scholarly journals Cardiovascular System Changes and Related Risk Factors in Acromegaly Patients: A Case-Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaopeng Guo ◽  
Lu Gao ◽  
Shuo Zhang ◽  
Yilin Li ◽  
Yue Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Duration ◽  
Early Stage ◽  
Cardiovascular Complications ◽  
Control Group ◽  
Great Vessel ◽  
Healthy Weight ◽  
Great Vessels ◽  
Main Determinants ◽  
And Gender

Background. Cardiovascular complications are known to be the main determinants of reduced life expectancy and decreased quality of life in acromegaly patients. Our study aimed to provide insight into the cardiovascular changes that occur in acromegaly patients and to investigate the correlative risk factors.Methods. A total of 108 patients definitively diagnosed with acromegaly and 108 controls matched for age and gender were recruited into study and control groups, respectively. Standard echocardiography was performed on all of the participants, and data were collected and analyzed.Results. All acromegaly patients presented with structural cardiac changes, including a larger heart cavity, thicker myocardial walls, and increased great vessel diameters compared with the control group. Additionally, the acromegaly patients presented with reduced diastolic function. Aging and increased body mass index (BMI) were correlated with myocardial hypertrophy and diastolic dysfunction; a longer disease duration was correlated with larger great vessel diameters.Conclusions. Ageing and increased BMI are independent risk factors for acromegalic cardiomyopathy, and a long disease duration results in the expansion of great vessels. Increased efforts should be made to diagnose acromegaly at an early stage and to advise acromegaly patients to maintain a healthy weight.

Predictors of atherosclerosis in rheumatoid arthritis

VASA ◽  
2012 ◽  
Vol 41 (5) ◽  
pp. 353-359 ◽  
Author(s):  
Ahmad ◽  
Garg ◽  
Dhar ◽  
Srivastava ◽  
Biswas ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Disease Duration ◽  
Early Stage ◽  
Subclinical Atherosclerosis ◽  
Disease Onset ◽  
Intima Media Thickness ◽  
Qt Dispersion ◽  
Control Group ◽  
Age And Sex

Background: Atherosclerosis is emerging as an important complication of rheumatoid arthritis (RA), with coronary artery disease being projected as the major cause of mortality in these patients.This study was undertaken to evaluate the presence of subclinical atherosclerosis and to identify the risk factors of atherosclerosis in patients with RA. Patients and methods: All consecutive in- and out-patients of rheumatoid arthritis (n = 100) irrespective of the disease duration were included in the study. A group of 100 age and sex matched controls were also studied. Increased carotid intima media thickness (beyond the 75th percentile for age and sex), presence of plaques, ankle brachial pressure index and QT dispersion were deemed as non-invasive measures of atherosclerotic burden. Results: Fifty patients (50.0 %) with RA had evidence of subclinical atherosclerosis as compared to the control group (n = 11, 11 %); plaques were observed in 26 patients. Eighteen (36 %) of these developed this evidence within 1 - 5 years of disease onset. Low HDL levels among the conventional risk factors and advanced patient age, longer disease duration, greater number of involved joint areas, steroid use and indices of inflammation in particular in RA, were associated with subclinical atherosclerosis. Sustained inflammation was observed throughout the sub-group with atherosclerosis irrespective of the disease duration. Conclusions: RA is a pro-atherogenic state with the process of atherosclerosis initiated in the early stage of the disease. Besides the traditional risk factors, sustained inflammation contributes to atherogenesis.

scholarly journals Pola makan berhubungan dengan sindrom metabolik pada lanjut usia di Poliklinik Geriatri RSUP Sanglah Denpasar

2010 ◽  
Vol 6 (3) ◽  
pp. 105
Author(s):  
IGA Sagung Kusuma Dewi ◽  
I Dewa Putu Pramantara ◽  
Retno Pangastuti
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Multivariate Analysis ◽  
The Elderly ◽  
Control Group ◽  
Chi Square ◽  
Eating Pattern ◽  
Significant Difference ◽  
And Gender ◽  
Obesity Hypertension

