scholarly journals Determination of Glucocorticoids in UPLC-MS in Environmental Samples from an Occupational Setting

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Enrico Oddone ◽  
Sara Negri ◽  
Massimo Bellinzona ◽  
Silvia Martino ◽  
Marcello Di Tuccio ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Environmental Samples ◽  
Simple Technique ◽  
Occupational Exposures ◽  
Work Environments ◽  
Analytical Methodology ◽  
Pad Test ◽  
Occupational Setting ◽  
Wipe Tests

Occupational exposures to glucocorticoids are still a neglected issue in some work environments, including pharmaceutical plants. We developed an analytical method to quantify simultaneously 21 glucocorticoids using UPLC coupled with mass spectrometry to provide a basis to carry out environmental monitoring. Samples were taken from air, hand-washing tests, pad-tests and wipe-tests. This paper reports the contents of the analytical methodology, along with the results of this extensive environmental and personal monitoring of glucocorticoids. The method in UPLC-MS turned out to be suitable and effective for the aim of the study. Wipe-test and pad-test desorption was carried out using 50 mL syringes, a simple technique that saves time without adversely affecting analyte recovery. Results showed a widespread environmental pollution due to glucocorticoids. This is of particular concern. Evaluation of the dose absorbed by each worker and identification of a biomarker for occupational exposure will contribute to assessment and prevention of occupational exposure.

scholarly journals Vacuum-assisted sorbent extraction: An analytical methodology for the determination of ultraviolet filters in environmental samples

Talanta ◽  
2020 ◽  
Vol 208 ◽  
pp. 120390 ◽  
Author(s):  
María J. Trujillo-Rodríguez ◽  
Jared L. Anderson ◽  
Sage J.B. Dunham ◽  
Victoria L. Noad ◽  
Daniel B. Cardin
Keyword(s):  
Environmental Samples ◽  
Analytical Methodology

Occupational Exposures in the Homecare Environment: Piloting an Observation Tool

2021 ◽  
pp. 108482232098691
Author(s):  
Elizabeth Bien ◽  
Kermit Davis ◽  
Susan Reutman ◽  
Gordon Gillespie
Keyword(s):  
Home Care ◽  
Patient Care ◽  
Occupational Safety ◽  
Occupational Exposures ◽  
Care Patient ◽  
Home Healthcare ◽  
Occupational Hazards ◽  
Cross Sectional ◽  
Direct Observations ◽  
Occupational Setting

The population of home healthcare workers (HHCWs) is rapidly expanding. Worker tasks and the unique home care environments place the worker at increased risks of occupational exposures, injury, and illness. Previous studies focusing on occupational exposures of HHCWs are limited to self-reports and would benefit from direct observations. The purpose of this study is to describe the occupational hazards observed in the unique work environment of home healthcare. HHCWs and home care patient participants were recruited from one home care agency in the Midwest to be observed during a routine home visit. This cross-sectional study used a trained occupational health nurse for direct observation of the occupational setting. Standardized observations and data collection were completed using the Home Healthcare Worker Observation Tool. The observer followed a registered nurse and occupational therapist into 9 patient homes observing visits ranging from 22 to 58 minutes. Hazards observed outside of and within the home include uneven pavements (n = 6, 67%), stairs without railings (n = 2, 22%), throw rugs (n = 7, 78%), unrestrained animals (n = 2, 22%), dust (n = 5, 56%), and mold (n = 2, 22%). Hand hygiene was observed prior to patient care 2 times (22%) and after patient care during 5 visits (56%). Observations have identified hazards that have the potential to impact workers’ and patients’ health. The direct observations of HHCWs provided opportunities for occupational safety professionals to understand the occupational exposures and challenges HHCWs encounter in the home care environment and begin to identify ways to mitigate occupational hazards.

Field analysis Cr(VI) in water samples by a smartphone-based ultralong absorption path reflection colorimetric device

2021 ◽  
Author(s):  
Xiaolan Chen ◽  
Cheng Ma ◽  
Qi Kang ◽  
Yu-Qin Chen ◽  
Dazhong Shen
Keyword(s):  
Hexavalent Chromium ◽  
Water Samples ◽  
Environmental Samples ◽  
Field Analysis ◽  
Absorption Path

Hexavalent chromium is highly toxic and regarded as one of the main pollutants in environmental samples. Sophisticated laboratory instruments are commercially available for in-field determination of chromium. It is highly...

scholarly journals Application of Bar Adsorptive Microextraction for the Determination of Levels of Tricyclic Antidepressants in Urine Samples

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3101
Author(s):  
Mariana N. Oliveira ◽  
Oriana C. Gonçalves ◽  
Samir M. Ahmad ◽  
Jaderson K. Schneider ◽  
Laiza C. Krause ◽  
...  
Keyword(s):  
Tricyclic Antidepressants ◽  
Matrix Effects ◽  
Activated Carbons ◽  
Process Efficiency ◽  
Gas Chromatography Mass Spectrometry ◽  
Selected Ion Monitoring ◽  
Experimental Conditions ◽  
Analytical Methodology ◽  
Low Efficiency

This work entailed the development, optimization, validation, and application of a novel analytical approach, using the bar adsorptive microextraction technique (BAμE), for the determination of the six most common tricyclic antidepressants (TCAs; amitriptyline, mianserin, trimipramine, imipramine, mirtazapine and dosulepin) in urine matrices. To achieve this goal, we employed, for the first time, new generation microextraction devices coated with convenient sorbent phases, polymers and novel activated carbons prepared from biomaterial waste, in combination with large-volume-injection gas chromatography-mass spectrometry operating in selected-ion monitoring mode (LVI-GC-MS(SIM)). Preliminary assays on sorbent coatings, showed that the polymeric phases present a much more effective performance, as the tested biosorbents exhibited low efficiency for application in microextraction techniques. By using BAμE coated with C18 polymer, under optimized experimental conditions, the detection limits achieved for the six TCAs ranged from 0.2 to 1.6 μg L−1 and, weighted linear regressions resulted in remarkable linearity (r2 > 0.9960) between 10.0 and 1000.0 μg L−1. The developed analytical methodology (BAμE(C18)/LVI-GC-MS(SIM)) provided suitable matrix effects (90.2–112.9%, RSD ≤ 13.9%), high recovery yields (92.3–111.5%, RSD ≤ 12.3%) and a remarkable overall process efficiency (ranging from 84.9% to 124.3%, RSD ≤ 13.9%). The developed and validated methodology was successfully applied for screening the six TCAs in real urine matrices. The proposed analytical methodology proved to be an eco-user-friendly approach to monitor trace levels of TCAs in complex urine matrices and an outstanding analytical alternative in comparison with other microextraction-based techniques.

Facile and Sensitive Spectrophotometric Determination of Carbosulfan in Formulations and Environmental Samples

2006 ◽  
Vol 129 (1-3) ◽  
pp. 271-276 ◽  
Author(s):  
K. Suresh Kumar ◽  
K. Suvardhan ◽  
D. Rekha ◽  
K. Kiran ◽  
G. Chalapathi Rao ◽  
...  
Keyword(s):  
Spectrophotometric Determination ◽  
Environmental Samples

Development and validation of an analytical methodology for the determination of p,p′-DDT, p,p′-DDE and p,p′-DDD in fish oil pills

2007 ◽  
Vol 86 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Juan José Berzas Nevado ◽  
Rosa Carmen Rodríguez Martín-Doimeadiós ◽  
Francisco Javier Guzmán Bernardo ◽  
Nuria Rodríguez Fariñas
Keyword(s):  
Fish Oil ◽  
Analytical Methodology ◽  
Development And Validation
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