scholarly journals Markers of Perioperative Bowel Complications in Colorectal Surgery Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Radomír Hyšpler ◽  
Alena Tichá ◽  
Milan Kaška ◽  
Lenka Žaloudková ◽  
Lenka Plíšková ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
Intestinal Resection ◽  
Specific Marker ◽  
Exhaled Breath ◽  
Fatty Acid Binding ◽  
Gastrointestinal Complications ◽  
Reactive Protein ◽  
The Difference ◽  
Low Sensitivity

Colorectal cancer is a clinical condition whose treatment often involves intestinal resection. Such treatment frequently results in two major gastrointestinal complications after surgery: anastomotic leakage and prolonged ileus. Anastomotic leakage is a serious complication which, more often than not, is diagnosed late; to date, C-reactive protein is the only available diagnostic marker. A monocentric, prospective, open case-control study was performed in patients(n=117)undergoing colorectal surgery. Intestinal fatty acid binding protein (i-FABP), citrulline, D-lactate, exhaled hydrogen,Escherichia coligenomic DNA, and ischemia modified albumin (IMA) were determined preoperatively, postoperatively, and on the following four consecutive days. Bacterial DNA was not detected in any sample, and i-FABP and D-lactate lacked any distinct potential to detect postoperative bowel complications. Exhaled breath hydrogen content showed unacceptably low sensitivity. However, citrulline turned out to be a specific marker for prolonged ileus on postoperative days 3-4. Using a cut-off value of 20 μmol/L, a sensitivity and specificity of ~75% was achieved on postoperative day 4. IMA was found to be an efficient predictor of anastomosis leak by calculating the difference between preoperative and postoperative values. This test had 100% sensitivity and 80% specificity and 100% negative and 20% positive predictive value.

Monitoring of procalcitonin but not interleukin-6 is useful for the early prediction of anastomotic leakage after colorectal surgery

2017 ◽  
Vol 55 (7) ◽  
Author(s):  
Urszula Zielińska-Borkowska ◽  
Naser Dib ◽  
Wiesław Tarnowski ◽  
Tomasz Skirecki
Keyword(s):  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
Interleukin 6 ◽  
Early Recognition ◽  
Surgical Trauma ◽  
Serum Samples ◽  
Elective Colorectal Surgery ◽  
Surgical Infections ◽  
Bowel Diseases ◽  
The Difference

AbstractBackground:Early recognition of patients who have developed anastomotic leakage (AL) after colorectal surgery is crucial for the successful treatment of this complication. The aim of this study was to assess the usefulness of the assessment of procalcitonin (PCT) and interleukin-6 (IL-6) levels in the prognosis of AL.Methods:This observational study included 157 patients who underwent major elective colorectal surgery. The most common indications for surgery were cancer and inflammatory bowel diseases. Serum samples were obtained directly before surgery (D0) and 1 day (D1) after surgery, and the relationships between the serum concentrations of PCT and IL-6 and development of AL were assessed.Results:In total, 10.2% of patients developed post-surgical infections due to AL. PCT levels on D1 were significantly higher in patients who developed AL [2.73 (1.40–4.62)] than in those who recovered without complications [0.2 (0.09–0.44)]. The area under the ROC curve for PCT on D1 was 0.94, 95% CI (0.89–0.98). The sensitivity and specificity of the prediction of an infection were 87% and 87%, respectively, for PCT on D1, which was higher than 1.09 ng/mL. The increase in PCT concentration between D0 and D1 was significantly higher in patients with AL (p<0.001). Patients who developed AL had higher concentrations of IL-6 on D1, but the difference was not significant (p=0.28).Conclusions:This study confirms that surgical trauma increases serum PCT concentrations and that the concentration of PCT on D1 can predict AL after colorectal surgery. However, IL-6 is not a good early marker for developing AL.

