scholarly journals Intradural Solitary Fibrous Tumor of the Lumbar Spine: A Distinctive Case Report

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Recep Basaran ◽  
Mustafa Kaksi ◽  
Mustafa Onoz ◽  
Ece Balkuv ◽  
Aydin Sav
Keyword(s):  
Primary Treatment ◽  
Proliferation Index ◽  
Aged Patients ◽  
Ki 67 ◽  
Lower Extremity Weakness ◽  
Solitary Fibrous Tumors ◽  
Mesenchymal Neoplasms ◽  
Lumbar Mri ◽  
Fibrous Tumor ◽  
Central Nervous System Parenchyma

Background. Solitary fibrous tumors are ubiquitous mesenchymal neoplasms of putative fibroblastic origin. They were originally described in the pleura but subsequently have been reported in many extraserosal sites. Solitary fibrous tumors may also occur in the meninges, central nervous system parenchyma, and spinal cord.Case. A 67-year-old male patient with progressive lower extremity weakness, urinary urgency, and sexual dysfunction has been admitted to our hospital. On his lumbar MRI, we detected an intradural lesion posterior to the L3 vertebral corpus. We resected the lesion by L3 total laminectomy. Immunohistological findings revealed strong and diffuse immunopositivity with vimentin, CD34, and bcl-2. Ki-67 proliferation index was 5–8%. We did not detect any recurrence 12 months after his operation.Conclusion. SFT is mostly seen in young and middle-aged patients and should be considered among differential diagnosis in cases suffering from pain, hypoesthesia, and urinary dysfunction. Gross total resection should be primary treatment. Tumors that have high Ki-67 labeling should be followed up for potential recurrences.

scholarly journals The Relationship Between The Apparent Diffusion Coefficient and The Ki-67 Proliferation Index in Intracranial Solitary Fibrous Tumor/Hemangiopericytoma

2021 ◽  
Author(s):  
Shenglin Li ◽  
Qing Zhou ◽  
Peng Zhang ◽  
Shize Ma ◽  
Caiqiang Xue ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Solitary Fibrous Tumor ◽  
Proliferation Index ◽  
Ki 67 ◽  
Solitary Fibrous Tumors ◽  
Average Maximum ◽  
Apparent Diffusion ◽  
Grade Ii ◽  
Fibrous Tumor

Abstract Objiective: This study evaluated the value of the apparent diffusion coefficient (ADC) in distinguishing grade II and III intracranial solitary fibrous tumors /hemangiopericytomas and explored the correlation between ADC and Ki-67. Methods The preoperative MRIs of 37 patients treated for solitary fibrous tumor/hemangiopericytoma (grade II, n = 15 and grade III, n = 22) in our hospital from 2011 to October 2020 were retrospectively analyzed. We compared the difference between the minimum, average, maximum, and relative ADCs based on tumor grade and examined the correlation between ADC and Ki-67. Receiver operating characteristic curve analysis was used to analyze the diagnostic efficiency of the ADC. Results There were significant differences in the average, minimum, and relative ADCs between grade II and III patients. The optimal cutoff value for the relative ADC value to differentiate grade II and III tumors was 0.998, which yielded an area under the curve of 0.879. The Ki-67 proliferation indexes of grade II and III tumors were significantly different, and the average (r = -0.427), minimum (r = -0.356), and relative (r = -0.529) ADCs were significantly negatively correlated with the Ki-67 proliferation index. Conclusions ADC can be used to differentiate grade II and III intracranial solitary fibrous tumors/hemangiopericytomas. Our results can be used to formulate a personalized surgical treatment plan before surgery.

Solitary Fibrous Tumor of the Larynx: A Case Report and Review of the Literature

2006 ◽  
Vol 130 (2) ◽  
pp. 213-216 ◽  
Author(s):  
Jorge E. Dotto ◽  
William Ahrens ◽  
David J. Lesnik ◽  
Diane Kowalski ◽  
Clarence Sasaki ◽  
...  
Keyword(s):  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Review Of The Literature ◽  
Solitary Fibrous Tumors ◽  
Subsequent Investigation ◽  
Mesenchymal Neoplasms ◽  
Fibrous Tumor

Abstract Solitary fibrous tumors are relatively rare mesenchymal neoplasms that were originally described as pleural- or peritoneal-based lesions. Although they were considered a form of mesothelioma, subsequent investigation failed to reveal mesothelial differentiation. Characterization of their histologic and immunohistochemical features, as well as identification in a multitude of nonmesothelial-based locations has further served to distinguish these lesions from the more diffuse and aggressive mesothelioma. Reports of solitary fibrous tumor in the larynx are extremely rare. We report a case of solitary fibrous tumor of the larynx in a 38-year-old man.

