scholarly journals Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Débora González ◽  
Marta Torrens ◽  
Magí Farré
Keyword(s):  
Subjective Effects ◽  
Cardiovascular Effects ◽  
Well Being ◽  
The Novel ◽  
Limited Information ◽  
Acute Effects ◽  
Emotional Stimuli ◽  
Visual Analog Scales ◽  
Chronic Effects ◽  
Acute And Chronic Effects

Background. 2C-B (Nexus) is one of the most widespread novel psychoactive substances. There is limited information about its pharmacological properties, and few studies in humans concern its acute and chronic effects. 2C-B has been classified as a stimulant, hallucinogen, entactogen, and/or empathogen.Objectives. To evaluate the emotional, subjective, and cardiovascular effects of 2C-B.Methods. Twenty healthy recreational 2C-B users (12 women) self-administered a 20 mg dose of 2C-B. Evaluations included emotional (IAPS, FERT, and speech), subjective (visual analog scales, ARCI, VESSPA, HRS, and POMS questionnaires), and cardiovascular effects (blood pressure and heart rate).Results. Positive subjective effects predominated with a reduction of anger under the influence of 2C-B. It did, however, increase reactivity to negative emotional stimuli and decrease the ability to recognize expressions of happiness. Augmented emotionality in speech could be appreciated by others. 2C-B induced euphoria and well-being, changes in perceptions, and slight hallucinogenic states. Mild sympathetic actions were observed.Conclusions. The specific profile that 2C-B exerts on emotions suggests its classification as an entactogen with psychedelic properties.

scholarly journals Acute Pharmacological Effects of Oral and Intranasal Mephedrone: An Observational Study in Humans

2021 ◽  
Vol 14 (2) ◽  
pp. 100
Author(s):  
Esther Papaseit ◽  
Eulalia Olesti ◽  
Clara Pérez-Mañá ◽  
Marta Torrens ◽  
Francina Fonseca ◽  
...  
Keyword(s):  
Observational Study ◽  
Oral Fluid ◽  
Subjective Effects ◽  
Vital Signs ◽  
Cardiovascular Effects ◽  
Well Being ◽  
Research Centre ◽  
New Psychoactive Substances ◽  
Pharmacological Effects ◽  
Self Administration

Mephedrone (4-methylmethcathinone) is a synthetic cathinone with psychostimulant properties which remains one of the most popular new psychoactive substances (NPS). It is frequently used orally and/or intranasally. To date, no studies have evaluated the acute effects and pharmacokinetics after self-administration of mephedrone orally (ingestion) and intranasally (insufflation) in naturalistic conditions. An observational study was conducted to assess and compare the acute pharmacological effects, as well as the oral fluid (saliva) concentrations of mephedrone self-administered orally and intranasally. Ten healthy experienced drug users (4 females and 6 males) self-administered a single dose of mephedrone, orally (n = 5, 100–200 mg; mean 150 mg) or intranasally (n = 5, 50–100 mg, mean 70 mg). Vital signs (blood pressure, heart rate, and cutaneous temperature) were measured at baseline (0), 1, 2, and 4 h after self-administration. Each participant completed subjective effects questionnaires: A set of Visual Analogue Scales (VAS), the 49-item Addiction Research Centre Inventory (ARCI), and Evaluation of the Subjective Effects of Substances with Abuse Potential (VESSPA-SSE) at baseline, 1, 2, and 4 h after self-administration. Oral fluid and urine were collected during 4 h. Both routes of mephedrone self-administration enhanced ratings of euphoria and well-being effects and increased cardiovascular effects in humans. Although it was at times assessed that the oral route produced greater and larger effects than the intranasal one, concentrations of mephedrone in oral fluid and also the total amount of mephedrone and metabolites in urine showed that concentrations of mephedrone are considerably higher when self-administered intranasally in comparison to orally. Controlled clinical trials are needed to confirm our observational results.

scholarly journals The effect of acute and chronic exposure to ethanol on the developing encephalon: a review

2008 ◽  
Vol 8 (3) ◽  
pp. 241-249
Author(s):  
Tales Alexandre Aversi-Ferreira ◽  
Guilherme Nobre Lima do Nascimento
Keyword(s):  
Neural Development ◽  
Ethanol Exposure ◽  
Acute Effects ◽  
Neural Structure ◽  
Chronic Effects ◽  
Ethanol Toxicity ◽  
Ontogenic Development ◽  
Acute Ethanol ◽  
Acute And Chronic Exposure ◽  
Acute And Chronic Effects

OBJECTIVES: to compare the acute and chronic effects of ethanol on the neural development, by analysis of the ontogenetic neural structure of mammals. METHODS: searches were performed in the following electronic databases: MEDLINE, SciElo, PubMed, LILACS, CAPES periodical, and the Open Journal System. The descriptors used were: "chronic ethanol toxicity", "chronic alcohol toxicity", "acute ethanol toxicity", "acute alcohol", "neural ontogenic development", "neuronal migration disturbances", "neural structure". The following inclusion criteria were used: articles published between 2003 and 2007, some classic articles in the field and an important neuropsychology textbook. RESULTS: the analysis of papers revealed that, although several studies of the chronic effects of ethanol exposure on the mammalian nervous system have been conducted, only a few have investigated the acute effects of ethanol on specific days of gestation, and these studies have revealed important disorders relating to the cerebral tissue. CONCLUSIONS: it should be recommended that women refrain from the consumption of ethanol during gestational phase to protect the fetus' health. Furthermore, the acute consumption of ethanol by women nearing the eighth or ninth week of gestation has been shown to be potentially harmful to the nervous tissue of the fetus.

