scholarly journals Oxidative Stress and Immune System in Vitiligo and Thyroid Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Roberta Colucci ◽  
Federica Dragoni ◽  
Silvia Moretti
Keyword(s):  
Oxidative Stress ◽  
Immune System ◽  
Thyroid Autoimmunity ◽  
Thyroid Diseases ◽  
Thyroid Disorders ◽  
Autoimmune Thyroid ◽  
Dermatological Disease ◽  
Growing Body ◽  
And Oxidative Stress

Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Currently, the autocytotoxic and the autoimmune theories are the most accredited hypothesis, since they are sustained by several important clinical and experimental evidences. A growing body of evidences shows that autoimmunity and oxidative stress strictly interact to finally determine melanocyte loss. In this scenario, associated thyroid autoimmunity might play an active and important role in triggering and maintaining the depigmentation process of vitiligo.

scholarly journals The link between thyroid autoimmunity, depression and bipolar disorder

Open Medicine ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Neringa Jucevičiūtė ◽  
Birutė Žilaitienė ◽  
Rosita Aniulienė ◽  
Virginija Vanagienė
Keyword(s):  
Bipolar Disorder ◽  
Immune System ◽  
Mental Disorders ◽  
Thyroid Autoimmunity ◽  
Mental Illnesses ◽  
Thyroid Disorders ◽  
Autoimmune Thyroid ◽  
Psychiatric Illnesses ◽  
Data Support ◽  
Potential Factor

AbstractDepression and bipolar disorder are two major psychiatric illnesses whose pathophysiology remains elusive. Newly emerging data support the hypothesis that the dysfunction of the immune system might be a potential factor contributing to the development of these mental disorders. The most common organ affected by autoimmunity is the thyroid; therefore, the link between autoimmune thyroid disorders and mental illnesses has been studied since the 1930s. The aim of this review is to discuss the associations between thyroid autoimmunity, depression and bipolar disorder.

scholarly journals Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1562 ◽  
Author(s):  
Mohammed Iddir ◽  
Alex Brito ◽  
Giulia Dingeo ◽  
Sofia Sosa Fernandez Del Campo ◽  
Hanen Samouda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune System ◽  
Nutrient Status ◽  
Short Chain Fatty Acids ◽  
World Health ◽  
Adequate Diet ◽  
Micronutrient Status ◽  
Anti Inflammatory ◽  
Health Organization ◽  
And Oxidative Stress

The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the World Health Organization. Challenges arise concerning how to optimally support the immune system in the general population, especially under self-confinement. An optimal immune response depends on an adequate diet and nutrition in order to keep infection at bay. For example, sufficient protein intake is crucial for optimal antibody production. Low micronutrient status, such as of vitamin A or zinc, has been associated with increased infection risk. Frequently, poor nutrient status is associated with inflammation and oxidative stress, which in turn can impact the immune system. Dietary constituents with especially high anti-inflammatory and antioxidant capacity include vitamin C, vitamin E, and phytochemicals such as carotenoids and polyphenols. Several of these can interact with transcription factors such as NF-kB and Nrf-2, related to anti-inflammatory and antioxidant effects, respectively. Vitamin D in particular may perturb viral cellular infection via interacting with cell entry receptors (angiotensin converting enzyme 2), ACE2. Dietary fiber, fermented by the gut microbiota into short-chain fatty acids, has also been shown to produce anti-inflammatory effects. In this review, we highlight the importance of an optimal status of relevant nutrients to effectively reduce inflammation and oxidative stress, thereby strengthening the immune system during the COVID-19 crisis.

Salt sensitivity in experimental thyroid disorders in rats

2011 ◽  
Vol 301 (2) ◽  
pp. E281-E287 ◽  
Author(s):  
Rocío Perez-Abud ◽  
Isabel Rodríguez-Gómez ◽  
Ana Belén Villarejo ◽  
Juan Manuel Moreno ◽  
Rosemary Wangensteen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Injury ◽  
Salt Intake ◽  
Salt Sensitivity ◽  
High Salt ◽  
Thyroid Disorders ◽  
High Salt Intake ◽  
Male Wistar Rats ◽  
Experimental Thyroid ◽  
And Oxidative Stress

