scholarly journals Mucoepidermoid Carcinoma of Uterine Cervix: A Distinct Pathological and Clinical Entity

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ilker Selcuk ◽  
Bulent Ozdal ◽  
Mengu Turker ◽  
Alp Usubutun ◽  
Tayfun Gungor ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cancer Patients ◽  
Uterine Cervix ◽  
Treatment Modality ◽  
Aggressive Behaviour ◽  
Mucoepidermoid Carcinoma ◽  
Postoperative Treatment ◽  
Rare Tumor

Mucoepidermoid carcinoma of uterine cervix is a rare tumor that has some individual features. Defining risk factors after surgery shape the postoperative treatment modality on cervical cancer patients. Although there is not a well-known strategy for the postoperative follow-up of mucoepidermoid carcinoma, the aggressive behaviour of this tumor makes the gynecological oncologists choose liberal therapies on these patients.

Post-operative small pelvic intensity-modulated radiation therapy for early-stage cervical cancer with intermediate-risk factors: efficacy and toxicity

2021 ◽  
Author(s):  
Guangyu Zhang ◽  
Fangfang He ◽  
Li Miao ◽  
Haijian Wu ◽  
Youzhong Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cancer Patients ◽  
Early Stage ◽  
Intensity Modulated Radiotherapy ◽  
Disease Free Survival ◽  
Intermediate Risk ◽  
Intensity Modulated ◽  
Early Stage Cervical Cancer

Abstract Objective The aim of the present study was to retrospectively evaluate the toxicity and efficacy of post-operative small pelvic intensity-modulated radiotherapy in early-stage cervical cancer patients with intermediate-risk factors. Methods Between 2012 and 2016, 151 patients who had cervical cancer (International Federation of Gynecology and Obstetrics stage I–IIA) with intermediate-risk factors were treated with post-operative small pelvic intensity-modulated radiotherapy. The median dose of 50.4 Gy in 28 fractions with small pelvic intensity-modulated radiotherapy was prescribed to the planning target volume. The intensity-modulated radiotherapy technique used was conventional fixed-field intensity-modulated radiotherapy or helical tomotherapy. Results The median follow-up was 37 months. The 3-year disease-free survival and overall survival rates were 89 and 96%, respectively. A total of 144 patients (95.3%) were alive at the last follow-up. In total, 6 patients (3.9%) had recurrence: locoregional recurrence in 3 patients (2%), distant metastasis in 2 (1.3%), and both in 1 (0.6%). Diarrhoea was the most common acute toxicity. There were no patients suffering from acute or late grade ≥ 3 toxicity. Only 4 patients (2.6%) had late grade 2 toxicities. Conclusions For early-stage cervical cancer patients with intermediate-risk factors, post-operative small pelvic intensity-modulated radiotherapy was safe and well tolerated. The rates of acute and late toxicities were quite satisfactory.

scholarly journals Evaluation of Pelvic Floor Muscle Function(PFMF) in Cervical Cancer Patients with Querleu-Morrow type C Hysterectomy：A Multicenter Study

2020 ◽  
Author(s):  
Shiyan Wang ◽  
Hongwu Wen ◽  
Yunong Gao ◽  
Qiubo Lv ◽  
Hongyu Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Logistic Regression ◽  
Pelvic Floor ◽  
Cancer Patients ◽  
Muscle Function ◽  
Pelvic Floor Muscle ◽  
Fibre Strength ◽  
Independent Risk Factors

Abstract Introduction and Hypothesis To evaluate the pelvic floor muscle function (PFMF) of cervical cancer patients after type QM-C hysterectomy and to explore the relationship between decreased PFMF and related factors.. Methods This was a multi-centered retrospective cohort study. 181 cervical cancer patients underwent type QM-C hysterectomy were enrolled from 9 tertiary hospitals. Strength of PFMF were measured by using neuromuscular apparatus (Phenix U8, French). Risk factors contributed to decreased PFMF was analyzed by univariate and multivariate ordinal ploytomous logistic regression. Results Totally 181 patients were investigated in this study.0-3 level of type I muscle fibre strength(MFSI) was 52.6%(95/181),0-3 level of type ⅡA muscle fibre strength(MFSⅡA) was 50%(91/181). Subjective stress urinary incontinence was 46%(84/181),urinary retention was 27.3%(50/181),dyschezia was 41.5%(75/181),fecal incontinence was 9%(18/181).①MFSI：Multivariate ordinal ploytomous logistic regression shows that the follow-up time(p<0.05),chemotherapy and radiotherapy (p=0.038) are independent risk factors of MFSI’s reduction after type QM-C hysterectomy.② MFSⅡA：Multivariate ordinal ploytomous logistic regression shows that the follow-up time(p<0.05) are independent risk factors of MFSⅡA’s reduction after type QM-C hysterectomy. The pelvic floor muscle strength(PFMS) increased after 9 months than in 9 months after operation, which showed that the PFMS could be recovered after operation. Conclusions We advocate for more attention and emphasis on the PFMF of Chinese female patients with cervical cancer postoperation. Contribution of the Paper The key messages of the article is that PFMF after QM-C hysterectomy have not been analyzed by current study.The new knowledge added by this study is that 3 months after radical hysterectomy patients’ should do pelvic floor rehabilitation exercises.

