scholarly journals Investigation of Occupational Asthma: Do Clinicians Fail to Identify rRelevant Occupational Exposures?

2015 ◽  
Vol 22 (6) ◽  
pp. 341-347 ◽  
Author(s):  
Carlo de Olim ◽  
Denis Bégin ◽  
Louis-Philippe Boulet ◽  
André Cartier ◽  
Michel Gérin ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Occupational Asthma ◽  
Occupational Exposures ◽  
Epidemiological Studies ◽  
Assessment Method ◽  
Causal Agent ◽  
Work Place ◽  
Expert Assessment ◽  
Almost All ◽  
Specific Agent

BACKGROUND: Specific inhalation challenges (SIC) enable the identification of the agent responsible of occupational asthma (OA). A clinician may fail to identify a specific agent in the workplace, which may potentially lead to a misdiagnosis. The expert assessment method performed by an occupational hygienist has been used to evaluate occupational exposures in epidemiological studies.OBJECTIVE: The broad aim of the present study was to evaluate the contribution of an expert assessment performed by an occupational hygienist to the diagnosis of OA. The specific aim was to compare work-place exposures identified by an occupational hygienist and by chest physicians in subjects with positive SICs and subjects with asthma, but with a negative SIC.METHODS: SICs were performed in 120 cases: 67 were positive and 53 were negative. A clinician assessed occupational exposures to sensitizers during a routine clinical evaluation preceding the performance of the SIC. An expert assessment of occupational exposures was performed by an occupational hygienist blind to the result of the SIC.RESULTS: The occupational hygienist identified the causal agent in 96.7% of the 61 cases of positive SIC. In 33 (62.3%) cases of negative SICs, the occupational hygienist identified ≥1 sensitizing agent(s) that had not been identified by the clinician.CONCLUSION: The hygienist identified the causal agent in almost all subjects with OA. In contrast, the clinician failed to identify potential exposures to sensitizers in >60% of the negative SIC subjects, which may have resulted in some subjects being misdiagnosed as not having OA.

scholarly journals OccIDEAS: Retrospective Occupational Exposure Assessment in Community-Based Studies Made Easier

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Lin Fritschi ◽  
Melissa C. Friesen ◽  
Deborah Glass ◽  
Geza Benke ◽  
Jennifer Girschik ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Epidemiological Studies ◽  
Assessment Method ◽  
Expert Assessment ◽  
The Novel ◽  
Case Control Studies ◽  
Community Based ◽  
Web Based ◽  
Software Application ◽  
Assessment Development

Assessing occupational exposure in retrospective community-based case-control studies is difficult as measured exposure data are very seldom available. The expert assessment method is considered the most accurate way to attribute exposure but it is a time consuming and expensive process and may be seen as subjective, nonreproducible, and nontransparent. In this paper, we describe these problems and outline our solutions as operationalized in a web-based software application (OccIDEAS). The novel aspects of OccIDEAS are combining all steps in the assessment into one software package; enmeshing the process of assessment into the development of questionnaires; selecting the exposure(s) of interest; specifying rules for exposure assignment; allowing manual or automatic assessments; ensuring that circumstances in which exposure is possible for an individual are highlighted for review; providing reports to ensure consistency of assessment. Development of this application has the potential to make high-quality occupational assessment more efficient and accessible for epidemiological studies.

A Comparison of Methods for the Measurement of Activated Factor VII

1992 ◽  
Vol 68 (03) ◽  
pp. 301-305 ◽  
Author(s):  
S Kitchen ◽  
R G Malia ◽  
F E Preston
Keyword(s):  
Factor Viia ◽  
Epidemiological Studies ◽  
Factor Vii ◽  
Haemophilia A ◽  
Reference Ranges ◽  
Activated Factor Vii ◽  
Normal Individuals ◽  
Antigen Assay ◽  
Activity State ◽  
Almost All

