scholarly journals The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson’s Disease Severity

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Rokhsareh Meamar ◽  
Pooria Shaabani ◽  
Seyed Reza Tabibian ◽  
Mohammad Reza Aghaye Ghazvini ◽  
Awat Feizi

Objectives. In current study, the relationships between serum vitamin D3 levels and serum UA concentrations as well as their interaction with severity of PD were evaluated in a sample of Iranian PD patients.Method. In a cross sectional study at the one of the main referral hospitals in central region of Iran, during September to November 2011, 112 patients were recruited. Severity of PD was evaluated sing H&R stages and UPDRS.Results. The Spearman rank correlation coefficient suggests the negative significant association between serum vitamin D3 and UPDRS in patients aged >62 (r=-0.34,P<0.05). No statistically significant association was observed between the UA levels and severity of PD (represented by H&Y categories) in different levels of serum vitamin D3 not only in total sample but also in separate age and sex groups. The linear regression coefficients suggested positive association between UA and serum vitamin D3 with UPDRSIII scores while negative relationship between UA and serum vitamin D3 interaction with UPDRSIII; however it was only statistically significant in age group ≤62 (P<0.05).Conclusion. Our study revealed a negative correlation between interaction of serum vitamin D3 and UA with severity of PD; other studies are required to confirm our findings.

SLEEP ◽  
2020 ◽  
Vol 43 (10) ◽  
Author(s):  
Jeehee Min ◽  
Tae-Won Jang ◽  
Yeon Soon Ahn ◽  
Chang Sun Sim ◽  
Kyoung Sook Jeong

Abstract Study Objectives Shift work is known to be detrimental to an individual’s health as it disrupts the circadian rhythm and is a risk factor for cancer. It has been reported that elevated fibroblast growth factor (FGF)-23, increased serum soluble α-klotho, and decreased vitamin D3 are associated with cancer progression. We studied the relationship between shift work and the levels of FGF-23, α-klotho, and vitamin D3 amongst firefighters, as they work in long shifts outside the traditional daytime schedule. Methods The study consisted of 450 participants who were firefighters. We measured FGF-23, α-klotho, and vitamin D3 levels in their blood and a set of questionnaires were given to the participants to evaluate their health habits. After determining and adjusting for potential confounding factors, we compared the levels of FGF-23, α-klotho, and serum vitamin D3 by job and shift types. Results FGF-23 and α-klotho levels were significantly higher in shift workers than traditional day workers, and in 3-day cycle shift workers than workers with another shift schedule. When the levels of these substances were compared based on different types of jobs, firefighters had a lower level of vitamin D3. We conclude that shift work is positively correlated with the levels of FGF-23 and α-klotho. Conclusions Levels of FGF-23 and α-klotho were linked to shift work and job types. Although vitamin levels did not differ by shift types, vitamin D3 levels were lower in firefighters. These findings suggest that high levels of FGF-23 and α-klotho are potential risk factors for cancer among firefighters.


Author(s):  
Ramin Ghodsi ◽  
Hosein Rostami ◽  
Karim Parastouei ◽  
Maryam Taghdir

BACKGROUND: Military staff are required to be in a proper condition of mental health and weight standards and have a specific level of physical performances (PP). Dairy products are rich sources of essential nutrients. It was demonstrated that Iranians consume much less milk and its products and there is no exception in the military staff. OBJECTIVES: To examine the association between consumption of low or whole-fat dairy and psychological disorders and PP in military personnel. METHODS: This cross-sectional study was conducted in four military zones of Iran. Dairy products intake were evaluated by using a semi-quantitative food-frequency questionnaire (FFQ). The Persian version of Depression, Anxiety, Stress Scale-21 (DASS-21) were used to assess participants’ depression, anxiety and stress and PP were assessed by a 2-mile run, sit-up, push-up and pull-up. RESULTS: There was a significant negative relationship between the tertiles of total and low-fat dairy consumption and depression (OR 0.28, 95% CI 0.10 to 0.79, P <  0.05), and low-fat dairy consumption and stress (OR 0.34, 95% CI 0.13 to 0.93, P <  0.05). Also, there was a positive association between the last tertiles of low-fat dairy consumption and suitable PP (OR 5.28, 95% CI 1.08 to 25.71, P <  0.05). CONCLUSIONS: We concluded that consumption of dairy products and particularly low-fat products are related to less psychological problems and a better PP level.


