scholarly journals Association between Portal Vein Thrombosis and Survival in Non-Liver-Transplant Patients with Liver Cirrhosis: A Systematic Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Xingshun Qi ◽  
Junna Dai ◽  
Man Yang ◽  
Weirong Ren ◽  
Jia Jia ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Cirrhosis ◽  
Portal Vein ◽  
Liver Transplant ◽  
Portal Vein Thrombosis ◽  
Cochrane Library ◽  
Review Of The Literature ◽  
Vein Thrombosis ◽  
Transplant Patients ◽  
Overall Mortality

A systematic review of the literature was performed to analyze the association between portal vein thrombosis (PVT) and survival in non-liver-transplant patients with liver cirrhosis. PubMed, EMBASE, and Cochrane Library databases were searched for all relevant papers which evaluated the prognostic value of PVT in predicting the survival of liver cirrhosis. Meta-analyses were not conducted because the ways of data expression and lengths of follow-up were heterogeneous among studies. Overall, 13 papers were included. The 5-day, 6-week, and 1-year mortality were investigated in 1, 3, and 1 studies, respectively; and all of them were not significantly different between cirrhotic patient with and without PVT. By comparison, the 3-year mortality was reported in 1 study; and it was significantly increased by the presence of PVT. The overall mortality was analyzed in 5 studies; and the association with overall mortality and PVT was significant in 4 studies, but not in another one. However, as for the cirrhotic patients undergoing surgical or interventional shunts, the overall mortality was not significantly associated with the presence of PVT in 4 studies. In conclusion, the presence of PVT might be associated with the long-term mortality in non-liver-transplant patients with liver cirrhosis, but not with the short-term mortality.

scholarly journals Safety and Efficacy of Anticoagulation in Patients with Cirrhosis: A Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-20
Author(s):  
Huan Chen ◽  
Jiaming Lei ◽  
Sicheng Liang ◽  
Gang Luo ◽  
Mingming Deng ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Adverse Events ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Anticoagulant Therapy ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Control Group ◽  
Safety And Efficacy ◽  
Vein Thrombosis

Background and Aims. Portal vein thrombosis is a serious adverse event that occurs during liver cirrhosis. We performed a meta-analysis to evaluate the safety and efficacy of anticoagulant therapy and prophylactic anticoagulant therapy in cirrhosis patients with (/without) portal vein thrombosis. Methods. Eligible comparative studies were identified by searching the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, and CNKI. A meta-analysis was performed to calculate odds ratios and 95% confidence intervals using fixed-effects models. Recanalization and thrombus progression were defined as the primary outcomes. Secondary outcomes included adverse events and death mortality. Results. A total of 3479 patients were included in this analysis. Compared with the control group, the recanalization rate in the anticoagulant therapy group was increased P < 0.00001 in patients with cirrhosis and portal vein thrombosis without increasing adverse events. Multiple use of enoxaparin in small doses is safer than single large doses P = 0.004 . Direct oral anticoagulants are more effective P < 0.00001 and safer than traditional anticoagulants. Prophylactic anticoagulant therapy can effectively prevent portal vein thrombosis formation P < 0.00001 . Conclusions. Anticoagulation therapy can treat or prevent portal vein thrombosis in patients with liver cirrhosis and is a relatively safe treatment.

scholarly journals The role of TIPS for portal vein patency in liver transplant patients with portal vein thrombosis

2006 ◽  
Vol 12 (10) ◽  
pp. 1544-1551 ◽  
Author(s):  
Jason Bauer ◽  
Stephen Johnson ◽  
Janette Durham ◽  
Michael Ludkowski ◽  
James Trotter ◽  
...  
Keyword(s):  
Portal Vein ◽  
Liver Transplant ◽  
Portal Vein Thrombosis ◽  
Vein Thrombosis ◽  
Transplant Patients

scholarly journals Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic Review

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Geneviève Huard ◽  
Marc Bilodeau
Keyword(s):  
Systematic Review ◽  
Liver Cirrhosis ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Current Knowledge ◽  
Vein Thrombosis ◽  
Advantages And Disadvantages ◽  
Risk Of Bleeding ◽  
Coagulation Abnormalities ◽  
Increased Risk