Interactions between mephedrone and alcohol in humans: Cardiovascular and subjective effects

2016 ◽  
Vol 33 (S1) ◽  
pp. S115-S115 ◽  
Author(s):  
M. Farré ◽  
C. Perez-Maña ◽  
E. de Souza ◽  
J. Mateus ◽  
E. Theunisen ◽  
...  
Keyword(s):  
Short Form ◽  
Subjective Effects ◽  
Vital Signs ◽  
Cardiovascular Effects ◽  
Well Being ◽  
Abuse Liability ◽  
Double Blind ◽  
New Novel ◽  
Synthetic Cathinone ◽  
Competing Interest

IntroductionMephedrone is a synthetic cathinone derivative included in the class of “New-Novel Psychoactive Substances”. Synthetic cathinones are marketed as “bath salts” or “plant food” and gained notable popularity for similar effects to 4-methylenedioxymethamphetamine (MDMA, ecstasy), or amphetamines. Mephedrone is commonly consumed simultaneously with alcohol.Objectives and aimsThe aim of the present study was to evaluate the interactions between mephedrone and ethanol in humans.MethodsTwelve healthy male, recreational users of psychostimulants participated as outpatients in four experimental sessions. They received a single oral dose of mephedrone (200 mg) and alcohol (0.8 g/kg), mephedrone placebo and alcohol (0.8 g/kg), mephedrone (200 mg) and placebo alcohol, and both placebos. Design was double-blind, double-dummy, randomized, cross-over and controlled with placebo. Study variables included: vital signs (blood pressure, heart rate, temperature, and pupil diameter), subjective effects (visual analogue scales-VAS, ARCI-49 item short form, and VESSPA questionnaire).ResultsThe combination produced an increase in the cardiovascular effects of mephedrone and induced more intense feeling of euphoria and well-being in comparison to mephedrone and alcohol. Mephedrone reduced the drunkenness and sedation produced by alcohol.ConclusionsThese results are similar to those obtained with the combination of other psychostimulants as amphetamines and MDMA. Abuse liability of the combination is greater that induced by mephedrone.Disclosure of interestThe authors have not supplied their declaration of competing interest.

The Perpetuation of Gender Norms and White Hegemonic Patriarchy in the South African Defence Force as Represented in André van der Merwe’s Moffie (2006)

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Bernard Nolen Fortuin
Keyword(s):  
South Africa ◽  
Military Service ◽  
Well Being ◽  
The Novel ◽  
White Family ◽  
White Children ◽  
White Masculinity ◽  
Party Government ◽  
Compulsory Military Service ◽  
The Military

With the institution of compulsory military service in South Africa in 1948 the National Party government effected a tool well shaped for the construction of hegemonic masculinities. Through this, and other structures like schools and families, white children were shaped into submissive abiding citizens. Due to the brutal nature of a militarised society, gender roles become strictly defined and perpetuated. As such, white men’s time served on the border also “toughened” them up and shaped them into hegemonic copies of each other, ready to enforce patriarchal and racist ideologies. In this article, I look at how the novel Moffie by André Carl van der Merwe (2006) illustrates hegemonic white masculinity in South Africa and how it has long been strictly regulated to perpetuate the well-being of the white family as representative of the capitalist state. I discuss the novel by looking at the ways in which the narrator is marked by service in the military, which functions as a socialising agent, but as importantly by the looming threat of the application of the term “moffie” to himself, by self or others.  

Acute, medium and long-term effects of yellow sand and air pollutants on allergy and biomarker search

Impact ◽  
2020 ◽  
Vol 2020 (3) ◽  
pp. 63-65
Author(s):  
Tomomi Higashi
Keyword(s):  
Air Pollutants ◽  
Genetic Factors ◽  
Long Term Effects ◽  
Emergency Rooms ◽  
Improve Treatment ◽  
Treatment And Prevention ◽  
Chronic Effects ◽  
Difficulty Breathing ◽  
Acute And Chronic Effects

Talk to any allergy sufferer and they will tell you how awful it can be. Runny noses, itchy eyes, coughing and difficulties breathing. For many these symptoms rise only to the level of annoyance and can be avoided by steering clear of the source of their allergy. What many people don't realise though is that allergies can become a far more serious issue for a large segment of the population. Shortness of breath and difficulty breathing due to allergies bring many people to emergency rooms and these are just the acute symptoms. Along with the potential for an allergic attack during a windy or dusty day, researchers and medical professionals are beginning to recognise that there are chronic, long term effects associated with allergies. In order to mitigate both the acute and chronic effects of allergies a better understanding of how genetic factors combine with environmental conditions to produce the ranges of symptoms and effects of allergy suffers is needed. Professor Tomomi Higashi, from the Department of Hygiene at Kanazawa University in Japan, is an expert in this field and is currently working to improve treatment and prevention of allergic disease.

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