scholarly journals The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Yu He ◽  
Feng Wang ◽  
Shiqiang Chen ◽  
Mi Liu ◽  
Wei Pan ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Neuroprotective Effect ◽  
Diabetic Rats ◽  
Control Group ◽  
Dependent Manner ◽  
Diabetic Encephalopathy ◽  
Diabetes Group ◽  
Group A ◽  
Group B ◽  
Kinase Expression

Currently there has been no effective treatment of diabetic encephalopathy. Radix Polygoni Multiflori, a famous traditional Chinese medicine, is widely used in antiaging treatment, especially in prevention and treatment of Alzheimer’s diseases. In this study we tried to explore the effect of Radix Polygoni Multiflori on cognitive function among diabetic rats with demonstrated cognitive impairment. SD rats were divided into group A (control group), group B (diabetes), group C (treated with Radix Polygoni Multiflori at the dose of 2 g/kg/d), and group D (treated with same drug at the dose of 1 g/kg/d). The results showed that 8 weeks of Radix Polygoni Multiflori treatment could improve the cognitive dysfunction of diabetic rats (P<0.01), recover the ultrastructure of hippocampal neurons, and increase the number of synapses in a dose-dependent manner. Further experiment also suggested that the neuroprotective effect of Radix Polygoni Multiflori was partly achieved by downregulating MLCK expression in hippocampus via ERK signaling.

scholarly journals Neuroprotective Effect of Grewia carpinifolia Extract against Vanadium Induced Behavioural Impairment

2016 ◽  
Vol 60 (4) ◽  
pp. 5-13 ◽  
Author(s):  
O. E. Adebiyi ◽  
J. O. Olopade ◽  
F. O. Olayemi
Keyword(s):  
Neuroprotective Effect ◽  
Ethanolic Extract ◽  
Control Group ◽  
Protective Agent ◽  
Central Nervous System Toxicity ◽  
Sodium Metavanadate ◽  
Latent Time ◽  
Group A ◽  
Vanadium Toxicity ◽  
Group B

Abstract Vanadium (V), a heavy metal, has been reported to induce central nervous system toxicity leading to various behavioural impairments. It is characterized by the production of reactive oxygen. The present study was designed to test the possibility of Grewia carpinifolia ethanolic extract in preventing behavioural alterations following acute vanadium toxicity in mice. Twenty five Swiss albino mice (25—27 g) were completely randomized into 5 groups (A—E) of 5 animals each. Group A received distilled water and served as a control; group B, received vitamin E (500 mg.kg−1 b. w. every 72 hours), a known antioxidant orally, along with a daily dose of sodium metavanadate intraperitoneally (i. p.) for 7 days; group C and group D received Grewia carpinifolia leaf extract at 100 and 200 mg.kg−1 b.w orally respectively, along with the sodium metavanadate i. p. for 7 days; while group E received sodium metavanadate i. p. only for 7 days. The behavioural and motor functions were analysed by the open field, negative geotaxis, and hanging wire tests; the daily body and brain weights were recorded. Grewia carpinifolia ethanolic extracts significantly reduced the number of grooming, stretched attend posture, and freezing time that were significantly increased in the vanadium only group and also enhanced the vestibular functions. In addition, the latent time spent on the hanging wire in groups simultaneously administered with the extract and V compared favourably (P > 0.05) with the control groups but a decrease in latent time was observed in the V only group. The results suggest that acute V toxicity results in various behavioural deficits and support a possible role of Grewia carpinifolia as a protective agent against acute vanadium-toxicity with a better result at 200 mg.kg−1 b. w.

scholarly journals Protective effect of LIF-huMSCs on the retina of diabetic model rats

2021 ◽  
Vol 14 (10) ◽  
pp. 1508-1517
Author(s):  
Shan-Na Chen ◽  
◽  
Ying-Xue Ma ◽  
Song Chen ◽  
Guang-Hui He ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Control Group ◽  
Diabetic Model ◽  
Group A ◽  
Retinal Structure ◽  
Hs Crp ◽  
Group B ◽  
And Function ◽  
Group D ◽  
Control Group Group

