scholarly journals FoxP3 Tregs Response to Sublingual Allergen Specific Immunotherapy in Children Depends on the Manifestation of Allergy

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Anna Stelmaszczyk-Emmel ◽  
Anna Zawadzka-Krajewska ◽  
Eliza Głodkowska-Mrówka ◽  
Urszula Demkow
Keyword(s):  
Specific Immunotherapy ◽  
Clinical Manifestations ◽  
Specific Treatment ◽  
Relative Number ◽  
Allergic Diseases ◽  
Respiratory Allergy ◽  
Allergen Specific Immunotherapy ◽  
Major Health Problem ◽  
Major Health ◽  
Forkhead Box

Over the last decades allergic diseases has become a major health problem worldwide. The only specific treatment to date is allergen specific immunotherapy (ASIT). Although it was shown that ASIT generates allergen-tolerant T cells, detailed mechanism underlying its activity is still unclear and there is no reliable method to monitor its effectiveness. The aim of our study was to evaluate ASIT influence on the frequency of forkhead box P3 (FoxP3) Tregs in allergic children with various clinical manifestations. The relative number of FoxP3 Tregs in 32 blood samples from allergic children at baseline and/or after 1 year of ASIT was assessed by flow cytometry. In the entire studied group, the percentage of FoxP3 Tregs did not increase 1 year after ASIT. Nevertheless, the percentage of FoxP3 Tregs after ASIT significantly increased in children with respiratory allergy (conjunctivitis, asthma, and rhinitis) coexisting with nonrespiratory manifestations (food allergy and/or atopic dermatitis), whereas, in patients with respiratory allergy only, the percentage of FoxP3 Tregs decreased. To the best of our knowledge, this is the first report showing various differential FoxP3 Tregs response to ASIT in allergic children. FoxP3 Tregs number could be useful in treatment monitoring. Further studies are warranted to confirm these observations.

Immunotheraphy in Allergic Diseases

2018 ◽  
Vol 24 (11) ◽  
pp. 1174-1194
Author(s):  
Albert Roger ◽  
Maria Basagana ◽  
Aina Teniente-Serra ◽  
Nathalie Depreux ◽  
Yanina Jurgens ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Specific Ige ◽  
World Population ◽  
Allergen Specific Immunotherapy ◽  
Routes Of Administration ◽  
Disease Modifying Therapy ◽  
History Of ◽  
Ige Mediated ◽  
Special Case

The prevalence of allergic diseases is increasing worldwide. It is estimated that more than 30% of the world population is now affected by one or more allergic conditions and a high proportion of this increase is in young people. The diagnosis of allergy is dependent on a history of symptoms on exposure to an allergen together with the detection of allergen-specific IgE. Accurate diagnosis of allergies opens up therapeutic options. Allergen specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. New therapeutic strategies have been developed or are currently under clinical trials. Besides new routes of administration, new types of allergens are being developed. The use of adjuvants may amplify the immune response towards tolerance to the antigens. In this review, we analyze different antigen-specific immunotherapies according to administration route, type of antigens and adjuvants, and we address the special case of food allergy.

Allergen-Specific Immunotherapy for Respiratory Allergy in Children: Unmet Needs and Future Goals

2017 ◽  
Vol 5 (4) ◽  
pp. 946-950 ◽  
Author(s):  
Pasquale Comberiati ◽  
Gian Luigi Marseglia ◽  
Salvatore Barberi ◽  
Giovanni Passalacqua ◽  
Diego G. Peroni
Keyword(s):  
Specific Immunotherapy ◽  
Unmet Needs ◽  
Respiratory Allergy ◽  
Allergen Specific Immunotherapy ◽  
Future Goals

scholarly journals Allergen-specific immunotherapy. Analytic review of current international and Russian federal position papers

2017 ◽  
Vol 14 (1) ◽  
pp. 24-32
Author(s):  
O M Kurbacheva ◽  
K S Pavlova ◽  
M A Galitzkaya
Keyword(s):  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Allergen Specific Immunotherapy ◽  
Detailed Understanding ◽  
Analytic Review ◽  
Ige Mediated ◽  
Federal Guidelines

The article analyses the international position papers devoted to allergen-specific immunotherapy published in recent years. It also describes in details Russian federal guidelines, published in the 2013-2016 years and dedicated to allergen-specific immunotherapy as a method of treatment of IgE-mediated allergic diseases, as well as Russian federal guidelines. Detailed understanding of indications, contraindications, and usage of AIT in various clinical situations are widely discussed.

scholarly journals Evaluation Of Clinical Changes In Pediatric Patients With Atopic Dermatitis And Respiratory Allergy Receiving Allergen-specific Immunotherapy

2019 ◽  
Vol 143 (2) ◽  
pp. AB61
Author(s):  
Cindy Elizabeth de Lira-Quezada ◽  
Alfredo Arias Cruz ◽  
Sandra N. González Diaz ◽  
David Eugenio Roman Canamar ◽  
Rosalaura Villarreal Gonzalez ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pediatric Patients ◽  
Specific Immunotherapy ◽  
Respiratory Allergy ◽  
Allergen Specific Immunotherapy ◽  
Clinical Changes

scholarly journals Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy

2021 ◽  
Author(s):  
Ekaterina Pashkina ◽  
Veronika Evseenko ◽  
Natalya Dumchenko ◽  
Maxim Zelikman ◽  
Alina Aktanova ◽  
...  
Keyword(s):  
Side Effects ◽  
Delivery System ◽  
Glycyrrhizic Acid ◽  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Treg Cells ◽  
Delivery Systems ◽  
New Drugs ◽  
Allergen Specific Immunotherapy

The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. At the same time, it is known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, which means that in the future it can enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects. Thus, the study of the immunomodulatory effect of supramolecular complexes (micelles) of GA with extracts of allergens seems to be very promising for the development of new drugs for AIT.

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