scholarly journals Betatrophin Acts as a Diagnostic Biomarker in Type 2 Diabetes Mellitus and Is Negatively Associated with HDL-Cholesterol

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Min Yi ◽  
Rong-ping Chen ◽  
Rui Yang ◽  
Xian-feng Guo ◽  
Jia-chun Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Roc Curve ◽  
Diagnostic Value ◽  
Curve Analysis ◽  
Newly Diagnosed ◽  
Diagnostic Biomarker ◽  
Roc Curve Analysis

Objective. By assessing its circulating concentrations in type 2 diabetes mellitus (T2DM) patients, we aimed to explore the associations of betatrophin with various metabolic parameters and evaluate its diagnostic value in T2DM.Methods. A total of 58 non-diabetes-mellitus (NDM) subjects and 73 age- and sex-matched newly diagnosed T2DM patients were enrolled. Correlation analyses between circulating betatrophin levels and multiple metabolic parameters were performed. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic value of betatrophin concentration in T2DM.Results. Circulating betatrophin levels were approximately 1.8 times higher in T2DM patients than in NDM individuals (median 747.12 versus 407.41 pg/mL,P<0.001). Correlation analysis showed that betatrophin was negatively associated with high-density lipoprotein cholesterol (HDL-C) levels in all subjects. ROC curve analysis identified betatrophin as a potent diagnostic biomarker for T2DM. The optimal cut-off point of betatrophin concentration for predicting T2DM was 501.23 pg/mL.Conclusions. Serum betatrophin levels were markedly increased in newly diagnosed T2DM patients and further elevated in obese T2DM subjects. Betatrophin was negatively correlated with HDL-C levels. Our findings indicate that betatrophin could be a potent diagnostic biomarker for T2DM.

scholarly journals Anthropometric indices as predictors of 10-year cardiovascular risk among Sub-Sahara Africans with type 2 diabetes

2021 ◽  
Vol 8 (4) ◽  
pp. 072-078
Author(s):  
TA Azeez
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Risk ◽  
Curve Analysis ◽  
Roc Curve Analysis ◽  
Anthropometric Indices

Background: Body mass index, waist circumference, waist-hip ratio and waist-height ratio are simple clinical tools for determining obesity. Type 2 diabetes mellitus is often associated with multiple cardiovascular risk factors and increased cardiovascular death. The study was aimed at determining the relationship between these anthropometric indices and 10-year cardiovascular risk among sub-saharan Africans with type 2 diabetes mellitus. Methods: It was a cross-sectional study involving 67 adults (with 50.7% females) managed for type 2 diabetes mellitus in a referral hospital in Nigeria. Ethical approval was obtained at the institution review board and the participants also gave written consent. Anthropometric indices were determined using standard protocols. Fasting lipid profile, fasting plasma glucose, glycated haemoglobin and plasma creatinine were assayed using standard laboratory techniques. Atherogenic index of plasma, estimated glomerular filtration rate and the WHO-ISH cardiovascular risk score were also determined. Data was analyzed with SPSS version 22. Pearson correlation coefficient, Students’ t test, Chi square test, ROC curve analysis were performed as appropriate. Results: The mean age was 54.12±9.03 years. Obesity was found in 37.3%, 66.5%, 70.1% and 95.5% of the participants using BMI, WHR, WC and WHtR respectively. Intermediate/high cardiovascular risk was found in 38.2% and 24.2% of the males and females respectively. BMI and WC significantly correlated with blood pressure. There was no significant correlation between anthropometric indices and other cardiovascular risk factors studied. Using ROC curve analysis, BMI and WHtR had the highest AUC of 0.613 and 0.577 respectively. Conclusion: Among sub-sahara Africans with type 2 diabetes mellitus, there is a significant association between WC and BMI with the blood pressure. BMI and WHtR have the highest 10-year cardiovascular risk predictability among the anthropometric indices in this cohort of individuals. Larger and prospective studies are needed to validate these findings.

scholarly journals Total Protein to Creatinine Ratio as an Alternative to Albumin to Creatinine Ratio To Predict Microalbuminuria In Type 2 Diabetes Mellitus

