scholarly journals Correlation of Clinicohaematological Parameters in Paediatric Dengue: A Retrospective Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ramakrishna Pai Jakribettu ◽  
Rekha Boloor ◽  
Andrew Thaliath ◽  
Sharanya Yesudasan George ◽  
Thomas George ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Leucocyte Count ◽  
Clinical Presentation ◽  
Wide Spectrum ◽  
Tertiary Care ◽  
Hemorrhagic Fever ◽  
Haematological Parameters ◽  
Total Leucocyte Count ◽  
Care Hospital ◽  
Significant Difference

Dengue is one of the arthropod-borne (arbo) viral diseases transmitted by female mosquitoAedes aegypti. Dengue fever has a wide spectrum of clinical presentation ranging from flu-like illness to severe complicated stage of dengue hemorrhagic fever leading to mortality. This was a retrospective study conducted in a tertiary care hospital in Coastal Karnataka, South India, to know the correlation between the clinical presentation and haematological parameters in the paediatric cases presented with dengue symptoms. A total of 163 paediatric cases who presented fever and dengue-like illness were included in the study. Of which, 69 were confirmed dengue patients. Critical analysis showed that there was a significant difference in the haematological parameters like total leucocyte count, percent differential leucocyte count, and platelets count, in the erythrocyte sedimentation rate (P<0.05to 0.0001). Additionally, when compared to nondengue patients, even the liver function and renal function parameters were significantly deranged (P<0.05to 0.0001). Stratification based on NS1, IgG, and IgM showed significant alterations in the haematological, hepatic, and renal parameters. With respect to the treatment a small percentage of patients, that is, 8% (4 patients), required platelet transfusion as their counts went below 20,000/μL. Two patients succumbed to their illness while three required ICU stay.

scholarly journals A Cross Sectional Study to Assess the Status of Hemoglobin and Other Blood Indices among Pregnant Women Attending Tertiary Care Hospital of Vadodara

2021 ◽  
pp. 106-111
Author(s):  
Vruti Patel ◽  
J. D. Lakhani
Keyword(s):  
Pregnant Women ◽  
Leucocyte Count ◽  
Tertiary Care Hospital ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Haematological Parameters ◽  
Moderate Degree ◽  
Care Hospital ◽  
Cross Sectional ◽  
Blood Indices

Introduction: A number of adaptations happen in the anatomy, physiology and metabolic processes within the mother which aids in successful progression of the pregnancy. The different blood indices such as haemoglobin concentration, packed cell volume (PCV), red blood cell count; total WBC count etc. can be measured to evaluate haematological status in a pregnant woman. The hematological profile of the pregnant women has an impact on both pregnancy and its outcome. Anaemia in pregnancy can be leads to morbidity and mortality in mother and fetus. The current study was designed to determine the variation in status of hemoglobin and other blood indices in anemic and non-anemic pregnant women. Aims ans Objectives: 1. To study the hematological and other blood indices among pregnant women, 2. To assess the degree of anemia in pregnant women, 3. To compare the Various hematological parameters between anemic and non -anemic pregnant women. Materials and Methods: A Cross-sectional comparative descriptive survey design and quantitative approach was adopted to achieve the goal of the study. The study was conducted at the tertiary care hospital of Vadodara, Gujarat. Total 300 pregnant women were recruited and socio demographic information was collected. Hemoglobin concentration (Hb), total leucocyte count (TLC), differential leucocyte count (DLC), and platelet count, blood indices of the recruited samples were studied.Mean and SD of Haematological parameters were calculated and unpaired t-test was used to compare the pregnant anaemic women data with non-anaemic pregnant women. Results: Out of 300, 204 pregnant women were found anemic and most of the pregnant women 84% belonged to rural area. In accordance with severity of anemia, Moderate degree of anemia was found to be highest (41%) in anemic pregnant women. Comparison of non - anaemic pregnant women with anaemic pregnant women shows significant changes in haematological parameters (p <0.05). Conclusion: It can be concluded that there is significant changes in hematological parameters in each trimesters of pregnancy as well compare to non-anemic to anemic pregnant women. Most of the hematological changes occur in order to physiological adaptation of pregnancy but abnormal status of Haemoglobin and other blood indices cause adverse outcome of the pregnancy.

scholarly journals A retrospective study on histomorphological spectrum of ovarian lesions in a tertiary care hospital

