scholarly journals Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract fromCamellia euphlebiaMerr. ex Sealy in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Dongye He ◽  
Xitao Wang ◽  
Ping Zhang ◽  
Xinxing Luo ◽  
Xiaoyu Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Emotional Disorders ◽  
Aqueous Extract ◽  
Southern China ◽  
Antidepressant Activity ◽  
Guangxi Province ◽  
Traditional Use ◽  
Immobility Time ◽  
Camellia Euphlebia

Camellia euphlebiaMerr. ex Sealy is a traditional Chinese medicine that has been widely used for improvement of human emotions in the Guangxi Province of southern China. However, there are no studies about the anxiolytic and antidepressant activities ofCamellia euphlebia. This study evaluated the anxiolytic and antidepressant activities of the aqueous extract fromCamellia euphlebia(CEE) in mice. We found that administration of 400 mg/kg CEE or 20 mg/kg fluoxetine for 7 days significantly reduced the immobility time in both TST and FST. Oral administration of 100 mg/kg extract or 4 mg/kg diazepam for 7 days significantly increased the percentage of time spent and the number of entries into the open arms of the EPMT. In addition, the time spent by mice in the illuminated side of the LDBT was increased. Furthermore, pretreatment with 400 mg/kg CEE for 7 days significantly elevated the level of 5-HT and DA in the whole brain of mice. These results provide support for the potential anxiolytic and antidepressant activity ofCamellia euphlebiaand contribute towards validation of the traditional use ofCamellia euphlebiain the treatment of emotional disorders.

Traditional Medicinal Systems

2020 ◽  
pp. 1-24
Author(s):  
Aashaq Hussain Bhat ◽  
Shahla Nigar
Keyword(s):  
Chinese Medicine ◽  
Side Effects ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Modern Science ◽  
Blood Purification ◽  
Traditional Use ◽  
Korean Medicine

Medicinal plants are a great source of medicine for treating various human ailments. Traditional use of herbal medicine, which was developed within an ethnic group before the development and spread of modern science, is the very basis and an integral part of various cultures. Different medicinal systems throughout the globe are still operational and use natural herbs for treating diseases. Traditional Chinese Medicine (TCM), Ayurveda, Kampo, Traditional Korean Medicine (TKM), and Unani are some commonly found traditional medicinal systems in use today. They are used directly, or their secondary metabolites are used as anti-bacterial, antifungal, immunomodulators, anti-hair fall, and multiple other purposes. However, their blood purification properties prevent blood from toxicity. Hundreds of medicinal plants are used in Ayurveda for blood purification, particularly plants which are astringent or bitter (pungent or sharp tastes). In addition, medicinal herbs do not have side effects.

scholarly journals Preclinical evaluation of antidepressant activity of aqueous extract of Piper betle leaves in Swiss albino mice

2018 ◽  
Vol 8 (1) ◽  
pp. 143
Author(s):  
Uttara Krishna ◽  
Roopa P. Nayak ◽  
Chaitra S. R.
Keyword(s):  
Aqueous Extract ◽  
Antidepressant Activity ◽  
Natural Antioxidants ◽  
Screening Tests ◽  
Piper Betle ◽  
Force Swim Test ◽  
Indigenous Plants ◽  
Swiss Albino Mice ◽  
Immobility Time ◽  
Albino Mice

Background: There is a growing demand for alternative medicines derived from indigenous plants having natural antioxidants and neuroprotective actions for the treatment of many behavioural disorders such as anxiety and depression. This study was designed to screen antidepressant activity of aqueous extract of Piper betle L. leaf (betel leaf) in Swiss albino mice.Methods: Swiss albino mice of both sexes weighing 25-30grams were used in the present study. Piper betle leaves aqueous extract (PBAE) was administered to the animals at a dose of 100, 200mg/kg body weight orally for 14 days. On the 14th day, after 1 hour of PBAE administration, experiments on force swim test (FST) and tail suspension (TST) were carried out for studying the level of depression. In FST and TST, time of immobility was noted for a period of 5 minutes.Results: Data was analyzed by one-way ANOVA followed by Tukey Kramer’s multiple comparison test at P = 0.05. The results were represented as Mean±SE. PBAE at a dose of 100mg/kg has shown significant antidepressant activity, as evidenced by decrease in the immobility time in both the screening tests of depression.Conclusions: Present results demonstrated that PBAE possess potent antidepressant property. The exact mechanism(s) related to the active compound(s) in Piper betle leaf extract have to be elucidated in future studies.