AIM: To investigate the protective effect of human umbilical cord mesenchymal stem cells (hUCMSCs) modified by the LIF gene on the retinal function of diabetic model rats and preliminarily explore the possible mechanism. METHODS: A stably transfected cell line of hUCMSCs overexpressing leukemia inhibitory factor (LIF) was constructed. Overexpression was verified by fluorescent quantitative polymerase chain reaction (qPCR). Forty-eight adult Sprague-Dawley rats were randomly divided into a normal control group (group A), streptozotocin-induced diabetic control group (group B), diabetic rats at 3mo injected with empty vector-transfected hUCMSCs (group C) or injected with LIF-hUCMSCs (group D). Four weeks after the intravitreal injection, analyses in all groups included retinal function using flash electroretinogram (F-ERG), retinal blood vessel examination of retinal flat mounts perfused with fluorescein isothiocyanate-dextran (FITC-dextran), and retinal structure examination of sections using hematoxylin and eosin staining. Expression levels of adiponectin (APN), high-sensitivity C-reactive protein (hs-CRP), and neurotrophin-4 (NT-4) in each group was detected using immunohistochemistry, PCR, Western blotting, and ELISA, respectively. RESULTS: A stable transgenic cell line of LIF-hUCMSCs was constructed. F-ERG and FITC-dextran examinations revealed no abnormalities of retinal structure and function in group A, severe damage of the retinal blood vessels and function in group B, and improved retinal structure and function in group C and especially group D. qPCR, ELISA, and Western blot analyses revealed progressively higher APN and NT-4 expression levels in groups B, C, and D than in group A. hs-CRP expression was significantly higher in group B than in groups A, C, and D, and was significantly higher in group C than in group D (P<0.05). CONCLUSION: LIF-hUCMSCs protect the retina of diabetic rats by upregulating APN and NT-4 expression and downregulating hs-CRP expression in the retina.

scholarly journals Effect of Fenugreek (Methi) on the Thymic volume in Streptozotocin-induced Diabetic Rats

1970 ◽  
Vol 16 (1) ◽  
pp. 1-4
Author(s):  
DK Mondal ◽  
MM Karim ◽  
S Mohal ◽  
BMA Yousuf ◽  
KM Shamim
Keyword(s):  
Body Weight ◽  
Treated Group ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Control Group ◽  
Final Body Weight ◽  
Diabetic Control Group ◽  
Group A ◽  
Group B

Effect of fenugreek (Trigonella foenumgraecum) on thymic volume was studied in 30 long Evansrats. Among the total, 10 were treated with only vehicle (non-diabetic control - group A); 10 weretreated with streptozotocin only (diabetic control - group B) and 10 were treated with fenugreek(fenugreek treated - group C). Mean relative thymic volumes were 0.22210.018 ml/100 gm ofcorresponding final body weight (Mean 1 SEM), 0.14710.015 and 0.19910.020 in group A, B and Crespectively. In non-diabetic control group the thymic volume was significantly higher (p=0.005)than that of diabetic control group. In fenugreek treated diabetic group the volume was alsosignificantly higher (p=0.05) from that of diabetic control group and very much nearer to nondiabeticcontrol group (p=0.398). Fenugreek may preserve the thymic volume considerably indiabetic rats.doi: 10.3329/taj.v16i1.3892TAJ June 2003; Vol.16(1): 1-4

scholarly journals Effects of Consuming Different Varieties of Bambara Nut (Vigna subterranea) Seeds on Liver and Kidney of Diabetic and Non-diabetic Subject

2021 ◽  
pp. 25-35
Author(s):  
Abdulrashid Mohammed ◽  
Daniel Hassan Mhya
Keyword(s):  
Biological Effects ◽  
Diabetic Rats ◽  
Diabetic Subject ◽  
Dietary Therapy ◽  
Dependent Manner ◽  
High Fiber ◽  
Plant Seeds ◽  
Liver And Kidney ◽  
Group A ◽  
Group B