scholarly journals The kinetic profile and clinical implication of SCC-Ag in squamous cervical cancer patients undergoing radical hysterectomy using the Simoa assay: a prospective observational study

2019 ◽  
Author(s):  
Shuang Ye ◽  
Xiaohua Sun ◽  
Bin Kang ◽  
Fei Wu ◽  
Zhong Zheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Single Molecule ◽  
Clinicopathological Characteristics ◽  
Postoperative Treatment ◽  
Serum Samples ◽  
Kinetic Profile ◽  
Highly Correlated

Abstract Background: To study the kinetic profile and clinicopathological implications of squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients who underwent surgery by a self-developed SCC-Ag single molecule assay (Simoa) prototype immunoassay. Methods: Participants were prospectively enrolled between 04/2016 and 06/2017. Consecutive serum samples were collected at five points: day 0 (the day before surgery), postoperative day 4, weeks 2-4, months 2-4 and months 5-7. In total, 92 patients and 352 samples were included. The kinetic change in SCC-Ag levels and their associations with clinicopathological characteristics were studied. Results: Simoa SCC-Ag was validated by comparison with the Architect assay. SCC-Ag levels measured by the Simoa assay were highly correlated with the Architect assay’s levels (Pearson’s correlation coefficient = 0.979, Passing-Bablok regression slope 0.894 (0.847 to 0.949), intercept -0.009 (-0.047 to 0.027). The median values for each time-point detected by the Simoa assay were 2.49, 0.66, 0.61, 0.72, and 0.71 ng/mL, respectively. The SCC-Ag levels decreased dramatically after surgery and then stabilized and fluctuated to some extent within six months. Patients with certain risk factors had significantly higher SCC-Ag values than their negative counterparts before surgery and at earlier time points after surgery, while no difference existed at the end of observation. Furthermore, although patients with positive lymph nodes had sustained higher SCC-Ag levels compared to those with negative lymph nodes, similar kinetic patterns of SCC-Ag levels were observed after surgery. Patients who received postoperative treatment had significantly higher SCC-Ag values than those with surgery only at diagnosis, while no difference existed after treatment. Conclusions: The Simoa SCC-Ag prototype was established for clinical settings. The SCC-Ag levels were higher in patients with risk factors, whereas the kinetic trend of SCC-Ag might be mainly affected by postoperative adjuvant therapy. These data indicate that the SCC-Ag level might be a good predictor for the status of cervical cancer, including disease aggressiveness and treatment response.

scholarly journals Evaluation of Pelvic Floor Muscle Function(PFMF) In Cervical Cancer Patients With Querleu-Morrow Type C Hysterectomy: A Multicenter Study

2021 ◽  
Author(s):  
Shiyan Wang ◽  
Hongwu Wen ◽  
Yunong Gao ◽  
Qiubo Lv ◽  
Hongyu Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Logistic Regression ◽  
Pelvic Floor ◽  
Cancer Patients ◽  
Muscle Function ◽  
Pelvic Floor Muscle ◽  
Fibre Strength ◽  
Independent Risk Factors

Abstract Introduction To evaluate the pelvic floor muscle function (PFMF) of cervical cancer patients after type QM-C hysterectomy and to explore the relationship between decreased PFMF and related factors..Methods This was a multi-centered retrospective cohort study. 181 cervical cancer patients who underwent type QM-C hysterectomy were enrolled from 9 tertiary hospitals. Strength of PFMF were measured by using neuromuscular apparatus (Phenix U8, French). Risk factors contributing to decreased PFMF were analyzed by univariate and multivariate ordinal ploytomous logistic regression. Results Totally 181 patients were investigated in this study. 0-3 level of type I muscle fibre strength(MFSI) was 52.6% (95/181), 0-3 level of type ⅡA muscle fibre strength(MFSⅡA) was 50% (91/181). Subjective stress urinary incontinence was 46%(84/181), urinary retention was 27.3% (50/181), dyschezia was 41.5% (75/181), fecal incontinence was 9%(18/181). ① MFSI：Multivariate ordinal ploytomous logistic regression shows that the follow-up time(p<0.05), chemotherapy and radiotherapy (p=0.038) are independent risk factors of MFSI’s reduction after type QM-C hysterectomy. ② MFSⅡA：Multivariate ordinal ploytomous logistic regression shows that the follow-up time (p<0.05) are independent risk factors of MFSⅡA’s reduction after type QM-C hysterectomy. The pelvic floor muscle strength (PFMS) increased after 9 months than in 9 months after operation, which showed that the PFMS could be recovered after operation. Conclusions We advocate for more attention and emphasis on the PFMF of Chinese female patients with cervical cancer postoperation.Contribution of the Paper PFMF after QM-C hysterectomy has not been analyzed by current study. The contribution is that patients with radical hysterectomy should do pelvic floor rehabilitation exercises in 3 months after operation.