Extrapleural Solitary Fibrous Tumor of the Foot

2015 ◽  
Vol 105 (6) ◽  
pp. 557-559
Author(s):  
Charles A. Kean ◽  
Bridget R. Moore ◽  
Ashley M. Nettles ◽  
Richard P. Bui
Keyword(s):  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Solitary Fibrous Tumors ◽  
Mesenchymal Neoplasms ◽  
Complete Surgical Excision ◽  
Rare Manifestation ◽  
Painless Mass ◽  
Fibrous Tumor ◽  
Extrapleural Solitary Fibrous Tumor ◽  
Male Veteran

Solitary fibrous tumors are uncommon mesenchymal neoplasms that were initially described as pleural tumors, but in recent years, numerous extrapleural sites have been reported. A solitary fibrous tumor is characterized as a circumscribed, painless mass with a patternless growth pattern, positive CD34 spindle-shaped cells, bcl-2, and dense keloidal collagen with areas of hypercellularity and hypocellularity. This case report describes a 55-year-old male veteran who presented with a rare manifestation of an extrapleural solitary fibrous tumor of the medial right hallux. Microscopic and immunohistochemical findings were consistent with the previously documented characteristics of solitary fibrous tumors. Complete surgical excision of the tumor is the treatment of choice.

scholarly journals Rare solitary fibrous tumor of the stomach: A case report

2015 ◽  
Vol 72 (11) ◽  
pp. 1035-1038 ◽  
Author(s):  
Tamara Boskovic ◽  
Mirjana Zivojinov ◽  
Jelena Ilic-Sabo ◽  
Zorana Budakov ◽  
Radovan Veljkovic ◽  
...  
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Solitary Fibrous Tumor ◽  
Soft Tissue Tumors ◽  
Biological Behavior ◽  
Histopathological Analysis ◽  
Dystrophic Calcification ◽  
Ki 67 ◽  
Solitary Fibrous Tumors ◽  
Fibrous Tumor

Introduction. Solitary fibrous tumors are rare soft tissue tumors of submesothelial origin and variable malignant potential. The most common localization is pleural, whereas only 0.6% are of extrapleural localization. Solitary fibrous tumor of the peritoneum, especially of gastric serosa is an extremely rare form of this tumor. Case report. We presented a 65- year-old female patient with solitary fibrous tumor of the stomach. Histopathological analysis of removed tissue showed the presence of tumor tissue built of spindle cells, elongated nuclei with moderately abundant cytoplasm. Cells were in a noncohesive arrangement, in smaller areas distributed in the form of palisade. There were amounts of hipocellular connective tissue, hyalinised, with small foci of dystrophic calcification. Mitoses were rare (less than 3/10 HPF). Blood vessels surrounded the connective tissue. Reviewed material did not contain elements of the parent organ. Immunohistochemically there were positivity on CD34 and vimentin, and negativity to S100, SMA, CD117, dezmin, and Ki-67 is < 2%. The change was diagnosed as a solitary fibrous tumor. Conclusion. Considering that benign solitary fibrous tumors of extrathoracic localizations are extremely rare neoplasms with unpredictable biological behavior and the possibility of recurrence, a long-term clinical and endoscopic follow-up on yearly basis of patients with this disease is recommended.

scholarly journals HAEMANGIOPERICYTOMA

2015 ◽  
Vol 22 (03) ◽  
pp. 312-316
Author(s):  
Xiang Longquan ◽  
Henry Mwakyoma
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumor Cells ◽  
Clinical Manifestations ◽  
Proliferation Index ◽  
High Recurrence Rate ◽  
Imaging Features ◽  
Rare Tumor ◽  
Ki 67 ◽  
Fibrous Tumor