scholarly journals Trade in pegasid fishes (sea moths), primarily for traditional Chinese medicine

Oryx ◽  
1997 ◽  
Vol 31 (3) ◽  
pp. 199-208
Author(s):  
Amanda C. J. Vincent
Keyword(s):  
Hong Kong ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Southern China ◽  
The Philippines ◽  
The Past ◽  
China Trade ◽  
Trawl Fishing

Pegasid fishes (sea moths) have only entered the arsenal of traditional Chinese medicine within the past few decades, but are now used in southern China and Hong Kong to treat respiratory ailments and cancers. Brief trade surveys suggest that millions of individuals of two pegasid species are used each year, and that they cost relatively little compared with other ingredients. Most pegasids are apparently a bycatch of trawl fishing, which has recently intensified near China. Trade and use of these fishes is expanding – they have been sought in the Philippines, Indonesia and Vietnam – and should be monitored, particularly because the biology of pegasids makes these fishes vulnerable to exploitation.

scholarly journals Therapeutic Roles of Goji Berry and Ginseng in Traditional Chinese

2019 ◽  
Author(s):  
Wenli Sun ◽  
Mohamad Hesam Shahrajabian ◽  
Qi Cheng
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Liver Glycogen ◽  
Lycium Barbarum ◽  
Traditional Use ◽  
Stress Ulcers ◽  
Positive Effects ◽  
Goji Berry ◽  
The Central Nervous System ◽  
Goji Berries

Background: Goji berries (Lycium barbarum), widely used in traditional Chinese medicine, can be applied as a dietary supplement. They are classified as nutraceutical food due to their long and safe traditional use. Ginseng has been increasingly used in the last decades and has become well known for its significant role in preventing and treating many diseases. Methods: The keywords of Goji berry, Ginseng, Traditional Chinese medicine were searched in Google Scholar, Scopus, Research Gate, and PubMed in both English and Chinese languages. Results: Goji berry significantly inhibited the generation and spread of cancer cells, improved eyesight, and increased reserves of muscle glycogen and liver glycogen, which may increase human energy and has anti-fatigue effect. Usage of Goji berries improved brain function and enhanced learning and memory. It had positive effects on anti-cancer, anti-oxidant activities, retinal function preservation, anti-diabetes, immune function, and anti-fatigue. Pharmacological activities of ginseng extracts affected the central nervous system, antipsychotic action, tranquilizing effects, protection from stress ulcers, increase of gastrointestinal motility, anti-fatigue action, endocrinological effects, enhancement of sexual behavior, acceleration of metabolism, or synthesis of carbohydrates, lipids, RNA, and proteins. In Traditional Chinese Medicine, ginseng helps to maintain a healthy immune system. Conclusions: In this review article we found that Goji berries and Ginseng were sources of compounds with valuable nutritional and bioactive properties. Therefore, they could be incorporated into foods with functional properties. More clinical studies are necessary to uncover the numerous substances and their effects in goji berries and ginseng that contribute to public health.  

Antidepressant-like effect of Albizia zygia root extract in murine models

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Victor Wumbor-Apin Kumbol ◽  
Wonder Kofi Mensah Abotsi ◽  
Robert Peter Biney
Keyword(s):  
Open Space ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Root Extract ◽  
Murine Models ◽  
Tail Suspension ◽  
Traditional Use ◽  
Swim Test ◽  
Forced Swim ◽  
Immobility Time