Aims: Bambara nut seeds have been reported as a good source of food with high fiber and nutritional contents, and is consumed by persons with diabetes as one of the dietary therapy. However, the plant seeds are of different varieties and whether they might have vary biological effects on renal and liver functions is not fully known. This has prompted the study to evaluate effects of consuming different varieties of Bambara Nut seeds on liver and kidney of both diabetic and non-diabetic rats. Methodology: Four Bambara nut seeds varieties were dehulled and each heated at 60oC, cooled then grounded into flour using a mechanical grinder. The flours were used to formulate feeds which were given to different diabetic and non-diabetic rats’ groups as follows; group A (ALK01 feed), group B (ALK02 feed), group C (ALK03 feed), group D (ALK04 feed), group E (Basal feed), and group F (Normal animal’s feed). The animals were fed for 28 days then sacrifice, blood collected and serum separated and used for hepatic and renal parameters analysis. Results: The results of the study showed decrease levels of serum total protein and albumin, and elevation of AST and ALT activities as well as urea and creatinine concentrations in diabetic rats fed basal and normal diets, whereas, reverse in these parameters were recorded from diabetic rats fed varieties of Bambara nut seeds’ formulated feeds.  Conclusion: Findings from the study suggest consumption of Bambara nut seeds of different varieties is safe and has ability to ameliorate diabetic hepatic and renal failure in a variety dependent manner where; ALK 04 is more likely the most effective.

scholarly journals Effect of Consuming Different Varieties of Bambara Groundnut (Vigna subterranea) Seeds on Glycaemia and Lipid Profile of Diabetic and Non-Diabetic Rats

2021 ◽  
Vol 11 (5-S) ◽  
pp. 6-12
Author(s):  
Daniel Hassan Mhya ◽  
Abdulrashid Mohammed
Keyword(s):  
Lipid Profile ◽  
Diabetic Rats ◽  
Bambara Groundnut ◽  
Dietary Therapy ◽  
Diabetic Patients ◽  
Dependent Manner ◽  
Plant Seed ◽  
Continuous Increase ◽  
Group A ◽  
Group B

Background: Bambara groundnut seed is reported to possess high fibre and good nutritional content, and is locally used as a daily dietary therapy by diabetic patients in northern Nigeria. The plant seeds are of different varieties and whether the antidiabetic effect may vary with the varieties is largely unknown. This has prompted the current study to investigate effect of consuming different varieties of Bambara groundnut seeds on glycaemia and lipid profile of diabetic and non-diabetic rats. Materials and Methods: Bambara groundnut seed’s varieties were processed into flour and use in formulating feeds which were given to diabetic and non-diabetic rats as follows; group A (ALK01 feed), group B (ALK02 feed), group C (ALK03 feed), group D (ALK04 feed), group E (Basal feed), and group F (Normal animal’s feed) for 28 days during which blood glucose and weights were measured weekly while lipid profile was assayed at the end of the study. Results: The result of the study showed continuous increase in glycemic levels for diabetic rats fed basal and normal feeds compared to those fed plant seed formulated feeds. While, glycemic levels for non-diabetic rats fed plant seed formulated feeds, normal or basal feeds remain within normal range. The lipid components of diabetic rats fed basal and normal feeds were elevated and are significantly different (P<.05) from those fed plant seed formulated feeds. Conclusion: The study concluded that consumption of different varieties of Bambara groundnut seed could ameliorate hyperglycemia and hyperlipidemia by a variety dependent manner.  Keywords:  Bambara groundnut, seed varieties, effect, glycaemia, lipid profile, rats

Histomorphometric Alterations in Hepatic Tissue from Malathion-Induced Toxicity: An Experimental Animal Study

2021 ◽  
Vol 10 (1) ◽  
pp. 370-375
Author(s):  
Shazia Parveen Channar ◽  
Nasreen Qazi ◽  
Sajjad Ali Almani ◽  
Sehar Gul Memon ◽  
Mansoor Mukhtar Qazi ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
The Body ◽  
Hepatic Tissue ◽  
Control Group ◽  
High Dose ◽  
Dependent Manner ◽  
Histopathological Changes ◽  
Group A ◽  
Group B