Hemangiopericytoma (HPC) in central nervous system is a rare tumor, his tumorhas a high recurrence rate and the characteristics of extracranial metastases. Objectives:To investigate the clinicopathological features, imaging features, immunohistochemicalphenotype of haemangiopericytoma (HPC) of central nervous system. Design: Hospital basedcrossectional prospective study. Period: From 24th October to 26th October 2012. Setting: FirstPeople’s Hospital of Jining City, China. Methods: The clinical manifestations, imaging features,histopathological and immunohistochemical features were analyzed combining the review of theliterature in one case of central HPC. Results: The Gross examination revealed the size of thetumor was 5cm × 4cm× 1.5cm; the section is gray, medium soft texture, and part of the area hadcapsule. The microscopic examination showed that the tumor cells were abundant and the samesize, showing round, oval or short spindle shape. The cytoplasm was eosinophilic, and part ofit was slightly translucent. The nuclei were ovoid, and the nucleoli were inconspicuous.A lot ofcapillaries lined by endothelial cells were seen in the tumor tissue, and the blood vessels weredilated like “staghorn” in some areas. Immunohistochemistry showed that tumor cells expressedVimentin, CD34, CD99, Bcl-2, PR protein. They didn’t express EMA, SMA, and S-100 protein.The proliferation index of ki-67 is about 4%. Conclusions: The central haemangiopericytomais a rare tumor, having no specific clinical manifestations and imaging features. The finaldiagnosis requires a combination of histopathological and immunohistochemical examination,and it should be differentiated from meningioma, solitary fibrous tumor, hemangioblastoma andmesenchymal chondrosarcoma, etc.

Solitary fibrous tumor of the scalp in a child

2013 ◽  
Vol 11 (1) ◽  
pp. 79-81 ◽  
Author(s):  
Tony Rizk ◽  
Adnan Awada ◽  
Amer Sebaaly ◽  
Roula Hourani
Keyword(s):  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Muscle Actin ◽  
Solitary Fibrous Tumors ◽  
Mesenchymal Neoplasms ◽  
Wide Range ◽  
Fibrous Tumor ◽  
Scalp Mass

Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that arise most commonly in the pleura but have been increasingly reported in extrapleural sites. The authors report the case of an SFT of the scalp that manifested as an enlarging scalp mass in a 2-year-old boy. The mass was surgically excised. Histological examination showed it to be composed of fusiform cells of variable cellularity with a central hyalinization zone. Immunohistochemical staining was positive for CD34 and negative for smooth muscle actin, S100 protein, desmin, and h-caldesmon. On 1-year follow-up, there was no recurrence of the mass. This case presented some diagnostic difficulty because of the wide range of possible diagnoses for a pediatric scalp mass; however, the distinct immunohistochemical profile helped to eliminate other more frequent fibrous tumors of the scalp. The behavior of scalp SFTs is usually benign, but their course can be unpredictable, and recognition of these lesions is essential.

scholarly journals Doege–Potter Syndrome and Hypoglycemia associated with Solitary Fibrous Tumor of the Pleura: Two Case Reports

2020 ◽  
Vol 14 ◽  
pp. 117954842096475
Author(s):  
Liliana Fernández-Trujillo ◽  
Jhon E Bolaños ◽  
Carolina Álvarez ◽  
Julián Giraldo ◽  
Mauricio Velásquez ◽  
...  
Keyword(s):  
Growth Factor ◽  
Solitary Fibrous Tumor ◽  
Incidental Finding ◽  
Case Reports ◽  
Tumor Resection ◽  
Insulin Like Growth Factor ◽  
Solitary Fibrous Tumors ◽  
Mesenchymal Neoplasms ◽  
Single Mass ◽  
Fibrous Tumor

Solitary fibrous tumors of the pleura (SFTP) are rare mesenchymal neoplasms that originate from mesenchymal growth in the pleura, tend to be single tumors, usually have an indolent course and show nonspecific symptoms. SFTP can be often diagnosed from an incidental finding of a single mass in the thorax and should be confirmed by biopsy and immunohistochemistry. A minority of cases may present Doege–Potter syndrome (DPS, episodes of refractory hypoglycemia) associated with production of insulin-like growth factor 2 (IGF-2). Both SFTP and DPS are rare occurrences with less than 2000 cases reported worldwide. The curative treatment is tumor resection. Two cases of patients with DPS caused by SFTP are presented below.

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