SummaryA number of different methods are available for the measurement of factor VIIa. Almost all of these employ ratios of two different measurements of factor VII. In order to determine which is the most sensitive to activated factor VII we have compared currently available methods in the following groups: two patients with haemophilia A following treatment with activated recombinant factor VII (rVII a); 6 normal plasmas during cold promoted activation of factor VII; normal individuals (n = 23); and patients with unequivocal disseminated intravascular coagulation (DIC, n = 19). Factor VII was measured in an amidolytic assay (VII: Amid) and an antigen assay (VII:Ag). Clotting activity was measured using rabbit (VII:C Rab), human (VII:C Hum) and bovine (VII:C Bov) thromboplastin.Of the clotting assays the most sensitive to the presence of factor VIIa was that which utilised bovine thromboplastin. Amidolytic and immunological measurements were unaffected by the activity state of factor VII. The ratios VII:C Rab/VII: Ag and VII:C Rab/VII:Amid were insensitive to activated factor VII. The ratios most sensitive to the presence of factor VII a were VII:C Bov/VII: Amid and VII: C Bov/VII:Ag. The ratios VII:C Bov/VII:C Rab and VII:C Bov/VII:C Hum are less sensitive but have the advantage for epidemiological studies of narrower reference ranges.

Improving the financial investment system as an object of business economics

2020 ◽  
Vol 26 (3) ◽  
pp. 508-526
Author(s):  
O.T. Astanakulov ◽  
E.G. Sheina
Keyword(s):  
Deductive Reasoning ◽  
Methodological Approach ◽  
Investment Project ◽  
Assessment Method ◽  
Expert Assessment ◽  
Business Economics ◽  
Financial Investment ◽  
Economic Relations ◽  
Investment Projects ◽  
Investment Control

Subject. This article explores the economic relations of economic entities concerning effective investment activities, combining elements of investment control and assessment of related risk. Objectives. The article aims to analyze and logically substantiate the stages and types of investment activities of enterprises and investment projects in-progress, as well as define a methodological approach to assessing project risks. Methods. For the study, we used a structural and logical analysis, and deductive reasoning. The methodological base of the study is based on the principles of the theory of finance, investment and risk management. Results. The article defines stages of assessing the financial condition of enterprises and proposes a methodological approach to assessing certain risks of an investment project based on the risk ranking by degree of probability and significance of an event through applying the expert assessment method. The article also presents a practice-oriented risk map for investment projects and clarifies the concept of Investment Control. Conclusions. The results of the study can help address the significant for the Russian economy issue of stimulating and developing investment activities at enterprises, as well as implementing and evaluating the effectiveness of investment projects at the micro-and macro-levels of the country's economy.

Developing the basis of the matrix model of the regional innovation subsystem

2020 ◽  
Vol 18 (11) ◽  
pp. 2183-2204
Author(s):  
E.I. Moskvitina
Keyword(s):  
Russian Federation ◽  
Matrix Model ◽  
Federal District ◽  
Assessment Method ◽  
Expert Assessment ◽  
Regional Innovation ◽  
Regional Strategies ◽  
Analysis And Synthesis ◽  
The Matrix ◽  
The Russian Federation

Subject. This article deals with the issues related to the formation and implementation of the innovation capacity of the Russian Federation subjects. Objectives. The article aims to develop the organizational and methodological foundations for the formation of a model of the regional innovation subsystem. Methods. For the study, I used the methods of analysis and synthesis, economics and statistics analysis, and the expert assessment method. Results. The article presents a developed basis of the regional innovation subsystem matrix model. It helps determine the relationship between the subjects and the parameters of the regional innovation subsystem. To evaluate the indicators characterizing the selected parameters, the Volga Federal District regions are considered as a case study. The article defines the process of reconciliation of interests between the subjects of regional innovation. Conclusions. The results obtained can be used by regional executive bodies when developing regional strategies for the socio-economic advancement of the Russian Federation subjects.