This study assessed salt sensitivity, analyzing the effects of an increased saline intake on hemodynamic, morphological, and oxidative stress and renal variables in experimental thyroid disorders. Six groups of male Wistar rats were used: control, hypothyroid, hyperthyroid, and the same groups treated with salt (8% via food intake). Body weight, blood pressure (BP), and heart rate (HR) were recorded weekly for 6 wk. Finally, BP and HR were recorded directly, and morphological, metabolic, plasma, and renal variables were measured. High-salt intake increased BP in thyroxine-treated rats but not in control or hypothyroid rats. High-salt intake increased cardiac mass in all groups, with a greater increase in hyperthyroid rats. Urinary isoprostanes and H2O2 were higher in hyperthyroid rats and were augmented by high-salt intake in all groups, especially in hyperthyroid rats. High-salt intake reduced plasma thyroid hormone levels in hyperthyroid rats. Proteinuria was increased in hyperthyroid rats and aggravated by high-salt intake. Urinary levels of aminopeptidases (glutamyl-, alanyl-, aspartyl-, and cystinylaminopeptidase) were increased in hyperthyroid rats. All aminopeptidases were increased by salt intake in hyperthyroid rats but not in hypothyroid rats. In summary, hyperthyroid rats have enhanced salt sensitivity, and high-salt intake produces increased BP, cardiac hypertrophy, oxidative stress, and signs of renal injury. In contrast, hypothyroid rats are resistant to salt-induced BP elevation and renal injury signs. Urinary aminopeptidases are suitable biomarkers of renal injury.

scholarly journals The Evaluation of Thyroid Diseases in Patients with Pemphigus Vulgaris

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Mukaddes Kavala ◽  
Esra Kural ◽  
Emek Kocaturk ◽  
Ilkin Zindanci ◽  
Zafer Turkoglu ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Systemic Corticosteroid ◽  
Thyroid Autoimmunity ◽  
Pemphigus Vulgaris ◽  
Hashimoto Thyroiditis ◽  
Thyroid Diseases ◽  
Control Group ◽  
Thyroid Disorders ◽  
Thyroid Function Tests ◽  
Antithyroid Antibodies

Background. Thyroid disorders may affect all of the organ systems of the body and they are also highly associated with a wide variety of skin disorders. The aim of this study was to investigate the prevalence of thyroid function abnormalities and thyroid autoimmunity in patients with pemphigus vulgaris (PV) and to determine the association between thyroid disorders and clinical involvement and systemic corticosteroid treatment in patients with PV.Methods. The study consisted of eighty patients with PV and eighty healthy individuals. Thyroid functions (fT3, fT4, and TSH) and thyroid autoimmunity (anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg) antibodies) were investigated in both groups. Primary thyroid disease (PTD) was diagnosed with one or more of the following diagnostic criteria: (i) positive antithyroid antibodies, (ii) primary thyroid function abnormalities.Results. Significant changes in the serum thyroid profile were found in 16% (13/80) of the PV group and 5% (4/80) of the control group. Positive titers of antithyroid antibodies (anti-TPO and anti-Tg) were observed in 7 patients (9%) with PV and one in the control group (1,2%). Hashimoto thyroiditis was diagnosed in 9% of PV patients and it was found to be more prevalent in the mucosal form of PV. PTD was found in 13 of (%16) PV patients which was significantly high compared to controls. PTD was not found to be associated with systemic corticosteroid use. Free T3 levels were significantly lower in PV group compared to the control group and free T4 levels were significantly higher in PV group compared to the controls.Conclusions. PV may exist together with autoimmune thyroid diseases especially Hashimoto thyroiditis and primer thyroid diseases. Laboratory work-up for thyroid function tests and thyroid autoantibodies should be performed to determine underlying thyroid diseases in patients with PV.

scholarly journals Immunological Mechanisms of Autoimmune Thyroid Diseases: A Shift in The Traditional TH1/TH2 Paradigm

2019 ◽  
Vol 73 (2) ◽  
pp. 67-77
Author(s):  
Tatjana Zaķe ◽  
Sandra Skuja ◽  
Aivars Lejnieks ◽  
Valērija Groma ◽  
Ilze Konrāde
Keyword(s):  
Thyroid Autoimmunity ◽  
Treg Cells ◽  
Thyroid Diseases ◽  
Autoimmune Response ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Th17 Lymphocytes ◽  
Immunological Mechanisms ◽  
Thyroid Autoantigens ◽  
The Impact

Abstract Autoimmune thyroid diseases (AITD) mainly include Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), which are characterised by the presence of circulating antibodies against various thyroid autoantigens and infiltration of the thyroid gland by autoreactive lymphocytes. Despite the significant advancement in the knowledge of AITD pathogenesis in the last decade, the specific immunological mechanisms responsible for development of the disease are not thoroughly understood. Classically, HT has long been considered as a T helper (Th)1-mediated disease, while a Th2-driven autoimmune response is dominant for GD development. However, this classification has changed due to the description of Th17 lymphocytes, which suggested participation of these cells in AITD, particularly HT pathogenesis. Moreover, a shift in the balance between Th17 and T regulatory (Treg) cells has been observed in thyroid autoimmunity. We have observed overexpression of IL-17, the prominent effector cytokine of Th17, within thyroid tissues from HT and GD patients in our studies. The present review will focus on recent data regarding the role of Treg and Th17 lymphocytes in AITD pathogenesis. In addition, the impact and proposed mechanisms of the predominant environmental factors triggering the autoimmune response to the thyroid will be discussed.

scholarly journals Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?