2019 ◽  
Vol 9 (2) ◽  
pp. 36-41
Author(s):  
Kabita Khaniya Pokharel ◽  
Santosh Pradhan ◽  
Sweta Shrestha
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Total Protein ◽  
Curve Analysis ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Roc Curve Analysis ◽  
Cutoff Value

Background: Diabetic nephropathy is the most common complication of diabetes mellitus. Early detection of microalbumin in urine plays an im­portant role in preventing the progression to late stages of chronic kidney disease. For a country like Nepal, the cost of assessment of microalbumin in urine is unaffordable by many patients for regular monitoring. Total pro­tein to creatinine ratio (TPCR) might be a cheaper alternative for this. This study assessed the feasibility of using TPCR as an alternative method for predicting microalbuminuria in diabetic patients. Methods: Type 2 Diabetic patients with age ranging 30-80 years were in­cluded in the study after ethical clearance. Urinary total protein was deter­mined by pyrogallol red method and urinary creatinine by Jaffe’s method. Urine for microalbumin was determined by nephelometry. Relationships between variables were examined by Pearson correlation or Spearman’s correlation analysis as appropriate. Receiver operating characteristic (ROC) curve analysis was performed to obtain the cutoff value of TPCR for detection of albuminuria Results: The mean age of the study population was 55.9 ± 11.8 years. There was significant positive correlation between TPCR and urine albu­min (ρ = 0.56; p <0.01) and between TPCR and ACR (ρ = 0.47; p < 0.01). The regression equation for TPCR and ACR was, ACR = 0.82 TPCR = 70.5, r2 = 0.88. ROC curve analysis showed that the urine TPCR had a sensitivity and specificity of 76% and 58% respectively, for the detection of albuminuria with a cutoff value of 95 mg/g(AUC=0.74, p < 0.01). Conclusions: TPCR might be the cheaper alternative for the prediction of microalbuminuria in patients with type 2 diabetes mellitus.

scholarly journals Clinical Applications of Adiponectin Measurements in Type 2 Diabetes Mellitus: Screening, Diagnosis, and Marker of Diabetes Control

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Nabila A. Abdella ◽  
Olusegun A. Mojiminiyi
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Roc Curve ◽  
Diabetes Control ◽  
Undiagnosed Diabetes ◽  
Protective Effects ◽  
Roc Curve Analysis

Background. Adipose tissue-derived adiponectin has pleiotropic protective effects with suppression of inflammatory and metabolic derangements that may result in insulin resistance, metabolic syndrome, type 2 diabetes mellitus (T2DM), and cardiovascular disease. The aim of this study was to evaluate adiponectin as a diagnostic marker of T2DM and diabetes control.Methods. Fasting adiponectin, insulin, glucose, and HbA1c were determined in 376 patients with known T2DM and 575 subjects with undiagnosed diabetes but with family history of T2DM. Clinical and anthropometric data were recorded. Subjects were classified on the basis of degree of adiposity, insulin resistance (IR), and achievement of target HbA1c levels. Receiver operating characteristic (ROC) curve analysis was used to examine the diagnostic performance for undiagnosed DM.Results. In undiagnosed subjects, adiponectin was significantly lower in subjects with IR and diabetic subjects compared with those without. The area under the adiponectin ROC curve for diagnosis of DM was 0.740. In known T2DM subjects, those with good control had significantly higher adiponectin (8.6 versus 7.4 μg/mL) compared to subjects with poor control.Conclusions. Adiponectin levels are associated with better glycemic control and could be a useful adjunct for screening for IR and T2DM. Therapeutic measures that increase adiponectin levels might be valuable targets for improving diabetes control and decreasing complications.

Circulating Netrin-1 as a Novel Biomarker for Impaired Fasting Glucose and Newly Diagnosed Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1535-P ◽  
Author(s):  
HYE-IN JUNG ◽  
JAEHYUN BAE ◽  
EUGENE HAN ◽  
GYURI KIM ◽  
JI-YEON LEE ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Newly Diagnosed

scholarly journals Effect of Sitagliptin on Serum Irisin Levels in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

2021 ◽  
Vol 12 (4) ◽  
pp. 1029-1039
Author(s):  
Qiu Wang ◽  
Lirong Ma ◽  
Yuanying Zhang ◽  
Lin Zhang ◽  
Yu An ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Newly Diagnosed
Sign in / Sign up

Export Citation Format

Share Document