scholarly journals Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Alani Sulaimon Akanmu ◽  
Olufemi Abiola Oyedeji ◽  
Titilope Adenike Adeyemo ◽  
Ann Abiola Ogbenna
Keyword(s):  
Blood Group ◽  
Teaching Hospital ◽  
Blood Donors ◽  
University Teaching ◽  
Abo Blood Group ◽  
Hemolytic Disease ◽  
Gene Frequencies ◽  
Abo Incompatibility ◽  
Population Prevalence ◽  
Abo Hemolytic Disease

Background. ABO hemolytic disease of the newborn is the most common hemolytic consequence of maternofetal blood group incompatibility restricted mostly to non-group-O babies of group O mothers with immune anti-A or anti-B antibodies. Aim. We estimated the risk of ABO HDN with view to determining need for routine screening for ABO incompatibility between mother and fetus. Materials and Methods. Prevalence of ABO blood group phenotypes in blood donors at the donor clinic of the Lagos University Teaching Hospital and arithmetic methods were used to determine population prevalence of ABO genes. We then estimated proportion of pregnancies of group O mothers carrying a non-group-O baby and the risk that maternofetal ABO incompatibility will cause clinical ABO HDN. Results. Blood from 9138 donors was ABO typed. 54.3%, 23%, 19.4%, and 3.3% were blood groups O, A, B, and AB, respectively. Calculated gene frequencies were 0.1416, 0.1209, and 0.7375 for A, B, and O genes, respectively. It was estimated that 14.3% of deliveries will result in a blood group O woman giving birth to a child who is non-group-O. Approximately 4.3% of deliveries are likely to suffer ABO HDN with 2.7% prone to suffer from moderately severe to severe hemolysis.

scholarly journals Prevalence of Weak D (Du) in Blood Donors in a Referral Teaching Hospital

2017 ◽  
Vol 6 (2) ◽  
pp. 1509
Author(s):  
H. S. Lamba ◽  
Kulbir Kaur ◽  
Kulwant Kaur ◽  
Amarjit Singh Vij
Keyword(s):  
Patient Care ◽  
Blood Group ◽  
Teaching Hospital ◽  
Blood Donors ◽  
Blood Product ◽  
Blood Group Antigen ◽  
Abo Blood Group ◽  
Blood Samples ◽  
Donor Population ◽  
Gel Technique

<p><strong>Background:</strong> Rh D is the most important Blood Group antigen after ABO Blood group antigen for transfusion purpose. All negative blood units by routine methods must be tested to detect weak D using IAT method. When the test for D and D<sup>u</sup> is positive, the label should read Rh(D) Positive . When the test for D and D<sup>u</sup> is negative, the label should read Rh(D) Negative.</p><p><strong>Objective:</strong> To know the prevalence of weak D in the donor population. No study has been done in this part of the country earlier. It will help in the knowledge of weak D, which is very important for better patient care and prevent allo-immunzation in blood recipients.</p><p><strong>Materials and Methods:</strong> Blood samples were tested by ID Gel technique or by tube method with two anti D reagents - anti-D IgM monoclonal and blend of anti-D IgM&amp;amp;IgG. All negative samples were further tested for weak D in IAT phase by LISS/Coombs' gel card.</p><p><strong>Results:</strong> A total of 13043 samples were tested from January 2011 to December 2013. 12196 were Rh positive and 847 were Rh D negative. Weak D was positive in 8 samples.</p><p><strong>Conclusion:</strong> The study shows the prevalence of weak D as 0.07% in blood donors who were primarily from in and around Jalandhar in Punjab. These donors may have posed problem to the recipients of blood and blood product and their detection prevented them from alloimunisation.</p>

scholarly journals HEMOLYTIC DISEASE OF THE NEWBORN

2018 ◽  
Vol 18 (2) ◽  
pp. 104-109
Author(s):  
Vivi Keumala Mutiawati
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Maternal Antibodies ◽  
Placental Barrier ◽  
Abo Blood Groups ◽  
Hemolytic Disease ◽  
Gene Frequencies ◽  
Mild Degree ◽  
Abo Incompatibility ◽  
Low Incidence

Abstrak. Pemahaman penyakit hemolitik pada bayi baru lahir telah berubah selama beberapa dekade terakhir. Penyakit hemolitik akibat inkompatibilitas ABO dan aloantibodi lainnya kini muncul sebagai penyebab utama. Banyak negara telah mengidentifikasi aloantibodi selain anti D sebagai penyebab penyakit hemolitik dengan gejala klinis sedang sampai dengan berat. Prevalensi dan frekuensi populasi antibodi anti-A dan anti B dari golongan darah ABO berguna dalam memprediksi perkiraan anak yang lahir oleh wanita golongan darah O yang menikahi suami golongan darah bukan O yang berisiko menjadi ABO HDN. Kelainan ABO HDN disebabkan oleh antibodi IgG pada ibu disebabkan kemampuan IgG untuk melewati sawar darah plasenta. Eritrosit yang peka oleh antibodi dihancurkan oleh makrofag pada limpa janin dengan gejala klinis hiperbilirubinemia. Kelainan ABO HDN memberikan gambaran klinis yang lebih ringan pada populasi, dan ditandai dengan derajat hemolisis yang ringan. Diagnosis biasanya dilakukan dengan pemeriksaan bayi baru lahir yang telah mengalami ikterus pada hari pertama kehidupan. Keywords: Penyakit hemolitik bayi baru lahir, aloantibodi golongan darah, ikterus Abstract. The spectrum of hemolytic disease of the newborn has changed over the last decades. Hemolytic disease due to ABO incompatibility and other alloantibodies has now emerged as major causes. Many countries have identified alloantibodies other than anti D as a cause of moderate-severe hemolytic disease. The prevalence of immune anti A and anti B antibodies and the population and gene frequencies of the various ABO blood groups are useful in predicting an estimate of children born by blood group O women married to non-group O husband who are at risk of developing ABO HDN. ABO HDN is caused by IgG maternal antibodies which have the ability to cross the placental barrier. The red cells which are sensitized by the antibodies are destroyed by macrophages in fetal spleen with consequent hyperbilirubinemai. ABO HDN is described as a condition having a very low incidence in the population and characterized by a a mild degree of hemolysis. Diagnosis is usually made by investigation of a newborn baby who has developed jaundice during the first day of life. Keywords: Hemolytic disease of the newborn, blood groups alloantibodies, joundice 

