scholarly journals Animal Models of Diabetes and Metabolic Disease 2014

2015 ◽  
Vol 2015 ◽  
pp. 1-2 ◽  
Author(s):  
Tomohiko Sasase ◽  
Norihide Yokoi ◽  
Marcus G. Pezzolesi ◽  
Masami Shinohara
Keyword(s):  
Metabolic Disease ◽  
Animal Models ◽  
Animal Models Of Diabetes

scholarly journals Animal Models of Diabetes and Metabolic Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-2 ◽  
Author(s):  
Tomohiko Sasase ◽  
Marcus G. Pezzolesi ◽  
Norihide Yokoi ◽  
Takahisa Yamada ◽  
Kozo Matsumoto
Keyword(s):  
Metabolic Disease ◽  
Animal Models ◽  
Animal Models Of Diabetes

scholarly journals Animal Models of Diabetes and Its Associated Complications

2013 ◽  
Vol 2013 ◽  
pp. 1-1 ◽  
Author(s):  
Md. Shahidul Islam ◽  
Daisuke Koya ◽  
Bernard Portha
Keyword(s):  
Animal Models ◽  
Animal Models Of Diabetes

Noninsulin-Dependent Animal Models of Diabetes Mellitus

2018 ◽  
pp. 337-398
Author(s):  
Christopher H. S. McIntosh ◽  
Raymond A. Pederson
Keyword(s):  
Diabetes Mellitus ◽  
Animal Models ◽  
Animal Models Of Diabetes

scholarly journals Hypoglycemic effect of quercetin in animal models of diabetes

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Haneul Choi ◽  
Jungin Kim ◽  
Jihye Kim ◽  
Heejeong Joo ◽  
Younghee Kang
Keyword(s):  
Animal Models ◽  
Hypoglycemic Effect ◽  
Animal Models Of Diabetes

scholarly journals Minireview: Epigenetic Programming of Diabetes and Obesity: Animal Models

Endocrinology ◽  
2012 ◽  
Vol 153 (3) ◽  
pp. 1031-1038 ◽  
Author(s):  
Yoshinori Seki ◽  
Lyda Williams ◽  
Patricia M. Vuguin ◽  
Maureen J. Charron
Keyword(s):  
Metabolic Disease ◽  
Animal Models ◽  
Posttranslational Modifications ◽  
Cytosine Methylation ◽  
Metabolic Diseases ◽  
Later Life ◽  
Epigenetic Modifications ◽  
Micro Rna ◽  
Fetal Origins ◽  
Diabetes And Obesity

A growing body of evidence suggests that the intrauterine (IU) environment has a significant and lasting effect on the long-term health of the growing fetus and the development of metabolic disease in later life as put forth in the fetal origins of disease hypothesis. Metabolic diseases have been associated with alterations in the epigenome that occur without changes in the DNA sequence, such as cytosine methylation of DNA, histone posttranslational modifications, and micro-RNA. Animal models of epigenetic modifications secondary to an altered IU milieu are an invaluable tool to study the mechanisms that determine the development of metabolic diseases, such as diabetes and obesity. Rodent and nonlitter bearing animals are good models for the study of disease, because they have similar embryology, anatomy, and physiology to humans. Thus, it is feasible to monitor and modify the IU environment of animal models in order to gain insight into the molecular basis of human metabolic disease pathogenesis. In this review, the database of PubMed was searched for articles published between 1999 and 2011. Key words included epigenetic modifications, IU growth retardation, small for gestational age, animal models, metabolic disease, and obesity. The inclusion criteria used to select studies included animal models of epigenetic modifications during fetal and neonatal development associated with adult metabolic syndrome. Experimental manipulations included: changes in the nutritional status of the pregnant female (calorie-restricted, high-fat, or low-protein diets during pregnancy), as well as the father; interference with placenta function, or uterine blood flow, environmental toxin exposure during pregnancy, as well as dietary modifications during the neonatal (lactation) as well as pubertal period. This review article is focused solely on studies in animal models that demonstrate epigenetic changes that are correlated with manifestation of metabolic disease, including diabetes and/or obesity.

Animal Models of Diabetes-Induced Neuropathic Pain

2014 ◽  
pp. 147-170 ◽  
Author(s):  
Corinne A. Lee-Kubli ◽  
Teresa Mixcoatl-Zecuatl ◽  
Corinne G. Jolivalt ◽  
Nigel A. Calcutt
Keyword(s):  
Neuropathic Pain ◽  
Animal Models ◽  
Animal Models Of Diabetes
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