scholarly journals Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid

2015 ◽  
Vol 2015 ◽  
pp. 1-9
Author(s):  
Plumelle Yves ◽  
Michel Stephane ◽  
Banydeen Rishika ◽  
Delaunay Christine ◽  
Panelatti Gérard
Keyword(s):  
Valproic Acid ◽  
T Cell ◽  
Prognostic Significance ◽  
Total Duration ◽  
Skin Lesions ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Long Survival ◽  
Adult T Cell Leukemia ◽  
Beneficial Role

We describe the clinical and biological features of ten patients with a survival superior to ten years (long survival), out of 175 patients diagnosed with Adult T-cell Leukemia/Lymphoma (ATL) in Martinique (1983–2013). There were 5 lymphoma and 5 chronic subtypes. Five of them (3 chronic, 2 lymphoma) had been treated with valproic acid (VA) for neurological disorders developed before or after ATL diagnosis, suggesting a beneficial role for VA as a histone deacetylase inhibitor (HDI) in ATL treatment. Total duration of uninterrupted VA treatment ranged from 8 to 37 years. Overall, the 175 incident ATL cases presented with a median survival of 5.43 months. The five VA-treated (VA+) patients presented with longer survival compared to VA treatment-free patients (VA−). For chronic subtypes, survival periods were of 213 months for 3 VA+ patients and of 33 months for 11 VA− patients (p=0.023). For lymphoma subtypes, survival periods were of 144 months for 2 VA+ patients versus 6 months for 49 VA− patients (p=0.0046). ATL cases with skin lesions, particularly lymphoma subtypes, had a longer survival (13.96 months) compared to those without skin lesions (6.06 months, p=0.002). Eight out of the 10 patients presenting with long survival had skin lesions.

scholarly journals Prognostic significance of the proportion of Ki-67-positive cells in adult t-cell leukemia

Cancer ◽  
1991 ◽  
Vol 67 (10) ◽  
pp. 2605-2609 ◽  
Author(s):  
Yasuaki Yamada ◽  
Ken Murata ◽  
Sunao Atogami ◽  
Kunihiro Tsukasaki ◽  
Hisashi Sohda ◽  
...  
Keyword(s):  
T Cell ◽  
Prognostic Significance ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Ki 67 ◽  
Adult T Cell Leukemia

Scabies superimposed on skin lesions of adult T-cell leukemia/lymphoma: case report and literature review

2008 ◽  
Vol 47 (11) ◽  
pp. 1168-1171 ◽  
Author(s):  
Rieko Kabashima ◽  
Kenji Kabashima ◽  
Ryosuke Hino ◽  
Takatoshi Shimauchi ◽  
Yoshiki Tokura
Keyword(s):  
Case Report ◽  
T Cell ◽  
Literature Review ◽  
Skin Lesions ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals Adult T-cell leukemia/lymphoma: report of two cases

2008 ◽  
Vol 41 (3) ◽  
pp. 288-292 ◽  
Author(s):  
Ricardo Aparecido Olivo ◽  
Fabrício Frederico Mendes Martins ◽  
Sheila Soares ◽  
Helio Moraes-Souza
Keyword(s):  
T Cell ◽  
Clinical Laboratory ◽  
Skin Lesions ◽  
Type I ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Laboratory Findings ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
Disease Case

Adult T-cell leukemia/lymphoma is a lymphoproliferative disorder of mature T lymphocytes associated with infection with human T-cell lymphotrophic virus type I (HTLV-I). Adult T-cell leukemia/lymphoma is characterized by clinical and laboratory polymorphism that allows it to be classified into four distinct subgroups: smoldering, chronic, acute and lymphomatous types. We present here two cases of adult T-cell leukemia/lymphoma, respectively in the acute and lymphomatous forms of the disease. Case 1 was a 35-year-old woman who presented abdominal distension accompanied by hepatosplenomegaly, adenomegaly, skin lesions, positivity for anti-HTLV-I antibodies and leukocytosis with the presence of flower cells. Case 2 was a 38-year-old man who was admitted with generalized lymphadenomegaly, positivity for anti-HTLV-I antibodies, hypercalcemia and osteolytic lesions. In this paper, we correlate the clinical-laboratory findings of these two cases with data in the literature.

