scholarly journals Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Chao Dong ◽  
Xiao-li Wang ◽  
Bin-lin Ma
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Poor Prognosis ◽  
Clinical Stage ◽  
Tumor Development ◽  
Immunohistochemical Analysis ◽  
Papillary Thyroid ◽  
Spindle Microtubules ◽  
Polymerase Chain ◽  
The Relationship

Aim. Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development.Methods. In this study, immunohistochemical analysis was used to determine the expression of SKA1 in papillary thyroid carcinoma (PTC) and adjacent tissues. We used quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis to further verify the results.Results. We found that SKA1 expression was significantly higher in PTC tissues than normal adjacent tissues(P<0.05). There existed a significant correlation among a higher SKA1 expression, including lymphoid node(P=0.005), clinical stage(P=0.015), and extrathyroid invasion(P=0.004). Survival analysis showed high SKA1 expression in PTC patients more likely to relapse after surgery.Conclusion. High SKA1 expression is predictive of poor prognosis of PTC, implying that SKA1 may be a promising new target for targeted therapies for PTC.

Overexpression of serum lncRNA-ABHD11-AS1 as poor prognosis of patients with papillary thyroid carcinoma

2021 ◽  
pp. 104658
Author(s):  
Sen Hou ◽  
Yu-Ying Zhuang ◽  
Qiu-Yu Lin ◽  
Zhen Chen ◽  
Hong-Guang Zhao ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Poor Prognosis ◽  
Papillary Thyroid

scholarly journals Should a family history of papillary thyroid carcinoma indicate more aggressive therapy in patients with this tumor?

2014 ◽  
Vol 58 (8) ◽  
pp. 812-816 ◽  
Author(s):  
Pedro Weslley Rosario ◽  
Maria Regina Calsolari
Keyword(s):  
Lymph Node ◽  
Family History ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Node Dissection ◽  
Poor Prognosis ◽  
Tumor Resection ◽  
Papillary Thyroid ◽  
Node Dissection ◽  
History Of

Objective To determine whether the currently recommended therapy for papillary thyroid carcinoma (PTC) that show no classical factors indicating a poor prognosis is also effective in cases with a family history of this tumor. Subjects and methods: Forty-two patients were studied; 10 were submitted to lobectomy and 32 to total thyroidectomy, including 23 without lymph node dissection and 9 with lymph node dissection. None of the patients received radioiodine or was maintained under TSH suppression. Results No case of recurrence was detected by imaging methods and there was no increase in thyroglobulin or antithyroglobulin antibodies during follow-up (24 to 72 months). Conclusion The treatment usually recommended for patients with PTC does not need to be modified in the presence of a family history of this tumor if no factors indicating a poor prognosis are present (tumor ≤2 cm, non-aggressive histology, no extensive extrathyroid invasion or important lymph node involvement, complete tumor resection, no evidence of persistent disease after surgery).

scholarly journals Association between Thyroiditis and Multifocality in Papillary Thyroid Carcinoma

2020 ◽  
Author(s):  
Rogério Aparecido Dedivitis ◽  
Leandro Luongo de Matos ◽  
Felipe Guilherme Silva Souza ◽  
Jose Luis Bogado Ortiz
Keyword(s):  
Retrospective Study ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Direct Relationship ◽  
Statistical Significance ◽  
Hashimoto Thyroiditis ◽  
Papillary Thyroid ◽  
Multifocal Lesions ◽  
The Relationship

Abstract Introduction Hashimoto thyroiditis (HT) shares many characteristics with papillary thyroid carcinoma (PTC), and some studies show that, when associated, PTC is diagnosed mostly with smaller lesions and multifocal pattern. Objective To evaluate the relationship between HT and PTC. Methods A retrospective study of 155 patients who underwent total thyroidectomy from 2009 to 2015. Demographical, clinical and ultrasonographical data, as well as anatomopathological findings were evaluated. Results There were signs of thyroidits in 35 patients, and 114 patients had a unifocal disease. There was no statistical significance between the variables studied and thyroiditis. However, when compared with the occurrence of unifocal or multifocal lesions, there was statistical significance regarding age (p = 0.038) and mass (p = 0.031). There was no direct relationship between thyroiditis and multifocality (p = 0.325) nor between thyroiditis and cervical extension of the disease (p = 0.300 e p = 0.434). Conclusion There was no relationship between thyroiditis and multifocality in cases of PTC.

Abstract 3117: Pleiotrophin is a marker of poor prognosis in Middle Eastern papillary thyroid carcinoma

2016 ◽  
Author(s):  
Shaham Beg ◽  
Maqbool Ahmed ◽  
Azhar Hussein ◽  
Rong Bu ◽  
Zeeshan Qadri ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Poor Prognosis ◽  
Middle Eastern ◽  
Papillary Thyroid

CHI3L1 overexpression is associated with metastasis and is an indicator of poor prognosis in papillary thyroid carcinoma

2017 ◽  
Vol 18 (3) ◽  
pp. 273-284 ◽  
Author(s):  
Dingyuan Luo ◽  
Haibo Chen ◽  
Penghui Lu ◽  
Xiaojuan Li ◽  
Miaoyun Long ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Poor Prognosis ◽  
Papillary Thyroid

scholarly journals Analysis of the prognostic significance and potential mechanisms of lncRNAs associated with m6A methylation in papillary thyroid carcinoma

2021 ◽  
Author(s):  
Yinde Huang ◽  
Xin Li ◽  
Wenbin Chen ◽  
Yuzhen He ◽  
Song Wu ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Tumor Microenvironment ◽  
Thyroid Carcinoma ◽  
Immune Checkpoint ◽  
Prognostic Model ◽  
Prognostic Markers ◽  
Clinicopathological Characteristics ◽  
Papillary Thyroid ◽  
The Relationship ◽  
Pan Cancer

Abstract Background : m6A methylation-related long non-coding RNAs (lncRNAs) play a significant role in the progression of various tumors and can be used as prognostic markers. However, whether m6A-related lncRNAs also play the same function as prognostic markers in papillary thyroid carcinoma (PTC) remains unclear. Methods : Consensus cluster analysis was performed to divide PTC samples obtained from The Cancer Genome Atlas database into two clusters according to the expression of m6A-related lncRNAs. Then, the least absolute shrinkage and selection operator (LASSO) regression analysis was performed to create and verify a prognostic model. Furthermore, the relationship among risk scores, clusters, programmed death-ligand 1 (PD-L1), tumor microenvironment (TME), clinicopathological characteristics, immune infiltration, immune checkpoint, and tumor mutation burden (TMB) was analyzed. In addition, a nomogram was created, and subsequently, the drug sensitivity of lncRNAs in the prognostic model was analyzed. Finally, the relationship between these lncRNAs and prognosis in pan-cancer was investigated. Results: The prognosis, RAS, BRAF, M, and TME were found to be different in two clusters. The prognostic model included three lncRNAs: PSMG3-AS1 , BHLHE40-AS1 , and AC016747.3 . The risk score was associated with clusters, PD-L1, tumor microenvironment, clinicopathological characteristics, immune cell infiltration, immune checkpoint, and TMB, and thus, risk score was confirmed as useful prognostic indicators. Differentially expressed lncRNAs are involved in many malignancies and can be identified as cancer prognostic makers. Conclusion : According to our research, we can regard m6A-related lncRNAs involved in the procession of PTC as a biomarker of PFS for PTC patients, and pan-cancer.

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