Non-neoplastic portal vein thrombosis (PVT) is an increasingly recognized complication of liver cirrhosis. It is often diagnosed fortuitously and can be either partial or complete. The clinical significance of PVT is not obvious except in some situations such as when patients are on the waiting list for liver transplantation. The only known therapy is anticoagulation which has been shown to permit the disappearance of thrombosis and to prevent further extension. Anticoagulation is a challenging therapy in individuals with liver cirrhosis because of the well-recognized coagulation abnormalities observed in that setting and because of the increased risk of bleeding, especially from gastrointestinal tract caused by portal hypertension. We herein review the current knowledge on that topic in order to highlight the advantages and disadvantages of the currently proposed therapeutic attitudes in face of the diagnosis of PVT in individuals with cirrhosis.

Nonselective beta-blockers and development of portal vein thrombosis in liver cirrhosis: a systematic review and meta-analysis

2019 ◽  
Vol 13 (4) ◽  
pp. 468-481 ◽  
Author(s):  
Xiangbo Xu ◽  
Xiaozhong Guo ◽  
Valerio De Stefano ◽  
Gilberto Silva-Junior ◽  
Hemant Goyal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Cirrhosis ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Beta Blockers ◽  
Meta Analysis ◽  
Vein Thrombosis

Postoperative Anticoagulants in Preventing Portal Vein Thrombosis in Patients Undergoing Splenectomy Because of Liver Cirrhosis: A Meta-Analysis

2016 ◽  
Vol 82 (12) ◽  
pp. 1169-1177 ◽  
Author(s):  
Jian-Ying Zhang ◽  
Yun-Bing Wang ◽  
Jian-Ping Gong ◽  
Fan Zhang ◽  
Yong Zhao
Keyword(s):  
Adverse Reaction ◽  
Liver Cirrhosis ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Fixed Effects Model ◽  
Case Control Studies ◽  
Vein Thrombosis

Portal vein thrombosis (PVT) frequently occurs in patients undergoing splenectomy because of liver cirrhosis. Whether the use of postoperative anticoagulants can decrease the incidence of PVT in these subjects is inconclusive. Moreover, the safety of the use of postoperative anticoagulants in the aforementioned patients is a concern. This meta-analysis aims to explore the effectiveness and safety of the preventive anticoagulants to prevent PVT in patients undergoing splenectomy because of liver cirrhosis. Four English language databases (i.e., PubMed, Embase, Cochrane Library, and Web of Science) and four Chinese language databases (i.e., Wanfang, CNKI, Cqvip, and CBM) were searched for randomized controlled trials, cohort studies, and case-control studies on the use of preventive anticoagulants to prevent PVT in patients undergoing splenectomy because of liver cirrhosis from their inception to September 15, 2015. The primary outcome was postoperative PVT incidence. The secondary outcomes included postoperative complications and adverse reaction. Study-specific odds ratios were combined to calculate pooled value through a fixed effects model. A total of 17 original studies were included, involving 1,497 patients. This meta-analysis showed that the preventive anticoagulant group had a lower incidence of PVT than the no anticoagulant group (odds ratio, 0.31; 95% confidence interval, 0.23–0.40; P < 0.05). According to the description of limited studies, the upper gastrointestinal hemorrhage mainly occurred in the no anticoagulant group. Meanwhile, the adverse reaction was trivial in the group using anticoagulants, which could easily be released with no special management. Postoperative anticoagulants can effectively decrease PVT incidence in subjects undergoing splenectomy because of liver cirrhosis. These published studies are more prone to show that no serious negative influence of anticoagulants exists in the aspect of safety. However, further studies are still needed.

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