scholarly journals Follicular Thyroid Carcinoma Metastatic to the Kidney: Report of a Case with Cytohistologic Correlation

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Vikas Nath ◽  
Mithra Baliga ◽  
Jack Lewin ◽  
Frederico Souza ◽  
Israh Akhtar
Keyword(s):  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Follicular Carcinoma ◽  
Ct Guided ◽  
Thyroid Transcription Factor 1 ◽  
Positron Emission ◽  
Thyroid Transcription Factor ◽  
Resected Tumor ◽  
Thyroid Metastases ◽  
Transcription Factor 1

Here we report a case of a 45-year-old female who underwent thyroidectomy for thyroid cancer and presented 20 years later with a left renal mass. CT-guided core biopsy was performed, and imprints and histologic sections of the biopsy showed cells resembling thyroid follicular cells with a background containing colloid. Immunohistochemistry revealed positivity for thyroglobulin and thyroid transcription factor 1, consistent with metastatic follicular thyroid carcinoma (FTC). The patient later underwent radical nephrectomy; histologic sections of the resected tumor revealed an encapsulated lesion morphologically similar to the biopsy specimen. Thyroid metastases to the kidney are extremely rare and are often detected during postthyroidectomy surveillance by elevation in thyroid hormone levels,131I scintigraphy, or18F-fluorodeoxyglucose uptake in positron emission tomography studies. Treatment involves total thyroidectomy, resection of the metastatic foci, and131I therapy. The differential diagnoses of renal metastasis of FTC include the encapsulated follicular variant of papillary thyroid carcinoma (PTC), which possesses some of the nuclear features seen in conventional PTC but may occasionally be indistinguishable from FTC in cytologic preparations, and renal lesions such as benign thyroidization of the kidney and thyroid-like follicular carcinoma of the kidney, which mimic FTC in histologic appearance but do not stain with thyroid markers.

Papillary Carcinoma of Thyroid Metastatic to the Pituitary Gland

2001 ◽  
Vol 125 (7) ◽  
pp. 935-938 ◽  
Author(s):  
C. David Bell ◽  
Kalman Kovacs ◽  
Eva Horvath ◽  
Harley Smythe ◽  
Sylvia Asa
Keyword(s):  
Thyroid Carcinoma ◽  
Pituitary Gland ◽  
Papillary Carcinoma ◽  
Pulmonary Metastases ◽  
Hematogenous Metastasis ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Conventional Histology ◽  
Transcription Factor 1 ◽  
Pituitary Metastasis

Abstract We describe a 35-year-old woman who presented with diabetes insipidus caused by metastatic papillary carcinoma of the thyroid involving the pituitary gland, 25 years after treatment for a papillary carcinoma of thyroid and 17 years after treatment for multiple pulmonary metastases. The literature contains 10 previously described cases of metastatic thyroid carcinoma involving the sella, but only 2 of these cases had unequivocal metastases to the pituitary gland, making the present case, to our knowledge, the third reported case of unequivocal hematogenous metastasis of thyroid carcinoma to the pituitary gland. The pituitary tumor was removed by transsphenoidal surgery, and the tissue was examined by conventional histology, extensive immunohistochemistry, and electron microscopy. The findings confirmed the tumor to be papillary thyroid carcinoma. To our knowledge, this is the first report citing use of thyroid transcription factor-1 to establish a thyroid source of a pituitary metastasis.

scholarly journals Clinical Analysis of Thyroid Carcinoma Showing Thymus-Like Differentiation: Report of 8 Cases

2013 ◽  
Vol 98 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Zhen Liu ◽  
Xu-Yong Teng ◽  
Da-Xin Sun ◽  
Wei-Xue Xu ◽  
Shao-Long Sun
Keyword(s):  
Thyroid Carcinoma ◽  
Postoperative Radiotherapy ◽  
Radical Resection ◽  
Clinical Analysis ◽  
Treatment Recommendation ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Medical University ◽  
Transcription Factor 1

Abstract Thyroid carcinoma showing thymus-like differentiation (CASTLE) is a kind of rare neoplasm of the thyroid gland. Because thyroid CASTLE is rare and difficult to diagnose, its clinicopathologic features have not been well defined, and no universally accepted treatment recommendation is available. We analyzed retrospectively the clinicopathologic data of 8 patients with thyroid CASTLE who underwent surgery and radiotherapy at the Shengjing Hospital of China Medical University between December 2008 and June 2012. All patients accepted radical surgery. All patients accepted postoperative radiotherapy, except one 79-year-old patient. There was no evidence of recurrence or metastasis during the follow-up period. The pattern of immunohistochemical staining was similar to that of thymic carcinoma. Six of 8 CASTLE cases expressed CD5. All 8 CASTLE patients were negatively expressed in thyroglobulin, thyroid transcription factor 1, and calcitonin. Patients with thyroid CASTLE have good outcomes after radical resection and postoperative radiotherapy. Positive CD5 immunoreactivity can contribute to diagnosis of this disease.

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