scholarly journals Effect of a novel anti-CCR4 monoclonal antibody (Mogamulizmab) on skin lesions of adult T-cell leukemia-lymphoma (ATL) and its adverse skin reactions (ASR)

Retrovirology ◽  
2014 ◽  
Vol 11 (S1) ◽  
Author(s):  
Kentaro Yonekura ◽  
Tamotsu Kanzaki ◽  
Nobuaki Nakano ◽  
Masahito Tokunaga ◽  
Ayumu Kubota ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cell ◽  
Skin Lesions ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Skin Reactions ◽  
Adult T Cell Leukemia

scholarly journals A proposal for smoldering adult T-cell leukemia: a clinicopathologic study of five cases

Blood ◽  
1983 ◽  
Vol 62 (4) ◽  
pp. 758-766 ◽  
Author(s):  
K Yamaguchi ◽  
H Nishimura ◽  
H Kohrogi ◽  
M Jono ◽  
Y Miyamoto ◽  
...  
Keyword(s):  
T Cell ◽  
Skin Lesions ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Normal Range ◽  
Adult T Cell Leukemia ◽  
Clinicopathologic Study ◽  
Cryptococcus Meningitis

We have observed five patients with smoldering adult T-cell leukemia (ATL) who had skin lesions as premonitory symptoms. The illness developed slowly, but flared up after several years. Skin lesions appeared in the form of erythema, papules, or nodules. Infiltration of the skin by ATL cells was slight, and the proportion of ATL cells in the peripheral blood was 0%-2%. The serum lactate dehydrogenase (LDH) value was within normal range and was not associated with hypercalcemia; lymphadenopathy, hepatosplenomegaly, and bone marrow infiltration were very slight. In most cases, hypergammaglobulinemia was seen, and in one case, monoclonal hypergammaglobulinemia was observed. All five patients had lived in an area in which ATL was endemic, and their anti-ATLA antibodies were positive; none had ever received a blood transfusion. One patient developed typical ATL after more than 13 yr of illness and died of renal insufficiency. Another patient developed typical ATL after 5 yr of illness and died of cryptococcus meningitis. Based on clinical and pathologic differences, we believe that these cases should be distinguished from typical ATL cases for the purposes of prognosis and treatment.

scholarly journals Clinical characteristics of adult T-cell leukemia/lymphoma infiltration in the gastrointestinal tract

2020 ◽  
Author(s):  
Tadashi Miike ◽  
Hiroshi Kawakami ◽  
Takuro Kameda ◽  
Shojiro Yamamoto ◽  
Yoshihiro Tahara ◽  
...  
Keyword(s):  
T Cell ◽  
Clinical Characteristics ◽  
Skin Lesions ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Gi Tract ◽  
Cell Leukemia Virus Type ◽  
Gi Endoscopy ◽  
Adult T Cell Leukemia ◽  
Fold Type

Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type 1. The clinical course of ATLL is very heterogeneous, and many organs, including the gastrointestinal (GI) tract, can be involved. However, there are few detailed reports on ATLL infiltration in the GI tract. We investigated the clinical characteristics of ATLL infiltration in the GI tract.Methods: This retrospective observational single-center study included 40 consecutive ATLL patients who underwent GI endoscopy. The patients’ demographic and clinical characteristics and endoscopic findings were analyzed retrospectively. Patients with ATLL who were diagnosed by histological examination were divided into two groups based on GI tract infiltration.Results: Multivariate analysis revealed that the absence of skin lesions was significantly associated with GI infiltration (P < 0.05). Furthermore, the infiltration group tended to have similar macroscopic lesions in the upper and lower GI tracts, such as diffuse type, tumor-forming type, and giant-fold type.Conclusions: GI endoscopy may be considered for ATLL patients without skin lesions.

