these compounds on test fish. Fish were exposed to sublethal concentrations (80% of LC50 of 24h) of these compounds for one week. Control fish were also administered for one week. Thereafter, blood samples were obtained from the control and experimental fish. Blood was assayed for selected hematological parameters (hematocrit, hemoglobin, red blood cell count, white blood cell count total plasma protein and plasma glucose concentration). The derived hematological indices of mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) were calculated. Sublethal concentrations of these compounds caused a dose dependent decrease in hemoglobin values coupled with a decrease in hematocrit values and red blood cell counts are an obvious indication of anemia. The total white blood cell counts and the differential white blood cell counts were decreased except for the lymphocytes, where there was a slight increase. Plasma protein and glucose were also lower in exposed fish when compared with control. The hematological indices MCH, MCHC, MCV were also lowered. The result from this study reveals high mortality rate and deleterious consequences on the health of fish subjected to acute exposure of Rutin, Taraxerol and Apigenin and therefore, should not be used directly in aquaculture without having the proper knowledge.

scholarly journals Comparative study on hematological parameters of farmed matrinxã, Brycon amazonicus Spix and Agassiz, 1829 (Characidae: Bryconinae) with others Bryconinae species

2008 ◽  
Vol 38 (4) ◽  
pp. 799-805 ◽  
Author(s):  
Marcos Tavares-Dias ◽  
Elizabeth Gusmão Affonso ◽  
Sarah Ragonha Oliveira ◽  
Jaydione Luiz Marcon ◽  
Mizue Imoto Egami
Keyword(s):  
Blood Cells ◽  
Mean Corpuscular Volume ◽  
Hematological Parameters ◽  
Natural Populations ◽  
Blood Parameters ◽  
Economic Importance ◽  
Corpuscular Volume ◽  
Cell Counts ◽  
Great Economic Importance ◽  
Leukocyte Counts

The aim of this study was not only to determine the red blood cells parameters, thrombocyte and leukocyte counts in farmed Brycon amazonicus (matrinxã), to compare these parameters among Bryconinae species from literature, and also to investigate the presence of special granulocytic cells in these fish. The results of the blood cells parameters here established for farmed B. amazonicus, a species of great economic importance in Brazilian aquaculture, could help a better understanding of the blood features in natural populations of this Amazon species. Blood parameters varied between Bryconinae species investigated, mainly the red blood cell counts, hemoglobin, hematocrit and mean corpuscular volume (MCV). The presence of the blood granulocytes, neutrophils and heterophils in matrinxã suggest that both leukocytes can be a characteristic for Bryconinae family. Furthermore, it indicates that the existence of special granulocytic cells in the blood of Bryconinae species from literature is an artifact, and this was herein discussed.

scholarly journals Hematological parameters and prevalence of anemia in white and British Indian vegetarians and nonvegetarians in the UK Biobank

2019 ◽  
Vol 110 (2) ◽  
pp. 461-472 ◽  
Author(s):  
Tammy Y N Tong ◽  
Timothy J Key ◽  
Kezia Gaitskell ◽  
Timothy J Green ◽  
Wenji Guo ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Hematological Parameters ◽  
Diet Group ◽  
Uk Biobank ◽  
Platelet Counts ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts ◽  
The Uk