Background: Food intake is a factor determining health status and risk for degenerative diseases including metabolic syndrome. The fundamental function of someone’s nutritional status in the process of the emergence of generative disease and metabolic syndrome can be identified through the effect of food to the prevalence of obesity, hypertension, dyslipidemia or glucose tolerance disorder.Objective: To identify the association between eating pattern and the prevalence of metabolic syndrome among the elderly at Geriatric Polyclinic of Sanglah Hospital Denpasar.Method: The study was analytic observational with matched case control study design using ratio 1:1. There were 80 samples consisting of 40 as control group and 40 as cases matched by age and gender. Eating pattern was identified through food frequency questionnaire and calculated and compared to the need. Statistical analysis used chi square and risk factors were measured using odds ratio (OR). Multivariate analysis used double logistic regression to find out risk factors dominantly affected metabolic syndrome.Result: The result of bivariate statistical test showed significant difference in the prevalence of metabolic syndrome (p < 0.05) for energy intake (OR: 9.1; CI95%: 1.9-43.8), protein (OR: 3.8; CI95%: 1.5-9.7), fat (OR: 3.8; CI95%: 1.1-13.2), carbohydrate (OR:11.4; CI95%: 2.3-54.2). The result of multivariate analysis showed that the variables having dominant risk and significant difference in the prevalence of metabolic syndrome were carbohydrate consumption (OR: 8.1; CI95%: 1.29–50.89), fat consumption (OR: 4.9; CI95%: 1.17-20.61) and protein consumption (OR: 3.9; CI95%: 1.27-12.30).Conclusion: There was difference in eating pattern, i.e. high consumption of carbohydrate, fat and protein which became risk factor for the prevalence of metabolic syndrome among the elderly at Geriatric Polyclinic of Sanglah Hospital Denpasar.

scholarly journals A-065 Weakness in Holistic Processing in Preschool Children is a Risk for SLI

2020 ◽  
Vol 35 (6) ◽  
pp. 855-855
Author(s):  
Kiselev S
Keyword(s):  
Risk Factors ◽  
Language Impairment ◽  
Specific Language Impairment ◽  
Holistic Processing ◽  
Control Group ◽  
Complex Figure ◽  
Figure Test ◽  
And Gender ◽  
And Control ◽  
Experimental Group

Abstract Objectives Children with specific language impairment (SLI) have difficulties with producing and understanding language. It is important to search for the risk factors for this deficit in children. The goal of this research was to examine the hypothesis that children at the age of 5 with weakness in holistic processing have a risk for emerging deficit in grammar understanding at the age of 7. Methods 98 children at the age of 5 were assessed with the Rey-Osterieth Complex Figure Test to reveal children with weakness in holistic processing. It was proposed that part-oriented strategy in copying Complex Figure is related to weakness in holistic processing (Luria, 1973). We have revealed 19 children with weakness in holistic processing. These children were included in the experimental group. The control group included 19 children with typical level of holistic processing. Children from experimental and control group were matched for IQ and gender. Children at the age of 7 from both groups were assessed by Grammar Understanding Test from Luria’s neuropsychological assessment technique. Results One-way ANOVA has revealed significant differences [p ≤ 0,05] between groups for scores in Grammar Understanding Test. Children from the experimental group showed a lower level of grammar understanding. Conclusion This research has shown that weakness in holistic processing can predict the delay in development of grammar understanding in children. The received results shed light into underlying nature of SLI. It can be assumed that weakness in holistic processing is one of the risk factors for emerging deficit in grammar understanding in children.

Neonatal and Maternal Outcomes among Women with Glomerulonephritis

2020 ◽  
Vol 51 (7) ◽  
pp. 534-541
Author(s):  
Anna Madej ◽  
Natalia Mazanowska ◽  
Anna Cyganek ◽  
Joanna Pazik ◽  
Bronisława Pietrzak
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Kidney Function ◽  
Gestational Hypertension ◽  
Early Stage ◽  
Renal Diseases ◽  
Control Group ◽  
Maternal Outcomes ◽  
Intrauterine Death ◽  
Fetal Malformation

