scholarly journals Statistical Methods for Establishing Personalized Treatment Rules in Oncology

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Junsheng Ma ◽  
Brian P. Hobbs ◽  
Francesco C. Stingo

The process for using statistical inference to establish personalized treatment strategies requires specific techniques for data-analysis that optimize the combination of competing therapies with candidate genetic features and characteristics of the patient and disease. A wide variety of methods have been developed. However, heretofore the usefulness of these recent advances has not been fully recognized by the oncology community, and the scope of their applications has not been summarized. In this paper, we provide an overview of statistical methods for establishing optimal treatment rules for personalized medicine and discuss specific examples in various medical contexts with oncology as an emphasis. We also point the reader to statistical software for implementation of the methods when available.

2022 ◽  
pp. 0272989X2110728
Author(s):  
Anna Heath ◽  
Petros Pechlivanoglou

Background Clinical care is moving from a “one size fits all” approach to a setting in which treatment decisions are based on individual treatment response, needs, preferences, and risk. Research into personalized treatment strategies aims to discover currently unknown markers that identify individuals who would benefit from treatments that are nonoptimal at the population level. Before investing in research to identify these markers, it is important to assess whether such research has the potential to generate value. Thus, this article aims to develop a framework to prioritize research into the development of new personalized treatment strategies by creating a set of measures that assess the value of personalizing care based on a set of unknown patient characteristics. Methods Generalizing ideas from the value of heterogeneity framework, we demonstrate 3 measures that assess the value of developing personalized treatment strategies. The first measure identifies the potential value of personalizing medicine within a given disease area. The next 2 measures highlight specific research priorities and subgroup structures that would lead to improved patient outcomes from the personalization of treatment decisions. Results We graphically present the 3 measures to perform sensitivity analyses around the key drivers of value, in particular, the correlation between the individual treatment benefits across the available treatment options. We illustrate these 3 measures using a previously published decision model and discuss how they can direct research in personalized medicine. Conclusion We discuss 3 measures that form the basis of a novel framework to prioritize research into novel personalized treatment strategies. Our novel framework ensures that research targets personalized treatment strategies that have high potential to improve patient outcomes and health system efficiency. Highlights It is important to undertake research prioritization before conducting any research that aims to discover novel methods (e.g., biomarkers) for personalizing treatment. The value of unexplained heterogeneity can highlight disease areas in which personalizing treatment can be valuable and determine key priorities within that area. These priorities can be determined under assumptions of the magnitude of the individual-level treatment effect, which we explore in sensitivity analyses.


2013 ◽  
Vol 1 (2) ◽  
pp. 69-74
Author(s):  
Ashok Kumar

The data forms the main base at the very grass root level and is the BACK BONE for application of all the statistical methods, be it in the field of medical sciences, social sciences or any such allied field. The present paper, in this direction, attempts to HIGHLIGHT the main considerations and points to be taken care of in DATA ANALYSIS, towards statistical Inference(s)DOI: http://dx.doi.org/10.3126/jucms.v1i2.8414 Journal of Universal College of Medical Sciences Vol.1(2) 2013: 69-74


Technometrics ◽  
1994 ◽  
Vol 36 (3) ◽  
pp. 332
Author(s):  
Eric R. Ziegel ◽  
Lyman Ott

2021 ◽  
pp. 107110072110510
Author(s):  
Hanci Zhang ◽  
Amanda N. Fletcher ◽  
Daniel J. Scott ◽  
James Nunley

Avascular osteonecrosis (AVN) of the talus (AVNT) is a painful and challenging clinical diagnosis. AVNT has multiple known risk factors and etiologies and presents at different stages in severity. Given these unique factors, the optimal treatment solution has yet to be determined. Both joint-preserving and joint-sacrificing procedures are available, including core decompression and arthrodeses. Recently, new salvage and replacement techniques have been described including vascularized pedicle bone grafts and total talus replacement using patient-specific prosthesis; however, evidence remains limited. This review examines the current trends AVNT treatment and the emerging data behind these novel techniques.


