scholarly journals Metastasis of Ciliary Body Melanoma to the Contralateral Eye: A Case Report and Review of Uveal Melanoma Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Nouritza M. Torossian ◽  
Roy T. Wallace ◽  
Wen-Jen Hwu ◽  
Agop Y. Bedikian
Keyword(s):  
Uveal Melanoma ◽  
Medical Literature ◽  
Recurrent Disease ◽  
Clinical History ◽  
Plaque Radiotherapy ◽  
Systemic Metastasis ◽  
History Of ◽  
Contralateral Eye ◽  
The Right ◽  
Ciliary Body Melanoma

Many types of cancers metastasize to the eye. However, uveal melanoma metastasizing to the contralateral choroid is very rare. We report the case of a 68-year-old man with history of treated uveal melanoma of the right eye that developed metastasis to the liver and the choroid of the left eye. Ten years earlier, he was diagnosed to have uveal melanoma of the right eye and was initially treated with plaque radiotherapy. Two years later, upon progression of the disease in the right eye he had enucleation of the eye. We describe the patient’s clinical history, the diagnosis of recurrent disease in the contralateral eye, therapy of the left eye, and systemic metastasis. In addition, we reviewed the published medical literature and described the recent advances in the management of uveal melanoma.

scholarly journals BAP1 Germline Mutation Associated with Bilateral Primary Uveal Melanoma

2019 ◽  
Vol 6 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Michael D. Yu ◽  
Babak Masoomian ◽  
Jerry A. Shields ◽  
Carol L. Shields
Keyword(s):  
Visual Acuity ◽  
Uveal Melanoma ◽  
Choroidal Melanoma ◽  
Pathogenic Mutation ◽  
Clinical Testing ◽  
Plaque Radiotherapy ◽  
Systemic Metastasis ◽  
History Of ◽  
History Of Cancer

Purpose: To describe the occurrence of bilateral primary uveal melanoma in 2 patients with mutation on the gene encoding BRCA1-associated protein 1 (BAP1). Methods: Retrospective chart review of patients with bilateral primary uveal melanoma and subsequent positive germline BAP1 mutation. Results: There were 2 patients with bilateral uveal melanoma and BAP1 germline positivity. Neither patient demonstrated oculodermal melanocytosis. Patient 1 underwent enucleation of his right eye (OD) at the age of 44 years for a 9.6-mm-thick choroidal melanoma. He returned 4 years later with a 10.0-mm-thick choroidal melanoma in his left eye (OS) and was treated with plaque radiotherapy. He had a strong family history of cancer, and clinical testing for germline BAP1 mutation identified a pathogenic mutation in BAP1. At the 18-month follow-up, visual acuity was 20/200 OS without evidence of systemic metastasis. Patient 2 initially presented at age 54 years with extensive, diffuse iris melanoma OD, initially treated with plaque radiotherapy, but local recurrence after 3 years necessitated enucleation. Four years later, a 6.0-mm-thick ciliary body melanoma OS was found and successfully treated with plaque radiotherapy. Clinical testing for germline BAP1 mutation identified a pathogenic mutation in BAP1. At the 8-year follow-up, visual acuity was 20/40 OS without evidence of local recurrence or systemic metastasis. The patient expired secondary to an unrelated brain infarction. Conclusion: Bilateral uveal melanoma is exceedingly rare. Patients with bilateral uveal melanoma, especially when coincident with remote systemic cancers or a family history of cancer, should be evaluated for germline BAP1 mutation. Lifelong monitoring for related systemic malignancies is advised.