Expert methods of developing of innovative technologies for the production of cast tools. Part 1. Formation of a complex of functional indicators of technology

2021 ◽  
pp. 57-61
Author(s):  
Keyword(s):  
High Speed ◽  
High Reliability ◽  
Assessment Method ◽  
Innovative Technology ◽  
Expert Assessment ◽  
Innovative Technologies ◽  
Design Expert ◽  
Effective Technology ◽  
Casting Design

A method for the development an effective technology for casting of billets of insert cutters with specified properties from high-speed steels for milling cutters of rotors of mining combines is proposed, including the identification of a set of goals, the choice of priority technology and the determination of the specified characteristics of the technology. An alternative method of expert assessment is proposed, which ensures high reliability of the results. Keywords: innovative technology, casting, design, expert assessment method. [email protected], [email protected]

PERFORMANCE ANALYSIS OF ARTISTIC GYMNASTICS FINALISTS AT THE WORLD CHAMPIONSHIP UNEVEN BARS 2019

2020 ◽  
Vol 8 (2) ◽  
pp. 52-57
Author(s):  
Larisa Saveleva ◽  
Botova
Keyword(s):  
Performance Analysis ◽  
Olympic Games ◽  
Assessment Method ◽  
Expert Assessment ◽  
World Championship ◽  
Research Outcomes ◽  
The World ◽  
Competition Rules ◽  
Instructional Literature ◽  
Quantitative Indicators

Experts in artistic gymnastics are constantly analyzing the outcomes of the gymnasts' performance at world and continental championships. However, the analyses cover only the assessment of the final scores of athletes and their ranks. There is a lack of research focused on the structure of routines and components of the scores obtained for the performance of combinations. The purpose of this study was to determine the content of competitive programs performed by the finalists of the World Championship Uneven Bars 2019 and to identify areas for the exercise development in this kind of all-around events on the eve of the Olympic Games. Methods and organization of the research: we carried out the analysis of video materials of the International Gymnastics Federation (FIG), the analysis of the competition rules for the current Olympic cycle, additional newsletters, and scientific instructional literature. We used an expert assessment method to identify the components of competitive combinations. Research results. The study determined quantitative indicators of the content of gymnast combinations on uneven bars (the number and difficulty groups of elements, including jumps and dismounts, modal and frequently performed elements, connection value bonus). We have revealed the trend for reduction of the total number of elements of competitive routines. It occurs due to reduction of the number of binders (“dilution”) elements, reduction of the number of elements of difficulty groups below 0.4 points, and increasing number of flight elements performed in a “cascade” way. We have revealed the trend for the use of elements of F (0.6 points) and G (0.7 points) difficulty groups in competitive combinations of the strongest gymnasts, which characterizes a significant increase in the coordination complexity of the programs and increases the requirements for the training of gymnasts. Conclusion. The research outcomes can provide the basis for predicting competitive programs on uneven bars at the upcoming Olympic Games, making amendments to the system of training gymnasts and the content of combinations to increase competitiveness at major international competitions, as well as making competition rules proposals for the next Olympic cycle.

TOOLS FOR ASSESSING THE COMPETITIVENESS OF A COMMERCIAL ENTERPRISE

2020 ◽  
Vol 10 (9) ◽  
pp. 2047-2061
Author(s):  
I.V. Sibiryatkina ◽  
Keyword(s):  
Weighted Average ◽  
Assessment Method ◽  
Practical Significance ◽  
Expert Assessment ◽  
Complex Coefficient ◽  
Advantages And Disadvantages ◽  
Proposed Model ◽  
Commercial Enterprise ◽  
Business Entities ◽  
Adaptation Model