2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Gretty C. Runtukahu ◽  
Jehosua Sinolungan ◽  
Henry Opod

Abstract: Low self-control makes teenagers are not able to organize and direct the behavior that appears uncontrolled actions such as smoking. Changes in the state of teenages who should learn to be more interested in smoking, associated with high–low self-control. This study aimed to determine the relationship between self-control and smoking behavior among adolescents. The research method using cross sectional design and quantitative analytic. The study involved 176 active students of the school as a sample, smoking and non smoking, male or female, and is willing to participate. Collecting data through questionnaires. Data analysis technique using the Spearman rank correlation test. The results show the value of r = -0,756 with p = 0,000 ( p < 0,05 ), meaning that the higher self-control teenagers applied, the lower the level of smoking behavior. Analysis of the 44 smokers from the total sample of 176 respondents, the value of r =-0,766 with p = 0,000 ( p < 0.05 ), meaning that the lower self-control teenagers applied, the higher the level of smoking behavior. Thus the hypothesis H1 is accepted, that there is a significant negative relationship between self-control and smoking behavior .Keywords : self-control, smoking behavior, adolescentAbstrak: Kontrol diri yang rendah membuat remaja tidak mampu mengatur dan mengarahkan perilakunya sehingga muncul tindakan tidak terkontrol seperti perilaku merokok. Perubahan keadaan dari remaja yang seharusnya belajar menjadi remaja yang lebih tertarik merokok berkaitan dengan tinggi-rendah kontrol diri. Penelitian ini bertujuan untuk mengetahui hubungan antara kontrol diri dengan perilaku merokok kalangan remaja. Metode penelitian menggunakan desain Cross Sectional dan bersifat analitik kuantitatif. Penelitian ini melibatkan 176 siswa aktif sekolah sebagai sampel, merokok dan tidak merokok, berjenis kelamin laki-laki atau perempuan, dan bersedia berpartisipasi. Pengambilan data melalui kuesioner. Teknik analisa data menggunakan uji korelasi Spearman Rank. Hasil penelitian menunjukan nilai r =-0,756 dengan p=0,000 (p<0,05), artinya semakin tinggi kontrol diri remaja, semakin rendah perilaku merokoknya. Analisis terhadap 44 responden perokok dari total sampel 176, diperoleh nilai r =-0,766 dengan nilai p=0,000 (p<0,05), artinya semakin rendah kontrol diri remaja, semakin tinggi perilaku merokoknya. Dengan demikian hipotesis H1 diterima yaitu terdapat hubungan negatif yang signifikan antara kontrol diri dengan perilaku merokok.Kata kunci: kontrol diri, perilaku merokok, remaja


2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mehdi Dehghani ◽  
Anush Khajeh ◽  
Reza Vojdani ◽  
Mozhdeh Sanei ◽  
Pedram Keshavarz ◽  
...  

Background: Studies conducted in recent years have proposed a protective effect of vitamin D3 (VitD3) against various types of cancers. Thus, in this research, we investigated the serum levels of VitD3and its relation with prognostic clinical factors in chronic lymphocytic leukemia (CLL). Method: In this cross-sectional study, 86 CLL patients were investigated for a one-year period and evaluated for the relationship between Vit D3serum levels, Rai stages, age, gender, and pathological factors. A control group was added to the study in order to compare the VitD3 levels of CLL patients with that of the normal population. Results: The mean serum VitD3level in CLL patients was 29.76 ± 18.75 ng/ml, and most of the patients were in stage I and II. There was no significant association between age, sex, and Rai stages of CLL with VitD3 level. Except for splenomegaly (P < 0.001), the leukemia-related phenotypes, complications, and prognostic factors had no meaningful association with VitD3 (P > 0.05) level. VitD3 serum level was meaningfully different between case and control groups (P < 0.001). Conclusion: In the current research, there was no significant relationship between VitD3serum levels and investigated variables, except splenomegaly; these findings are in concordance with other studies.


2008 ◽  
Vol 3 (1) ◽  
pp. 12
Author(s):  
Marissa Indreswari ◽  
Hardinsyah Hardinsyah ◽  
M. Rizal Martua Damanik

<p class="MsoNormal" style="margin: 0cm 12.75pt 6pt 14.2pt; text-align: justify;"><span style="font-size: 10pt;">Pregnant mother is one of the group gristle nutrition. Pregnant mother need to do medical check during pregnancy to support quality of good health. Pregnancy inspection is suggested minimum four times during pregnancy. The aim of this study is to analyze correlation between intensity of pregnancy inspection, facility of health service and the iron tablet </span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">consumption </span><span style="font-size: 10pt;">with mount the sigh experienced during pregnancy.</span><span style="font-size: 10pt;">This study use</span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">d</span><span style="font-size: 10pt;"> the</span><span style="font-size: 10pt;">cross sectional study method</span><span style="font-size: 10pt;">with sample taking method by purposive in Kramat Jati </span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">S</span><span style="font-size: 10pt;">ub-district (East Jakarta) and Ragunan </span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">S</span><span style="font-size: 10pt;">ub-district (South Jakarta). Total sample taken for this study </span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">we</span><span style="font-size: 10pt;">re 100 pregnant mother</span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">s</span><span style="font-size: 10pt;">(50 from each regional). Data obtained </span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">was </span><span style="font-size: 10pt;">process</span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">ed</span><span style="font-size: 10pt;"> by Microsoft Excel 2003 and analyze</span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">d</span><span style="font-size: 10pt;"> by SPSS 13.0 for windows. Analyze data use</span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">d</span><span style="font-size: 10pt;"> Rank Correlation Spearman to know the correlation between variable</span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">s</span><span style="font-size: 10pt;">.</span><span style="font-size: 10pt;">Result</span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">s</span><span style="font-size: 10pt;"> showed significant correlations between</span><span style="font-size: 10pt;">iron tablet </span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">consumption </span><span style="font-size: 10pt;">obedience with intensity of pregnancy inspection. Significant correlation </span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">wa</span><span style="font-size: 10pt;">s also shown by intensity of pregnancy inspection variable with facility of health service which got by pregnant mother during pregnancy inspection. This result study </span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">wa</span><span style="font-size: 10pt;">s strenghtened by previous study that showed intensity of pregnancy inspection to the health service ha</span><span style="font-size: 10pt;" lang="en-us" xml:lang="en-us">d</span><span style="font-size: 10pt;"> strong correlation with antenatal care which obtained by pregnant mother.</span></p>