Background: Malathion, a widely used insecticide readily absorbed through skin and seriously affects different tissues and organs of the body. The main objective of this study was to compare the histomorphometric alterations resulting from hazardous effects of different doses of Malathion on hepatic tissue of male albino Wistar rats. Material and Methods: This animal experimental study was conducted at the Department of Anatomy and Postgraduate Research Laboratory at the Isra University, Hyderabad, Sindh Pakistan from February to July 2019. Thirty male albino Wistar rats between 250-300 grams weight were distributed equally into group A (control), group B (low-dose Malathion group; 27mg/kg 1/50 of LD50), and group C (high-dose Malathion group; 50mg/kg). Bodyweight of all rats was taken twice, before and after the experiment. The liver was dissected out, washed and weighed. Histopathological examination was done under the light microscope. Grading was done for severity in histopathological changes in each group. Data was analyzed using one-way ANOVA and Post-hoc Tukey test for comparison with the level of significance set at P-value ≤ .05. Results: Statistically significant (P < .05) decline in body weight was observed in groups B and C in comparison with group A. The relative weight of the liver was increased significantly (P < .05) in the experimental groups, when compared with the control group. Mild-to-moderate histopathological changes were observed in the low-dose Malathion group (Group B) while moderate-to-severe histopathological changes were demonstrated in the high-dose group (Group C). Conclusions: Malathion is a potent toxic pesticide and its exposure can exhibit damage to the hepatic tissues in a dose-dependent manner.

Clinical effect of Suvarna Bindu Prashan

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Patil Aniket ◽  
Dindore Pallavi ◽  
Arbar Aziz ◽  
Kadam Avinash ◽  
Saroch Vikas
Keyword(s):  
Physical Health ◽  
Eating Habits ◽  
Control Group ◽  
Inform Consent ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Immune Booster ◽  
Mental And Physical Health ◽  
Apparently Healthy

The quest for excellence in mental and physical health is not new. We find various references and formulations in Ayurvedic classics meant for promoting mental and physical health of a child. Suvarna Prashan is one of the formulations explained in age old Ayurvedic classic Kashyap Samhita. This formulation is very widely used now days as a memory and immune booster for children. But there is very little systematic documented study which can be used to evaluate the efficacy of the formulation. Suvarna Bhasma was prepared in Ayurved Rasayani Pharmacy, Pune. Madhu and Ghrita were collected from KLE Ayurveda Pharmacy, Belgaum. Suvarna Bindu Prashan was prepared in KLE Ayurved pharmacy, Belgaum. It contains Suvarna Bhasma, Ghrita and Madhu. Twenty apparently healthy male and female children with age group of three to four years were ready to sign inform consent form were selected into two groups each. Subjects in Group A received Suvarna Bindu Prashan where as Group B (Control group) did not receive any treatment. Both the groups were observed for six months. Children in Suvarna Bindu Prashan group showed significant reduction in the scores of eating habits, behavior, mood, temperament and scores of event of illness. However there was no significant difference in the score of sleeping habit. There was significant increase in IQ percentage.

scholarly journals Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yong Hoon Kim ◽  
Ae-Young Her ◽  
Myung Ho Jeong ◽  
Byeong-Keuk Kim ◽  
Sung-Jin Hong ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Clinical Outcomes ◽  
Secondary Outcome ◽  
Drug Eluting Stent ◽  
Diabetes Group ◽  
Repeat Revascularization ◽  
Group A ◽  
Group B ◽  
Diabetes Patients

AbstractWe investigated the effects of stent generation on 2-year clinical outcomes between prediabetes and diabetes patients after acute myocardial infarction (AMI). A total of 13,895 AMI patients were classified into normoglycemia (group A: 3673), prediabetes (group B: 5205), and diabetes (group C: 5017). Thereafter, all three groups were further divided into first-generation (1G)-drug-eluting stent (DES) and second-generation (2G)-DES groups. Patient-oriented composite outcomes (POCOs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any repeat revascularization were the primary outcome. Stent thrombosis (ST) was the secondary outcome. In both prediabetes and diabetes groups, the cumulative incidences of POCOs, any repeat revascularization, and ST were higher in the 1G-DES than that in the 2G-DES. In the diabetes group, all-cause death and cardiac death rates were higher in the 1G-DES than that in the 2G-DES. In both stent generations, the cumulative incidence of POCOs was similar between the prediabetes and diabetes groups. However, in the 2G-DES group, the cumulative incidences of Re-MI and all-cause death or MI were significantly higher in the diabetes group than that in the prediabetes group. To conclude, 2G-DES was more effective than 1G-DES in reducing the primary and secondary outcomes for both prediabetes and diabetes groups.