The article presents the systematization of approaches to assess the enterprises' level of competitiveness. The advantages and disadvantages of the most famous models for assessing the competitiveness of business entities are considered. The identified shortcomings made it possible to form a hypothesis for studying the enterprises' competitiveness, taking into account the industry factor, financial criteria and quality indicators of the enterprise. For the formation of an objective adaptation model for assessing the competitiveness of an enterprise, taking into account its industry specificity, the author's approach to assessing the competitiveness of an enterprise, taking into account industry specifics, based on the relative and qualitative indicators of the enterprise's activities, selected by the expert assessment method, is considered. For trade enterprises, groups of the most significant indicators have been formed that characterize the competitiveness in the areas of observation of the sales of a trade enterprise, its costs, financial position and financial results, for the market share of the trade enterprise, the level of prices for goods, for the level of service of the trade enterprise. The indicators characterizing the level of competitiveness of a trading enterprise are divided into relative critical indicators and a group of qualitative critical indicators, which are included in the calculation of the complex coefficient of enterprise competitiveness model based on the theory of effective competition according to the weighted average arithmetic formula. The article presents the results of approbation of the proposed methodology on the example of the “PAO Magnit” trading enterprise and its trade competitors operating in Voronezh. The obtained results of the author's methodology for assessing the competitiveness of a trading enterprise have practical significance; the proposed model can be adapted according to the criteria for selecting indicators and their quantitative indicator, which contributes to the use of this toolkit in future studies of the competitiveness of trading enterprises.

scholarly journals Organizational and technological solutions justifying use of non-destructive methods of control when building monolithic constructions of civil buildings and structures

2018 ◽  
Vol 251 ◽  
pp. 05014 ◽  
Author(s):  
Azariy Lapidus ◽  
Alan Khubaev ◽  
Tembot Bidov
Keyword(s):  
Control Method ◽  
Assessment Method ◽  
Expert Assessment ◽  
Mathematical Apparatus ◽  
Industrial Buildings ◽  
Object Parameters ◽  
Non Destructive ◽  
Destructive Methods ◽  
Methods Of Control

The parameters influencing on the use of non-destructive methods of control are considered when building monolithic constructions of civil and industrial buildings and structures. The analysis of the factor influence on the capacity of the method of the non-destructive control with the expert assessment method is made. Based on the qualimetric analysis three the most significant groups of the factors which can influence on the capacity of the use of the non-destructive control method (Pnc) are determined. The mathematical apparatus base is prepared, which characterize the object parameters.

scholarly journals Additional Og-Typing PCR Techniques Targeting Escherichia coli-Novel and Shigella-Unique O-Antigen Biosynthesis Gene Clusters

2020 ◽  
Vol 58 (11) ◽  
Author(s):  
Atsushi Iguchi ◽  
Hironobu Nishii ◽  
Kazuko Seto ◽  
Jiro Mitobe ◽  
Kenichi Lee ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Strong Association ◽  
Gene Clusters ◽  
Epidemiological Studies ◽  
Content Type ◽  
E Coli ◽  
O Antigen ◽  
Wide Range ◽  
Biosynthesis Gene ◽  
Almost All

ABSTRACT The O-serogrouping of pathogenic Escherichia coli is a standard method for subtyping strains for epidemiological studies and controls. O-serogroup diversification shows a strong association with the genetic diversity in some O-antigen biosynthesis gene clusters. Through genomic studies, in addition to the types of O-antigen biosynthesis gene clusters (Og-types) from conventional O-serogroup strains, a number of novel Og-types have been found in E. coli isolates. To assist outbreak investigations and surveillance of pathogenic E. coli at inspection institutes, in previous studies, we developed PCR methods that could determine almost all conventional O-serogroups and some novel Og-types. However, there are still many Og-types that may not be determined by simple genetic methods such as PCR. Thus, in the present study, we aimed to develop an additional Og-typing PCR system. Based on the novel Og-types, including OgN32, OgN33, and OgN34, presented in this study, we designed an additional 24 PCR primer pairs targeting 14 novel and 2 diversified E. coli Og-types and 8 Shigella-unique Og-types. Subsequently, we developed 5 new multiplex PCR sets consisting of 33 primers, including the aforementioned 24 primers and 9 primers reported in previous studies. The accuracy and specificity of the PCR system was validated using approximately 260 E. coli and Shigella O-serogroup and Og-type reference strains. The Og-typing PCR system reported here can determine a wide range of Og-types of E. coli and may help epidemiological studies, in addition to the surveillance of pathogenic E. coli.

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