scholarly journals Levothyroxine Augmentation in Clozapine Resistant Schizophrenia: A Case Report and Review

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Ruohollah Seddigh ◽  
Somayeh Azarnik ◽  
Amir-Abbas Keshavarz-Akhlaghi

There are many reports that show different thyroid abnormalities in schizophrenia without clear establishment of their role in etiology and treatment outcome of schizophrenia. Among these reports, there are only a few that consider a role for thyroid hormones as augmenting agents in the treatment with antipsychotic drugs. This case report outlines symptom subsidence of a patient with clozapine refractory paranoid schizophrenia and normal thyroid function who added levothyroxine to clozapine and found that symptoms of psychosis returned once levothyroxine was discontinued. Although this observation needs to be confirmed in controlled clinical trials, we aimed to discuss possible hypothesized mechanisms underlying this observation.

1978 ◽  
Vol 12 (10) ◽  
pp. 580-581 ◽  
Author(s):  
Timothy H. Self ◽  
Mark S. Soloway ◽  
Don Vaughn

A case report of a possible interaction between indomethacin and warfarin is presented. The effect of warfarin on the prothrombin time (PT) was enhanced while indomethacin was given concurrently. Substitution of Ibuprofen for indomethacin resulted in the desired control of the prothrombin time. Based on the results of controlled clinical trials and on the rarity of case reports, there is probably an extremely low incidence of enhancement of warfarin-induced hypoprothrombinemia by indomethacin.


2002 ◽  
Vol 88 (6) ◽  
pp. 527-529 ◽  
Author(s):  
Marzia Palma ◽  
Andrea Mancuso ◽  
Federico Grifalchi ◽  
Antonio Lugini ◽  
Nicoletta Pizzardi ◽  
...  

A 46-year-old woman had an episode of atrial fibrillation during infusion of docetaxel as adjuvant chemotherapy for an infiltrating ductal carcinoma of the breast. All cardiological tests performed before treatment were normal and there was no evidence of thyroid dysfunction nor any objective or anamnestic data indicating acute or chronic cardiovascular disease. None of the drugs administered has ever shown any proarrhythmic activity. In controlled clinical trials docetaxel was found to have a very low cardiotoxicity.


2011 ◽  
Vol 44 (13) ◽  
pp. S107-S108
Author(s):  
Rahim Rostami ◽  
Asghar Beiranvand ◽  
Jaffar Nourooz-zadeh

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sheng-Ru Liang ◽  
Jing Cai ◽  
Yang Yang ◽  
Lei Zhang ◽  
Peter Taylor ◽  
...  

Obesity ◽  
2010 ◽  
Vol 18 (4) ◽  
pp. 854-857 ◽  
Author(s):  
Chiara Dall'Asta ◽  
Michele Paganelli ◽  
Alberto Morabito ◽  
Paola Vedani ◽  
Michelangela Barbieri ◽  
...  

2002 ◽  
Vol 10 (4) ◽  
pp. 403-404 ◽  
Author(s):  
Mosunmola Tunde-Ayinmode ◽  
Ashok Singh ◽  
Karen Marsden

Objective: To highlight the therapeutic potential of oestrogen in schizophrenia and raise awareness about the need for more clinical trials. Method: Case Report. Results: The case concerns a woman suffering from chronic paranoid schizophrenia, who complied poorly with antipsychotic medication and had severely impaired psychological and social functioning. Oestrogen therapy in the form of an oral contraceptive pill (brevinor- norethisterone/ ethinyloestradiol) was used with effect. Conclusions: Oestrogen therapy shows promise in select cases in the treatment of schizophrenia and warrants further study.


2018 ◽  
Vol 52 ◽  
pp. 5-7 ◽  
Author(s):  
Mohamed Regal ◽  
Mohammed Maamoun Kamel ◽  
Hassan Alyami ◽  
Emad M. AL-Osail

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