Background: The outcomes of pregnancy in women with renal diseases remain controversial. The purpose of the study was to report fetal and maternal outcomes among women with glomerular disease in comparison with healthy pregnant women and a review of the current literature on this issue. Methods: Retrospective analysis included 72 pregnancies in 62 women with biopsy-proven glomerulonephritis (GN) (in 65.3% of cases, immunoglobulin A nephropathy was found). The control group consisted of 315 healthy pregnant women. We assessed fetal (prematurity, low birth weight, hypotrophy, fetal malformation, or intrauterine death) and maternal (gestational hypertension, preeclampsia, deterioration in kidney function, and maternal death) outcomes. Descriptive data analysis, Fisher’s exact test, unpaired Student’s t test, and ANOVA were performed. Results: Hypertension prevalence among the GN group and controls was 76.4 and 10.2%, respectively. Preeclampsia complicated 29.2% of pregnancies among women with GN and 2.9% of controls. In 8.3% of patients, at least a 50% decrease in GFR during pregnancy was observed. Preterm delivery prevalence in the GN group and controls was 74.7 and 12.7%, respectively. Hypotrophy was diagnosed in 12.5% of cases from the GN group and 5.4% of controls. The analysis showed that low estimated glomerular filtration rate, hypertension, and proteinuria were risk factors of adverse neonatal outcomes. Conclusion: Women with GN are a risk factor of adverse pregnancy outcomes. As pregnancy complications are more prevalent across all the CKD stages, even in patients with near-normal kidney function, they require specialized care. It might be advisable to screen pregnant women for the presence of CKD, as especially in the early stage, it is often asymptomatic. Both hypertension and proteinuria are risk factors for neonatal and maternal complications.

scholarly journals IN WHICH PATIENTS IS IT POSSIBLE TO PERFORM STANDALONE LATERAL LUMBAR INTERBODY FUSION WITHOUT CAGE SUBSIDENCE?

2016 ◽  
Vol 15 (3) ◽  
pp. 226-229 ◽  
Author(s):  
LUIS MARCHI ◽  
LUIZ PIMENTA ◽  
RODRIGO AMARAL ◽  
FERNANDA FORTTI ◽  
JOES NOGUEIRA-NETO ◽  
...  
Keyword(s):  
Risk Factors ◽  
Interbody Fusion ◽  
Risk Scores ◽  
Control Group ◽  
Lumbar Interbody Fusion ◽  
Lateral Lumbar Interbody Fusion ◽  
Cage Subsidence ◽  
And Gender ◽  
Correlation Factors ◽  
Control Study

ABSTRACT Objective: To identify the factors related to the non-occurrence of cage subsidence in standalone lateral lumbar interbody fusion procedures. Methods: Case-control study of single level standalone lateral lumbar interbody fusion (LLIF) including 86 cases. Patients without cage subsidence composed the control group (C), while those in the subsidence group (S) developed cage subsidence. Preoperative data were examined to create a risk score based on correlation factors with S group. The proven risk factors were part of an evaluation score. Results: Of the 86 cases included, 72 were in group C and 14 in group S. The following risk factors were more prevalent in group S compared to C group: spondylolisthesis (93% vs 18%; p<0.001); scoliosis (31% vs 12%; p=0.033); women (79% vs 38%; p=0.007); older patients (average 57.0 vs 68.4 years; p=0.001). These risk factors were used in a score (0-4) to evaluate the risk in each case. The patients with higher risk scores had greater subsidence (p<0.001). Scores ≥2 were predictive of subsidence with 92% sensitivity and 72% specificity. Conclusions: It was possible to correlate the degree of subsidence in standalone LLIF procedures using demographic (age and gender) and pathological (spondylolisthesis and scoliosis) data. With a score based on risk factors and considering any score <2, the probability of non-occurrence of subsidence following standalone LLIF (negative predictive value) was 98%.

scholarly journals Frequency and Risk Factors of Narrow Angles in Patients with Pseudoexfoliation: A Case-Control Study

2021 ◽  
Author(s):  
Adi Mohammed Al Owaifeer ◽  
Ibrahim AlObaida ◽  
Sultan Alzuhairy ◽  
Syed J Raheman ◽  
Leyla Aljasim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gender Difference ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Study Group ◽  
Age Group ◽  
And Gender ◽  
Control Study ◽  
Prospective Case Control Study

