scholarly journals Fatigue Modeling via Mammalian Auditory System for Prediction of Noise Induced Hearing Loss

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Pengfei Sun ◽  
Jun Qin ◽  
Kathleen Campbell
Keyword(s):  
Hearing Loss ◽  
High Cycle Fatigue ◽  
Basilar Membrane ◽  
Organ Of Corti ◽  
Noise Induced Hearing Loss ◽  
Occupational Noise ◽  
Cycle Fatigue ◽  
Auditory Model ◽  
Auditory Fatigue ◽  
Velocity Level

Noise induced hearing loss (NIHL) remains as a severe health problem worldwide. Existing noise metrics and modeling for evaluation of NIHL are limited on prediction of gradually developing NIHL (GDHL) caused by high-level occupational noise. In this study, we proposed two auditory fatigue based models, including equal velocity level (EVL) and complex velocity level (CVL), which combine the high-cycle fatigue theory with the mammalian auditory model, to predict GDHL. The mammalian auditory model is introduced by combining the transfer function of the external-middle ear and the triple-path nonlinear (TRNL) filter to obtain velocities of basilar membrane (BM) in cochlea. The high-cycle fatigue theory is based on the assumption that GDHL can be considered as a process of long-cycle mechanical fatigue failure of organ of Corti. Furthermore, a series of chinchilla experimental data are used to validate the effectiveness of the proposed fatigue models. The regression analysis results show that both proposed fatigue models have high corrections with four hearing loss indices. It indicates that the proposed models can accurately predict hearing loss in chinchilla. Results suggest that the CVL model is more accurate compared to the EVL model on prediction of the auditory risk of exposure to hazardous occupational noise.

scholarly journals Auditory fatigue model applications to predict noise induced hearing loss in human and chinchilla

2017 ◽  
Vol 119 ◽  
pp. 57-65 ◽  
Author(s):  
Pengfei Sun ◽  
Daniel Fox ◽  
Kathleen Campbell ◽  
Jun Qin
Keyword(s):  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
Fatigue Model ◽  
Auditory Fatigue

scholarly journals Multiphoton NAD(P)H FLIM reveals metabolic changes in individual cell types of the intact cochlea upon sensorineural hearing loss

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Paromita Majumder ◽  
Thomas S. Blacker ◽  
Lisa S. Nolan ◽  
Michael R. Duchen ◽  
Jonathan E. Gale
Keyword(s):  
Oxidative Stress ◽  
Hearing Loss ◽  
Cell Model ◽  
Organ Of Corti ◽  
Cell Types ◽  
Fluorescence Lifetime Imaging ◽  
Noise Induced Hearing Loss ◽  
Label Free ◽  
Age Related ◽  
The Individual

AbstractAn increasing volume of data suggests that changes in cellular metabolism have a major impact on the health of tissues and organs, including in the auditory system where metabolic alterations are implicated in both age-related and noise-induced hearing loss. However, the difficulty of access and the complex cyto-architecture of the organ of Corti has made interrogating the individual metabolic states of the diverse cell types present a major challenge. Multiphoton fluorescence lifetime imaging microscopy (FLIM) allows label-free measurements of the biochemical status of the intrinsically fluorescent metabolic cofactors NADH and NADPH with subcellular spatial resolution. However, the interpretation of NAD(P)H FLIM measurements in terms of the metabolic state of the sample are not completely understood. We have used this technique to explore changes in metabolism associated with hearing onset and with acquired (age-related and noise-induced) hearing loss. We show that these conditions are associated with altered NAD(P)H fluorescence lifetimes, use a simple cell model to confirm an inverse relationship between τbound and oxidative stress, and propose such changes as a potential index of oxidative stress applicable to all mammalian cell types.

scholarly journals Prevalence of Occupational noise induced hearing loss (ONIHL) among industrial workers in Bhutan.

2020 ◽  
Vol 6 (1) ◽  
pp. 25-31
Author(s):  
Pelden Wangchuk ◽  
Phuntsho Dendup
Keyword(s):  
Hearing Loss ◽  
Binary Logistic Regression ◽  
Noise Induced Hearing Loss ◽  
Occupational Noise ◽  
Industrial Workers ◽  
Hearing Conservation ◽  
Hearing Sensitivity ◽  
Exposure Limit ◽  
Strict Enforcement ◽  
Hearing Assessment

Introduction: Exposure to any type of noise has a potential risk. Higher the level of noise and longer duration of exposure, the more the risk for the hearing sensitivity and health as a whole. The objective of the study is to determine the prevalence of Occupational Noise Induced Hearing Loss (ONIHL) among the industrial workers in Bhutan and to ascertain high risk establishment and vulnerable occupations. Methods: The hearing assessment was conducted among 1638 workers considering different types of industries and occupations to ascertain the prevalence of occupational noise induced hearing loss and vulnerable group amongdifferent industries and occupations. Descriptive statistics and binary logistic regression were performed to test the significance of ONIHL among the various independent variables. Results: The study found that the prevalence of ONIHL stands at 27.9% among industrial workers in Bhutan. 42.45% of candidates who had ONIHL reported with tinnitus in either or both ears. This study founda significant association between the exposure duration and the severity of ONIHL among the industrial workers. Considering the type of industry, wood based industry, hydro services, cement and polymer were found to have a higher prevalence of ONIHL and similarly, higher prevalence of ONIHL were found among occupations such as blaster, chipper, carpenters, dryer (knife grinder) and crusher operators. Conclusions: This study conduces that prevalence of ONIHL among industrial workers is found to be at the higher side and some of the occupations and industries impose higher risk. The study suggests that there is need for intervention such as strict enforcement of the permissible exposure limit, monitor and evaluate hearing conservation programs, and providing advice and recommendation to address such issues by the relevant agencies and industries

OCCUPATIONAL NOISE EXPOSURE, NOISE-INDUCED HEARING LOSS, AND THE EPIDEMIOLOGY OF HIGH BLOOD PRESSURE

1985 ◽  
Vol 121 (4) ◽  
pp. 501-514 ◽  
Author(s):  
ELELYN TALBOTT ◽  
JAMES HELMKAMP ◽  
KARAN MATHEWS ◽  
LEWIS KULLER ◽  
ERIC COTTINGTON ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Hearing Loss ◽  
High Blood Pressure ◽  
Noise Exposure ◽  
Noise Induced Hearing Loss ◽  
Occupational Noise ◽  
Occupational Noise Exposure

scholarly journals Interventions to prevent occupational noise-induced hearing loss

2012 ◽  
Author(s):  
Jos H Verbeek ◽  
Erik Kateman ◽  
Thais C Morata ◽  
Wouter A Dreschler ◽  
Christina Mischke
Keyword(s):  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
Occupational Noise
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