scholarly journals Clinical characteristics of adult T-cell leukemia/lymphoma infiltration in the gastrointestinal tract

2020 ◽  
Author(s):  
Tadashi Miike ◽  
Hiroshi Kawakami ◽  
Takuro Kameda ◽  
Shojiro Yamamoto ◽  
Yoshihiro Tahara ◽  
...  
Keyword(s):  
T Cell ◽  
Clinical Characteristics ◽  
Skin Lesions ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Gi Tract ◽  
Adult T Cell Leukemia ◽  
Endoscopic Findings ◽  
Human T Cell ◽  
Single Center Study

Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1). The clinical course of ATLL is very heterogeneous, and many organs, including the gastrointestinal (GI) tract, can be involved. However, there are few detailed reports on ATLL infiltration in the GI tract. We investigated the clinical characteristics of ATLL infiltration in the GI tract.Methods: This retrospective observational single center study included 40 consecutive ATLL patients who underwent GI endoscopy. The patients’ demographic and clinical characteristics and endoscopic findings were analyzed retrospectively. Patients with ATLL who were diagnosed via histological examination, were divided into two groups based on GI tract infiltration.Results: Multivariate analysis revealed that the absence of skin lesions was significantly associated with GI infiltration (P < 0.05). Furthermore, the infiltration group tended to have similar macroscopic lesions in the upper and lower GI tracts.Conclusions: The absence of skin lesions and characteristic endoscopic findings may aid in detecting ATLL infiltration in the GI tract.

scholarly journals Clinical characteristics of adult T-cell leukemia/lymphoma infiltration in the gastrointestinal tract

2020 ◽  
Author(s):  
Tadashi Miike ◽  
Hiroshi Kawakami ◽  
Takuro Kameda ◽  
Shojiro Yamamoto ◽  
Yoshihiro Tahara ◽  
...  
Keyword(s):  
T Cell ◽  
Clinical Characteristics ◽  
Skin Lesions ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Gi Tract ◽  
Cell Leukemia Virus Type ◽  
Gi Endoscopy ◽  
Adult T Cell Leukemia ◽  
Fold Type

Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type 1. The clinical course of ATLL is very heterogeneous, and many organs, including the gastrointestinal (GI) tract, can be involved. However, there are few detailed reports on ATLL infiltration in the GI tract. We investigated the clinical characteristics of ATLL infiltration in the GI tract.Methods: This retrospective observational single-center study included 40 consecutive ATLL patients who underwent GI endoscopy. The patients’ demographic and clinical characteristics and endoscopic findings were analyzed retrospectively. Patients with ATLL who were diagnosed by histological examination were divided into two groups based on GI tract infiltration.Results: Multivariate analysis revealed that the absence of skin lesions was significantly associated with GI infiltration (P < 0.05). Furthermore, the infiltration group tended to have similar macroscopic lesions in the upper and lower GI tracts, such as diffuse type, tumor-forming type, and giant-fold type.Conclusions: GI endoscopy may be considered for ATLL patients without skin lesions.

A Case of CD30-Positive Adult T-Cell Leukemia/Lymphoma Presenting Spontaneous Regression and Recurrence of Skin Lesions

2014 ◽  
Vol 76 (3) ◽  
pp. 210-213
Author(s):  
Yumiko KAKU ◽  
Monji KOGA ◽  
Shinichi IMAFUKU ◽  
Juichiro NAKAYAMA ◽  
Kaori KOGA ◽  
...  
Keyword(s):  
T Cell ◽  
Spontaneous Regression ◽  
Skin Lesions ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma

2015 ◽  
Vol 21 (12) ◽  
pp. 2830-2839 ◽  
Author(s):  
Ayako Masaki ◽  
Takashi Ishida ◽  
Yasuhiro Maeda ◽  
Susumu Suzuki ◽  
Asahi Ito ◽  
...  
Keyword(s):  
T Cell ◽  
Prognostic Significance ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Tryptophan Catabolism
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