2020 ◽  
Vol 6 (7) ◽  
pp. 430-436
Author(s):  
Subashree Kannan ◽  
◽  
Sneha Ravindran ◽  
S. Balaji ◽  
◽  
...  
Keyword(s):  
Retrospective Study ◽  
Clinical Presentation ◽  
Tertiary Care ◽  
World Health ◽  
Care Hospital ◽  
Follicular Cyst ◽  
Serous Cystadenomas ◽  
Tertiary Teaching ◽  
Tertiary Teaching Hospital ◽  
The Right

Introduction: Gynecological morbidity is defined as any condition, disease, or dysfunction of thereproductive system which is not related to pregnancy, abortion, or childbirth. A significant numberof ovarian lesions have been known to cause Gynecological morbidity among most females. With theincreased use of screening modalities, ovarian lesions have increasingly been encountered forpathological analysis. It is important to evaluate the pattern of clinical presentation, corroboratingwith histological diagnosis. Purpose: The present study was carried out to evaluate thehistomorphological spectrum of various ovarian lesions among women in Puducherry. Material andMethods: This retrospective study was conducted on 350 ovarian samples received for five years inthe Department of Pathology, of our tertiary teaching hospital. Clinicopathological data wereretrieved from the hospital records. The histomorphological analysis was reviewed and neoplasticand non-neoplastic ovarian lesions were segregated according to the World Health Organizationclassification. Results: Based on histology, the predominant ovarian lesions diagnosed were non-neoplastic conditions including simple and follicular cyst, corpus luteal cyst, corpus hemorrhagiccyst, and cystic follicles constituting 40.6% on the right side and 34% on the left side. Malignancywas predominant on the right side (1.7%) while the same was 0.6% on the left side. Conclusion:The present study has identified that non-neoplastic lesions are more common in ovaries thanneoplastic lesions and it has identified that serous cystadenomas are the most common ovarianneoplastic lesions.

scholarly journals Influence of donor demographics on the platelet yield during plateletpheresis - experience of 1100 procedures at a tertiary-care hospital

2014 ◽  
Vol 4 (7) ◽  
pp. 525-529
Author(s):  
S Mangwana
Keyword(s):  
Blood Volume ◽  
Processing Time ◽  
Leucocyte Count ◽  
Blood Donors ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Total Leucocyte Count ◽  
Care Hospital ◽  
Single Donor ◽  
Multiple Donors

Background: Transfusion of plateletpheresis is effective for treating patients with platelet relatedinsufficiencies while limiting recipient’sexposure to platelets from multiple donors. A larger yield isobtained when donor has a greater number of initial platelets and separation done in a shorter time. Theaim of the study was to analyze the effect of various donors and procedure related parameters on the yieldof single donor platelet so that blood donors can be screened effectively in less time.Materials and Methods: One thousand and one hundred plateletpheresis procedures were performed ina tertiary-care super-specialty hospital onFenwal AMICUS machine using closed system kits. Statisticalanalysis was done to establish cause and effect relationship and to find the extent of relationship betweendifferent variables.Results: Height, weight,BMI, platelet count and total leucocyte count had significant correlation withplatelet yield, processing time and blood volume processed while haemoglobin especially in femalescorrelated significantlywith processing time(p<0.0001)and blood volume processed. Rh “negative”donors had shorter processing time than Rh “positive” donors while ABO group did not show anycorrelation with machine variables.Conclusion: Platelet yield correlated positively with pre-donation count, height, weight and BMI.Haemoglobin correlated with processing time and blood volume processed. Optimization of platelet yieldis an emerging issue to identify factors which may help in selecting donors to obtain higher platelet yieldsin shorter time and consequently better clinical outcome.DOI: http://dx.doi.org/10.3126/jpn.v4i7.10292 Journal of Pathology of Nepal (2014) Vol. 4, 525-529 

A RETROSPECTIVE STUDY ON ANTIBIOTIC USAGE IN A TERTIARY CARE HOSPITAL

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Anna Joy ◽  
Aparna Anand ◽  
Arathy R Nath ◽  
Meera S Nair ◽  
Dr. K. G. Prasanth
Keyword(s):  
Retrospective Study ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Sensitivity Test ◽  
Actual Process ◽  
Care Hospital ◽  
Rational Use ◽  
Antibiotic Susceptibility Test ◽  
Antibiotic Sensitivity Test ◽  
Rational Use Of Antibiotics