Author(s):  
Regina Gražulevičienė ◽  
Inga Bendokienė

The aim of the study was to assess the influence of truck traffic on acoustic pollution in two Kaunas districts crossed by highways‐ Eiguliai and Šilainiai. Composition of traffic flow and noise measurements were conducted near the main streets and national highways that cross the districts. GIS and statistical software SPSS 12.01 were used for the data analysis. The study results showed that mean noise level near the main streets was 70 dB(A) in the daytime,‐ 68.6 dB(A) in the evening and at night it was 61.1 dB(A) in Eiguliai, and in Šilainiai it was 67 dB(A), 65 dB(A) and 58 dB(A), correspondingly. On the highways, crossing the districts, heavy vehicles compose about 3 times higher part of total traffic flow during the day and about 2 times in the evening compared to other main streets. The noise level depended on the traffic flow and correlation coefficient fluctuated from 0.77 to 0.85. The modelling of traffic flow showed, that the increase of trucks proportion by 2 percent would increase the traffic noise by 1.1 dB(A) in the streets with traffic flow of 300 veh./hour or more, and by 1.8 dB(A) with traffic flow of 200 veh./hour or less. Our findings suggest that the influence of heavy vehicles on acoustic pollution is higher in the districts with lower traffic flow. Santrauka Tyrimo tikslas – nustatyti krovininio autotransporto įtaką akustinei taršai Kauno mikrorajonuose, kuriuos kerta respublikinės reikšmės magistralės – Islandijos plentas ir vakarinis lankstas. Aplinkos triukšmo lygis ir transporto srautų intensyvumas Eigulių ir Šilainių seniūnijoje buvo matuotas 34 taškuose – dieną, vakare ir naktį. Duomenims apdoroti taikyta geografinių informacinių (GIS) sistemų technologijos, SPSS 12.0.1 ir Statistica 15 statistinės analizės paketai. Tyrimų rezultatai: vidutinis ekvivalentinis triukšmo lygis Eigulių seniūnijoje dieną prie pagrindinių gatvių siekė 70 dBA, vakare – 68,6 dBA, o naktį – 61,1 dBA ir iš esmės nesiskyrė nuo Šilainių seniūnijos, atitinkamai 67 dBA, 65 dBA ir 58 dBA. Magistraliniuose keliuose, kertančiuose Eigulių ir Šilainių seniūnijas, vidutinis transporto srautų intensyvumas dieną ir vakare buvo 5 kartus, naktį 6 kartus didesnis nei vidutinis srautų intensyvumas pagrindinėse gatvėse tuo pačiu metu, o krovininio autotransporto dalis dieną 3 kartus, o vakare 2 kartus viršijo vidutinius pagrindinių gatvių srautus. Nustatyta sąsaja tarp transporto srautų intensyvumo ir triukšmo lygio: Eigulių seniūnijos dienos koreliacijos koeficientas buvo 0,85, vakaro ir nakties – 0,83, o Šilainių seniūnijos – atitinkamai 0,78, 0,77 ir 0,80. Transporto srautų sudėties modeliavimo duomenimis, padidėjus krovininio transporto proporcijai 2 %, gatvėse, kuriose transporto srautas didesnis nei 300 aut./val., triukšmo lygis padidėtų 1,1 dBA, o kur transporto srautas mažesnis nei 200 aut./val., triukšmo lygis padidėtų 1,8 dBA (koreliacijos koeficientas – 0,63). Krovininio transporto įtaka akustinei taršai didesnė mikrorajonuose, kuriuose transporto srautai nedideli. Резюме Целью данной работы было изучить влияние грузового автотранспорта на акустическое загрязнение в микрорайонах города Каунаса, которые пересекают трассы государственного значения. Это шоссе Исландиос и объезд Вакаринис. Состав транспортного потока определялся и уровень шума измерялся около главных улиц микрорайонов. Результаты исследования показали, что средний уровень шума днем был 70 dBA, вечером – 68,6 dBA, ночью – 61,1 dBA. На трассах государственного значения, пересекающих микрорайоны, по сравнению с другими улицами потоки грузовых автомобилей были в 3 раза больше днем и 2 раза больше вечером. Установлена зaвисимость между величиной транспортного потока и шума (r = 0,77–0,85). Моделирование состава транспортного потока показало, что при увеличении на улицах грузового транспорта на 2% с 300 авт./час и больше шум увеличивается на 1,1 dBA, а при количестве грузового транспорта, составляющем 200 авт./час и меньше, шум возрастает на 1,8 dBA. Влияние грузового автотранспорта на акустическое загрязнение больше в микрорайонах с небольшим транспортным потоком.


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