scholarly journals Utilisation of a Novel Test to Measure Severity and Treatment Efficacy of Posterior Blepharitis

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Steven T. H. Yun ◽  
David M. Woo ◽  
Calum W. K. Chong ◽  
Ying Liu ◽  
Katherine E. Francis ◽  
...  

Background. This study evaluated the effectiveness of managing posterior blepharitis (PB) using a novel Posterior Blepharitis Management Protocol (PBMP).Design. Prospective, consecutive case series with 100% followup to one month.Participants. 27 patients (54 eyes) with PB from an Ophthalmology practice in Sydney, Australia.Methods. Each patient’s PB was assessed by grading the nature and expressibility of the central lower lid tarsal gland secretions on Compression Of The Eyelid (COTE). Patients were then instructed in detail to undertake daily PB management sessions at home using our modified PBMP.Main Outcome Measures. On a subjective scale, patients compared their symptoms at one month with baseline. COTE scores were reevaluated to assess the objective effectiveness of each individual’s PBMP. COTE scoring was described as grades 1 (clear oil), 2 (pus, liquid), 3 (toothpaste-like secretions), and 4 (complete tarsal gland obstruction).Results. Patients reported a mean 77.8% ± 13.5% subjective improvement in symptoms. There was a trend towards improvement in COTE grading at one month compared with baseline: grades 1 (0 to 7.4%), 2a (22.2 to 16.6%), 2b (7.4 to 3.7%), 3 (18.5 to 27.7%), and 4 (51.8 to 44%).Conclusions. PBMP provided a rapid, inexpensive, simple, effective, and safe method of treating PB.

2021 ◽  
Vol 20 ◽  
pp. 153473542110322
Author(s):  
Tahj Blow ◽  
Parker N. Hyde ◽  
John N. Falcone ◽  
Aaron Neinstein ◽  
Neil Vasan ◽  
...  

Alpelisib is a α-selective phosphatidylinositol 3-kinase (PI3K) inhibitor approved for treatment of postmenopausal women, and men, with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2–), PIK3CA-mutated, advanced breast cancer (ABC). Hyperglycemia is a common, on-target adverse effect that impairs treatment efficacy and increases the rate of treatment delays, dose reductions, and discontinuation. Currently, there are no clear guidelines on how to manage hyperglycemia due to alpelisib when metformin is not effective. In this case series, we review 3 subjects with ABC that developed hyperglycemia during alpelisib-fulvestrant therapy and were successfully managed with dietary and pharmacologic interventions. These cases provide anecdotal evidence to support the use of sodium-glucose co-transporter-2 inhibitors (SGLT2i) and very low carbohydrate diets to minimize hyperglycemia during alpelisib therapy.


2012 ◽  
Vol 94 (8) ◽  
pp. 736-744 ◽  
Author(s):  
John A Abraham ◽  
Michael J Weaver ◽  
Jason L Hornick ◽  
David Zurakowski ◽  
John E Ready

2017 ◽  
Vol 26 (5) ◽  
pp. e166 ◽  
Author(s):  
Gary M. Gartsman ◽  
Wame N. Waggenspack ◽  
Hussein A. Elkousy ◽  
T. Bradley Edwards

2014 ◽  
Vol 1 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Cathryn Rodway ◽  
Sandra Flynn ◽  
David While ◽  
Mohammed S Rahman ◽  
Navneet Kapur ◽  
...  

2003 ◽  
Vol 74 (7) ◽  
pp. 1071-1079 ◽  
Author(s):  
Charles S. Zahedi ◽  
S. Asghar Miremadi ◽  
Gérard Brunel ◽  
Eric Rompen ◽  
Jean-Pierre Bernard ◽  
...  

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