scholarly journals Antitumor Phenylpropanoids Found in Essential Oils

2015 ◽  
Vol 2015 ◽  
pp. 1-21 ◽  
Author(s):  
Adriana Andrade Carvalho ◽  
Luciana Nalone Andrade ◽  
Élida Batista Vieira de Sousa ◽  
Damião Pergentino de Sousa
Keyword(s):  
Natural Products ◽  
Pharmaceutical Industry ◽  
Medicinal Plants ◽  
Essential Oils ◽  
Anticancer Activity ◽  
Research Effort ◽  
Mechanisms Of Action ◽  
Pharmacological Activities ◽  
Bioactive Substances ◽  
Chemical Structures

The search for new bioactive substances with anticancer activity and the understanding of their mechanisms of action are high-priorities in the research effort toward more effective treatments for cancer. The phenylpropanoids are natural products found in many aromatic and medicinal plants, food, and essential oils. They exhibit various pharmacological activities and have applications in the pharmaceutical industry. In this review, the anticancer potential of 17 phenylpropanoids and derivatives from essential oils is discussed. Chemical structures, experimental report, and mechanisms of action of bioactive substances are presented.

scholarly journals Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies

Marine Drugs ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. 610
Author(s):  
Junjie Yan ◽  
Weiwei Liu ◽  
Jiatong Cai ◽  
Yiming Wang ◽  
Dahong Li ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Natural Compounds ◽  
Mechanisms Of Action ◽  
Biosynthetic Pathways ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
The Past ◽  
Synthetic Derivatives

Phenazines are a large group of nitrogen-containing heterocycles, providing diverse chemical structures and various biological activities. Natural phenazines are mainly isolated from marine and terrestrial microorganisms. So far, more than 100 different natural compounds and over 6000 synthetic derivatives have been found and investigated. Many phenazines show great pharmacological activity in various fields, such as antimicrobial, antiparasitic, neuroprotective, insecticidal, anti-inflammatory and anticancer activity. Researchers continued to investigate these compounds and hope to develop them as medicines. Cimmino et al. published a significant review about anticancer activity of phenazines, containing articles from 2000 to 2011. Here, we mainly summarize articles from 2012 to 2021. According to sources of compounds, phenazines were categorized into natural phenazines and synthetic phenazine derivatives in this review. Their pharmacological activities, mechanisms of action, biosynthetic pathways and synthetic strategies were summarized. These may provide guidance for the investigation on phenazines in the future.

scholarly journals Antitumor Activity of Monoterpenes Found in Essential Oils

2014 ◽  
Vol 2014 ◽  
pp. 1-35 ◽  
Author(s):  
Marianna Vieira Sobral ◽  
Aline Lira Xavier ◽  
Tamires Cardoso Lima ◽  
Damião Pergentino de Sousa
Keyword(s):  
Public Health ◽  
Antitumor Activity ◽  
Essential Oils ◽  
Genetic Disease ◽  
Public Health Problem ◽  
Mechanisms Of Action ◽  
Experimental Models ◽  
Major Public Health Problem ◽  
Bioactive Substances ◽  
Chemical Structures

Cancer is a complex genetic disease that is a major public health problem worldwide, accounting for about 7 million deaths each year. Many anticancer drugs currently used clinically have been isolated from plant species or are based on such substances. Accumulating data has revealed anticancer activity in plant-derived monoterpenes. In this review the antitumor activity of 37 monoterpenes found in essential oils is discussed. Chemical structures, experimental models, and mechanisms of action for bioactive substances are presented.

Novel Phytochemical Constituents and their Potential to Manage Diabetes

2020 ◽  
Vol 26 ◽  
Author(s):  
Shaik Ibrahim Khalivulla ◽  
Arifullah Mohammed ◽  
Kokkanti Mallikarjuna
Keyword(s):  
Natural Products ◽  
Large Population ◽  
World Health ◽  
In Vivo Studies ◽  
Antidiabetic Activity ◽  
Therapeutic Drug ◽  
Pharmacological Activities ◽  
Chemical Structures