Abstract Purpose To determine the frequency and risk factors of narrow angles in pseudoexfoliation (PXF) patients.Methods A prospective case-control study was conducted during the period from March 2017 to December 2020. Adult patients (above 40 years) presenting with PXF were consecutively enrolled (study group). Cases were matched with individuals above 40 years presenting to a comprehensive ophthalmology clinic without evidence of PXF (control group).Results We enrolled 196 PXF patients and 98 controls. The occurrence of narrow angles was 25% in the PXF group and 5.1% in the control group (P = 0.0001). Compared to controls, PXF patients were older (72.6 ± 9.6 vs. 64.4 ± 8.5, P < 0.0001) and had a lower mean ACD (2.79 ± 0.4 vs. 3.05 ± 0.4, P < 0.0001). There was no difference in AL measurements between both groups (23.3 ± 1.4 vs. 23.7 ± 1.0, P = 0.0714). After stratification by age group and gender, the risk of narrow angles was higher in PXF patients above 60 years (OR, 5.71; 95% CI, 1.01-32.27; P, 0.048). There was no gender difference in the risk of developing narrow angles. Conclusion Narrow angles are more frequently encountered in PXF patients compared to controls. Advanced age (> 60 years) is significantly associated with an increased likelihood of developing narrow angles.

scholarly journals POS0290 PREDICTING RISK FACTORS OF MALT LYMPHOMA IN SJÖGREN’S SYNDROME

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 370.1-371
Author(s):  
L. Chatzis ◽  
V. Pezoulas ◽  
A. Goules ◽  
I. Stergiou ◽  
C. Mavragani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Malt Lymphoma ◽  
Autoimmune Thyroiditis ◽  
Disease Duration ◽  
Control Group ◽  
Lung Involvement ◽  
Palpable Purpura ◽  
Gland Enlargement

Background:Primary Sjögren Syndrome (SS) is a slowly progressive systemic autoimmune disease complicated by lymphoma, with mucosa associated lymphoid tissue (MALT) type being the most common lymphoma form. Several predictors related to pSS associated lymphomas have been described, but there are no studies focusing on specific risk factors for the MALT histologic subtype.Objectives:To identify predictors at SS diagnosis for MALT lymphoma development in pSS patients using simple clinical features.Methods:From 815 SS patients of a single center fulfilling the 2016 ACR/EULAR criteria, those with subsequent development of MALT lymphoma according to the 2016 WHO classification were identified and matched in 1:2 ratio, with non-lymphoma SS control patients according to age, disease duration from SS diagnosis and gender. Lymphoma patients diagnosed within a year from SS diagnosis were excluded from the current study. Clinical, laboratory, histologic data as well as the ESSDAI scores at the time of SS diagnosis were recorded and compared between lymphoma and non-lymphoma patients. Independent lymphoma predictors were identified by a data driven Fast Correlation Based Feature selection (FCBF)/Logistic Regression (LR) algorithm.Results:A unified dataset of 57 MALT lymphoma patients and 114 non lymphoma controls along with 39 features/variables was generated. The median age of SS diagnosis and the disease duration from SS diagnosis to lymphoma diagnosis (lymphoma group) or last follow up (control group) was 50,5 years old (range 25-77) and 7 years (range 0- 30) for the control group and 50 years old (range 24-70) and 8 years (range 1 -30) for the lymphoma group, respectively. MALT lymphoma patients presented more frequently with palpable purpura (23,2% vs 5,3% p=0,001), cryoglobulinemia (30,2% vs 1,6% p<0,0001), low C4 serum levels (62,9% vs 32,1% p=0,0003), rheumatoid factor (76,9% vs 56,1% p=0,01), anti La/SSB antibodies (33,9% vs 50,8% p=0,049) and higher median ESSDAI score (5 vs 2, p<0,0001). In contrast, autoimmune thyroiditis was more prevalent in controls (48,2% vs 18,6%, p=0,004). The FCBF/LR model revealed cryoglobulinemia (p=0,03) and ESSDAI at SS Diagnosis (p<0,001) as the only independent lymphoma predictors.Conclusion:MALT is the predominant pSS related lymphoproliferative histologic type, associated with systemic disease activity and vasculitic manifestations at SS diagnosis. Cryoglobulinemia and ESSDAI score were proven independent risk factors for MALT lymphoma development.Table 1.An FCBF-based multivariable logistic regression analysis results for investigating risk factors for MALT lymphoma developmentProminent featureRegression coefficientOdds ratiop-valueCI lowCI upperCryoglobulinemia1.675.3420.033*1.1824.327Total ESSDAI at diagnosis0.281.318<0.001*1.2081.439Kidney involvement0.071.0690.50.1010.351•< 0.05 (95% confidence interval). The rest of the features that participated in the analysis include the following: Palpable purpura, Low C4, Salivary gland enlargement, Lacrimal gland enlargement, ANA Titers, RF, Focus score at Sjögren diagnosis, PNS involvement, Anti-La, Disease duration from SS onset to SS diagnosis, Neutrophils<1500, Autoimmune thyroiditis, Lung involvement – interstitial disease Type, Lymphocytes<1000, Lymphadenopathy fixed, Arthralgias, Dry eyes, Raynaud, Gender, Age at Sjögren diagnosis, Dry mouth, Aca, Hb<12.5 g/dL, ANA, Disease duration from SS Diagnosis to Lymphoma diagnosis or last follow up, Anti-Ro, Arthritis, WBC<4000/μL, Lung involvement bronchocentric disease, Interstitial renal disease, PLTs<100.000/μL, Liver involvement-PBC, Liver involvement–autoimmune hepatitis, CNS involvement.•AUC=0.78Disclosure of Interests:None declared