Filiform polyposis in a 20-year-old patient with ulcerative colitis – a rare occurrence

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S60-S60
Author(s):  
R Ramanarasimhaiah ◽  
B Chae ◽  
M Toprak ◽  
L M Opitz ◽  
H Wu
Keyword(s):  
Ulcerative Colitis ◽  
Surgical Margin ◽  
Inflammatory Cells ◽  
Clinical History ◽  
Right Colon ◽  
Microscopic Evaluation ◽  
Bowel Diseases ◽  
History Of ◽  
Filiform Polyposis ◽  
The Right

Abstract Introduction/Objective Filiform polyposis (FP), also referred as inflammatory polyposis or pseudopolyposis, is an uncommon benign entity usually diagnosed in patients with history of Crohn’s disease, ulcerative colitis, interstitial tuberculosis or histiocytosis X. It is characterized by multiple finger-like mucosal projections/pseudopolyps seen more commonly in transverse and descending colon. Pathogenesis of FP is uncertain but it is hypothesized to be reactive process to chronic inflammation leading to formation of fingerlike projections. The term filiform polyposis was coined in 1974 by Appleman HD and his collegues to describe numerous long slender worm-like (filiform) colonic lesions seen in radiographs. Herein, we are going to present a case of FP diagnosed in a 20-year-old male with history of medically refractive ulcerative colitis. Methods/Case Report The patient is a 20-year-old male, with a history of medically refractive ulcerative colitis on systemic steroids and vedolizumab. He underwent sigmoidoscopy and colonoscopy which reveals multiple pedunculated, polypoid lesions, ranging from 0.5 to 3 cm in length with white tips (cap of purulent mucous). Patient underwent total abdominal colectomy with end ileostomy. The specimen received by our deparment consist of a segment of right colon (63 cm in length, 3.5 cm in diameter) with attached ileum (3 cm in length, 2 cm in diameter) and appendix (6 cm in length, 0.8 cm in diameter). The part of the right colon is constricted/strictured measuring 24 cm in length, 2 cm in diameter. Opening reveals numerous (>100) pedunculated, finger-like polypoid lesions measuring from 0.3 cm to 2 cm in length. The lesions involve the entire right colon including distal colonic surgical margin. Appendix and ileum are not involved by the lesion and grossly unremarkable. Microscopic evaluation of the lesions reveal acute and chronic inflammatory cells, granulation tissue, areas of necrosis and reactive changes with focal mucosal atrophy consistent with chronic ulcerative colitis. Results (if a Case Study enter NA) NA Conclusion Filiform polyposis (FP) is an uncommon benign entity commonly seen in association with Inflammatory Bowel Diseases. Diagnosing FP requires comprehensive gross and microscopic examination as well as review of clinical history and imaginig studies. Because of its uncommon nature, we recommend to report this entity to raise awareness and to educate the pathologists who have not diagnosed it before.

First report of the simultaneous occurrence of choroid plexus papilloma and meningioma in a dog

2009 ◽  
Vol 57 (3) ◽  
pp. 389-397 ◽  
Author(s):  
Luciano Espino ◽  
Maruska Suarez ◽  
German Santamarina ◽  
Mónica Vila ◽  
Natalia Miño ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Medical Literature ◽  
Choroid Plexus Papilloma ◽  
The Other ◽  
Simultaneous Occurrence ◽  
Falx Cerebri ◽  
History Of ◽  
The Central Nervous System ◽  
The Right ◽  
Plexus Papilloma

A 7-year-old spayed female English Cocker Spaniel was examined because of a 1-week history of lethargy, stumbling over objects and circling, and the presence of two tonic-clonic generalised seizures two days before presentation. The neurological signs suggested a lesion involving the right forebrain. Computed tomography revealed the presence of two intracranial masses, one located inside the right lateral ventricle and the other located in the right frontal lobe attached to the falx cerebri. Because of the poor prognosis, the owner refused to continue with the therapy and the dog was euthanised. On postmortem examination one mass was diagnosed histologically as a meningioma and the other as a papilloma of the choroid plexus. Information in the veterinary literature on multiple malignancies affecting the central nervous system is very limited. To the best of the authors’ knowledge, the association of meningioma and choroid plexus papilloma has never been reported either in the human or in the veterinary medical literature.

scholarly journals Distonía Periférica Post-Traumática. Reporte De Un Caso.