ABSTRACTBackgroundThere may be differences in hematological parameters between meat-eaters and vegetarians.ObjectiveThe aim of this study was to perform cross-sectional analyses of hematological parameters by diet group in a large cohort in the United Kingdom.MethodsA complete blood count was carried out in all UK Biobank participants at recruitment (2006–2010). We examined hemoglobin, red and white blood cell counts, and platelet counts and volume in regular meat eaters (>3 times/wk of red/processed meat consumption, n = 212,831), low meat eaters (n = 213,092), poultry eaters (n = 4815), fish eaters (n = 10,042), vegetarians (n = 6548), and vegans (n = 398) of white ethnicity and meat eaters (n = 3875) and vegetarians (n = 1362) of British Indian ethnicity.ResultsIn both white and British Indian populations, compared with regular meat eaters (or meat eaters in Indians), the other diet groups had up to 3.7% lower age-adjusted hemoglobin concentrations (difference not significant in white vegan women) and were generally more likely to have anemia (e.g., 8.7% of regular meat eaters compared with 12.8% of vegetarians in white premenopausal women; P < 0.05 after Bonferroni correction). In the white population, compared with regular meat eaters, all other diet groups had lower age- and sex-adjusted total white cells, neutrophils, lymphocytes, monocytes, and eosinophils (P-heterogeneity < 0.001 for all), but basophil counts were similar across diet groups; in British Indians, there was no significant difference in any of the white blood cell counts by diet group. Compared with white regular meat eaters, the low meat eaters, poultry eaters, fish eaters, and vegans had significantly lower platelet counts and higher platelet volume, whereas vegetarians had higher counts and lower volume. Compared with British Indian meat eaters, vegetarians had higher platelet count and lower volume.ConclusionsIn the UK Biobank, people with low or no red meat intake generally had lower hemoglobin concentrations and were slightly more likely to be anemic. The lower white blood cell counts observed in low and non-meat eaters, and differences in mean platelet counts and volume between diet groups, warrant further investigation. This observational study was registered at http://www.isrctn.com/ as ISRCTN10125697.

Secondary sexual coloration is related to white blood cell counts and testosterone in male southeastern five-lined skinks (Plestiodon inexpectatus)

2013 ◽  
Vol 34 (4) ◽  
pp. 585-589
Author(s):  
Ryan Seddon ◽  
Matthew Klukowski
Keyword(s):  
Plasma Testosterone ◽  
Male Quality ◽  
Cell Counts ◽  
The Status ◽  
Leukocyte Counts ◽  
Sexual Coloration ◽  
Immunocompetence Handicap Hypothesis ◽  
Handicap Hypothesis ◽  
White Blood Cell Counts ◽  
Secondary Sexual

The immunocompetence handicap hypothesis posits that secondary sexual coloration can honestly signal male quality because elevated testosterone, which is necessary for the expression of the coloration, also handicaps males through immunosuppression. Thus only high quality males can express the showiest coloration in spite of immunosuppression. Here we report a test of the immunocompetence handicap hypothesis in southeastern five-lined skinks, Plestiodon inexpectatus, which exhibit a reddish-orange head coloration during the breeding season. We tested whether head coloration is related to circulating testosterone concentrations and reflects the status of a male’s immune system, as measured by total leukocyte counts. As predicted, hue, saturation, and extent of head coloration were correlated with plasma testosterone, and the brightness of the head was negatively correlated with total circulating leukocytes. While results are consistent with the immunocompetence handicap hypothesis, additional studies that include experimental manipulations of testosterone levels and measure other aspects of immunity are warranted.

scholarly journals HEMATOLOGICAL PARAMETERS AND TUMOR SIZE IN RECTAL CANCER

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
O. Andronic ◽  
Alexandra Bolocan ◽  
Georgiana Radu ◽  
D.N. Păduraru ◽  
D. Ion ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Blood Cell ◽  
Hematological Parameters ◽  
Biological Parameters ◽  
Mortality And Morbidity ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
High Incidence ◽  
The World ◽  
White Blood Cell Counts

Rectal cancer is a pathology that still has a high incidence, mortality and morbidity all around the world. As with other types of neoplasm, researchers all around the world are attempting to find statistically significant linkages between easy and inexpensive hematological parameters and the progression of this disease which is affecting approximately 1.8 million individuals. The present study aims to investigate whether biological parameters measured in rectal cancer patients change significantly with tumor growth. The results show a significant change in WBC (white blood cell counts) (p = 0.002).

scholarly journals Evaluating the utility of provider-recorded clinical status in the medical records of HIV-positive adults in a limited-resource setting

2016 ◽  
Vol 28 (7) ◽  
pp. 685-692 ◽  
Author(s):  
Samantha Stonbraker ◽  
Montina Befus ◽  
Leonel Lerebours Nadal ◽  
Mina Halpern ◽  
Elaine Larson
Keyword(s):  
Disease Progression ◽  
Medical Records ◽  
Clinical Status ◽  
Cd4 Cell Count ◽  
Viral Loads ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Resource Setting ◽  
Cd4 Cell ◽  
The Relationship

