scholarly journals Frequency-Dependent Amplitude Alterations of Resting-State Spontaneous Fluctuations in Late-Onset Depression

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yingying Yue ◽  
Xize Jia ◽  
Zhenghua Hou ◽  
Yufeng Zang ◽  
Yonggui Yuan
Keyword(s):  
Resting State ◽  
Late Onset ◽  
Brain Activity ◽  
Low Frequency ◽  
Anterior Lobe ◽  
Posterior Lobe ◽  
Frequency Bands ◽  
Relationship Analysis ◽  
Intrinsic Brain Activity ◽  
The Impact

There is limited amplitude of low-frequency fluctuation (ALFF) of resting-state functional magnetic resonance imaging (fMRI) studies in late-onset depression (LOD) but reported different results. This may be due to the impact of different frequency bands. In this study, we examined the ALFF in five different frequency bands (slow-6: 0–0.01 Hz; slow-5: 0.01–0.027 Hz; slow-4: 0.027–0.073 Hz; slow-3: 0.073–0.167 Hz, and slow-2: 0.167–0.25 Hz) within the whole brain during resting-state fMRI in 16 LOD patients and 16 normal control (NC) subjects. The ALFF of primary effect of disease was widely distributed over left cerebellum anterior lobe, left cerebellum posterior lobe, left middle orbitofrontal gyrus, left superior occipital, and right superior parietal, while the interaction effect of disease and frequency was distributed over right superior frontal gyrus. Further relationship analysis findings suggest these abnormal ALFF may relate to cognitive dysfunction of LOD. Therefore, our data show that LOD patients have widespread abnormalities in intrinsic brain activity, which is dependent on the frequency band, and suggest that future studies should take the frequency bands into account when measuring intrinsic brain activity.

scholarly journals Dynamics and Concordance Abnormalities Among Indices of Intrinsic Brain Activity in Individuals With Subjective Cognitive Decline: A Temporal Dynamics Resting-State Functional Magnetic Resonance Imaging Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Yiwen Yang ◽  
Xinyi Zha ◽  
Xiaodong Zhang ◽  
Jun Ke ◽  
Su Hu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resting State ◽  
Temporal Dynamics ◽  
Brain Activity ◽  
Low Frequency ◽  
Subjective Cognitive Decline ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Intrinsic Brain Activity

Individuals with subjective cognitive decline (SCD) are more likely to develop into Alzheimer disease (AD) in the future. Resting-state functional magnetic resonance imaging (rs-fMRI) studies have shown alterations of intrinsic brain activity (IBA) in SCD individuals. However, rs-fMRI studies to date have mainly focused on static characteristics of IBA, with few studies reporting dynamics- and concordance-related changes in IBA indices in SCD individuals. To investigate these aberrant changes, a temporal dynamic analysis of rs-fMRI data was conducted on 94 SCD individuals (71.07 ± 6.18 years, 60 female), 75 (74.36 ± 8.42 years, 35 female) mild cognitive impairment (MCI) patients, and 82 age-, gender-, and education-matched controls (NCs; 73.88 ± 7.40 years, 49 female) from the Alzheimer's Disease Neuroimaging Initiative database. The dynamics and concordance of the rs-fMRI indices were calculated. The results showed that SCD individuals had a lower amplitude of low-frequency fluctuations dynamics in bilateral hippocampus (HP)/parahippocampal gyrus (PHG)/fusiform gyrus (FG) and bilateral cerebellum, a lower fractional amplitude of low-frequency fluctuation dynamics in bilateral precuneus (PreCu) and paracentral lobule, and a lower regional homogeneity dynamics in bilateral cerebellum, vermis, and left FG compared with the other two groups, whereas those in MCI patients were higher (Gaussian random field–corrected, voxel-level P < 0.001, cluster-level P < 0.05). Furthermore, SCD individuals had higher concordance in bilateral HP/PHG/FG, temporal lobe, and left midcingulate cortex than NCs, but those in MCI were lower than those in NCs. No correlation between concordance values and neuropsychological scale scores was found. SCD individuals showed both dynamics and concordance-related alterations in IBA, which indicates a compensatory mechanism in SCD individuals. Temporal dynamics analysis offers a novel approach to capturing brain alterations in individuals with SCD.