Antibiotics are one of the most commonly prescribed drugs today. Rational use of antibiotics is therefore extremely important as their injudicious use can adversely affect the patient. Drug Utilization Evaluation (DUE) is a system of ongoing systematic criteria based evaluation of drug that will help to ensure that medicines are used appropriately. It is drug/disease specific and can be structured so that it will assess the actual process of prescribing, dispensing, or administration of drug. The retrospective study was conducted At Pk Das Institute of Medical Sciences, Palakkad, Kerala for a duration of 6 months (February 2017 - January 2018). A source of data includes Patient case sheets &medication charts, nursing charts, culture & sensitivity reports. The inclusion criterion includes Patients aged between 18- 80 year, prescribed with oral and parenteral antibiotics. . On analyzing the gender, male gender (n= 111, 55.5%) were higher in numbers as compared to female counterparts (n=89, 44.5%). In our study the majority of the patients prescribed with antibiotics were with the clinical assessment of COPD (n=39, 19.5%), UTI (n=37, 18.5%) and LRTI (n=28, 14%), Bronchial asthma (n=19, 9.5%) respectively. On analyzing the data based on antibiotic sensitivity test, antibiotic test were performed and followed in (n=64,32%)prescriptions and in (n=47,23.5%)prescriptions were test is not followed respectively. In (n=89,44.5%) prescriptions, antibiotic sensitivity test is not performed. On analysis of antibiotics prescribed, the most commonly prescribed antibiotics were cephalosporins, of these ceftriaxone was highly prescribed of all (n=95). The high percentage of antibiotic prescriptions may indicate a high probability of irrational use. This study also point out irrational use of antibiotics are more leading to resistance, misuse and serious problems. So certain strategies should be put forward to strengthen rational use of antibiotics. Keywords: Antibiotics, Antibiotic Susceptibility Test, Irrational use, Resistance

A Retrospective Study of the Clinico-pathological Profile of Primary Extra Nodal Lymphomas in a Tertiary Care Hospital

2019 ◽  
Vol V-5 (I-1) ◽  
pp. 1-5
Author(s):  
Babu Janarthan ◽  
Krishna Nikhil ◽  
Dattatreya P.S. ◽  
Nirni S.S. ◽  
Vasini Vindhya
Keyword(s):  
Retrospective Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

Association of Rugae Pattern with Skeletal Malocclusion in Orthodontic Patients Visiting Tertiary Care Hospital

2020 ◽  
Author(s):  
Sarwat Memon
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Class Iii ◽  
Chi Square ◽  
Cross Sectional ◽  
Skeletal Malocclusion ◽  
Palatal Rugae ◽  
Significant Difference ◽  
Orthodontic Patients

Background: The palatal rugae are special constructions that are inalterable in their position and pattern during the lifestyles of an individual. This imparts them an exceptional role in the forensic dentistry and may play potential role in malocclusion identification. This study was aimed to see association of rugae pattern with sagittal skeletal malocclusion in orthodontic patients visiting tertiary care hospital. Methods: This cross-sectional examination was completed on pretreatment records (lateral Cephalometric radiographs and maxillary dental casts) of 384 subjects at the orthodontic department of Ziauddin Dental Hospital, Karachi. The study duration was from January to July 2019. The samples were sub-divided into three sagittal skeletal groups based on ANB angle proposed by Steiner’s on lateral Cephalometric radiographs (Class I with ANB angle between 0° to 4°; Class II: ANB angle greater than 5°; Class III: ANB angle less than 0°). The shapes of three most-anterior primary rugae were then evaluated bilaterally using Kapali et al., Classification. Chi Square test was applied to find association of rugae pattern among sagittal skeletal malocclusions groups. Results: Circular and curved rugae shapes were the most prevalent in all skeletal malocclusions. The primary palatal rugae pattern was seen to be significantly different among three skeletal malocclusion groups (p<0.05). The right and left sided palatal rugae pattern showed significant difference in all three skeletal malocclusion groups (p<0.05). Conclusion: The present study showed no specific palatal rugae pattern associated with sagittal skeletal malocclusion. Further studies on larger sample and use of modern 3D technologies to scan the maxillary casts are required for results that are more precise.