2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Farah Cherif ◽  
Hela G. Zouari ◽  
Wissal Cherif ◽  
Monia Hadded ◽  
Majda Cheour ◽  
...  

Introduction. The management of neuropathic pain remains complex, generally because of the psychiatric comorbidity that is often underdiagnosed. The objectives of our work were to determine the link between depression and the characteristics of NP on the one hand and quality of life on the other hand, in a sample of subjects consulting for neuropathic pain (NP) regardless of etiology. Methods. We conducted a cross-sectional study involving 61 neuropathic pain consulting patients in whom we assessed five parameters, namely, neuropathic pain based on DN4, pain intensity using EVA, anxiety, and depression according to the HADS and quality of life. Results. The study population mean age was 52.71 ± 14.29 years while the sex ratio (m/f) was 0.52. The neuropathic pain’s most common etiologies were postherpetic pain, carpal tunnel syndrome, and diabetic neuropathy. Depression and anxiety prevailed by 65.6% and 73.7%, respectively. The quality of life was impaired with average SF-12 physical and mental scores of 33.76 ± 8.03 and 37.78 ± 11.52, respectively. The overall mean BPI score was 5.53 ± 1.76. Patients with high DN4 scores were significantly more depressed (p=0.025). A significantly positive association was found between the depression score and the pain intensity (p=0.001, r = 0.41). Depressed subjects had a poor quality of life according to SF-12 and BPI. Conclusion. Given the depressive comorbidity impact on the neuropathic pain components as well as the quality of life, screening for this comorbidity should be part of the baseline ND assessment.


2020 ◽  
Vol 7 (6) ◽  
pp. 1391-1397
Author(s):  
Zemen Mengesha Yalew ◽  
Haymanot Zeleke ◽  
Abebe Dilie Afenigus ◽  
Yibeltal Asmamaw Yitayew ◽  
Biniam Minuye ◽  
...  

Patient experience of nursing care is the perception of the patient about the real existing nursing service. Addressing patient experience of nursing care is very important to improve nursing service quality because it identifies the factors that affect the nursing care quality better than patient satisfaction. Therefore, this study aimed to assess patient experience in nursing care and associated factors among adult admitted patients in Debre Markos and Dessie referral hospitals. An institution-based cross-sectional study was conducted from March 1, 2019, to March 30, 2019, among 528 consecutively selected adult admitted patients. Data were cleaned, coded, and entered in Epi-data version 3.1 then exported to Statistical Package for Social Sciences version 25 for analysis. Multivariate logistic regression, with a 95% CI was used to identify variables that had a significant association. The overall good patient experience in nursing care was 64%. Duration of admission ≥22 days (adjusted odds ratio [AOR] = 2.67, 95% CI = 1.013-7.025) and free service (AOR = 3.69, 95% CI = 2.381-5.730) showed a positive association with patient experience in nursing care. However, admission in gynecology ward (AOR = 0.43, 95%CI = 0.257-0.707), secondary education (AOR = 0.53, 95% CI: 0.308-0.907), and college or above education (AOR = 0.55, 95%CI = 0.320-0.957) showed a negative association with patient experience in nursing care.


2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.


2010 ◽  
Vol 26 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Marc Vierhaus ◽  
Arnold Lohaus ◽  
Indra Shah

This investigation focuses on the question whether assessments of the development of internalizing behavior from childhood to adolescence are affected by the kind of research design (longitudinal versus cross-sectional). Two longitudinal samples of 432 second-graders and 366 fourth graders participated in a longitudinal study with subsequent measurements taken 1, 2, and 3 years later. A third sample consisting of 849 children covering the same range of grades participated in a cross-sectional study. The results show that the development of internalizing symptoms in girls – but not in boys – varies systematically with the research design. In girls, there is a decrease of internalizing symptoms (especially between the first two timepoints) in the longitudinal assessment, which may reflect, for example, the influence of strain during the first testing situation. Both longitudinal trajectories converge to a common trajectory from grade 2 to grade 7 when controlling for this “novelty-distress effect.” Moreover, when we control this effect, the slight but significant decrease characterizing the common trajectory becomes similar to the one obtained in the cross-sectional study. Therefore, trajectories based on longitudinal assessments may suggest more changes with regard to internalizing symptoms over time than actually take place, while trajectories based on cross-sectional data may be characterized by an increased level of internalizing symptoms. Theoretical and practical implications of these results are discussed.


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