2019 ◽  
Vol 38 (2) ◽  
Author(s):  
Ana Raquel Goti Polanco ◽  
Fernando Gracia
Keyword(s):  
Spontaneous Recovery ◽  
Clinical History ◽  
Cervical Region ◽  
Multiple Drug ◽  
Number Of Patients ◽  
History Of ◽  
Post Traumatic ◽  
The Right ◽  
Plexus Block ◽  
Possible Cause

<p><strong>[Post-Traumatic Peripheral Dystonia. Report Of A Case]</strong></p><div><br />Resumen<br />Introducción: La distonía es un trastorno del movimiento caracterizado por contracciones musculares relativamente sostenidas que producen posturas anormales y repetitivas. Un pequeño número de pacientes con distonía representan los traumas como posible causa. Caso Clínico: Paciente femenina de 15 años de edad con historia de trauma con objeto contuso en región cervical con pérdida de conocimiento y recuperación espontánea. Inmediatamente refirió dolor cervical posterior. Dos días después, presentó movimientos distónicos en miembro superior derecho (MSD) y se agregaron mioclonías, por lo que se hospitalizó. Se manejó con múltiples esquemas de medicamentos, sin mejoría. Se realizó bloqueo de plexo braquial derecho con mejoría de la sintomatología. Conclusión: Los casos de distonía post-traumática son poco comunes. Se debe considerar al momento de evaluar un traumatismo. La historia clínica es la herramienta más valiosa para llegar al diagnóstico, siempre descartando otras posibles causas.</div><div> </div><div> </div><div>Abstract<br />Introduction: Dystonia is a movement disorder characterized by relatively sustained muscle contractions that produce abnormal and repetitive postures. A small number of patients with dystonia represent traumas as a possible cause. Clinical Case: Female patient of 15 years of age with a history of trauma with blunt object in the cervical region with loss of consciousness and spontaneous recovery. Immediately he reported posterior cervical pain. Two days later, he presented dystonic movements in the right upper limb (MSD) and myoclonus was added, so he was hospitalized. It was managed with multiple drug schemes, without improvement. Right brachial plexus block was performed with improvement of the symptomatology. Conclusion: Cases of post-traumatic dystonia are uncommon. It should be considered when assessing a trauma. The clinical history is the most valuable tool to reach the diagnosis, always discarding other possible causes.</div>

Abstract 1768: Magnetic Resonance Imaging Reveals Novel Phenotypic Expression of Desmosomal Mutation in First-Degree Relatives of Patients with Arrhythmogenic Right Ventricular Dysplasia (ARVD). Prevalence and Clinical Significance in Patients Evaluated For ARVD.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Harikrishna Tandri ◽  
Darshan Dalal ◽  
Aditya Jain ◽  
Daniel P Judge ◽  
Theodore Abraham ◽  
...  
Keyword(s):  
Family History ◽  
Right Ventricular ◽  
Phenotypic Expression ◽  
Clinical History ◽  
Arrhythmogenic Right Ventricular Dysplasia ◽  
First Degree Relatives ◽  
Group 4 ◽  
Right Ventricular Dysplasia ◽  
History Of ◽  
The Right

Background: In this report we present the prevalence and significance of a novel MRI abnormality that we identified in desmosomal mutation positive asymptomatic relatives of arrhythmogenic right ventricular dysplasia (ARVD) patients. Methods: MRI of 38 first-degree relatives was analyzed for abnormalities blinded to the mutation status. Focal crinkling of the right ventricle (accordion sign) was observed in 15/25 mutation positive vs. 0/13 mutation negative patients. The presence of this finding was sought in 207 patients evaluated for ARVD blinded to clinical history and was correlated with electrophysiologic findings. Results: Mean age of the population was 32±16, 61% had a family history of ARVD. Based on non-invasive testing the 207 patients were classified into 4 groups 1) 106 normal, 2) 57 Idiopathic ventricular tachycardia (VT), 3) 33 probable ARVD, 4) 11 definite ARVD. A family history of ARVD was present in 74%, 0%, 67% and 36% respectively. 43 patients had the “accordion sign” and the prevalence in the four groups was 10%, 5%, 70% and 100% respectively. The abnormality was seen in the sub-tricuspid region in 62%, outflow tract in 30% in both regions in 8%. After excluding group 4, 48% of patients with the accordion sign had T wave inversion’s beyond V1 compared with 7% of those without the sign (p<0.001). During electrophysiologic testing, reentrant VT could be induced in 44% (7/16) of patients with accordion sign compared to 2% (1/48) without the sign (p<0.01). Conclusion: Focal crinkling of the RV termed “Accordion sign” may represent an early manifestation of ARVD that correlates with mutation positive status and predicts inducibility of ventricular arrhythmias.