scholarly journals POS0116 HEART RATE VARIABILITY IN PATIENTS WITH BEHCETS DISEASE

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 269.2-269
Author(s):  
R. Goloeva ◽  
Z. Alekberova ◽  
T. Popkova ◽  
S. Glukhova ◽  
D. Novikova
Keyword(s):  
Risk Factors ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Disease Duration ◽  
Control Group ◽  
Healthy Controls ◽  
Positive Correlation ◽  
Cholesterol Levels

Background:Behcet’s disease (BD) is a systemic vasculitis affecting all types and sizes of blood vessels. Heart rate variability (HRV) reflects sympathetic -parasympathetic imbalance in the autonomic NS regulation. Low HRV values are known as independent risk factor of death and non-fatal cardiovascular events in both - survivors of a myocardial infarction and in asymptomatic population.Objectives:The aim of this study is to evaluate HRV in BD pts vs healthy controls.Methods:The study group included 74 BD pts (53males/21females) with disease duration of 9,0 (5,0;15,0)/9,0 (7;20) years, and the control group - 32/15 age-matched healthy m/f. The following HRV parameters from 24h ECG ambulatory recording were assessed: MeanNN and time-domain variables, adjusted by MeanNN (SDNNn%, SDNNin%, RMSSDn%). Additionally, all traditional cardiovascular risk factors such as systolic blood pressure (SPB), smoking status, BMI values, dyslipidemia profile, ultrasonographic values of carotid intima-media thickness (IMT), and levels high sensitive CRP (hsCRP) as a marker of inflammation were evaluated.Results:In BD patients HRV values (RMSSDn%) were significantly lower compared to healthy controls (table 1).Table 1.HRV parameters in BD patients and control groupParametersMalesFemalesBD (n=53)Control (n=32)BD (n=21)Control (n=15)Age, years30 (24; 36)30 (26; 35)32 (26; 37)28 (24; 31)MeanNN, ms810 (732; 849)782 (732; 835)776 (708; 830)764 (694; 832)SDNN n (%)16,9 (13,6; 19,4)17,2 (16,3; 21,1)13,1 (11,3; 5,3)12,2 (10,7; 14,6)SDNNi n (%)6,8 (5,1; 8,1)6,8 (5,0; 8,3)7,1 (6,1; 7,7)5,2 (4,9; 5,7)RMSSD n (%)2,1 (1,5; 2,3)**4,1 (2,7; 5,2)**1,7 (1,4; 3,7)*2,8 (2,2; 3,9)*Data are presented in median values and interquartile range, *p<0,05, **p<0,005 vs controls.There was a significant negative correlation in BD patients between HRV (SDNNin%) and age (r= -0,4; p=0,00), disease duration (r= -0,3; p=0,00), BMI (r= -0,2; p<0,01), cholesterol levels (r= -0,3; p=0,00), LDLP (r= -0,3; p=0,00) and increased IMT (r= -0,2; p=0,04), and also between HRV (RMSSD%) and age (r= -0,2; p=0,04), disease duration (r= -0,2; p=0,01), cholesterol levels (r= -0,3; p=0,00), HDLP (r= -0,2; p=0,04); a positive correlation was established between HRV (SNNN%) and smoking (r= -0,2; p=0,04). The control group showed positive correlation between HRV (SNNN%) and increased IMT (r= 0,4; p=0,01).Conclusion:HRV reduction reflects impaired sympathetic -parasympathetic regulation in BD pts, associated with pts’ age, disease duration and presence of traditional cardiovascular risk factors: BMI, increased cholesterol levels, LDLP, and such asymptomatic manifestation of atherosclerosis as increased IMT.Disclosure of Interests:None declared