Background: Diabetes is a chronic disease affecting a large population worldwide and stands as one of the major global health challenges to be tackled. According to World Health Organization, about 400 million are having diabetes worldwide and it is the seventh leading cause of deaths in 2016. Plant based natural products had been in use from ancient time as ethnomedicine for the treatment of several diseases including diabetes. As a result of that, there are several reports on plant based natural products displaying antidiabetic activity. In the current review, such antidiabetic potential compounds reported from all plant sources along with their chemical structures are collected, presented and discussed. This kind of reports are essential to pool the available information to one source followed by statistical analysis and screening to check the efficacy of all known compounds in a comparative sense. This kind of analysis can give rise to few numbers of potential compounds from hundreds, whom can further be screened through in vitro and in vivo studies, and human trails leading to the drug development. Methods: Phytochemicals along with their potential antidiabetic property were classified according to their basic chemical skeleton. The chemical structures of all the compounds with antidiabetic activities were elucidated in the present review. In addition to this, the distribution and their other remarkable pharmacological activities of each species is also included. Results: The scrutiny of literature led to identification of 44 plants with antidiabetic compounds (70) and other pharmacological activities. For the sake of information, the distribution of each species in the world is given. Many plant derivatives may exert antidiabetic properties by improving or mimicking the insulin production or action. Different classes of compounds including sulfur compounds (1-4), alkaloids (5-11), phenolic compounds (12-17), tannins (18-23), phenylpropanoids (24-27), xanthanoids (28-31), amino acid (32), stilbenoid (33), benzofuran (34), coumarin (35), flavonoids (36-49) and terpenoids (50-70) were found to be active potential compounds for antidiabetic activity. Of the 70 listed compounds, majorly 17 compounds are from triterpenoids, 13 flavonoids and 7 are from alkaloids. Among all the 44 plant species, maximum number (7) of compounds are reported from Lagerstroemia speciosa followed by Momordica charantia (6) and S. oblonga with 5 compounds. Conclusion: This is the first paper to summarize the established chemical structures of phytochemicals that have been successfully screened for antidiabetic potential and their mechanisms of inhibition. The reported compounds could be considered as potential lead molecules for the treatment of type-2 diabetes. Further, molecular and clinical trials are required to select and establish the therapeutic drug candidates.

Phytochemistry and Pharmacology of Genus Bombax

2019 ◽  
Vol 9 (3) ◽  
pp. 184-196
Author(s):  
Deepshikha Rathore ◽  
Geetanjali ◽  
Ram Singh
Keyword(s):  
Medicinal Plants ◽  
Health Care Needs ◽  
Human Beings ◽  
Care Needs ◽  
Pharmacological Activities ◽  
Therapeutic Applications ◽  
Chemical Structures ◽  
Supportive Role ◽  
The Family ◽  
History Of

Background: The history of traditional systems of medicine goes parallel with the history of human beings. Even today people have faith in traditional systems of medicine based on medicinal plants to meet primary health care needs. Hence, the scientific evaluation and documentation of extracts and active ingredients of medicinal plants always play a supportive role in their medicinal applications. Objective: This review aims to present the phytochemicals isolated from the genus Bombax and their pharmacological applications. Methods: The literature from research and review papers was analyzed and the information was compiled to present the pharmacological applications of various secondary metabolites from genus Bombax. Results: The genus Bombax belongs to the family Malvaceae and known for its therapeutic applications. The crude, semi-purified and purified extracts of different parts of this plant have shown potential therapeutic applications. A total of 96 articles including research and review papers were referred for the compilation of isolated phytochemicals and their chemical structures. Conclusion: We systematically summarized 176 isolated compounds from the genus Bombax. The findings show that this plant shows potential towards pharmacological activities. The activities were found more from extracts than the single isolated compounds.

scholarly journals A Review on Cistus sp.: Phytochemical and Antimicrobial Activities

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1214
Author(s):  
Imane Zalegh ◽  
Mohamed Akssira ◽  
Mohammed Bourhia ◽  
Fouad Mellouki ◽  
Naima Rhallabi ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Essential Oils ◽  
Mediterranean Sea ◽  
Scientific Literature ◽  
Antimicrobial Activities ◽  
Mechanisms Of Action ◽  
Pharmacological Activities ◽  
Global View ◽  
Chemical Profiles ◽  
Phytochemical Profiles

