scholarly journals Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mohamed H. Khattab ◽  
Ariel E. Marciscano ◽  
Simon S. Lo ◽  
Michael Lim ◽  
John J. Laterra ◽  
...  
Keyword(s):  
Case Report ◽  
Pulmonary Metastases ◽  
Targeted Agents ◽  
Extracranial Metastasis ◽  
Review Of The Literature ◽  
Aggressive Disease ◽  
Antiangiogenic Therapies ◽  
Extracranial Disease ◽  
Genetic Profiles ◽  
Mgmt Promoter Status

We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.

scholarly journals Low-grade intracranial meningioma with bilateral pulmonary metastases incidentally detected postpartum: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Parviz Mardani ◽  
Arash Safarian ◽  
Anita Ashari ◽  
Sarina Pourjafar ◽  
Mohammad Hossein Anbardar ◽  
...  
Keyword(s):  
Case Report ◽  
Pulmonary Metastases ◽  
Lung Metastases ◽  
Rare Event ◽  
Distant Metastases ◽  
Intracranial Meningioma ◽  
Low Grade ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Bilateral Lung

Abstract Introduction Meningiomas are the most commonly encountered intracranial tumors, usually showing indolent behavior. Extra-axial spreading and distant metastases are seldom detected in these tumors, and lung metastasis from a low-grade meningioma is a rare event. Case presentation This case report aimed to present the clinical, imaging, and pathological features of a 37-year-old Caucasian pregnant woman with bilateral lung metastases incidentally detected during preoperative workup ahead of surgery for a primary intracranial meningioma. The possible metastatic routes and risk factors of dissemination to the pulmonary circulation were discussed as well. Conclusion Metastasis must be considered in patients with intracranial meningiomas accompanied by venous sinus invasion and extension through the calvarium. Thorough paraclinical investigations are suggested in such cases.

scholarly journals Postoperative extracranial metastasis from glioblastoma: a case report and review of the literature

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Wenjiao Wu ◽  
Dequan Zhong ◽  
Zhan Zhao ◽  
Wentao Wang ◽  
Jun Li ◽  
...  
Keyword(s):  
Case Report ◽  
Extracranial Metastasis ◽  
Review Of The Literature

Pulmonary Metastases of a Tibia Adamantinoma Case Report and Review of the Literature

1990 ◽  
Vol 45 (1) ◽  
pp. 31-33 ◽  
Author(s):  
F. De Keyser ◽  
J. Vansteenkiste ◽  
P. Van Den Brande ◽  
M. Demedts ◽  
K.P. Van de Woestijne
Keyword(s):  
Case Report ◽  
Pulmonary Metastases ◽  
Review Of The Literature

scholarly journals Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Rui Bai ◽  
Zhen-Qun Zhao ◽  
Yu-Xin Wang ◽  
Wei Zhao ◽  
Li-Shuan Wu ◽  
...  
Keyword(s):  
Case Report ◽  
Pulmonary Metastases ◽  
Review Of The Literature

Long-Lasting Complete Remission of Pulmonary Metastases Consequent to Renal Cell Carcinoma Obtained with Interferon-β Therapy: Review of the Literature and a Case Report

1995 ◽  
Vol 81 (3) ◽  
pp. 201-203 ◽  
Author(s):  
Claudio Scoponi ◽  
Umberto Torresi ◽  
Michaela Di Giuseppe
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Complete Remission ◽  
Pulmonary Metastases ◽  
Interferon Α ◽  
Therapeutic Assessment ◽  
Review Of The Literature ◽  
Interferon Β ◽  
Clinical Conditions ◽  
Disease Free

This case report describes a complete remission of pulmonary metastases, consequent to renal cancer, achieved with interferon- β therapy. After nephrectomy (July 1990), this female patient was proposed for therapeutic assessment: vinblastine chemotherapy was carried out for 10 cycles, whereas concomitant immunotherapy of interferon-α was discontinued after 30 days owing to lack of tolerability. In replacement, interferon- β administration from the 5th cycle of chemotherapy at the dose of 3 MIU 3 times a week was well tolerated. Interferon- β was interrupted 27 months later, due to an increase in transaminase levels. Partial remission of pulmonary metastases was assessed after 9 months of interferon- β therapy, and a complete remission was assessed after 1 and 2 years of therapy. In November 1994, the patient was still in good clinical conditions and disease-free after 37 months from the achievement of complete remission.

Pulmonary metastases in pseudomyxoma peritonei – case report and review of the literature

2020 ◽  
Vol 99 (10) ◽  
Keyword(s):  
Case Report ◽  
Peritoneal Cavity ◽  
Pseudomyxoma Peritonei ◽  
Pulmonary Metastases ◽  
Lung Metastases ◽  
Left Lung ◽  
Clinical State ◽  
Review Of The Literature ◽  
Rare Case Report ◽  
Pleural Involvement

Introduction: Pseudomyxoma peritonei is a rare disease caused by dissemination of cancer forming mucous and gelatinous masses in the peritoneal cavity. Local recurrence is frequent; however, dissemination outside the peritoneal cavity is rare. Case report: We present the case report of a female patient treated for bilateral pulmonary metastases from pseudomyxoma peritonei. We removed 1 metastasis from her left lung and 12 metastases form her right lung. The patient remained in a good clinical state; however, additional lung metastases developed, as well as a metastasis in L2 vertebra for which the patient underwent a surgical procedure. Conclusion: Cytoreductive surgeries for intrathoracic involvement in pseudomyxoma peritonei with additional hyperthermic cytostatic intrapleural lavage in case of pleural involvement can lead to a longer lifespan in indicated patients.

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