Comparison of intrinsic brain activity in individuals with low/moderate myopia versus high myopia revealed by the amplitude of low-frequency fluctuations

2019 ◽  
Vol 61 (4) ◽  
pp. 496-507 ◽  
Author(s):  
Yi Cheng ◽  
Xin Huang ◽  
Yu-Xiang Hu ◽  
Mu-Hua Huang ◽  
Bo Yang ◽  
...  
Keyword(s):  
White Matter ◽  
High Myopia ◽  
Brain Activity ◽  
Low Frequency ◽  
Anterior Lobe ◽  
Frequency Fluctuation ◽  
Healthy Controls ◽  
Optic Radiation ◽  
Frequency Fluctuations ◽  
Intrinsic Brain Activity

Background Previous neuroimaging studies demonstrated that individuals with high myopia are associated with abnormalities in anatomy of the brain. Purpose The purpose of this study was to explore alterations in the intrinsic brain activity by studying the amplitude of low-frequency fluctuations. Material and Methods A total of 64 myopia individuals (41 with high myopia with a refractive error <–600 diopter [D], 23 with low/moderate myopia with a refractive error between –100 and –600 D, and similarly 59 healthy controls with emmetropia closely matched for age) were recruited. The amplitude of low-frequency fluctuations method was conducted to investigate the difference of intrinsic brain activity across three groups. Results Compared with the healthy controls, individuals with low/moderate myopia showed significantly decreased amplitude of low-frequency fluctuation values in the bilateral rectal gyrus, right cerebellum anterior lobe/calcarine, and bilateral thalamus and showed significantly increased amplitude of low-frequency fluctuation values in left white matter (optic radiation), right prefrontal cortex, and left primary motor cortex (M1)/primary somatosensory cortex (S1). In addition, individuals with high myopia showed significantly decreased amplitude of low-frequency fluctuation values in the right cerebellum anterior lobe/calcarine/bilateral parahippocampal gyrus, bilateral posterior cingulate cortex, and bilateral middle cingulate cortex and significantly increased amplitude of low-frequency fluctuation values in left white matter (optic radiation), bilateral frontal parietal cortex, and left M1/S1. Moreover, we found that the amplitude of low-frequency fluctuation values of the different brain areas was closely related to the clinical features in the high myopia group. Conclusion Our results demonstrated that individuals with low/moderate myopia and high myopia had abnormal intrinsic brain activities in various brain regions related to the limbic system, default mode network, and thalamo-occipital pathway.

scholarly journals The impact of body posture on intrinsic brain activity: the role of beta power at rest

2019 ◽  
Author(s):  
Brunella Donno ◽  
Daniele Migliorati ◽  
Filippo Zappasodi ◽  
Mauro Gianni Perrucci ◽  
Marcello Costantini
Keyword(s):  
Resting State ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Muscle Tension ◽  
Body Posture ◽  
State Condition ◽  
Oscillatory Activity ◽  
Beta Power ◽  
Intrinsic Brain Activity ◽  
The Impact

1.AbstractTying the hands behind the back has detrimental effect of sensorimotor perceptual tasks. Here we provide evidence that beta band oscillatory activity in a resting state condition might have a crucial role in such detrimental effects. EEG activity in a resting state condition was measured from thirty participants in two different body posture conditions. In one condition participants were required to keep their hands freely resting on the table. In the other condition, participants were required to keep the hands tied behind their back. Increased beta power was observed in the left inferior frontal gyrus (l-IFG) during the tied hands condition compared to the free hands condition. A control study ruled out alternative explanations including muscle tension that might have affected the EEG data. Our findings provide new insight on how body postural manipulations impact on perceptual tasks and intrinsic brain activity.

scholarly journals Frequency-Dependent Neural Activity in Patients with Unilateral Vascular Pulsatile Tinnitus

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Han Lv ◽  
Pengfei Zhao ◽  
Zhaohui Liu ◽  
Guopeng Wang ◽  
Rong Zeng ◽  
...  
Keyword(s):  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Occipital Lobe ◽  
Brain Regions ◽  
Pulsatile Tinnitus ◽  
Frequency Bands ◽  
Gender And Education ◽  
Intrinsic Brain Activity ◽  
Parietal Cortices

Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies have shown that neurological changes are important findings in vascular pulsatile tinnitus (PT) patients. Here, we utilized rs-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) in forty patients with unilateral PT and forty age-, gender-, and education-matched normal control subjects. Two different frequency bands (slow-4, 0.027–0.073 Hz, and slow-5, 0.010–0.027 Hz, which are more sensitive to subcortical and cortical neurological signal changes, resp.) were analyzed to examine the intrinsic brain activity in detail. Compared to controls, PT patients had increased ALFF values mainly in the PCu, bilateral IPL (inferior parietal lobule), left IFG (inferior frontal gyrus), and right IFG/anterior insula and decreased ALFF values in the multiple occipital areas including bilateral middle-inferior occipital lobe. For the differences of the two frequency bands, widespread ALFF differences were observed. The ALFF abnormalities in aMPFC/ACC, PCu, right IPL, and some regions of occipital and parietal cortices were greater in the slow-5 band compared to the slow-4 band. Additionally, the THI score of PT patients was positively correlated with changes in slow-5 and slow-4 band in PCu. Pulsatile tinnitus is a disease affecting the neurological activities of multiple brain regions. Slow-5 band is more sensitive in detecting the alternations. Our results also indicated the importance of pathophysiological investigations in patients with pulsatile tinnitus in the future.

