scholarly journals Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Anthony Kodzo-Grey Venyo
Keyword(s):  
Clear Cell ◽  
Treatment Options ◽  
Survival Rates ◽  
Specific Antigen ◽  
Female Genital Tract ◽  
Great Majority ◽  
Prostatic Acid Phosphatase ◽  
Clear Cell Adenocarcinoma ◽  
Biological Behaviour ◽  
Nephrogenic Adenoma

Background.Clear cell adenocarcinoma of the urethra (CCAU) is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour.Aims.To review the literature on CCAU.Methods.Various internet databases were used.Results/Literature Review.(i) CCAU occurs in adults and in women in the great majority of cases. (ii) It has a particular association with urethral diverticulum, which has been present in 56% of the patients; is indistinguishable from clear cell adenocarcinoma of the female genital tract but is not associated with endometriosis; and probably does not arise by malignant transformation of nephrogenic adenoma. (iii) It is usually, readily distinguished from nephrogenic adenoma because of greater cytological a-typicality and mitotic activity and does not stain for prostate-specific antigen or prostatic acid phosphatase. (iv) It has been treated by anterior exenteration in women and cystoprostatectomy in men and at times by radiotherapy; chemotherapy has rarely been given. (v) CCAU is aggressive with low 5-year survival rates. (vi) There is no consensus opinion of treatment options that would improve the prognosis.Conclusions.Few cases of CCAU have been reported. Urologists, gynaecologists, pathologists, and oncologists should report cases of CCAU they encounter and enter them into a multicentric trial to determine the best treatment options that would improve the prognosis.

Clear Cell Adenocarcinoma of the Female Genital Tract: Long-Term Outcome and Fertility Aspects After Brachytherapy Aimed at a Conservative Treatment

2012 ◽  
Vol 22 (8) ◽  
pp. 1378-1382 ◽  
Author(s):  
Nicolas Magné ◽  
Cyrus Chargari ◽  
Antonin Levy ◽  
Carlos Rodriguez ◽  
Véronique De Vos ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Pregnancy Rate ◽  
Genital Tract ◽  
Clear Cell ◽  
Female Genital Tract ◽  
Disease Free Survival ◽  
Good Survival ◽  
Clear Cell Adenocarcinoma ◽  
Long Term Outcome ◽  
Female Genital

ObjectivesTo assess the outcome and the fertility aspects in the particular population of cervical and/or vaginal clear cell adenocarcinoma (CCA) associated or not to previous in utero diethylstilbestrol exposure.MethodsFrom January 1970 to December 2003, data from 61 consecutive patients with cervical and/or vaginal histologically proven CCA treated with brachytherapy (BT) aimed at a conservative treatment at the Institut Gustave Roussy as a part of treatment were retrospectively analyzed.ResultsThe median follow-up was 9.4 years, ranging from 0.3 to 27.4 years. The 5-year specific overall survival rate was 79%. The median time of disease-free survival was 5.8 years. In the subgroup of 42 patients with a cervical CCA, 12 patients tried to be pregnant, 2 patients became pregnant and had miscarriages (P2M2 and P1M1). No pregnancy has been observed in 10 patients exclusively owing to anomalies of the reproductive tract: 6 patients had partial or total diaphragm, 2 patients had an anatomical alteration of the uterus, 1 patient had atrophic endometrium, and 1 patient had primary infertility. In the subgroup of 19 patients with a vaginal CCA, 7 patients tried to be pregnant. All of them had no morphological and/or functional anomalies of the genital tract. Three of 7 patients had delivered healthy babies (P1D1, P2D2, and P3M2D1), and another one had a miscarriage (P1M1). Moreover, all babies were delivered by cesarean section. The pregnancy rate was 10% (6 of 61 patients) with 3 healthy babies.ConclusionConservative approach in patients with female genital tract CCA including BT gives good results with good survival rates and an interesting global pregnancy rate.

Clear-cell adenocarcinoma of the female genital tract: Presence of Hyaline stroma and tigroid background in various types of cytologic specimens

2005 ◽  
Vol 32 (6) ◽  
pp. 336-340 ◽  
Author(s):  
Surapan Khunamornpong ◽  
Paul S. Thorner ◽  
Prapaporn Suprasert ◽  
Sumalee Siriaunkgul
Keyword(s):  
Genital Tract ◽  
Clear Cell ◽  
Female Genital Tract ◽  
Clear Cell Adenocarcinoma ◽  
Female Genital

scholarly journals Clear Cell Adenocarcinoma of the Renal Pelvis in a Male Patient

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Sarawut Kongkarnka ◽  
Pruit Kitirattakarn ◽  
Hironori Katayama ◽  
Surapan Khunamornpong
Keyword(s):  
Male Patient ◽  
Renal Pelvis ◽  
Clear Cell ◽  
Regional Lymph Node ◽  
Female Genital Tract ◽  
Renal Stones ◽  
Clear Cell Adenocarcinoma ◽  
Renal Neoplasm ◽  
Diagnostic Challenge ◽  
Effective Treatment Regimen