Potential risk factors and treatment of IOP elevation after operation in retinal detachment eyes of diabetic patients

2020 ◽  
Vol 1 (4) ◽  
pp. 234-239
Author(s):  
Rui Shi ◽  
◽  
Di Li ◽  
Xuan-Yi Che ◽  
Rechard Hom ◽  
...  
Keyword(s):  
Risk Factors ◽  
Potential Risk ◽  
High Myopia ◽  
Early Stage ◽  
Control Group ◽  
Diabetic Patients ◽  
Rnfl Thickness ◽  
Potential Risk Factors ◽  
Iop Elevation ◽  
Experimental Group

AIM: To observe the intraocular pressure (IOP) fluctuation at the early stage of pars plana vitrectomy (PPV) and silicon oil tamponade in high myopia with rhegmatogenous retinal detachment (RRD) eyes in diabetic patients and analyze the potential risk factors and effective treatment. METHODS: One hundred consecutive diabetic patients of RRD in highly myopic eyes were retrospectively reviewed. Patients were divided into two groups: the experimental group, those who used Tobramycin Dexamethasone Eye Drops (TDED), and control group. Pre- and postoperative IOPs, retinal nerve fiber thickness (RNFL) and optic nerve head parameters were recorded before and after IOP elevation, and in the contralateral eye before the operation. Graphpad 7.01 was used for data analysis. RESULTS: IOP elevation occurred in 42 eyes within 1wk after vitrectomy in all diabetic participants. Ocular hypertension (OHTN) was observed in 31 of 53 eyes in experimental group and 11 eyes of 47 eyes in control group at the early stage after operation. Significant differences were found between groups in 5d-1wk and 1mo after vitrectomy. In addition, IOP of 39 eyes had decreased by proper treatment and 3 eyes received glaucoma filtration surgery. Compared to the optic disc parameters before IOP elevation, the average and inferior RNFL thickness were thinner and rim area decreased as well as cup volume and vertical C/D radio increased after IOP elevation. The RNFL thickness of the opposite eyes in patients with IOP elevation was found thinner than the ones who never suffered ocular hypertension. CONCLUSION: Continual use of glucocorticoid after vitrectomy is a potential risk factor of IOP elevation in high myopia with diabetes, and doubtful open angle glaucoma should be focused on its sensibility to glucocorticoid and IOP elevation.

scholarly journals Demographical, Anatomical, Disease-Related, and Occupational Risk Factors for Carpal Tunnel Syndrome

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Mohaddeseh Azadvari ◽  
Mayam Haghshomar ◽  
Fatemeh Abbasi Feyjani ◽  
Hosseinali Abdolrazagh ◽  
Seyede Zahra Emami Razavi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Occupational History ◽  
Occupational Risk Factors ◽  
Statistical Relevance ◽  
History Of ◽  
Tunnel Syndrome ◽  
Main Determinants ◽  
And Gender

Background: Carpal tunnel syndrome (CTS) is the most common focal mononeuropathy. It causes characteristic symptoms, including numbness and paresthesia in hand due to median nerve compression at the wrist. Objectives: We aimed to investigate CTS prevalence and personal, psychosocial, biomedical, and occupational factors related to it comprehensively, according to scattered publications, without the simultaneous evaluation of all CTS risk factors. Methods: A total of 345 patients referred to a hand clinic with a complaint of paresthesia in upper extremities and suspected CTS. The patients underwent neurological assessment and electrodiagnostic (EDX) tests to confirm the diagnosis. The demographic information, past medical history, past trauma history, and occupational history of all the patients were recorded and finally analyzed with SPSS software. Results: Of the patients, 213 (67.1%) met the criteria for CTS, of whom 160 (75%) were female. Females were significantly more affected by CTS than males (P < 0.05). The mean age was higher in the CTS patients (53.80 ± 11.57 years) than in non-patients (42.39 ± 12.31 years, P < 0.001). No statistical relevance was found between CTS prevalence with occupational history, underlying medical conditions, positive Tinel’s and Phalen's tests, and muscle atrophy. Conclusions: We recognized age and gender as main determinants in developing CTS. We also found that older age was related to higher CTS intensity.

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