P0072 C-reactive protein 24h after colorectal surgery as an early predictor for anastomotic leakage: A preliminary study

2015 ◽  
Vol 51 ◽  
pp. e15
Author(s):  
E. Morandi ◽  
M. Monteleone ◽  
D.A. Merlini ◽  
G. Vignati ◽  
T. D’Aponte ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Preliminary Study ◽  
Early Predictor

Biomarkers and anastomotic leakage in colorectal surgery: C-reactive protein trajectory is the gold standard

2017 ◽  
Vol 88 (5) ◽  
pp. 440-444 ◽  
Author(s):  
Stephen R. Smith ◽  
Peter Pockney ◽  
Ryan Holmes ◽  
Fiona Doig ◽  
John Attia ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
Gold Standard ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Utility of C-reactive protein in the early diagnosis of anastomotic leakage in colorectal surgery

2019 ◽  
Vol 86 (5) ◽  
Author(s):  
Guillermo R. Guevara-Morales ◽  
Marco A. Regalado-Torres ◽  
Eduardo Cantarell-Castillo ◽  
Ricardo Castro-Salas ◽  
Rebeca Maldonado-Barrón ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Early Diagnosis ◽  
Anastomotic Leakage ◽  
C Reactive Protein ◽  
Reactive Protein

C Reactive Protein as a Predictor of Anastomotic Leakage in Colorectal Surgery. Comparison Between Open and Laparoscopic Surgery

2017 ◽  
Vol 95 (9) ◽  
pp. 529-535
Author(s):  
María Ramos Fernández ◽  
Francisco Rivas Ruiz ◽  
Alberto Fernández López ◽  
Carmelo Loinaz Segurola ◽  
José María Fernández Cebrián ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Anastomotic Leak after Colorectal Surgery. Our Experience in three Years.

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Kastriot Haxhirexha ◽  
Agron Dogjani ◽  
Lutfi Zylbehari ◽  
Nehat Baftiu ◽  
Ferizat Dika – Haxhirexha
Keyword(s):  
Risk Factors ◽  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
Anastomotic Leak ◽  
Intestinal Resection ◽  
Morbidity And Mortality ◽  
Multiple Risk Factors ◽  
Four Quadrant ◽  
Emergent Surgery ◽  
Large Bowel Resection

Background: One of the most severe complication after intestinal resection, often with catastrophic consequence for the patient is leakage from the anastomosis. The severity of complications after anastomotic leak may range from a small localized peritonitis or abscess formation without sepsis, to a development of a four quadrant peritonitis with septic shock. Until now despite the seriousness of this complications, the cause of anastomotic leakage are not yet definitively clear. Aim: The aim of this study is to submit our experience in treatment of patients with anastomotic leakage after intestinal resection and their outcome. Materials and Methods: The study included 63 patients with colorectal cancer operated in the Department of Surgery at the Clinical Hospital of Tetova. In all patients intestinal resection with end to end anastomosis was performed. Conclusions: Anastomotic leak after large bowel resection is a very serious complication with a great impact on patient’s morbidity and mortality.  Multiple risk factors are associated with occurrence of this complication whereas the more suspected are: preoperative anaemia, hypoalbuminemia, emergent surgery without adequate preparation of patient, intraoperative blood loss and blood transfusion during surgery etc. Early detection of AL is very important and helpful to improve the outcome of patients and to minimize postoperative rate of morbidity and mortality. Keywords: anastomotic leaks, colorectal surgery, risk factors  

scholarly journals Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Bruno A. Messias ◽  
Ricardo V. Botelho ◽  
Sarhan S. Saad ◽  
Erica R. Mocchetti ◽  
Karine C. Turke ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Elevated serum C-reactive protein as a predictive factor for anastomotic leakage in colorectal surgery

2012 ◽  
Vol 10 (2) ◽  
pp. 87-91 ◽  
Author(s):  
A.B. Almeida ◽  
G. Faria ◽  
H. Moreira ◽  
J. Pinto-de-Sousa ◽  
P. Correia-da-Silva ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Anastomotic Leakage ◽  
Predictive Factor ◽  
Elevated Serum ◽  
C Reactive Protein ◽  
Reactive Protein
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