Provider-reported summaries of clinical status may assist with clinical management of HIV in resource poor settings if they reflect underlying biological processes associated with HIV disease progression. However, their ability to do so is rarely evaluated. Therefore, we aimed to assess the relationship between a provider-recorded summary of clinical status and indicators of HIV progression. Data were abstracted from 201 randomly selected medical records at a large HIV clinic in the Dominican Republic. Multivariable logistic regressions were used to examine the relationship between provider-assigned clinical status and demographic (gender, age, nationality, education) and clinical factors (reported medication adherence, CD4 cell count, viral load). The mean age of patients was 41.2 (SD = ±10.9) years and most were female (n = 115, 57%). None of the examined characteristics were significantly associated with provider-recorded clinical status. Higher CD4 cell counts were more likely for females (OR = 2.2 CI: 1.12–4.31) and less likely for those with higher viral loads (OR = 0.33 CI: 0.15–0.72). Poorer adherence and lower CD4 cell counts were significantly associated with higher viral loads (OR = 4.46 CI: 1.11–20.29 and 6.84 CI: 1.47–37.23, respectively). Clinics using provider-reported summaries of clinical status should evaluate the performance of these assessments to ensure they are associated with biologic indicators of disease progression.

scholarly journals PROFIL HEMATOLOGI PASIEN ANAK DENGAN TIFOID SERTA KORELASINYA TERHADAP LAMA RAWAT INAP

2020 ◽  
Vol 15 (1) ◽  
pp. 98
Author(s):  
Rike Syahniar ◽  
Khayrul Fikri ◽  
Matahari Arumdini ◽  
Rayhana Rayhana
Keyword(s):  
Length Of Stay ◽  
Typhoid Fever ◽  
Hematological Parameters ◽  
Secondary Data ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Chi Square Test ◽  
Kolmogorov Smirnov ◽  
Leukocyte Counts ◽  
The Relationship

 ABSTRACTLeukopenia, thrombocytopenia and anemia are haematological abnormalities that are usually found in typhoid fever patients. This study aims to determine the relationship between platelet counts, leukocyte counts, hematocrit values and haemoglobin in pediatric typhoid patients. This research is a descriptive and analytic study using the parameters of hematology and length of stay in children at the Jakarta Cempaka Putih Islamic Hospital. The data used are secondary data in the form of medical records of patients from January to June 2018 who were diagnosed with typhoid fever. Data analysis using the Kolmogorov Smirnov and Chi-square test. The average age and length of stay of the patients were 9 years and 4.6 days. Bivariate analysis showed no relationship between length of stay with platelet count (p = 1.000), leukocytes (p = 0.969), hematocrit value (p = 1.000) and haemoglobin (p=0.549). There was no significant relationship between overall hematological parameters and length of hospital stay.Keywords: Length of stay, parameters of hematology, typhoid fever. AbstrakLeukopenia, trombositopenia dan anemia merupakan kelainan hematologis yang biasanya ditemukan pada pasien demam tifoid. Penelitian ini bertujuan untuk mengetahui hubungan antara jumlah trombosit, jumlah leukosit, nilai hematokit dan hemoglobin pada pasien tifoid anak. Penelitian ini merupakan deskriptif dan analitik menggunakan variabel parameter hematologi dan lama rawat pada anak di Rumah Sakit Islam Jakarta Cempaka Putih. Data yang digunakan yaitu data sekunder berupa rekam medik pasien periode Januari – Juni 2018 yang di diagnosis demam tifoid. Analisis data menggunakan uji Kolmogorov Smirnov dan Chi-square. Rata-rata usia dan lama rawat inap pasien yaitu 9 tahun dan 4,6 hari. Analisis bivariat menunjukkan tidak terdapat hubungan antara lama rawat dengan jumlah trombosit (p=1.000), leukosit (p=0.969),nilai hematokrit (p=1.000) dan hemoglobin (p=0.549). Tidak terdapat hubungan yang bermakna antara keseluruhan parameter hematologi dengan lama rawat inapKata kunci: Demam tifoid, lama rawat, parameter hematologi

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