Resistance to drugs is reaching alarming levels and is placing human health at risk. With the lack of new antimicrobials drugs, infectious diseases are becoming harder to treat. Hence, there is an increasing awareness of active phytochemicals with therapeutic functions. The tremendous research interest on the Cistus L. genus includes numerous plants used in traditional medicine by people living around the Mediterranean Sea, also resulted in some interesting discoveries and written literature. This review aimed at gathering scientific literature about Cistus species, describing phytochemical profiles and the various pharmacological activities. We also extensively reviewed the antimicrobial activities, including antiviral, antiparasitic, antifungal, and antibacterial potentials of Essential Oils (EO), raw extracts as well as isolated compounds. Mechanisms of action along with methods used are also investigated in this review. Considering the findings of the Cistus species extracts, this genus offers an adequate reserve of active phytochemicals since many have been used to create drugs. Therefore, this review work can serve society by providing a global view on Cistus L. sp. regarding pharmacological potentials and their chemical profiles.

scholarly journals Natural Products, Traditional Uses and Pharmacological Activities of the Genus Biebersteinia (Biebersteiniaceae)

Plants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 595 ◽  
Author(s):  
Benyin Zhang ◽  
Xiaona Jin ◽  
Hengxia Yin ◽  
Dejun Zhang ◽  
Huakun Zhou ◽  
...  
Keyword(s):  
Natural Products ◽  
Molecular Mechanisms ◽  
Chemical Properties ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Drug Discovery And Development ◽  
Chemical Structures ◽  
Traditional Uses ◽  
Novel Drugs ◽  
Major Chemical

Medicinal plants have been known as a rich source of natural products (NPs). Due to their diverse chemical structures and remarkable pharmacological activities, NPs are regarded as important repertoires for drug discovery and development. Biebersteinia plant species belong to the Biebersteiniaceae family, and have been used in folk medicines in China and Iran for ages. However, the chemical properties, bioactivities and modes of action of the NPs produced by medicinal Biebersteinia species are poorly understood despite the fact that there are only four known Biebersteinia species worldwide. Here, we reviewed the chemical classifications and diversity of the various NPs found in the four known Biebersteinia species. We found that the major chemical categories in these plants include flavonoids, alkaloids, phenylpropanoids, terpenoids, essential oils and fatty acids. We also discussed the anti-inflammatory, analgesic, antibacterial, antioxidant, antihypertensive and hypoglycemic effects of the four Biebersteinia species. We believe that the present review will facilitate the exploration of traditional uses and pharmacological properties of Biebersteinia species, extraction of the NPs and elucidation of their molecular mechanisms, as well as the development of novel drugs based on the reported properties and mode-of-action.

scholarly journals Trypanocidal Essential Oils: A Review

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4568 ◽  
Author(s):  
Mayara Castro de Morais ◽  
Jucieudo Virgulino de Souza ◽  
Carlos da Silva Maia Bezerra Filho ◽  
Silvio Santana Dolabella ◽  
Damião Pergentino de Sousa
Keyword(s):  
Experimental Data ◽  
Natural Products ◽  
Essential Oils ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Mechanisms Of Action ◽  
New Drugs ◽  
Important Group

Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical constituents and mechanisms of action are also discussed. In vitro and in vivo experimental data show the therapeutic potential of these natural products for the treatment of infections caused by species of Trypanosoma.

Recent investigations of bioactive natural products from endophytic, marine-derived, insect pathogenic fungi and Thai medicinal plants

2014 ◽  
Vol 86 (6) ◽  
pp. 979-993 ◽  
Author(s):  
Chulabhorn Mahidol ◽  
Prasat Kittakoop ◽  
Vilailak Prachyawarakorn ◽  
Phanruethai Pailee ◽  
Hunsa Prawat ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Biological Activities ◽  
Geographical Location ◽  
Pathogenic Fungi ◽  
Biologically Active ◽  
Bioactive Substances ◽  
Bioactive Natural Products ◽  
Insect Pathogenic Fungi ◽  
Living Organisms

AbstractLiving organisms in Thailand are very diverse due to the unique geographical location of Thailand. The diversity of Thai bioresources has proven to be a rich source of biologically active compounds. The present review covers bioactive substances from Thai endophytic, marine-derived, insect pathogenic fungi and medicinal plants. Many new compounds isolated from Thai bioresources have diverse skeletons belonging to various classes of natural products. These compounds exhibited an array of biological activities, and some are of pharmaceutical interest. Bioactive compounds from Thai bioresources have not only attracted organic chemists to develop strategies for total synthesis, but also attracted (chemical) biologists to investigate the mechanisms of action. The chemistry and biology of some selected compounds are also discussed in this review.

Sign in / Sign up

Export Citation Format

Share Document