scholarly journals Follow-Up in Head and Neck Cancer: A Management Dilemma

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Francesca De Felice ◽  
Daniela Musio ◽  
Vincenzo Tombolini
Keyword(s):  
Squamous Cell Carcinoma ◽  
Head And Neck ◽  
Locoregional Recurrence ◽  
Diagnostic Procedure ◽  
Imaging Modality ◽  
Point Of View ◽  
Second Primary ◽  
Primary Tumors ◽  
Second Primary Tumors

Follow-up program in squamous cell carcinoma of head and neck district is crucial to detect locoregional recurrence and second primary tumors and to manage treatment toxicities. The choice of the appropriate frequency of visits and imaging modality can be troublesome. Details of timing surveillance and type of diagnostic procedure are still not well defined. This review highlights the problem from a clinician’s point of view.

scholarly journals Study of the Incidence, Clinicopathological Profile, and Management of Second Primary Tumors in Patients with Index Head and Neck Tumors

2020 ◽  
Vol 6 (02) ◽  
pp. 53-60
Author(s):  
Chirag Jain ◽  
Mansi Jain ◽  
Ajay Kumar Dewan ◽  
Pavani Medisetty ◽  
Ankush Jajodia ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Head And Neck ◽  
Second Primary ◽  
Primary Tumors ◽  
Alive With Disease ◽  
Clinicopathological Profile ◽  
History Of ◽  
Second Primary Tumors ◽  
The Mean

Abstract Introduction This study was performed to study the incidence and clinicopathological profile of second primary tumors (SPTs) in patients with squamous cell carcinoma of head and neck at our institute. Materials and Methods In this study, we included the data of 120 patients who developed an SPT of the upper aerodigestive tract following treatment of their index tumor (IT). Since the online data of cancer patients in our cancer registry was available from January 2005, we started the study retrospectively from that time. At our institute, Rajiv Gandhi Cancer Institute and Research Centre, the incidence was found to be 8.4%. Warren and Gates criteria were followed for defining a second tumor. Results Our study results showed an incidence of 8.4% of SPTs among patients of head and neck squamous cell carcinoma (HNSCC). The mean age of the patients was 56.47 ± 10.42 years with a male predominance. The mean period of addiction in patients was 18.48 ± 4.63 years. It was found that patients with SPT had significant history of tobacco and alcohol use. The most common location for ITs and SPT was tongue and buccal mucosa. The main modality of treatment was surgery in all patient groups. Patients were followed up at three-month intervals for the first 2 years. The SPT was diagnosed with a confirmation biopsy. Majority of patients with SPT again underwent surgery with reconstruction with either free flaps or local flaps. Recurrence after SPT treatment was seen in 16.67% cases, and primarily, it was a locoregional recurrence. Only patients with at least 6 months follow-up posttreatment of SPT were included in this study. At the end of the study, 62.5% patients were disease free, 20.83% patients were alive with disease, and 16.67% patients were dead. Some of the patients who are alive with disease developed a third primary tumor which was managed as per guidelines. Conclusion The incidence of SPTs is 8.4% in our institute. This study adds to the theory of field cancerization proposed by Slaughter et al. We found a significant history of tobacco chewing in our patients who developed SPT. The clinical significance of this study is identifying the features of SPT in patients with HNSCC and allowing for a rational follow-up schedule. The most important part of treatment although still lies with the patient by quitting use of alcohol and tobacco.

scholarly journals Treatment and outcomes of second primary tumors in patients with head and neck squamous cell carcinoma

2017 ◽  
Vol 28 ◽  
pp. x106
Author(s):  
T. Siripoon ◽  
P. Pattaranutaporn ◽  
C. Jiarpinitnun ◽  
J. Juengsamarn ◽  
S. Bunbanjerdsuk ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Second Primary ◽  
Primary Tumors ◽  
Second Primary Tumors

scholarly journals Second primary tumors in patients with head and neck squamous cell carcinoma

Cancer ◽  
1995 ◽  
Vol 75 (6) ◽  
pp. 1343-1353 ◽  
Author(s):  
Andrew S. Jones ◽  
Pradeep Morar ◽  
David E. Phillips ◽  
John K. Field ◽  
David Husband ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Second Primary ◽  
Primary Tumors ◽  
Second Primary Tumors

scholarly journals Screening for synchronous esophageal second primary tumors in patients with head and neck cancer

2021 ◽  
Author(s):  
Steffi E M van de Ven ◽  
Wilmar de Graaf ◽  
Oisín Bugter ◽  
Manon C W Spaander ◽  
Suzan Nikkessen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Early Stage ◽  
Second Primary ◽  
Low Grade ◽  
Primary Tumors ◽  
Increased Risk ◽  
Second Primary Tumors

Summary Patients with head and neck squamous cell carcinoma (HNSCC) have an increased risk of developing esophageal second primary tumors (ESPTs). We aimed to determine the incidence, stage, and outcome of synchronous ESPTs in patients with HNSCC in a Western population. We performed a prospective, observational, and cohort study. Patients diagnosed with HNSCC in the oropharynx, hypopharynx, any other sub-location in combination with alcohol abuse, or patients with two synchronous HNSCCs, between February 2019 and February 2020 underwent screening esophagogastroduodenoscopy (EGD). ESPT was defined as presence of esophageal squamous cell carcinoma (ESCC) or high grade dysplasia (HGD). Eighty-five patients were included. A lesion suspected for ESPT was detected in 14 of 85 patients, which was pathologically confirmed in five patients (1 ESCC and 4 HGD). The radiotherapy field was extended to the esophagus in two of five patients, HGD was treated with endoscopic resection in three of five patients. None of the ESPTs were detected on MRI and/or CT-scan prior to EGD. Of the remaining nine patients, three had low grade dysplasia on histology whereas the other six patients had benign lesions. Incidence of synchronous ESPT was 5.9% in our cohort of HNSCC patients. All ESPTs were diagnosed at an early stage and treated with curative intent. We recommend that screening for synchronous ESPTs should be considered in a selected group of patients with HNSCC.

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