AbstractBackgroundAlbizia zygia (DC.) J.F. Macbr. (Leguminosae) has been used to treat mental disorders in traditional African medicine. Nonetheless, there is limited scientific evidence to justify its present use. The aim of this study was to evaluate the antidepressant activity of the hydroethanolic extract of A. zygia roots (AZE) in murine models.MethodsAZE was evaluated in the tail suspension test, forced swim test, and the repeated open-space swim test of depression. In order to elucidate the mechanisms of action, the activity of AZE was re-evaluated after treating mice with selective inhibitors of monoamine biosynthesis. The potential of AZE to influence spontaneous locomotion was also examined.ResultsAZE (100–1000 mg/kg, p.o.) reduced the immobility time of mice in the tail suspension and forced swim tests (at least p < 0.05). In the repeated open-space swim test, AZE reduced the immobility time (at least p < 0.05) while concomitantly increasing the distance swam by mice (p < 0.01). However, the antidepressant-like activity of AZE was attenuated by α-methyl-para-tyrosine and reserpine (p < 0.0001) but not para-chlorophenylalanine.ConclusionsThe results of this study indicate that AZE possesses antidepressant-like properties and support the traditional use of AZE for the treatment of depression.

scholarly journals Ethnopharmacokinetic- and Activity-Guided Isolation of a New Antidepressive Compound from Fructus Aurantii Found in the Traditional Chinese Medicine Chaihu-Shugan-San: A New Approach and Its Application

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Rong Fan ◽  
Xi Huang ◽  
Yang Wang ◽  
Xiao Chen ◽  
Ping Ren ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Spectral Data ◽  
Chromatographic Peak ◽  
Antidepressive Effect ◽  
New Approach ◽  
Immobility Time ◽  
High Doses ◽  
First Time

Aims. We aimed to identify an antidepressive compound found in traditional Chinese medicine (TCM) by a new approach called ethnopharmacokinetic- and activity-guided isolation (EAGI).Methods. The new approach targets an unknown chromatographic peak produced by an absorbed compound found in oral Chaihu-Shugan-San (CSS) taken by patients with depression. Once the compound was isolated from Fructus Aurantii (FA), spectral data was employed to identify the compound. The effects of this compound, FA, and CSS on depressive behaviors were investigated.Results. The identified compound was merazin hydrate (MH) according to the new approach. MH, FA, and CSS significantly reduced immobility time and increased locomotor activity. The effects of MH, FA and CSS were similar to Fluoxetine at high doses.Conclusion. MH, a compound whose antidepressive effect is similar to FA and CSS, was isolated for the first time from FA via targeting its corresponding unknown chromatographic peak, and its antidepressive effect was compared with FA or CSS. These findings highlight the potential for drug R&D and pharmacological research of ∼100,000 TCMs.

scholarly journals Traditional Chinese Medicine Extract from Huaier Increases the Expression of Duffy Antigen Receptor for Chemokines and Reduces the Expression of Its Ligands

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Ying Chen ◽  
Qianjun Chen ◽  
Fengfeng Xie ◽  
Hui Peng ◽  
Yanlan Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Aqueous Extract ◽  
Antigen Receptor ◽  
Matrix Metalloproteinase 2 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Duffy Antigen ◽  
Cxc Chemokine ◽  
Chemokine Ligand

Aims. The aim of the present study is to investigate whether the aqueous extract from Huaier, a traditional Chinese medicine (TCM), can affect the expression of Duffy antigen receptor for chemokines (DARC) and its ligands. Moreover, we compare the status of DARC in primary and metastatic breast cancer tissues from the same patient. Methods. Immunohistochemistry was used to detect the expression of DARC in primary and metastatic focuses in 30 patients with breast cancer. The effect of Huaier aqueous extract on the expression of DARC and its ligands was investigated by quantitative real-time polymerase chain reaction, Western blotting, and enzyme-linked immunosorbent assay. Results. The expression score of DARC in primary focuses was significantly higher than that in metastatic focuses, while changes of ER, PR, and HER2 receptors were not significantly different between primary and metastatic focuses. Huaier aqueous extract promoted the expression of DARC and reduced the secretion of CC chemokine ligand 2 (CCL-2), CXC chemokine ligand 8 (CXCL-8, IL-8), matrix metalloproteinase 2 (MMP-2), and CXC chemokine ligand 1 (CXCL-1). Conclusion. The present study demonstrates that difference in expression level of DARC between primary and metastatic focuses of breast cancer was significant, while differences in expression of ER, PR, and HER2 between primary and metastatic focuses were not significant. DARC may play a negative role in the metastasis of breast cancer. Traditional Chinese medicine extract from Huaier can increase DARC expression and reduce the expression of its ligands such as CCL-2, IL-8, MMP-2, and CXCL-1.

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