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in hospitalized patients at a tertiary referral center in North India (Preprint)

2020 ◽  
Author(s):  
Dr. Animesh Ray ◽  
Dr. Komal Singh ◽  
Souvick Chattopadhyay ◽  
Farha Mehdi ◽  
Dr. Gaurav Batra ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Age Groups ◽  
Hospitalized Patients ◽  
North India ◽  
P Value ◽  
Care Hospital ◽  
Igg Antibodies ◽  
Igg Antibody ◽  
Increased Risk ◽  
Significant Difference

BACKGROUND Seroprevalence of IgG antibodies against SARS-CoV-2 is an important tool to estimate the true extent of infection in a population. However, seroprevalence studies have been scarce in South East Asia including India, which, as of now, carries the third largest burden of confirmed cases in the world. The present study aimed to estimate the seroprevalence of anti-SARS-CoV-2 IgG antibody among hospitalized patients at one of the largest government hospital in India OBJECTIVE The primary objective of this study is to estimate the seroprevalence of SARS-CoV-2 antibody among patients admitted to the Medicine ward and ICU METHODS This cross-sectional study, conducted at a tertiary care hospital in North India, recruited consecutive patients who were negative for SARS-CoV-2 by RT-PCR or CB-NAAT. Anti-SARS-CoV-2 IgG antibody levels targeting recombinant spike receptor-binding domain (RBD) protein of SARS CoV-2 were estimated in serum sample by the ELISA method RESULTS A total of 212 hospitalized patients were recruited in the study with mean age (±SD) of 41.2 (±15.4) years and 55% male population. Positive serology against SARS CoV-2 was detected in 19.8%patients(95% CI 14.7-25.8). Residency in Delhi conferred a higher frequency of seropositivity 26.5% (95% CI 19.3-34.7) as compared to that of other states 8% (95% CI 3.0-16.4) with p-value 0.001. No particular age groups or socio-economic strata showed a higher proportion of seropositivity CONCLUSIONS Around, one-fifth of hospitalized patients, who were not diagnosed with COVID-19 before, demonstrated seropositivity against SARS-CoV-2. While there was no significant difference in the different age groups and socio-economic classes; residence in Delhi was associated with increased risk (relative risk of 3.62, 95% CI 1.59-8.21)

scholarly journals Gender-wise Comparative Assessment of Lifestyle Patterns and Well-being Status among Healthcare Employees at a Tertiary Care Hospital

2021 ◽  
Author(s):  
Vanajakshamma Velam ◽  
Vyshnavi Kancherla ◽  
Latheef Kasala ◽  
Anusha Kancherla ◽  
Mounica Reddy Pillaram
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Well Being ◽  
Care Hospital ◽  
Cross Sectional ◽  
Significant Difference ◽  
Female Employees ◽  
The Mean ◽  
Lifestyle Patterns ◽  
Comprehensive Study

Abstract Background This study was an attempt to assess and compare the gender-wise lifestyle patterns and well-being status among the employees of a tertiary care teaching hospital. Material and Methods This is a cross-sectional, questionnaire-based study conducted at a tertiary care hospital between May and August 2019. A total of 777 employees belonging to both genders (male and female) and working at different professional levels were assessed. All the enrolled employees were subjected to a comprehensive study tool consisting of various dimensions of their health, which included physical, mental, social, spiritual and intellectual health dimensions. Results Among the participants, 327 (42.1%) were male and 450 (57.9%) were female. There was no significant difference in the mean age of male (37.91 ± 7.52) and female (36.85 ± 8.16) employees (p = 0.07). A significantly higher proportion of diabetes and hypertension were seen in male employees (9.8% and 14.4%, respectively) than in female (5.6% and 6.2% respectively). The overall well-being was better in male employees than in females and was statistically significant (p < 0.0001). We found that male employees had statistically significant better well-being in terms of physical, mental and social health whereas female employees had intellectual health. Conclusion The overall well-being in healthcare staff was good at our tertiary care hospital, and the outstanding/good well-being rate was higher in male employees than in female employees. Female employees experienced risks with regard to their physical health.

scholarly journals Pattern and prevalence of neuropsychiatric lupus: a retrospective study from a tertiary level hospital in Bangladesh

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Fahima Hossain ◽  
Mohammad Delwer Hossain Hawlader ◽  
Dipak Kumar Mitra ◽  
Mohammad Hayatun Nabi ◽  
Md. Mujibur Rahman
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Retrospective Study ◽  
Cognitive Dysfunction ◽  
Lupus Erythematosus ◽  
Neuropsychiatric Symptoms ◽  
Tertiary Care ◽  
Care Hospital ◽  
Systemic Lupus ◽  
Case Definitions ◽  
American College Of Rheumatology