scholarly journals Cardiovascular risk factors during cancer treatment: prevalence, incidence and prognostic relevance

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
J Caro Codon ◽  
T Lopez-Fernandez ◽  
C Alvarez-Ortega ◽  
P Zamora Aunon ◽  
I Rodriguez Rodriguez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Cancer Therapy ◽  
Cancer Patients ◽  
Individual Risk ◽  
Funding Source ◽  
Number Of Patients ◽  
All Cause Mortality

Abstract Background The actual usefulness of CV risk factor assessment in the prognostic evaluation of cancer patients treated with cardiotoxic treatment remains largely unknown. Design Prospective multicenter study in patients scheduled to receive anticancer therapy related with moderate/high cardiotoxic risk. Methods A total of 1324 patients underwent follow-up in a dedicated cardio-oncology clinic from April 2012 to October 2017. Special care was given to the identification and control of CV risk factors. Clinical data, blood samples and echocardiographic parameters were prospectively collected according to protocol, at baseline before cancer therapy and then at 3 weeks, 3 months, 6 months, 1 year, 1.5 years and 2 years after initiation of cancer therapy. Results At baseline, 893 patients (67.4%) presented at least 1 risk factor, with a significant number of patients newly diagnosed during follow-up. Individual risk factors were not related with worse prognosis during a 2-year follow-up. However, a higher Systemic Coronary Risk Estimation (SCORE) was significantly associated with higher rates of severe cardiotoxicity and all-cause mortality [HR 1.79 (95% CI 1.16–2.76) for SCORE 5–9 and HR 4.90 (95% CI 2.44–9.82) for SCORE ≥10 when compared with patients with lower SCORE (0–4)]. Conclusions This large cohort of patients treated with a potentially cardiotoxic regimen showed a significant prevalence of CV risk factors at baseline and significant incidence during follow-up. Baseline cardiovascular risk assessment using SCORE predicted severe cardiotoxicity and all-cause mortality. Therefore, its use should be recommended in the evaluation of cancer patients. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): This study was partially funded by the Fondo Investigaciones Sanitarias (Spain), Centro de Investigaciόn Biomédica en Red Cardiovascular CIBER-CV (Spain)

Comparison of the Prognoses of FIGO Stage I to Stage II Adenosquamous Carcinoma and Adenocarcinoma of the Uterine Cervix Treated With Radical Hysterectomy

2012 ◽  
Vol 22 (8) ◽  
pp. 1389-1397 ◽  
Author(s):  
Seiji Mabuchi ◽  
Mika Okazawa ◽  
Yasuto Kinose ◽  
Koji Matsuo ◽  
Masateru Fujiwara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
High Risk ◽  
Uterine Cervix ◽  
Radical Hysterectomy ◽  
Adenosquamous Carcinoma ◽  
Early Stage ◽  
Univariate Analysis ◽  
Low Risk ◽  
Histological Subtype

ObjectivesTo evaluate the significance of adenosquamous carcinoma (ASC) compared with adenocarcinoma (AC) in the survival of surgically treated early-stage cervical cancer.MethodsWe retrospectively reviewed the medical records of 163 patients with International Federation of Gynecology and Obstetrics stage IA2 to stage IIB cervical cancer who had been treated with radical hysterectomy with or without adjuvant radiotherapy between January 1998 and December 2008. The patients were classified according to the following: (1) histological subtype (ASC group or AC group) and (2) pathological risk factors (low-risk or intermediate/high-risk group). Survival was evaluated using the Kaplan-Meier method and compared using the log-rank test. Multivariate analysis of progression-free survival (PFS) was performed using the Cox proportional hazards regression model to investigate the prognostic significance of histological subtype.ResultsClinicopathological characteristics were similar between the ASC and AC histology groups. Patients with the ASC histology displayed a PFS rate similar to that of the patients with the AC histology in both the low-risk and intermediate/high-risk groups. Neither the recurrence rate nor the pattern of recurrence differed between the ASC group and the AC group. Univariate analysis revealed that patients with pelvic lymph node metastasis and parametrial invasion achieved significantly shorter PFS than those without these risk factors.ConclusionsCharacteristics of the patients and the tumors as well as survival outcomes of ASC were comparable to adenocarcinoma of early-stage uterine cervix treated with radical hysterectomy. Our results in part support that the management of ASC could be the same as the one of AC of the uterine cervix.

A registry-based study of follow-up failures in the screening experience of cervical cancer patients

1998 ◽  
Vol 8 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Amadori ◽  
Gentilini ◽  
Bucchi ◽  
Innocenti ◽  
Falcini ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients
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