scholarly journals Photostability of Loratadine Inclusion Complexes with Natural Cyclodextrins

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Patricia Elizabeth Rivas-Granizo ◽  
Leandro Giorgetti ◽  
Humberto Gomes Ferraz
Keyword(s):  
Thermal Analysis ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Statistical Analysis ◽  
Inclusion Complexes ◽  
Active Ingredient ◽  
High Performance ◽  
Full Recovery ◽  
Stoichiometric Ratios ◽  
Histamine Antagonist

The purpose of this study was to evaluate the photostability of inclusion complexes of the histamine antagonist loratadine (LORA) withα-,β-, andγ-cyclodextrins (CDs). Accordingly, binary drug-CD complexes were prepared using the coevaporation method at 1 : 1, 1 : 2, and 1 : 3 stoichiometric ratios, which were characterized by thermal analysis. Subsequently, solutions of the complexes at 500 μg mL−1in HCl 0.1 M were subjected to irradiation in a photostability chamber for 12 hours, and the content of the remaining active ingredient was quantified by means of high-performance liquid chromatography. It is possible to observe the presence of two products originating from photodegradation (P1 and P2), which were identified in solutions of loratadine withα- andβ-CD. By means of statistical analysis, we conclude that the drug:α-CD and drug:γ-CD (1 : 1) complexes proved to be more efficient in the photostability assay, obtaining a nonsignificant level of degradation and full recovery of LORA.

Development and Validation of A Reversed Phase-High Performance Liquid Chromatography Method for the Quantitative Estimation of Ramipril Drug Content from Formulated Dosage Form

2016 ◽  
Vol 6 (3) ◽  
Author(s):  
Raju Chandra ◽  
Manisha Pant ◽  
Harchan Singh ◽  
Deepak Kumar ◽  
Ashwani Sanghi
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Active Ingredient ◽  
High Performance ◽  
Limit Of Detection ◽  
Quantitative Estimation ◽  
Reversed Phase ◽  
Uv Detector ◽  
Chromatography Method ◽  
Drug Content

A reliable and reproducible reversed-phase high performance liquid chromatography (RP-HPLC) was developed for the quantitative determination of Remipril drug content from marketed bulk tablets. The active ingredient of Remipril separation achieved with C18 column using the methanol water mobile phase in the ratio of 40:60 (v/v). The active ingredient of the drug content quantify with UV detector at 215 nm. The retention time of Remipril is 5.63 min. A good linearity relation (R2=0.999) was obtained between drug concentration and average peak areas. The limit of detection and limit of quantification of the instrument were calculated 0.03 and 0.09 µg/mL, respectively. The accuracy of the method validation was determined 102.72% by recoveries method.

Degradation of Resin Restorative Materials by Streptococcus Mutans: A Pilot Study

2017 ◽  
Vol 41 (3) ◽  
pp. 225-227 ◽  
Author(s):  
Ankit K Gautam ◽  
Ruchi Thakur ◽  
N D Shashikiran ◽  
Singla Shilpy ◽  
Nikita Agarwal ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Statistical Analysis ◽  
Pilot Study ◽  
High Performance ◽  
Restorative Material ◽  
Group Iii ◽  
Incubation Solution ◽  
Group I ◽  
Restorative Materials

Objective: To evaluate the degradation of three resin based restorative materials by S Mutans. Study design: Class I cavity was prepared in extracted premolars and were randomly divided into 3 groups (Group I – Conventional composite (CC), Group II – Resin Modified GIC and Group III–Giomer). Teeth were then restored by respective restorative material and equally divided in two subgroups (Control and Experimental). Experiment subgroup samples were then incubated in 2 ml of BHI with 1:10 dilution of SM (MTCC-497) grown overnight in BHI whereas control subgroup samples were incubated in BHI without SM. The incubation solution was collected at 2,14 and 30 days interval, and the analysis for identification and quantification of Bis-HPPP was done by High performance Liquid Chromatography. Results: Statistical analysis of the collected data revealed a statistically increased Bis HPPP production in the presence of SM in all the tested materials, with minimum in Resin Modified GIC and a maximum in Conventional Composite (CC). Conclusion: SM degrades the resin based restorative materials & among the tested materials Resin Modified GIC appears to be most Biostable.

scholarly journals Validation and statistical analysis of two high performance liquid chromatography methods for the determination of indinavir sulfate raw material and capsules

Química Nova ◽  
2005 ◽  
Vol 28 (1) ◽  
pp. 50-53 ◽  
Author(s):  
Breno de Carvalho e Silva ◽  
Lígia Maria Moreira de Campos ◽  
Elzíria Aguiar Nunan ◽  
Cristina Duarte Vianna Soares ◽  
Gisele Rodrigues Silva ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Statistical Analysis ◽  
High Performance ◽  
Raw Material ◽  
Indinavir Sulfate
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