2021 ◽  
pp. FSO699
Author(s):  
Giuseppa Graceffa ◽  
Gregorio Scerrino ◽  
Gabriella Militello ◽  
Iole Laise ◽  
Brenda Randisi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Thyroid Cancer ◽  
Observational Study ◽  
Thyroid Hormones ◽  
Thyroid Surgery ◽  
Thyroid Autoimmunity ◽  
Thyroid Diseases ◽  
Thyroid Disorders

The aim of this study was to evaluate whether there are thyroid diseases in which breast cancer will appear later as well as the role of autoimmunity. This was a retrospective observational study. A total of 410 females (thyroid surgery and later breast cancer) and 524 females (thyroid surgery only) were compared with regard to pathological thyroid findings, thyroid hormones, thyroid autoimmunity and type of breast cancer. Thyroid autoimmunity, especially antithyroid peroxidase antibodies, significantly increased the risk of breast cancer (p < 0.01); however, this was not true for other thyroid diseases, including thyroid cancer. No variant of breast cancer was predominant, and only thyroid autoimmunity was associated with the risk of breast cancer. Further research is needed to explain the impacts of different antithyroid antibodies.

scholarly journals Spontaneous Prematurity, Innate Immune System, and Oxidative Stress at the Maternal-Fetal Interface: An Overview

2020 ◽  
Author(s):  
Natália Prearo Moço ◽  
Bruna Ribeiro de Andrade Ramos ◽  
Mariana de Castro Silva ◽  
Jossimara Polettini ◽  
Ramkumar Menon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune System ◽  
Innate Immune System ◽  
Innate Immune ◽  
And Oxidative Stress ◽  
Maternal Fetal Interface

scholarly journals Effect of COVID-19 Infection on the Immune System and Risk of Developing Diabetes Complications: A Review

2020 ◽  
Author(s):  
Samir Derouiche ◽  
Cheradid Taissir ◽  
Djoumana Abdelmalek ◽  
Ikram Achi
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Immune System ◽  
Diabetes Complications ◽  
Vascular Complications ◽  
Health Concern ◽  
Diabetic Patients ◽  
Global Public Health ◽  
Chronic Hyperglycemia ◽  
And Oxidative Stress

Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. The pandemic outbreak of COVID-19 is rapidly spreading all over the world. In this review, we try to summarize studies of the relationship between the alteration of immune system during COVID-19 infection and the risk of developing diabetes complications. The data were collected by searching Science Direct, Google Scholar, PubMed, Scopus, Springer and National Center for Biotechnology Information (NCBI). The Keywords used as search terms were “COVID-19”, “SARS-COV2 induced inflammatory reaction”, “ACE2 and COVID-19 infection”, “Diabetes and Oxidative stress” and “COVID-19 induced Diabetes complication”. The risk of COVID-19 infection in patients is due to the severity of the viral infection and also to the host's immune response. The risk of infection is one of the main complications of diabetics, as it has been suggested that diabetes inhibits the immune response which contributes to infection and progression to symptoms. Also, the evidence of generation of oxygen free radicals and oxidative stress is a key process in the onset of diabetes mellitus which participate in the development of the systemic inflammatory response syndrome. In addition, chronic hyperglycemia during COVID-19 infection may increase the release of inflammatory cytokines, a high ability to bind to the virus ACE2 glycosylated, worsen the ketoacidosis and vascular complications that may explain the severity of the SARS-CoV-2 infection in diabetic patients.

Cytogenetic status and oxidative stress parameters in patients with thyroid diseases

2016 ◽  
Vol 810 ◽  
pp. 22-29 ◽  
Author(s):  
Marko Gerić ◽  
Ana Marija Domijan ◽  
Valentina Gluščić ◽  
Renato Janušić ◽  
Božena Šarčević ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Thyroid Diseases ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Relapsing Remitting Multiple Sclerosis and its Relationship with the Immune System and Oxidative Stress

2018 ◽  
Vol 14 (1) ◽  
pp. 15-23
Author(s):  
Ada Paloma Soto-Brambila ◽  
Genaro Gabriel Ortiz ◽  
Paloma Rivero-Moragrega ◽  
Ana Laura Briones-Torres ◽  
Luis Javier Gonzalez-Ortiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Immune System ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
And Oxidative Stress
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