Peran Computed Tomography (CT) Toraks dalam Diagnosis Abses yang Menyerupai Massa Mediastinum

2016 ◽  
Vol 1 (3) ◽  
pp. 178-184
Author(s):  
Krishna P. Wicaksono ◽  
Aziza G. Icksan
Keyword(s):  
Clinical History ◽  
Chest Ct ◽  
X Ray ◽  
Precise Diagnosis ◽  
Life Threatening ◽  
History Of ◽  
Facial Edema ◽  
Chest X Ray ◽  
The Right ◽  
Peripheral Enhancement

Mediastnal abscess is rare, yet it could be a life threatening infecton. A precise diagnosis followed by adequate treatments need to be quickly established. Clinical informaton is usually not diagnostc. Therefore, radiological examinatons have important role.We report a ffy-one years old female with clinical history of sore throat, cough and neck-facial edema since fve days before admission. Laboratory examinatons revealed leukocytosis and ESR elevaton. Chest x-ray depicted a homogenous consolidaton in the right paratracheal region which deviated trachea to the lef. On enhanced chest CT examinaton, we found a cystc mass in the right paratracheal region, extending to the right supero-anterior mediastnum, with peripheral enhancement, air-?uid level and minimal right pleural e?usion, suggestve for mediastnal abscess. Bronchoscopy found no abnormality.Several days later, mediastnal abscess was confrmed surgically and drained through thoracotomy. Although culture of pus failed to grow any bacteria, histopathological examinaton confrmed a non-specifc chronic in?ammaton with no sign of malignancy. The main purpose of this report is to emphasize the importance of enhanced chest CT in evaluatng patent with tumor mimicking mediastnal abscess.

Een zeldzame oorzaak van dementie: de bestralingsencephalopathie

2001 ◽  
Vol 13 (3) ◽  
pp. 76-78
Author(s):  
N. van de Weg ◽  
F.R.J. Verhey ◽  
P J.M. Raedts ◽  
F W. Vreeling
Keyword(s):  
Cystic Lesion ◽  
Clinical History ◽  
Memory Deficits ◽  
Attention And Memory ◽  
Long Period ◽  
Personality Changes ◽  
History Of ◽  
Radiation Encephalopathy ◽  
The Right ◽  
The Brain

SUMMARYWe describe the clinical history of a 49-year old woman, who demonstrated progressive personality changes more than twenty years after radiation of a pituitary adenoma (prolactinoma), with apathy, loss of initiative, memory deficits, postural instability, dysarthria and faecal incontinence. Neuropsychological assessment showed impulsivity, loss of overview, desinhibition, fluctuating deficits of attention, and memory disturbances. MRI-scanning of the brain revealed a cystic lesion along the right ventricle. The clinical picture and the findings of the other investigations are typical for dementia due to radiation encephalopathy. Such a long period between radiation and cognitive deterioration is rare, although it has been described before.

scholarly journals To Amputate or Not to Amputate: Management of Iatrogenic LASIK Flap Dehiscence and Epithelial Ingrowth with Overlying Pseudopterygium

2021 ◽  
pp. 967-974
Author(s):  
Dean Ouano ◽  
Rachel Huynh ◽  
Alyson Nicole Tukan ◽  
Nour Bundogji ◽  
Majid Moshirfar
Keyword(s):  
Retinal Detachment ◽  
Pars Plana Vitrectomy ◽  
Surgical Trauma ◽  
Corneal Epithelial ◽  
Epithelial Ingrowth ◽  
History Of ◽  
Pars Plana ◽  
Contralateral Eye ◽  
The Right