scholarly journals The impact of hyperoxia on brain activity: A resting-state and task-evoked electroencephalography (EEG) study

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176610 ◽  
Author(s):  
Min Sheng ◽  
Peiying Liu ◽  
Deng Mao ◽  
Yulin Ge ◽  
Hanzhang Lu
Keyword(s):  
Resting State ◽  
Brain Activity ◽  
The Impact ◽  
And Task

scholarly journals The impact of body posture on intrinsic brain activity: The role of beta power at rest

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0218977
Author(s):  
Brunella Donno ◽  
Daniele Migliorati ◽  
Filippo Zappasodi ◽  
Mauro Gianni Perrucci ◽  
Marcello Costantini
Keyword(s):  
Brain Activity ◽  
Body Posture ◽  
Beta Power ◽  
Intrinsic Brain Activity ◽  
The Impact

scholarly journals Beyond the low frequency fluctuations morning and evening differences in human brain

2019 ◽  
Author(s):  
Magdalena Fafrowicz ◽  
Bartosz Bohaterewicz ◽  
Anna Ceglarek ◽  
Monika Cichocka ◽  
Koryna Lewandowska ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Human Performance ◽  
Brain Activity ◽  
Activity Patterns ◽  
Low Frequency ◽  
Basic Mechanism ◽  
Time Of Day ◽  
Resting State Functional Connectivity ◽  
Circadian Typology

Human performance, alertness, and most biological functions express rhythmic fluctuations across a 24-hour-period. This phenomenon is believed to originate from differences in both circadian and homeostatic sleep-wake regulatory processes. Interactions between these processes result in time-of-day modulations of behavioral performance as well as brain activity patterns. Although the basic mechanism of the 24-hour clock is conserved across evolution, there are interindividual differences in the timing of sleep-wake cycles, subjective alertness and functioning throughout the day. The study of circadian typology differences has increased during the last few years, especially research on extreme chronotypes, which provide a unique way to investigate the effects of sleep-wake regulation on cerebral mechanisms. Using functional magnetic resonance imaging (fMRI), we assessed the influence of chronotype and time-of-day on resting-state functional connectivity. 29 extreme morning- and 34 evening-type participants underwent two fMRI sessions: about one hour after wake-up time (morning) and about ten hours after wake-up time (evening), scheduled according to their declared habitual sleep-wake pattern on a regular working day. Analysis of obtained neuroimaging data disclosed only an effect of time of day on resting-state functional connectivity; there were different patterns of functional connectivity between morning and evening sessions. The results of our study showed no differences between extreme morning-type and evening-type individuals. We demonstrate that circadian and homeostatic influences on the resting-state functional connectivity have a universal character, unaffected by circadian typology.

scholarly journals Dynamic Altered Amplitude of Low-Frequency Fluctuations in Patients With Major Depressive Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Ruiping Zheng ◽  
Yuan Chen ◽  
Yu Jiang ◽  
Mengmeng Wen ◽  
Bingqian Zhou ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Neural Activity ◽  
Temporal Variability ◽  
Brain Activity ◽  
Low Frequency ◽  
First Episode ◽  
Posterior Lobe ◽  
Major Depressive ◽  
Drug Naïve ◽  
The Right

Background: Major depressive disorder (MDD) has demonstrated abnormalities of static intrinsic brain activity measured by amplitude of low-frequency fluctuation (ALFF). Recent studies regarding the resting-state functional magnetic resonance imaging (rs-fMRI) have found the brain activity is inherently dynamic over time. Little is known, however, regarding the temporal dynamics of local neural activity in MDD. Here, we investigated whether temporal dynamic changes in spontaneous neural activity are influenced by MDD.Methods: We recruited 81 first-episode, drug-naive MDD patients and 64 age-, gender-, and education-matched healthy controls who underwent rs-fMRI. A sliding-window approach was then adopted for the estimation of dynamic ALFF (dALFF), which was used to measure time-varying brain activity and then compared between the two groups. The relationship between altered dALFF variability and clinical variables in MDD patients was also analyzed.Results: MDD patients showed increased temporal variability (dALFF) mainly focused on the bilateral thalamus, the bilateral superior frontal gyrus, the right middle frontal gyrus, the bilateral cerebellum posterior lobe, and the vermis. Furthermore, increased dALFF variability values in the right thalamus and right cerebellum posterior lobe were positively correlated with MDD symptom severity.Conclusions: The overall results suggest that altered temporal variability in corticocerebellar–thalamic–cortical circuit (CCTCC), involved in emotional, executive, and cognitive, is associated with drug-naive, first-episode MDD patients. Moreover, our study highlights the vital role of abnormal dynamic brain activity in the cerebellar hemisphere associated with CCTCC in MDD patients. These findings may provide novel insights into the pathophysiological mechanisms of MDD.

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