HEMOLYTIC DISEASE OF THE NEWBORN DUE TO ANTI-A AND ANTI-B

PEDIATRICS ◽  
1955 ◽  
Vol 15 (1) ◽  
pp. 54-62
Author(s):  
Clare N. Shumway ◽  
Gerald Miller ◽  
Lawrence E. Young
Keyword(s):  
B Cells ◽  
Red Blood Cells ◽  
Blood Group ◽  
Newborn Infant ◽  
Blood Cells ◽  
Osmotic Fragility ◽  
Red Cells ◽  
Hemolytic Disease ◽  
Abo Incompatibility

Ten infants with hemolytic disease of the newborn due to ABO incompatibility were studied. In every case the investigations were undertaken because of jaundice occurring in the first 24 hours of life. The clinical, hematologic and serologic observations in the infants and the serologic findings in the maternal sera are described. Evidence is presented to show that the diagnosis of the disorder rests largely upon the demonstration of spherocytosis, increased osmotic fragility of the red cells, reticulocytosis, and hyperbilirubinemia in a newborn infant whose red blood cells are incompatible with the maternal major blood group isoantibody and against whose cells no other maternal isoantibody is demonstrable. The anti-A or anti-B in each of the maternal sera tested in this series hemolyzed A or B cells in the presence of complement. Other serologic findings in the maternal sera were less consistently demonstrated.

scholarly journals Assessing ABO/Rh Blood Group Frequency and Association with Asymptomatic Malaria among Blood Donors Attending Arba Minch Blood Bank, South Ethiopia

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Getaneh Alemu ◽  
Mohammedaman Mama
Keyword(s):  
Blood Group ◽  
Malaria Infection ◽  
Blood Donors ◽  
Blood Groups ◽  
High Rate ◽  
Abo Blood Group ◽  
Asymptomatic Malaria ◽  
Abo Blood Groups ◽  
Group Frequency ◽  
Rh Blood Group

Background. Determination of the various ABO/Rh blood group distributions and their association with malaria infection has paramount importance in the context of transfusion medicine and malaria control. Methods. Facility based cross-sectional study was conducted from February to June, 2015, to assess ABO/Rh blood groups distribution and their association with asymptomatic malaria. A structured questionnaire was used to collect data. Blood grouping was done using monoclonal antibodies. Thin and thick blood films were examined for Plasmodium parasites. Data were analyzed using SPSS version 20.0. Results. A total of 416 blood donors participated with median age of 22±0.29 (median ± standard error of the mean). Distribution of ABO phenotypes, in decreasing order, was O (175, 42.1%), A (136, 32.7%), B (87, 20.9%), and AB (18, 4.3%). Most of them were Rh+ (386, 92.8%). The overall malaria prevalence was 4.1% (17/416). ABO blood group is significantly associated with malaria infection (P=0.022). High rate of parasitemia was seen in blood group O donors (6.899, P=0.003) compared to those with other ABO blood groups. Conclusion. Blood groups O and AB phenotypes are the most and the least ABO blood groups, respectively. There is significant association between ABO blood group and asymptomatic malaria parasitemia.

ABO blood group and risk of cancer: A register-based cohort study of 1.6 million blood donors

2016 ◽  
Vol 44 ◽  
pp. 40-43 ◽  
Author(s):  
Senthil K. Vasan ◽  
Jinseub Hwang ◽  
Klaus Rostgaard ◽  
Olof Nyrén ◽  
Henrik Ullum ◽  
...  
Keyword(s):  
Cohort Study ◽  
Blood Group ◽  
Blood Donors ◽  
Abo Blood Group ◽  
Risk Of Cancer

Influence of ABO blood group on von Willebrand factor tests in healthy Saudi blood donors

2018 ◽  
Vol 29 (2) ◽  
pp. 211-215 ◽  
Author(s):  
Abdullah Alharbi ◽  
Salwa Bakr Hassan ◽  
Abdul-Kareem Al-Momen ◽  
Khalid Al-Saleh ◽  
Rasheed Nasr ◽  
...  
Keyword(s):  
Blood Group ◽  
Von Willebrand Factor ◽  
Blood Donors ◽  
Abo Blood Group ◽  
Von Willebrand ◽  
Willebrand Factor
Sign in / Sign up

Export Citation Format

Share Document