A 73-year-old male with a history of myopic laser-assisted in situ keratomileusis (LASIK) 20 years earlier presented with a late LASIK flap dehiscence, epithelial ingrowth, conjunctivalization, and the development of a pseudopterygium in the right eye. The findings were consistent with surgical trauma, likely occurring after corneal epithelial debridement to improve visualization during pars plana vitrectomy for retinal detachment repair 3 months earlier. The patient underwent epithelial ingrowth debridement, LASIK flap reapproximation and suturing, and a conjunctival limbal autograft from the contralateral eye. The surgery was completed successfully without the need for flap amputation. Postoperatively, the patient had an uneventful course with a well-healing conjunctival graft and no interface opacity or evidence of recurrent pseudopterygium of the right eye. The graft and corneal topography remained stable after subsequent cataract surgery.

scholarly journals Ocular blastomycosis in a dog

2021 ◽  
Vol 14 (2) ◽  
pp. 133-136
Author(s):  
Bianca de Cecco ◽  
◽  
Mariano Carossino ◽  
Pilar Camacho-Luna ◽  
Christopher Alling ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Poor Prognosis ◽  
Emergency Service ◽  
Clinical History ◽  
Secondary Glaucoma ◽  
Response To Treatment ◽  
State University ◽  
Louisiana State University ◽  
History Of ◽  
The Right

Clinical History: A 2-year-old, female Poodle dog presented to the Emergency Service at the Veterinary Teaching Hospital (VTH), Louisiana State University School of Veterinary Medicine with a history of lethargy and anorexia. At clinical examination the dog was anemic and febrile. The dog was bilaterally blind. The right eye was buphthalmic and the intraocular pressure was elevated (42 mm Hg). During an ophthalmological consult, bilateral severe panuveitis and optic neuritis with secondary glaucoma in the right eye was diagnosed and treatment was instituted. Despite treatment, the intraocular pressure kept increasing (up to 72 mm Hg overnight), and the clinicians decided to enucleate the right eye due to poor prognosis. After one month, and no response to treatment, the left eye was also enucleated. Gross Findings: Right and left eyes: The vitreous chamber was filled with a yellow, gelatinous exudate while the anterior chamber was filled with a translucent, gelatinous fluid. The retina appeared detached and embedded within the exudate present in the vitreous chamber.

scholarly journals Unilateral Post-LASIK Ectasia in a Topographical Normal Eye with a Slight Asymmetry in the Contralateral Eye

2014 ◽  
Vol 3 (1) ◽  
pp. 47-51
Author(s):  
Marouen Berguiga ◽  
Alain Saad
Keyword(s):  
Visual Acuity ◽  
Refractive Surgery ◽  
Anterior Segment ◽  
Manifest Refraction ◽  
Uncorrected Visual Acuity ◽  
History Of ◽  
Orbscan Ii ◽  
Contralateral Eye ◽  
The Right ◽  
Radial Axis

ABSTRACT Purpose To report a case of post-LASIK unilateral corneal ectasia. Setting Department of anterior segment and Refractive surgery, Rothschild Foundation, Paris. Case report A 33-year-old woman was referred with a history of unilateral post-LASIK ectasia in her left eye, 18 months post operatively. Her best-corrected visual acuity was 20/20 with a manifest refraction of +1.75 (–4.75 × 90). Orbscan ii® revealed an inferior steepening associated with irregular astigmatism. The preoperative Placido topographies revealed a slight skewed radial axis in the right eye associated with an inferior-superior keratometry difference of 1.6 Diopters at 3 mm. in the left eye that developed ectasia, regular symmetric astigmatism was present. Uncorrected visual acuity improved to 20/25 2 weeks after keraRing® segment insertion. How to cite this article Berguiga M, saad a, Gatinel D. Unilateral Post-LASIK Ectasia in a Topographical Normal Eye with a slight asymmetry in the Contralateral Eye. int J kerat Ect Cor Dis 2014;3(1):47-51.

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