Carcinoma of the renal pelvis is an uncommon renal neoplasm. Clear cell adenocarcinoma in the urinary tract is rare and has a histomorphology resembling that of the female genital tract. We herein present a case of clear cell adenocarcinoma of the renal pelvis, which is the first example in a male patient to our knowledge. A 54-year-old man presented with right flank pain. The tumor was associated with renal stones and hydronephrosis and invaded into the peripelvic fat tissue with regional lymph node metastasis. The patient died of metastatic disease six months postoperatively. Histologically, the tumor showed complex papillary architecture lined with clear and hobnail cells. Clear cell adenocarcinoma of the renal pelvis may pose a diagnostic challenge on histological grounds, particularly in the distinction from renal cell carcinoma. The immunohistochemical stains could help confirm the diagnosis. Due to its rarity, an effective treatment regimen remains to be determined.

Clear Cell Adenocarcinoma of the Urinary Bladder: A Short Review

2009 ◽  
Vol 133 (6) ◽  
pp. 987-991 ◽  
Author(s):  
Adebowale J. Adeniran ◽  
Pheroze Tamboli
Keyword(s):  
Urinary Bladder ◽  
Patient Outcomes ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Short Review ◽  
Ca 125 ◽  
Clear Cell Adenocarcinoma ◽  
Gross Hematuria ◽  
Nephrogenic Adenoma ◽  
Clear Cytoplasm

Abstract In this short review, we discuss clear cell adenocarcinoma of the urinary bladder, a rare tumor that primarily affects women. The histogenesis of this neoplasm is uncertain; in some tumors the clinicopathologic and histologic features are suggestive of a müllerian origin. Clear cell adenocarcinoma consists of cells with abundant clear cytoplasm, arranged in solid, glandular, or tubulocystic patterns. These tumors are positive for pancytokeratin, cytokeratin 7, and CA 125 immunohistochemical stains. Patients typically present with gross hematuria, dysuria, and discharge. The natural history is poorly understood and patient outcomes remain unclear. Currently, surgery is the treatment of choice. Nephrogenic adenoma is the most important differential diagnostic consideration, followed by metastatic clear cell carcinoma.

Genital Tract Metastases from Renal Cell Carcinoma—A Case Report and Discussion

1985 ◽  
Vol 30 (1) ◽  
pp. 43-45 ◽  
Author(s):  
N. D. Sharma ◽  
G. B. McKelvie
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Genital Tract ◽  
World Literature ◽  
Clear Cell ◽  
Female Genital Tract ◽  
Clear Cell Adenocarcinoma ◽  
Menopausal Woman ◽  
First Case

A case of renal cell carcinoma presenting with metastases in the female genital tract is reported. Clinical and histological features distinguishing primary and secondary clear cell adenocarcinoma of the genital tract are discussed. It is emphasised that when a clear cell adenocarcinoma is found, particularly in a post-menopausal woman, metastatic renal carcinoma has to be excluded. Although so far there are 61 cases reported in the world literature from English speaking countries, we believe that this is the first case reported from the United Kingdom.

scholarly journals Clear Cell Adenocarcinoma Arising from Endometriosis in the Groin: Wide Resection and Reconstruction with a Fascia Lata Tensor Muscle Skin Flap

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Shozo Yoshida ◽  
Akira Onogi ◽  
Masamitsu Kuwahara ◽  
Tomoko Uchiyama ◽  
Hiroshi Kobayashi
Keyword(s):  
Clear Cell ◽  
Skin Flap ◽  
Subcutaneous Fat ◽  
Female Genital Tract ◽  
Rectus Sheath ◽  
Fascia Lata ◽  
Wide Resection ◽  
Clear Cell Adenocarcinoma ◽  
Surgical Biopsy ◽  
Abdominal Rectus Muscle

We herein report a case of clear cell carcinoma arising from endometriosis in the groin in a 53-year-old woman. The findings of MRI and FDG/PET-CT indicated a malignant tumor, and surgical biopsy confirmed adenocarcinoma of the female genital tract. The tumor including a part of the abdominal rectus muscle and rectus sheath, subcutaneous fat, skin, and the right inguinal ligament was resected en bloc. The defect in the abdominal wall was reconstructed with a fascia lata tensor muscle skin flap. The tumor was composed of clear cell adenocarcinoma arising from extrapelvic endometriosis. The patient received chemotherapy with gemcitabine and carboplatin for 6 cycles and had no evidence of recurrence 7 months after the treatment. We herein described the diagnosis and surgical management of endometriosis-associated carcinoma in the groin.

Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: A histopathologic and immunohistochemical comparison

1998 ◽  
Vol 29 (12) ◽  
pp. 1451-1456 ◽  
Author(s):  
Michael Z Gilcrease ◽  
Ruby Delgado ◽  
Frank Vuitch ◽  
Jorge Albores-Saavedra
Keyword(s):  
Urinary Bladder ◽  
Clear Cell ◽  
Clear Cell Adenocarcinoma ◽  
Nephrogenic Adenoma
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