Abstract Background Neuropsychiatric systemic lupus erythematosus (NPSLE) is well known for its varying presentations and poor outcomes, but little is evident about its distribution and characteristics among the Bangladeshi population. This study aimed to assess the pattern and prevalence of neuropsychiatric symptoms in female systemic lupus erythematosus (SLE) patients of Bangladesh. A retrospective study was conducted at a tertiary care hospital in Dhaka, Bangladesh, between January and December 2018. One hundred female SLE patients were included in the study purposively. Data were collected on sociodemographic and clinical characteristics of diagnosed SLE cases visiting the SLE clinic and indoor medicine department. Neuropsychiatric (NP) syndromes were defined according to the widely accepted American College of Rheumatology (ACR) nomenclature and case definitions. Results A total of 244 NP events were identified in fifty-five patients. Headache was the most frequent symptom (55%), followed by cognitive dysfunction (50%), anxiety (49%), psychosis (43%), seizure (23%), depression (17%), and cerebrovascular disease (ischemic type, 7%). The NP manifestations were more prevalent among urban residents (58.2%), younger patients (41.8%), and patients with graduate-level education (34.5%). Besides, young age at diagnosis (p = 0.038), Raynaud’s phenomenon (p = 0.015), other organ involvement (p < 0.001), and time of NPSLE development (p < 0.001) were found to be significantly associated with the development of these manifestations. Conclusion NP damage is prevalent among Bangladeshi female SLE patients (55%) with headache and cognitive dysfunction being the most common symptoms. Routine screening for neuropsychiatric symptoms among suspected SLE cases and further evaluation with a larger population are warranted.

scholarly journals The clinical profile, management, and outcome of febrile neutropenia in acute myeloid leukemia from resource constraint settings

2021 ◽  
Vol 8 ◽  
pp. 204993612110365
Author(s):  
Kundan Mishra ◽  
Suman Kumar ◽  
Sandeep Ninawe ◽  
Rajat Bahl ◽  
Ashok Meshram ◽  
...  
Keyword(s):  
Overall Survival ◽  
Acute Myeloid Leukemia ◽  
Febrile Neutropenia ◽  
Burkholderia Cepacia ◽  
Myeloid Leukemia ◽  
Tertiary Care ◽  
Care Hospital ◽  
Significant Difference ◽  
The Mean ◽  
Acute Myeloid

Introduction: Acute myeloid leukemia (AML) is the commonest leukemia in adults. Mortality in thew first 30-days ranges from 6% to 43%, while infections account for 30–66% of early deaths. We aim to present our experience of infections in newly-diagnosed AML. Method: This prospective, observational study, was undertaken at a tertiary care hospital in Northern India. Patients with confirmed AML (bone marrow morphology and flow cytometry) and who had developed febrile neutropenia (FN), were included. Result: A total of fifty-five patients were included in the study. The median age of the patients was 47.1 years (12–71) and 28 (50.9%) were males. Fever (33, 60%) was the commonest presentation at the time of diagnosis. One or more comorbid conditions were present in 20 patients (36.36%). Infection at presentation was detected in 17 patients (30.9%). The mean duration to develop febrile neutropenia since the start of therapy was 11.24 days. With each ten-thousand increase in white blood cell (WBC) count, the mean number of days of FN development decreased by 0.35 days ( p = 0.029). Clinical and/or radiological localization was possible in 23 patients (41.81%). Thirty-four blood samples (34/242, 14.04%) from 26 patients (26/55, 47.3%) isolated one or more organisms. Gram negative bacilli (GNB) were isolated in 24 (70.58%) samples. Burkholderia cepacia (8/34, 23.52%) was the commonest organism. The number of days required to develop febrile neutropenia was inversely associated with overall survival (OS). However, when compared, there was no statistically significant difference in OS between patients developing fever on day-10 and day-25 ( p = 0.063). Thirteen patients (23.63%) died during the study period. Discussion: Low percentage of blood culture positivity and high incidence of MDR organisms are a matter of concern. Days to develop febrile neutropenia were inversely associated with overall survival (OS), emphasizing the importance of preventive measures against infections. Conclusion: Infections continues to be a major cause of morbidity and mortality among AML patients.

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