scholarly journals Microecological preparation combined with an modified low-carbon diet improves glucolipid metabolism and cardiovascular complication in obese patients

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jianguo Liu ◽  
Liehui Xiao ◽  
Hezhongrong Nie ◽  
Yong Pan ◽  
Yan Liu ◽  
...  
Keyword(s):  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Control Group ◽  
Obese Patients ◽  
Carotid Atherosclerotic Plaque ◽  
Low Carbon ◽  
Balanced Diet ◽  
Group A ◽  
Group B ◽  
Control Group Group

Abstract Objective To investigate the impact of microecological preparation combined with modified low-carbon diet on the glucolipid metabolism and cardiovascular complication in obese patients. Methods From August 2017 to July 2020, 66 obese patients were recruited, and administrated with an modified low-carbon diet with (group A) or without (Group B) microecology preparation and a balanced diet in control group (group C) for 6 months. Meanwhile, 20 volunteers administrated with a balanced diet were recruited as the healthy control group (group D). Results After 6-month intervention, obese subjects in group A and B showed significant improvement of body and liver fat mass, reduction of serum lipid levels, intestinal barrier function markers, insulin resistance index (IRI), high blood pressure (HBP) and carotid intima thickness, as compared with subjects in group C. More importantly, subjects in group A had better improvement of vascular endothelial elasticity and intimal thickness than subjects in group B. However, these intervention had no effect on carotid atherosclerotic plaque. Conclusion Administration of microecological preparation combined with modified low-carbon diet had better improvement of intestinal barrier function, glucose and lipid metabolism, and cardiovascular complications than low-carbon diet in obese patients, but the effect of a simple low-carb diet on carotid atherosclerotic plaque need to be further addressed.

scholarly journals Effects of different thermal insulation methods on the nasopharyngeal temperature in patients undergoing laparoscopic hysterectomy: a prospective randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Guanyu Yang ◽  
Zefei Zhu ◽  
Hongyu Zheng ◽  
Shifeng He ◽  
Wanyue Zhang ◽  
...  
Keyword(s):  
Thermal Insulation ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Laparoscopic Hysterectomy ◽  
Control Group ◽  
Prospective Randomized Controlled Trial ◽  
Warming Blanket ◽  
Group A ◽  
Insulation Effect ◽  
Group B

Abstract Background This study explored the comparison of the thermal insulation effect of incubator to infusion thermometer in laparoscopic hysterectomy. Methods We assigned 75 patients enrolled in the study randomly to three groups: Group A: Used warming blanket; group B: Used warming blanket and infusion thermometer; group C: Used warming blanket and incubator. The nasopharyngeal temperature at different time points during the operation served as the primary outcome. Results The nasopharyngeal temperature of the infusion heating group was significantly higher than that of the incubator group 60 min from the beginning of surgery (T3): 36.10 ± 0.20 vs 35.81 ± 0.20 (P<0.001)90 min from the beginning of surgery (T4): 36.35 ± 0.20 vs 35.85 ± 0.17 (P<0.001). Besides, the nasopharyngeal temperature of the incubator group was significantly higher compared to that of the control group 60 min from the beginning of surgery (T3): 35.81 ± 0.20 vs 35.62 ± 0.18 (P<0.001); 90 min from the beginning of surgery (T4): 35.85 ± 0.17 vs 35.60 ± 0.17 (P<0.001). Regarding the wake-up time, that of the control group was significantly higher compared to the infusion heating group: 24 ± 4 vs 21 ± 4 (P = 0.004) and the incubator group: 24 ± 4 vs 22 ± 4 (P = 0.035). Conclusion Warming blanket (38 °C) combined infusion thermometer (37 °C) provides better perioperative thermal insulation. Hospitals without an infusion thermometer can opt for an incubator as a substitute. Trial registration This trial was registered with ChiCTR2000039162, 20 October 2020.

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